Kimura 3-parameter model with root distribution $\pi = \left(\frac{1}{4}, \frac{1}{4}, \frac{1}{4}, \frac{1}{4}\right)$.
The transition matrix associated with edge $i$ is of the form
$$M_j = \begin{pmatrix}
a_i & b_i & c_i & d_i\\
b_i & a_i & d_i & c_i\\
c_i & d_i & a_i & b_i\\
d_i & c_i & b_i & a_i
\end{pmatrix}$$ and the Fourier parameters are $\left(x_i, y_i, z_i, t_i\right)$ for all edges $i$.
For examples on how to load and use .mrdi files, please see our notions and notations page or refer to the official OSCAR documentation.
Tree 5-0-0-0-0-1-0
Evolutionary model
Summary
Dimension
-
Degree
-
Probability coordinates
256
Fourier coordinates
256
Dimension of Singular locus
-
Degree of Singular locus
-
ML degree
-
ED degree
-
Model parametrizations
Probability parametrization
This expression is too large to render. Here is the raw LaTeX:
$\begin{align}
p_{\texttt{ATTTT}} &= \frac{1}{4}(a_1a_3a_4a_5d_2d_6 + a_1a_6d_2d_3d_4d_5 + a_1b_3b_4b_5c_6d_2 + a_1b_6c_3c_4c_5d_2 + a_2a_3a_4a_5a_6d_1 + a_2b_3b_4b_5b_6d_1 + a_2c_3c_4c_5c_6d_1 + a_2d_1d_3d_4d_5d_6 + a_3a_4a_5b_1c_2c_6 + a_3a_4a_5b_2b_6c_1 + a_6b_1c_2c_3c_4c_5 + a_6b_2b_3b_4b_5c_1 + b_1b_3b_4b_5c_2d_6 + b_1b_6c_2d_3d_4d_5 + b_2c_1c_3c_4c_5d_6 + b_2c_1c_6d_3d_4d_5) \\[0.5em]
p_{\texttt{ATTTG}} &= \frac{1}{4}(a_1a_3a_4b_5d_2d_6 + a_1a_5b_3b_4c_6d_2 + a_1a_6c_5d_2d_3d_4 + a_1b_6c_3c_4d_2d_5 + a_2a_3a_4a_6b_5d_1 + a_2a_5b_3b_4b_6d_1 + a_2c_3c_4c_6d_1d_5 + a_2c_5d_1d_3d_4d_6 + a_3a_4b_1b_5c_2c_6 + a_3a_4b_2b_5b_6c_1 + a_5a_6b_2b_3b_4c_1 + a_5b_1b_3b_4c_2d_6 + a_6b_1c_2c_3c_4d_5 + b_1b_6c_2c_5d_3d_4 + b_2c_1c_3c_4d_5d_6 + b_2c_1c_5c_6d_3d_4) \\[0.5em]
p_{\texttt{ATTTC}} &= \frac{1}{4}(a_1a_3a_4c_5d_2d_6 + a_1a_5b_6c_3c_4d_2 + a_1a_6b_5d_2d_3d_4 + a_1b_3b_4c_6d_2d_5 + a_2a_3a_4a_6c_5d_1 + a_2a_5c_3c_4c_6d_1 + a_2b_3b_4b_6d_1d_5 + a_2b_5d_1d_3d_4d_6 + a_3a_4b_1c_2c_5c_6 + a_3a_4b_2b_6c_1c_5 + a_5a_6b_1c_2c_3c_4 + a_5b_2c_1c_3c_4d_6 + a_6b_2b_3b_4c_1d_5 + b_1b_3b_4c_2d_5d_6 + b_1b_5b_6c_2d_3d_4 + b_2b_5c_1c_6d_3d_4) \\[0.5em]
p_{\texttt{ATTTA}} &= \frac{1}{4}(a_1a_3a_4d_2d_5d_6 + a_1a_5a_6d_2d_3d_4 + a_1b_3b_4c_5c_6d_2 + a_1b_5b_6c_3c_4d_2 + a_2a_3a_4a_6d_1d_5 + a_2a_5d_1d_3d_4d_6 + a_2b_3b_4b_6c_5d_1 + a_2b_5c_3c_4c_6d_1 + a_3a_4b_1c_2c_6d_5 + a_3a_4b_2b_6c_1d_5 + a_5b_1b_6c_2d_3d_4 + a_5b_2c_1c_6d_3d_4 + a_6b_1b_5c_2c_3c_4 + a_6b_2b_3b_4c_1c_5 + b_1b_3b_4c_2c_5d_6 + b_2b_5c_1c_3c_4d_6) \\[0.5em]
p_{\texttt{ATTGT}} &= \frac{1}{4}(a_1a_3a_5b_4d_2d_6 + a_1a_4b_3b_5c_6d_2 + a_1a_6c_4d_2d_3d_5 + a_1b_6c_3c_5d_2d_4 + a_2a_3a_5a_6b_4d_1 + a_2a_4b_3b_5b_6d_1 + a_2c_3c_5c_6d_1d_4 + a_2c_4d_1d_3d_5d_6 + a_3a_5b_1b_4c_2c_6 + a_3a_5b_2b_4b_6c_1 + a_4a_6b_2b_3b_5c_1 + a_4b_1b_3b_5c_2d_6 + a_6b_1c_2c_3c_5d_4 + b_1b_6c_2c_4d_3d_5 + b_2c_1c_3c_5d_4d_6 + b_2c_1c_4c_6d_3d_5) \\[0.5em]
p_{\texttt{ATTGG}} &= \frac{1}{4}(a_1a_3b_4b_5d_2d_6 + a_1a_4a_5b_3c_6d_2 + a_1a_6c_4c_5d_2d_3 + a_1b_6c_3d_2d_4d_5 + a_2a_3a_6b_4b_5d_1 + a_2a_4a_5b_3b_6d_1 + a_2c_3c_6d_1d_4d_5 + a_2c_4c_5d_1d_3d_6 + a_3b_1b_4b_5c_2c_6 + a_3b_2b_4b_5b_6c_1 + a_4a_5a_6b_2b_3c_1 + a_4a_5b_1b_3c_2d_6 + a_6b_1c_2c_3d_4d_5 + b_1b_6c_2c_4c_5d_3 + b_2c_1c_3d_4d_5d_6 + b_2c_1c_4c_5c_6d_3) \\[0.5em]
p_{\texttt{ATTGC}} &= \frac{1}{4}(a_1a_3b_4c_5d_2d_6 + a_1a_4b_3c_6d_2d_5 + a_1a_5b_6c_3d_2d_4 + a_1a_6b_5c_4d_2d_3 + a_2a_3a_6b_4c_5d_1 + a_2a_4b_3b_6d_1d_5 + a_2a_5c_3c_6d_1d_4 + a_2b_5c_4d_1d_3d_6 + a_3b_1b_4c_2c_5c_6 + a_3b_2b_4b_6c_1c_5 + a_4a_6b_2b_3c_1d_5 + a_4b_1b_3c_2d_5d_6 + a_5a_6b_1c_2c_3d_4 + a_5b_2c_1c_3d_4d_6 + b_1b_5b_6c_2c_4d_3 + b_2b_5c_1c_4c_6d_3) \\[0.5em]
p_{\texttt{ATTGA}} &= \frac{1}{4}(a_1a_3b_4d_2d_5d_6 + a_1a_4b_3c_5c_6d_2 + a_1a_5a_6c_4d_2d_3 + a_1b_5b_6c_3d_2d_4 + a_2a_3a_6b_4d_1d_5 + a_2a_4b_3b_6c_5d_1 + a_2a_5c_4d_1d_3d_6 + a_2b_5c_3c_6d_1d_4 + a_3b_1b_4c_2c_6d_5 + a_3b_2b_4b_6c_1d_5 + a_4a_6b_2b_3c_1c_5 + a_4b_1b_3c_2c_5d_6 + a_5b_1b_6c_2c_4d_3 + a_5b_2c_1c_4c_6d_3 + a_6b_1b_5c_2c_3d_4 + b_2b_5c_1c_3d_4d_6) \\[0.5em]
p_{\texttt{ATTCT}} &= \frac{1}{4}(a_1a_3a_5c_4d_2d_6 + a_1a_4b_6c_3c_5d_2 + a_1a_6b_4d_2d_3d_5 + a_1b_3b_5c_6d_2d_4 + a_2a_3a_5a_6c_4d_1 + a_2a_4c_3c_5c_6d_1 + a_2b_3b_5b_6d_1d_4 + a_2b_4d_1d_3d_5d_6 + a_3a_5b_1c_2c_4c_6 + a_3a_5b_2b_6c_1c_4 + a_4a_6b_1c_2c_3c_5 + a_4b_2c_1c_3c_5d_6 + a_6b_2b_3b_5c_1d_4 + b_1b_3b_5c_2d_4d_6 + b_1b_4b_6c_2d_3d_5 + b_2b_4c_1c_6d_3d_5) \\[0.5em]
p_{\texttt{ATTCG}} &= \frac{1}{4}(a_1a_3b_5c_4d_2d_6 + a_1a_4b_6c_3d_2d_5 + a_1a_5b_3c_6d_2d_4 + a_1a_6b_4c_5d_2d_3 + a_2a_3a_6b_5c_4d_1 + a_2a_4c_3c_6d_1d_5 + a_2a_5b_3b_6d_1d_4 + a_2b_4c_5d_1d_3d_6 + a_3b_1b_5c_2c_4c_6 + a_3b_2b_5b_6c_1c_4 + a_4a_6b_1c_2c_3d_5 + a_4b_2c_1c_3d_5d_6 + a_5a_6b_2b_3c_1d_4 + a_5b_1b_3c_2d_4d_6 + b_1b_4b_6c_2c_5d_3 + b_2b_4c_1c_5c_6d_3) \\[0.5em]
p_{\texttt{ATTCC}} &= \frac{1}{4}(a_1a_3c_4c_5d_2d_6 + a_1a_4a_5b_6c_3d_2 + a_1a_6b_4b_5d_2d_3 + a_1b_3c_6d_2d_4d_5 + a_2a_3a_6c_4c_5d_1 + a_2a_4a_5c_3c_6d_1 + a_2b_3b_6d_1d_4d_5 + a_2b_4b_5d_1d_3d_6 + a_3b_1c_2c_4c_5c_6 + a_3b_2b_6c_1c_4c_5 + a_4a_5a_6b_1c_2c_3 + a_4a_5b_2c_1c_3d_6 + a_6b_2b_3c_1d_4d_5 + b_1b_3c_2d_4d_5d_6 + b_1b_4b_5b_6c_2d_3 + b_2b_4b_5c_1c_6d_3) \\[0.5em]
p_{\texttt{ATTCA}} &= \frac{1}{4}(a_1a_3c_4d_2d_5d_6 + a_1a_4b_5b_6c_3d_2 + a_1a_5a_6b_4d_2d_3 + a_1b_3c_5c_6d_2d_4 + a_2a_3a_6c_4d_1d_5 + a_2a_4b_5c_3c_6d_1 + a_2a_5b_4d_1d_3d_6 + a_2b_3b_6c_5d_1d_4 + a_3b_1c_2c_4c_6d_5 + a_3b_2b_6c_1c_4d_5 + a_4a_6b_1b_5c_2c_3 + a_4b_2b_5c_1c_3d_6 + a_5b_1b_4b_6c_2d_3 + a_5b_2b_4c_1c_6d_3 + a_6b_2b_3c_1c_5d_4 + b_1b_3c_2c_5d_4d_6) \\[0.5em]
p_{\texttt{ATTAT}} &= \frac{1}{4}(a_1a_3a_5d_2d_4d_6 + a_1a_4a_6d_2d_3d_5 + a_1b_3b_5c_4c_6d_2 + a_1b_4b_6c_3c_5d_2 + a_2a_3a_5a_6d_1d_4 + a_2a_4d_1d_3d_5d_6 + a_2b_3b_5b_6c_4d_1 + a_2b_4c_3c_5c_6d_1 + a_3a_5b_1c_2c_6d_4 + a_3a_5b_2b_6c_1d_4 + a_4b_1b_6c_2d_3d_5 + a_4b_2c_1c_6d_3d_5 + a_6b_1b_4c_2c_3c_5 + a_6b_2b_3b_5c_1c_4 + b_1b_3b_5c_2c_4d_6 + b_2b_4c_1c_3c_5d_6) \\[0.5em]
p_{\texttt{ATTAG}} &= \frac{1}{4}(a_1a_3b_5d_2d_4d_6 + a_1a_4a_6c_5d_2d_3 + a_1a_5b_3c_4c_6d_2 + a_1b_4b_6c_3d_2d_5 + a_2a_3a_6b_5d_1d_4 + a_2a_4c_5d_1d_3d_6 + a_2a_5b_3b_6c_4d_1 + a_2b_4c_3c_6d_1d_5 + a_3b_1b_5c_2c_6d_4 + a_3b_2b_5b_6c_1d_4 + a_4b_1b_6c_2c_5d_3 + a_4b_2c_1c_5c_6d_3 + a_5a_6b_2b_3c_1c_4 + a_5b_1b_3c_2c_4d_6 + a_6b_1b_4c_2c_3d_5 + b_2b_4c_1c_3d_5d_6) \\[0.5em]
p_{\texttt{ATTAC}} &= \frac{1}{4}(a_1a_3c_5d_2d_4d_6 + a_1a_4a_6b_5d_2d_3 + a_1a_5b_4b_6c_3d_2 + a_1b_3c_4c_6d_2d_5 + a_2a_3a_6c_5d_1d_4 + a_2a_4b_5d_1d_3d_6 + a_2a_5b_4c_3c_6d_1 + a_2b_3b_6c_4d_1d_5 + a_3b_1c_2c_5c_6d_4 + a_3b_2b_6c_1c_5d_4 + a_4b_1b_5b_6c_2d_3 + a_4b_2b_5c_1c_6d_3 + a_5a_6b_1b_4c_2c_3 + a_5b_2b_4c_1c_3d_6 + a_6b_2b_3c_1c_4d_5 + b_1b_3c_2c_4d_5d_6) \\[0.5em]
p_{\texttt{ATTAA}} &= \frac{1}{4}(a_1a_3d_2d_4d_5d_6 + a_1a_4a_5a_6d_2d_3 + a_1b_3c_4c_5c_6d_2 + a_1b_4b_5b_6c_3d_2 + a_2a_3a_6d_1d_4d_5 + a_2a_4a_5d_1d_3d_6 + a_2b_3b_6c_4c_5d_1 + a_2b_4b_5c_3c_6d_1 + a_3b_1c_2c_6d_4d_5 + a_3b_2b_6c_1d_4d_5 + a_4a_5b_1b_6c_2d_3 + a_4a_5b_2c_1c_6d_3 + a_6b_1b_4b_5c_2c_3 + a_6b_2b_3c_1c_4c_5 + b_1b_3c_2c_4c_5d_6 + b_2b_4b_5c_1c_3d_6) \\[0.5em]
p_{\texttt{ATGTT}} &= \frac{1}{4}(a_1a_3b_4b_5c_6d_2 + a_1a_4a_5b_3d_2d_6 + a_1a_6c_3d_2d_4d_5 + a_1b_6c_4c_5d_2d_3 + a_2a_3b_4b_5b_6d_1 + a_2a_4a_5a_6b_3d_1 + a_2c_3d_1d_4d_5d_6 + a_2c_4c_5c_6d_1d_3 + a_3a_6b_2b_4b_5c_1 + a_3b_1b_4b_5c_2d_6 + a_4a_5b_1b_3c_2c_6 + a_4a_5b_2b_3b_6c_1 + a_6b_1c_2c_4c_5d_3 + b_1b_6c_2c_3d_4d_5 + b_2c_1c_3c_6d_4d_5 + b_2c_1c_4c_5d_3d_6) \\[0.5em]
p_{\texttt{ATGTG}} &= \frac{1}{4}(a_1a_3a_5b_4c_6d_2 + a_1a_4b_3b_5d_2d_6 + a_1a_6c_3c_5d_2d_4 + a_1b_6c_4d_2d_3d_5 + a_2a_3a_5b_4b_6d_1 + a_2a_4a_6b_3b_5d_1 + a_2c_3c_5d_1d_4d_6 + a_2c_4c_6d_1d_3d_5 + a_3a_5a_6b_2b_4c_1 + a_3a_5b_1b_4c_2d_6 + a_4b_1b_3b_5c_2c_6 + a_4b_2b_3b_5b_6c_1 + a_6b_1c_2c_4d_3d_5 + b_1b_6c_2c_3c_5d_4 + b_2c_1c_3c_5c_6d_4 + b_2c_1c_4d_3d_5d_6) \\[0.5em]
p_{\texttt{ATGTC}} &= \frac{1}{4}(a_1a_3b_4c_6d_2d_5 + a_1a_4b_3c_5d_2d_6 + a_1a_5b_6c_4d_2d_3 + a_1a_6b_5c_3d_2d_4 + a_2a_3b_4b_6d_1d_5 + a_2a_4a_6b_3c_5d_1 + a_2a_5c_4c_6d_1d_3 + a_2b_5c_3d_1d_4d_6 + a_3a_6b_2b_4c_1d_5 + a_3b_1b_4c_2d_5d_6 + a_4b_1b_3c_2c_5c_6 + a_4b_2b_3b_6c_1c_5 + a_5a_6b_1c_2c_4d_3 + a_5b_2c_1c_4d_3d_6 + b_1b_5b_6c_2c_3d_4 + b_2b_5c_1c_3c_6d_4) \\[0.5em]
p_{\texttt{ATGTA}} &= \frac{1}{4}(a_1a_3b_4c_5c_6d_2 + a_1a_4b_3d_2d_5d_6 + a_1a_5a_6c_3d_2d_4 + a_1b_5b_6c_4d_2d_3 + a_2a_3b_4b_6c_5d_1 + a_2a_4a_6b_3d_1d_5 + a_2a_5c_3d_1d_4d_6 + a_2b_5c_4c_6d_1d_3 + a_3a_6b_2b_4c_1c_5 + a_3b_1b_4c_2c_5d_6 + a_4b_1b_3c_2c_6d_5 + a_4b_2b_3b_6c_1d_5 + a_5b_1b_6c_2c_3d_4 + a_5b_2c_1c_3c_6d_4 + a_6b_1b_5c_2c_4d_3 + b_2b_5c_1c_4d_3d_6) \\[0.5em]
p_{\texttt{ATGGT}} &= \frac{1}{4}(a_1a_3a_4b_5c_6d_2 + a_1a_5b_3b_4d_2d_6 + a_1a_6c_3c_4d_2d_5 + a_1b_6c_5d_2d_3d_4 + a_2a_3a_4b_5b_6d_1 + a_2a_5a_6b_3b_4d_1 + a_2c_3c_4d_1d_5d_6 + a_2c_5c_6d_1d_3d_4 + a_3a_4a_6b_2b_5c_1 + a_3a_4b_1b_5c_2d_6 + a_5b_1b_3b_4c_2c_6 + a_5b_2b_3b_4b_6c_1 + a_6b_1c_2c_5d_3d_4 + b_1b_6c_2c_3c_4d_5 + b_2c_1c_3c_4c_6d_5 + b_2c_1c_5d_3d_4d_6) \\[0.5em]
p_{\texttt{ATGGG}} &= \frac{1}{4}(a_1a_3a_4a_5c_6d_2 + a_1a_6c_3c_4c_5d_2 + a_1b_3b_4b_5d_2d_6 + a_1b_6d_2d_3d_4d_5 + a_2a_3a_4a_5b_6d_1 + a_2a_6b_3b_4b_5d_1 + a_2c_3c_4c_5d_1d_6 + a_2c_6d_1d_3d_4d_5 + a_3a_4a_5a_6b_2c_1 + a_3a_4a_5b_1c_2d_6 + a_6b_1c_2d_3d_4d_5 + b_1b_3b_4b_5c_2c_6 + b_1b_6c_2c_3c_4c_5 + b_2b_3b_4b_5b_6c_1 + b_2c_1c_3c_4c_5c_6 + b_2c_1d_3d_4d_5d_6) \\[0.5em]
p_{\texttt{ATGGC}} &= \frac{1}{4}(a_1a_3a_4c_6d_2d_5 + a_1a_5b_6d_2d_3d_4 + a_1a_6b_5c_3c_4d_2 + a_1b_3b_4c_5d_2d_6 + a_2a_3a_4b_6d_1d_5 + a_2a_5c_6d_1d_3d_4 + a_2a_6b_3b_4c_5d_1 + a_2b_5c_3c_4d_1d_6 + a_3a_4a_6b_2c_1d_5 + a_3a_4b_1c_2d_5d_6 + a_5a_6b_1c_2d_3d_4 + a_5b_2c_1d_3d_4d_6 + b_1b_3b_4c_2c_5c_6 + b_1b_5b_6c_2c_3c_4 + b_2b_3b_4b_6c_1c_5 + b_2b_5c_1c_3c_4c_6) \\[0.5em]
p_{\texttt{ATGGA}} &= \frac{1}{4}(a_1a_3a_4c_5c_6d_2 + a_1a_5a_6c_3c_4d_2 + a_1b_3b_4d_2d_5d_6 + a_1b_5b_6d_2d_3d_4 + a_2a_3a_4b_6c_5d_1 + a_2a_5c_3c_4d_1d_6 + a_2a_6b_3b_4d_1d_5 + a_2b_5c_6d_1d_3d_4 + a_3a_4a_6b_2c_1c_5 + a_3a_4b_1c_2c_5d_6 + a_5b_1b_6c_2c_3c_4 + a_5b_2c_1c_3c_4c_6 + a_6b_1b_5c_2d_3d_4 + b_1b_3b_4c_2c_6d_5 + b_2b_3b_4b_6c_1d_5 + b_2b_5c_1d_3d_4d_6) \\[0.5em]
p_{\texttt{ATGCT}} &= \frac{1}{4}(a_1a_3b_5c_6d_2d_4 + a_1a_4b_6c_5d_2d_3 + a_1a_5b_3c_4d_2d_6 + a_1a_6b_4c_3d_2d_5 + a_2a_3b_5b_6d_1d_4 + a_2a_4c_5c_6d_1d_3 + a_2a_5a_6b_3c_4d_1 + a_2b_4c_3d_1d_5d_6 + a_3a_6b_2b_5c_1d_4 + a_3b_1b_5c_2d_4d_6 + a_4a_6b_1c_2c_5d_3 + a_4b_2c_1c_5d_3d_6 + a_5b_1b_3c_2c_4c_6 + a_5b_2b_3b_6c_1c_4 + b_1b_4b_6c_2c_3d_5 + b_2b_4c_1c_3c_6d_5) \\[0.5em]
p_{\texttt{ATGCG}} &= \frac{1}{4}(a_1a_3a_5c_6d_2d_4 + a_1a_4b_6d_2d_3d_5 + a_1a_6b_4c_3c_5d_2 + a_1b_3b_5c_4d_2d_6 + a_2a_3a_5b_6d_1d_4 + a_2a_4c_6d_1d_3d_5 + a_2a_6b_3b_5c_4d_1 + a_2b_4c_3c_5d_1d_6 + a_3a_5a_6b_2c_1d_4 + a_3a_5b_1c_2d_4d_6 + a_4a_6b_1c_2d_3d_5 + a_4b_2c_1d_3d_5d_6 + b_1b_3b_5c_2c_4c_6 + b_1b_4b_6c_2c_3c_5 + b_2b_3b_5b_6c_1c_4 + b_2b_4c_1c_3c_5c_6) \\[0.5em]
p_{\texttt{ATGCC}} &= \frac{1}{4}(a_1a_3c_6d_2d_4d_5 + a_1a_4a_5b_6d_2d_3 + a_1a_6b_4b_5c_3d_2 + a_1b_3c_4c_5d_2d_6 + a_2a_3b_6d_1d_4d_5 + a_2a_4a_5c_6d_1d_3 + a_2a_6b_3c_4c_5d_1 + a_2b_4b_5c_3d_1d_6 + a_3a_6b_2c_1d_4d_5 + a_3b_1c_2d_4d_5d_6 + a_4a_5a_6b_1c_2d_3 + a_4a_5b_2c_1d_3d_6 + b_1b_3c_2c_4c_5c_6 + b_1b_4b_5b_6c_2c_3 + b_2b_3b_6c_1c_4c_5 + b_2b_4b_5c_1c_3c_6) \\[0.5em]
p_{\texttt{ATGCA}} &= \frac{1}{4}(a_1a_3c_5c_6d_2d_4 + a_1a_4b_5b_6d_2d_3 + a_1a_5a_6b_4c_3d_2 + a_1b_3c_4d_2d_5d_6 + a_2a_3b_6c_5d_1d_4 + a_2a_4b_5c_6d_1d_3 + a_2a_5b_4c_3d_1d_6 + a_2a_6b_3c_4d_1d_5 + a_3a_6b_2c_1c_5d_4 + a_3b_1c_2c_5d_4d_6 + a_4a_6b_1b_5c_2d_3 + a_4b_2b_5c_1d_3d_6 + a_5b_1b_4b_6c_2c_3 + a_5b_2b_4c_1c_3c_6 + b_1b_3c_2c_4c_6d_5 + b_2b_3b_6c_1c_4d_5) \\[0.5em]
p_{\texttt{ATGAT}} &= \frac{1}{4}(a_1a_3b_5c_4c_6d_2 + a_1a_4a_6c_3d_2d_5 + a_1a_5b_3d_2d_4d_6 + a_1b_4b_6c_5d_2d_3 + a_2a_3b_5b_6c_4d_1 + a_2a_4c_3d_1d_5d_6 + a_2a_5a_6b_3d_1d_4 + a_2b_4c_5c_6d_1d_3 + a_3a_6b_2b_5c_1c_4 + a_3b_1b_5c_2c_4d_6 + a_4b_1b_6c_2c_3d_5 + a_4b_2c_1c_3c_6d_5 + a_5b_1b_3c_2c_6d_4 + a_5b_2b_3b_6c_1d_4 + a_6b_1b_4c_2c_5d_3 + b_2b_4c_1c_5d_3d_6) \\[0.5em]
p_{\texttt{ATGAG}} &= \frac{1}{4}(a_1a_3a_5c_4c_6d_2 + a_1a_4a_6c_3c_5d_2 + a_1b_3b_5d_2d_4d_6 + a_1b_4b_6d_2d_3d_5 + a_2a_3a_5b_6c_4d_1 + a_2a_4c_3c_5d_1d_6 + a_2a_6b_3b_5d_1d_4 + a_2b_4c_6d_1d_3d_5 + a_3a_5a_6b_2c_1c_4 + a_3a_5b_1c_2c_4d_6 + a_4b_1b_6c_2c_3c_5 + a_4b_2c_1c_3c_5c_6 + a_6b_1b_4c_2d_3d_5 + b_1b_3b_5c_2c_6d_4 + b_2b_3b_5b_6c_1d_4 + b_2b_4c_1d_3d_5d_6) \\[0.5em]
p_{\texttt{ATGAC}} &= \frac{1}{4}(a_1a_3c_4c_6d_2d_5 + a_1a_4a_6b_5c_3d_2 + a_1a_5b_4b_6d_2d_3 + a_1b_3c_5d_2d_4d_6 + a_2a_3b_6c_4d_1d_5 + a_2a_4b_5c_3d_1d_6 + a_2a_5b_4c_6d_1d_3 + a_2a_6b_3c_5d_1d_4 + a_3a_6b_2c_1c_4d_5 + a_3b_1c_2c_4d_5d_6 + a_4b_1b_5b_6c_2c_3 + a_4b_2b_5c_1c_3c_6 + a_5a_6b_1b_4c_2d_3 + a_5b_2b_4c_1d_3d_6 + b_1b_3c_2c_5c_6d_4 + b_2b_3b_6c_1c_5d_4) \\[0.5em]
p_{\texttt{ATGAA}} &= \frac{1}{4}(a_1a_3c_4c_5c_6d_2 + a_1a_4a_5a_6c_3d_2 + a_1b_3d_2d_4d_5d_6 + a_1b_4b_5b_6d_2d_3 + a_2a_3b_6c_4c_5d_1 + a_2a_4a_5c_3d_1d_6 + a_2a_6b_3d_1d_4d_5 + a_2b_4b_5c_6d_1d_3 + a_3a_6b_2c_1c_4c_5 + a_3b_1c_2c_4c_5d_6 + a_4a_5b_1b_6c_2c_3 + a_4a_5b_2c_1c_3c_6 + a_6b_1b_4b_5c_2d_3 + b_1b_3c_2c_6d_4d_5 + b_2b_3b_6c_1d_4d_5 + b_2b_4b_5c_1d_3d_6) \\[0.5em]
p_{\texttt{ATCTT}} &= \frac{1}{4}(a_1a_3b_6c_4c_5d_2 + a_1a_4a_5c_3d_2d_6 + a_1a_6b_3d_2d_4d_5 + a_1b_4b_5c_6d_2d_3 + a_2a_3c_4c_5c_6d_1 + a_2a_4a_5a_6c_3d_1 + a_2b_3d_1d_4d_5d_6 + a_2b_4b_5b_6d_1d_3 + a_3a_6b_1c_2c_4c_5 + a_3b_2c_1c_4c_5d_6 + a_4a_5b_1c_2c_3c_6 + a_4a_5b_2b_6c_1c_3 + a_6b_2b_4b_5c_1d_3 + b_1b_3b_6c_2d_4d_5 + b_1b_4b_5c_2d_3d_6 + b_2b_3c_1c_6d_4d_5) \\[0.5em]
p_{\texttt{ATCTG}} &= \frac{1}{4}(a_1a_3b_6c_4d_2d_5 + a_1a_4b_5c_3d_2d_6 + a_1a_5b_4c_6d_2d_3 + a_1a_6b_3c_5d_2d_4 + a_2a_3c_4c_6d_1d_5 + a_2a_4a_6b_5c_3d_1 + a_2a_5b_4b_6d_1d_3 + a_2b_3c_5d_1d_4d_6 + a_3a_6b_1c_2c_4d_5 + a_3b_2c_1c_4d_5d_6 + a_4b_1b_5c_2c_3c_6 + a_4b_2b_5b_6c_1c_3 + a_5a_6b_2b_4c_1d_3 + a_5b_1b_4c_2d_3d_6 + b_1b_3b_6c_2c_5d_4 + b_2b_3c_1c_5c_6d_4) \\[0.5em]
p_{\texttt{ATCTC}} &= \frac{1}{4}(a_1a_3a_5b_6c_4d_2 + a_1a_4c_3c_5d_2d_6 + a_1a_6b_3b_5d_2d_4 + a_1b_4c_6d_2d_3d_5 + a_2a_3a_5c_4c_6d_1 + a_2a_4a_6c_3c_5d_1 + a_2b_3b_5d_1d_4d_6 + a_2b_4b_6d_1d_3d_5 + a_3a_5a_6b_1c_2c_4 + a_3a_5b_2c_1c_4d_6 + a_4b_1c_2c_3c_5c_6 + a_4b_2b_6c_1c_3c_5 + a_6b_2b_4c_1d_3d_5 + b_1b_3b_5b_6c_2d_4 + b_1b_4c_2d_3d_5d_6 + b_2b_3b_5c_1c_6d_4) \\[0.5em]
p_{\texttt{ATCTA}} &= \frac{1}{4}(a_1a_3b_5b_6c_4d_2 + a_1a_4c_3d_2d_5d_6 + a_1a_5a_6b_3d_2d_4 + a_1b_4c_5c_6d_2d_3 + a_2a_3b_5c_4c_6d_1 + a_2a_4a_6c_3d_1d_5 + a_2a_5b_3d_1d_4d_6 + a_2b_4b_6c_5d_1d_3 + a_3a_6b_1b_5c_2c_4 + a_3b_2b_5c_1c_4d_6 + a_4b_1c_2c_3c_6d_5 + a_4b_2b_6c_1c_3d_5 + a_5b_1b_3b_6c_2d_4 + a_5b_2b_3c_1c_6d_4 + a_6b_2b_4c_1c_5d_3 + b_1b_4c_2c_5d_3d_6) \\[0.5em]
p_{\texttt{ATCGT}} &= \frac{1}{4}(a_1a_3b_6c_5d_2d_4 + a_1a_4b_5c_6d_2d_3 + a_1a_5b_4c_3d_2d_6 + a_1a_6b_3c_4d_2d_5 + a_2a_3c_5c_6d_1d_4 + a_2a_4b_5b_6d_1d_3 + a_2a_5a_6b_4c_3d_1 + a_2b_3c_4d_1d_5d_6 + a_3a_6b_1c_2c_5d_4 + a_3b_2c_1c_5d_4d_6 + a_4a_6b_2b_5c_1d_3 + a_4b_1b_5c_2d_3d_6 + a_5b_1b_4c_2c_3c_6 + a_5b_2b_4b_6c_1c_3 + b_1b_3b_6c_2c_4d_5 + b_2b_3c_1c_4c_6d_5) \\[0.5em]
p_{\texttt{ATCGG}} &= \frac{1}{4}(a_1a_3b_6d_2d_4d_5 + a_1a_4a_5c_6d_2d_3 + a_1a_6b_3c_4c_5d_2 + a_1b_4b_5c_3d_2d_6 + a_2a_3c_6d_1d_4d_5 + a_2a_4a_5b_6d_1d_3 + a_2a_6b_4b_5c_3d_1 + a_2b_3c_4c_5d_1d_6 + a_3a_6b_1c_2d_4d_5 + a_3b_2c_1d_4d_5d_6 + a_4a_5a_6b_2c_1d_3 + a_4a_5b_1c_2d_3d_6 + b_1b_3b_6c_2c_4c_5 + b_1b_4b_5c_2c_3c_6 + b_2b_3c_1c_4c_5c_6 + b_2b_4b_5b_6c_1c_3) \\[0.5em]
p_{\texttt{ATCGC}} &= \frac{1}{4}(a_1a_3a_5b_6d_2d_4 + a_1a_4c_6d_2d_3d_5 + a_1a_6b_3b_5c_4d_2 + a_1b_4c_3c_5d_2d_6 + a_2a_3a_5c_6d_1d_4 + a_2a_4b_6d_1d_3d_5 + a_2a_6b_4c_3c_5d_1 + a_2b_3b_5c_4d_1d_6 + a_3a_5a_6b_1c_2d_4 + a_3a_5b_2c_1d_4d_6 + a_4a_6b_2c_1d_3d_5 + a_4b_1c_2d_3d_5d_6 + b_1b_3b_5b_6c_2c_4 + b_1b_4c_2c_3c_5c_6 + b_2b_3b_5c_1c_4c_6 + b_2b_4b_6c_1c_3c_5) \\[0.5em]
p_{\texttt{ATCGA}} &= \frac{1}{4}(a_1a_3b_5b_6d_2d_4 + a_1a_4c_5c_6d_2d_3 + a_1a_5a_6b_3c_4d_2 + a_1b_4c_3d_2d_5d_6 + a_2a_3b_5c_6d_1d_4 + a_2a_4b_6c_5d_1d_3 + a_2a_5b_3c_4d_1d_6 + a_2a_6b_4c_3d_1d_5 + a_3a_6b_1b_5c_2d_4 + a_3b_2b_5c_1d_4d_6 + a_4a_6b_2c_1c_5d_3 + a_4b_1c_2c_5d_3d_6 + a_5b_1b_3b_6c_2c_4 + a_5b_2b_3c_1c_4c_6 + b_1b_4c_2c_3c_6d_5 + b_2b_4b_6c_1c_3d_5) \\[0.5em]
p_{\texttt{ATCCT}} &= \frac{1}{4}(a_1a_3a_4b_6c_5d_2 + a_1a_5c_3c_4d_2d_6 + a_1a_6b_3b_4d_2d_5 + a_1b_5c_6d_2d_3d_4 + a_2a_3a_4c_5c_6d_1 + a_2a_5a_6c_3c_4d_1 + a_2b_3b_4d_1d_5d_6 + a_2b_5b_6d_1d_3d_4 + a_3a_4a_6b_1c_2c_5 + a_3a_4b_2c_1c_5d_6 + a_5b_1c_2c_3c_4c_6 + a_5b_2b_6c_1c_3c_4 + a_6b_2b_5c_1d_3d_4 + b_1b_3b_4b_6c_2d_5 + b_1b_5c_2d_3d_4d_6 + b_2b_3b_4c_1c_6d_5) \\[0.5em]
p_{\texttt{ATCCG}} &= \frac{1}{4}(a_1a_3a_4b_6d_2d_5 + a_1a_5c_6d_2d_3d_4 + a_1a_6b_3b_4c_5d_2 + a_1b_5c_3c_4d_2d_6 + a_2a_3a_4c_6d_1d_5 + a_2a_5b_6d_1d_3d_4 + a_2a_6b_5c_3c_4d_1 + a_2b_3b_4c_5d_1d_6 + a_3a_4a_6b_1c_2d_5 + a_3a_4b_2c_1d_5d_6 + a_5a_6b_2c_1d_3d_4 + a_5b_1c_2d_3d_4d_6 + b_1b_3b_4b_6c_2c_5 + b_1b_5c_2c_3c_4c_6 + b_2b_3b_4c_1c_5c_6 + b_2b_5b_6c_1c_3c_4) \\[0.5em]
p_{\texttt{ATCCC}} &= \frac{1}{4}(a_1a_3a_4a_5b_6d_2 + a_1a_6b_3b_4b_5d_2 + a_1c_3c_4c_5d_2d_6 + a_1c_6d_2d_3d_4d_5 + a_2a_3a_4a_5c_6d_1 + a_2a_6c_3c_4c_5d_1 + a_2b_3b_4b_5d_1d_6 + a_2b_6d_1d_3d_4d_5 + a_3a_4a_5a_6b_1c_2 + a_3a_4a_5b_2c_1d_6 + a_6b_2c_1d_3d_4d_5 + b_1b_3b_4b_5b_6c_2 + b_1c_2c_3c_4c_5c_6 + b_1c_2d_3d_4d_5d_6 + b_2b_3b_4b_5c_1c_6 + b_2b_6c_1c_3c_4c_5) \\[0.5em]
p_{\texttt{ATCCA}} &= \frac{1}{4}(a_1a_3a_4b_5b_6d_2 + a_1a_5a_6b_3b_4d_2 + a_1c_3c_4d_2d_5d_6 + a_1c_5c_6d_2d_3d_4 + a_2a_3a_4b_5c_6d_1 + a_2a_5b_3b_4d_1d_6 + a_2a_6c_3c_4d_1d_5 + a_2b_6c_5d_1d_3d_4 + a_3a_4a_6b_1b_5c_2 + a_3a_4b_2b_5c_1d_6 + a_5b_1b_3b_4b_6c_2 + a_5b_2b_3b_4c_1c_6 + a_6b_2c_1c_5d_3d_4 + b_1c_2c_3c_4c_6d_5 + b_1c_2c_5d_3d_4d_6 + b_2b_6c_1c_3c_4d_5) \\[0.5em]
p_{\texttt{ATCAT}} &= \frac{1}{4}(a_1a_3b_4b_6c_5d_2 + a_1a_4a_6b_3d_2d_5 + a_1a_5c_3d_2d_4d_6 + a_1b_5c_4c_6d_2d_3 + a_2a_3b_4c_5c_6d_1 + a_2a_4b_3d_1d_5d_6 + a_2a_5a_6c_3d_1d_4 + a_2b_5b_6c_4d_1d_3 + a_3a_6b_1b_4c_2c_5 + a_3b_2b_4c_1c_5d_6 + a_4b_1b_3b_6c_2d_5 + a_4b_2b_3c_1c_6d_5 + a_5b_1c_2c_3c_6d_4 + a_5b_2b_6c_1c_3d_4 + a_6b_2b_5c_1c_4d_3 + b_1b_5c_2c_4d_3d_6) \\[0.5em]
p_{\texttt{ATCAG}} &= \frac{1}{4}(a_1a_3b_4b_6d_2d_5 + a_1a_4a_6b_3c_5d_2 + a_1a_5c_4c_6d_2d_3 + a_1b_5c_3d_2d_4d_6 + a_2a_3b_4c_6d_1d_5 + a_2a_4b_3c_5d_1d_6 + a_2a_5b_6c_4d_1d_3 + a_2a_6b_5c_3d_1d_4 + a_3a_6b_1b_4c_2d_5 + a_3b_2b_4c_1d_5d_6 + a_4b_1b_3b_6c_2c_5 + a_4b_2b_3c_1c_5c_6 + a_5a_6b_2c_1c_4d_3 + a_5b_1c_2c_4d_3d_6 + b_1b_5c_2c_3c_6d_4 + b_2b_5b_6c_1c_3d_4) \\[0.5em]
p_{\texttt{ATCAC}} &= \frac{1}{4}(a_1a_3a_5b_4b_6d_2 + a_1a_4a_6b_3b_5d_2 + a_1c_3c_5d_2d_4d_6 + a_1c_4c_6d_2d_3d_5 + a_2a_3a_5b_4c_6d_1 + a_2a_4b_3b_5d_1d_6 + a_2a_6c_3c_5d_1d_4 + a_2b_6c_4d_1d_3d_5 + a_3a_5a_6b_1b_4c_2 + a_3a_5b_2b_4c_1d_6 + a_4b_1b_3b_5b_6c_2 + a_4b_2b_3b_5c_1c_6 + a_6b_2c_1c_4d_3d_5 + b_1c_2c_3c_5c_6d_4 + b_1c_2c_4d_3d_5d_6 + b_2b_6c_1c_3c_5d_4) \\[0.5em]
p_{\texttt{ATCAA}} &= \frac{1}{4}(a_1a_3b_4b_5b_6d_2 + a_1a_4a_5a_6b_3d_2 + a_1c_3d_2d_4d_5d_6 + a_1c_4c_5c_6d_2d_3 + a_2a_3b_4b_5c_6d_1 + a_2a_4a_5b_3d_1d_6 + a_2a_6c_3d_1d_4d_5 + a_2b_6c_4c_5d_1d_3 + a_3a_6b_1b_4b_5c_2 + a_3b_2b_4b_5c_1d_6 + a_4a_5b_1b_3b_6c_2 + a_4a_5b_2b_3c_1c_6 + a_6b_2c_1c_4c_5d_3 + b_1c_2c_3c_6d_4d_5 + b_1c_2c_4c_5d_3d_6 + b_2b_6c_1c_3d_4d_5) \\[0.5em]
p_{\texttt{ATATT}} &= \frac{1}{4}(a_1a_3a_6d_2d_4d_5 + a_1a_4a_5d_2d_3d_6 + a_1b_3b_6c_4c_5d_2 + a_1b_4b_5c_3c_6d_2 + a_2a_3d_1d_4d_5d_6 + a_2a_4a_5a_6d_1d_3 + a_2b_3c_4c_5c_6d_1 + a_2b_4b_5b_6c_3d_1 + a_3b_1b_6c_2d_4d_5 + a_3b_2c_1c_6d_4d_5 + a_4a_5b_1c_2c_6d_3 + a_4a_5b_2b_6c_1d_3 + a_6b_1b_3c_2c_4c_5 + a_6b_2b_4b_5c_1c_3 + b_1b_4b_5c_2c_3d_6 + b_2b_3c_1c_4c_5d_6) \\[0.5em]
p_{\texttt{ATATG}} &= \frac{1}{4}(a_1a_3a_6c_5d_2d_4 + a_1a_4b_5d_2d_3d_6 + a_1a_5b_4c_3c_6d_2 + a_1b_3b_6c_4d_2d_5 + a_2a_3c_5d_1d_4d_6 + a_2a_4a_6b_5d_1d_3 + a_2a_5b_4b_6c_3d_1 + a_2b_3c_4c_6d_1d_5 + a_3b_1b_6c_2c_5d_4 + a_3b_2c_1c_5c_6d_4 + a_4b_1b_5c_2c_6d_3 + a_4b_2b_5b_6c_1d_3 + a_5a_6b_2b_4c_1c_3 + a_5b_1b_4c_2c_3d_6 + a_6b_1b_3c_2c_4d_5 + b_2b_3c_1c_4d_5d_6) \\[0.5em]
p_{\texttt{ATATC}} &= \frac{1}{4}(a_1a_3a_6b_5d_2d_4 + a_1a_4c_5d_2d_3d_6 + a_1a_5b_3b_6c_4d_2 + a_1b_4c_3c_6d_2d_5 + a_2a_3b_5d_1d_4d_6 + a_2a_4a_6c_5d_1d_3 + a_2a_5b_3c_4c_6d_1 + a_2b_4b_6c_3d_1d_5 + a_3b_1b_5b_6c_2d_4 + a_3b_2b_5c_1c_6d_4 + a_4b_1c_2c_5c_6d_3 + a_4b_2b_6c_1c_5d_3 + a_5a_6b_1b_3c_2c_4 + a_5b_2b_3c_1c_4d_6 + a_6b_2b_4c_1c_3d_5 + b_1b_4c_2c_3d_5d_6) \\[0.5em]
p_{\texttt{ATATA}} &= \frac{1}{4}(a_1a_3a_5a_6d_2d_4 + a_1a_4d_2d_3d_5d_6 + a_1b_3b_5b_6c_4d_2 + a_1b_4c_3c_5c_6d_2 + a_2a_3a_5d_1d_4d_6 + a_2a_4a_6d_1d_3d_5 + a_2b_3b_5c_4c_6d_1 + a_2b_4b_6c_3c_5d_1 + a_3a_5b_1b_6c_2d_4 + a_3a_5b_2c_1c_6d_4 + a_4b_1c_2c_6d_3d_5 + a_4b_2b_6c_1d_3d_5 + a_6b_1b_3b_5c_2c_4 + a_6b_2b_4c_1c_3c_5 + b_1b_4c_2c_3c_5d_6 + b_2b_3b_5c_1c_4d_6) \\[0.5em]
p_{\texttt{ATAGT}} &= \frac{1}{4}(a_1a_3a_6c_4d_2d_5 + a_1a_4b_5c_3c_6d_2 + a_1a_5b_4d_2d_3d_6 + a_1b_3b_6c_5d_2d_4 + a_2a_3c_4d_1d_5d_6 + a_2a_4b_5b_6c_3d_1 + a_2a_5a_6b_4d_1d_3 + a_2b_3c_5c_6d_1d_4 + a_3b_1b_6c_2c_4d_5 + a_3b_2c_1c_4c_6d_5 + a_4a_6b_2b_5c_1c_3 + a_4b_1b_5c_2c_3d_6 + a_5b_1b_4c_2c_6d_3 + a_5b_2b_4b_6c_1d_3 + a_6b_1b_3c_2c_5d_4 + b_2b_3c_1c_5d_4d_6) \\[0.5em]
p_{\texttt{ATAGG}} &= \frac{1}{4}(a_1a_3a_6c_4c_5d_2 + a_1a_4a_5c_3c_6d_2 + a_1b_3b_6d_2d_4d_5 + a_1b_4b_5d_2d_3d_6 + a_2a_3c_4c_5d_1d_6 + a_2a_4a_5b_6c_3d_1 + a_2a_6b_4b_5d_1d_3 + a_2b_3c_6d_1d_4d_5 + a_3b_1b_6c_2c_4c_5 + a_3b_2c_1c_4c_5c_6 + a_4a_5a_6b_2c_1c_3 + a_4a_5b_1c_2c_3d_6 + a_6b_1b_3c_2d_4d_5 + b_1b_4b_5c_2c_6d_3 + b_2b_3c_1d_4d_5d_6 + b_2b_4b_5b_6c_1d_3) \\[0.5em]
p_{\texttt{ATAGC}} &= \frac{1}{4}(a_1a_3a_6b_5c_4d_2 + a_1a_4c_3c_6d_2d_5 + a_1a_5b_3b_6d_2d_4 + a_1b_4c_5d_2d_3d_6 + a_2a_3b_5c_4d_1d_6 + a_2a_4b_6c_3d_1d_5 + a_2a_5b_3c_6d_1d_4 + a_2a_6b_4c_5d_1d_3 + a_3b_1b_5b_6c_2c_4 + a_3b_2b_5c_1c_4c_6 + a_4a_6b_2c_1c_3d_5 + a_4b_1c_2c_3d_5d_6 + a_5a_6b_1b_3c_2d_4 + a_5b_2b_3c_1d_4d_6 + b_1b_4c_2c_5c_6d_3 + b_2b_4b_6c_1c_5d_3) \\[0.5em]
p_{\texttt{ATAGA}} &= \frac{1}{4}(a_1a_3a_5a_6c_4d_2 + a_1a_4c_3c_5c_6d_2 + a_1b_3b_5b_6d_2d_4 + a_1b_4d_2d_3d_5d_6 + a_2a_3a_5c_4d_1d_6 + a_2a_4b_6c_3c_5d_1 + a_2a_6b_4d_1d_3d_5 + a_2b_3b_5c_6d_1d_4 + a_3a_5b_1b_6c_2c_4 + a_3a_5b_2c_1c_4c_6 + a_4a_6b_2c_1c_3c_5 + a_4b_1c_2c_3c_5d_6 + a_6b_1b_3b_5c_2d_4 + b_1b_4c_2c_6d_3d_5 + b_2b_3b_5c_1d_4d_6 + b_2b_4b_6c_1d_3d_5) \\[0.5em]
p_{\texttt{ATACT}} &= \frac{1}{4}(a_1a_3a_6b_4d_2d_5 + a_1a_4b_3b_6c_5d_2 + a_1a_5c_4d_2d_3d_6 + a_1b_5c_3c_6d_2d_4 + a_2a_3b_4d_1d_5d_6 + a_2a_4b_3c_5c_6d_1 + a_2a_5a_6c_4d_1d_3 + a_2b_5b_6c_3d_1d_4 + a_3b_1b_4b_6c_2d_5 + a_3b_2b_4c_1c_6d_5 + a_4a_6b_1b_3c_2c_5 + a_4b_2b_3c_1c_5d_6 + a_5b_1c_2c_4c_6d_3 + a_5b_2b_6c_1c_4d_3 + a_6b_2b_5c_1c_3d_4 + b_1b_5c_2c_3d_4d_6) \\[0.5em]
p_{\texttt{ATACG}} &= \frac{1}{4}(a_1a_3a_6b_4c_5d_2 + a_1a_4b_3b_6d_2d_5 + a_1a_5c_3c_6d_2d_4 + a_1b_5c_4d_2d_3d_6 + a_2a_3b_4c_5d_1d_6 + a_2a_4b_3c_6d_1d_5 + a_2a_5b_6c_3d_1d_4 + a_2a_6b_5c_4d_1d_3 + a_3b_1b_4b_6c_2c_5 + a_3b_2b_4c_1c_5c_6 + a_4a_6b_1b_3c_2d_5 + a_4b_2b_3c_1d_5d_6 + a_5a_6b_2c_1c_3d_4 + a_5b_1c_2c_3d_4d_6 + b_1b_5c_2c_4c_6d_3 + b_2b_5b_6c_1c_4d_3) \\[0.5em]
p_{\texttt{ATACC}} &= \frac{1}{4}(a_1a_3a_6b_4b_5d_2 + a_1a_4a_5b_3b_6d_2 + a_1c_3c_6d_2d_4d_5 + a_1c_4c_5d_2d_3d_6 + a_2a_3b_4b_5d_1d_6 + a_2a_4a_5b_3c_6d_1 + a_2a_6c_4c_5d_1d_3 + a_2b_6c_3d_1d_4d_5 + a_3b_1b_4b_5b_6c_2 + a_3b_2b_4b_5c_1c_6 + a_4a_5a_6b_1b_3c_2 + a_4a_5b_2b_3c_1d_6 + a_6b_2c_1c_3d_4d_5 + b_1c_2c_3d_4d_5d_6 + b_1c_2c_4c_5c_6d_3 + b_2b_6c_1c_4c_5d_3) \\[0.5em]
p_{\texttt{ATACA}} &= \frac{1}{4}(a_1a_3a_5a_6b_4d_2 + a_1a_4b_3b_5b_6d_2 + a_1c_3c_5c_6d_2d_4 + a_1c_4d_2d_3d_5d_6 + a_2a_3a_5b_4d_1d_6 + a_2a_4b_3b_5c_6d_1 + a_2a_6c_4d_1d_3d_5 + a_2b_6c_3c_5d_1d_4 + a_3a_5b_1b_4b_6c_2 + a_3a_5b_2b_4c_1c_6 + a_4a_6b_1b_3b_5c_2 + a_4b_2b_3b_5c_1d_6 + a_6b_2c_1c_3c_5d_4 + b_1c_2c_3c_5d_4d_6 + b_1c_2c_4c_6d_3d_5 + b_2b_6c_1c_4d_3d_5) \\[0.5em]
p_{\texttt{ATAAT}} &= \frac{1}{4}(a_1a_3a_4a_6d_2d_5 + a_1a_5d_2d_3d_4d_6 + a_1b_3b_4b_6c_5d_2 + a_1b_5c_3c_4c_6d_2 + a_2a_3a_4d_1d_5d_6 + a_2a_5a_6d_1d_3d_4 + a_2b_3b_4c_5c_6d_1 + a_2b_5b_6c_3c_4d_1 + a_3a_4b_1b_6c_2d_5 + a_3a_4b_2c_1c_6d_5 + a_5b_1c_2c_6d_3d_4 + a_5b_2b_6c_1d_3d_4 + a_6b_1b_3b_4c_2c_5 + a_6b_2b_5c_1c_3c_4 + b_1b_5c_2c_3c_4d_6 + b_2b_3b_4c_1c_5d_6) \\[0.5em]
p_{\texttt{ATAAG}} &= \frac{1}{4}(a_1a_3a_4a_6c_5d_2 + a_1a_5c_3c_4c_6d_2 + a_1b_3b_4b_6d_2d_5 + a_1b_5d_2d_3d_4d_6 + a_2a_3a_4c_5d_1d_6 + a_2a_5b_6c_3c_4d_1 + a_2a_6b_5d_1d_3d_4 + a_2b_3b_4c_6d_1d_5 + a_3a_4b_1b_6c_2c_5 + a_3a_4b_2c_1c_5c_6 + a_5a_6b_2c_1c_3c_4 + a_5b_1c_2c_3c_4d_6 + a_6b_1b_3b_4c_2d_5 + b_1b_5c_2c_6d_3d_4 + b_2b_3b_4c_1d_5d_6 + b_2b_5b_6c_1d_3d_4) \\[0.5em]
p_{\texttt{ATAAC}} &= \frac{1}{4}(a_1a_3a_4a_6b_5d_2 + a_1a_5b_3b_4b_6d_2 + a_1c_3c_4c_6d_2d_5 + a_1c_5d_2d_3d_4d_6 + a_2a_3a_4b_5d_1d_6 + a_2a_5b_3b_4c_6d_1 + a_2a_6c_5d_1d_3d_4 + a_2b_6c_3c_4d_1d_5 + a_3a_4b_1b_5b_6c_2 + a_3a_4b_2b_5c_1c_6 + a_5a_6b_1b_3b_4c_2 + a_5b_2b_3b_4c_1d_6 + a_6b_2c_1c_3c_4d_5 + b_1c_2c_3c_4d_5d_6 + b_1c_2c_5c_6d_3d_4 + b_2b_6c_1c_5d_3d_4) \\[0.5em]
p_{\texttt{ATAAA}} &= \frac{1}{4}(a_1a_3a_4a_5a_6d_2 + a_1b_3b_4b_5b_6d_2 + a_1c_3c_4c_5c_6d_2 + a_1d_2d_3d_4d_5d_6 + a_2a_3a_4a_5d_1d_6 + a_2a_6d_1d_3d_4d_5 + a_2b_3b_4b_5c_6d_1 + a_2b_6c_3c_4c_5d_1 + a_3a_4a_5b_1b_6c_2 + a_3a_4a_5b_2c_1c_6 + a_6b_1b_3b_4b_5c_2 + a_6b_2c_1c_3c_4c_5 + b_1c_2c_3c_4c_5d_6 + b_1c_2c_6d_3d_4d_5 + b_2b_3b_4b_5c_1d_6 + b_2b_6c_1d_3d_4d_5) \\[0.5em]
p_{\texttt{AGTTT}} &= \frac{1}{4}(a_1a_3a_4a_5c_2d_6 + a_1a_6c_2d_3d_4d_5 + a_1b_3b_4b_5c_2c_6 + a_1b_6c_2c_3c_4c_5 + a_2a_3a_4a_5b_6c_1 + a_2a_6b_3b_4b_5c_1 + a_2c_1c_3c_4c_5d_6 + a_2c_1c_6d_3d_4d_5 + a_3a_4a_5a_6b_2d_1 + a_3a_4a_5b_1c_6d_2 + a_6b_1c_3c_4c_5d_2 + b_1b_3b_4b_5d_2d_6 + b_1b_6d_2d_3d_4d_5 + b_2b_3b_4b_5b_6d_1 + b_2c_3c_4c_5c_6d_1 + b_2d_1d_3d_4d_5d_6) \\[0.5em]
p_{\texttt{AGTTG}} &= \frac{1}{4}(a_1a_3a_4b_5c_2d_6 + a_1a_5b_3b_4c_2c_6 + a_1a_6c_2c_5d_3d_4 + a_1b_6c_2c_3c_4d_5 + a_2a_3a_4b_5b_6c_1 + a_2a_5a_6b_3b_4c_1 + a_2c_1c_3c_4d_5d_6 + a_2c_1c_5c_6d_3d_4 + a_3a_4a_6b_2b_5d_1 + a_3a_4b_1b_5c_6d_2 + a_5b_1b_3b_4d_2d_6 + a_5b_2b_3b_4b_6d_1 + a_6b_1c_3c_4d_2d_5 + b_1b_6c_5d_2d_3d_4 + b_2c_3c_4c_6d_1d_5 + b_2c_5d_1d_3d_4d_6) \\[0.5em]
p_{\texttt{AGTTC}} &= \frac{1}{4}(a_1a_3a_4c_2c_5d_6 + a_1a_5b_6c_2c_3c_4 + a_1a_6b_5c_2d_3d_4 + a_1b_3b_4c_2c_6d_5 + a_2a_3a_4b_6c_1c_5 + a_2a_5c_1c_3c_4d_6 + a_2a_6b_3b_4c_1d_5 + a_2b_5c_1c_6d_3d_4 + a_3a_4a_6b_2c_5d_1 + a_3a_4b_1c_5c_6d_2 + a_5a_6b_1c_3c_4d_2 + a_5b_2c_3c_4c_6d_1 + b_1b_3b_4d_2d_5d_6 + b_1b_5b_6d_2d_3d_4 + b_2b_3b_4b_6d_1d_5 + b_2b_5d_1d_3d_4d_6) \\[0.5em]
p_{\texttt{AGTTA}} &= \frac{1}{4}(a_1a_3a_4c_2d_5d_6 + a_1a_5a_6c_2d_3d_4 + a_1b_3b_4c_2c_5c_6 + a_1b_5b_6c_2c_3c_4 + a_2a_3a_4b_6c_1d_5 + a_2a_5c_1c_6d_3d_4 + a_2a_6b_3b_4c_1c_5 + a_2b_5c_1c_3c_4d_6 + a_3a_4a_6b_2d_1d_5 + a_3a_4b_1c_6d_2d_5 + a_5b_1b_6d_2d_3d_4 + a_5b_2d_1d_3d_4d_6 + a_6b_1b_5c_3c_4d_2 + b_1b_3b_4c_5d_2d_6 + b_2b_3b_4b_6c_5d_1 + b_2b_5c_3c_4c_6d_1) \\[0.5em]
p_{\texttt{AGTGT}} &= \frac{1}{4}(a_1a_3a_5b_4c_2d_6 + a_1a_4b_3b_5c_2c_6 + a_1a_6c_2c_4d_3d_5 + a_1b_6c_2c_3c_5d_4 + a_2a_3a_5b_4b_6c_1 + a_2a_4a_6b_3b_5c_1 + a_2c_1c_3c_5d_4d_6 + a_2c_1c_4c_6d_3d_5 + a_3a_5a_6b_2b_4d_1 + a_3a_5b_1b_4c_6d_2 + a_4b_1b_3b_5d_2d_6 + a_4b_2b_3b_5b_6d_1 + a_6b_1c_3c_5d_2d_4 + b_1b_6c_4d_2d_3d_5 + b_2c_3c_5c_6d_1d_4 + b_2c_4d_1d_3d_5d_6) \\[0.5em]
p_{\texttt{AGTGG}} &= \frac{1}{4}(a_1a_3b_4b_5c_2d_6 + a_1a_4a_5b_3c_2c_6 + a_1a_6c_2c_4c_5d_3 + a_1b_6c_2c_3d_4d_5 + a_2a_3b_4b_5b_6c_1 + a_2a_4a_5a_6b_3c_1 + a_2c_1c_3d_4d_5d_6 + a_2c_1c_4c_5c_6d_3 + a_3a_6b_2b_4b_5d_1 + a_3b_1b_4b_5c_6d_2 + a_4a_5b_1b_3d_2d_6 + a_4a_5b_2b_3b_6d_1 + a_6b_1c_3d_2d_4d_5 + b_1b_6c_4c_5d_2d_3 + b_2c_3c_6d_1d_4d_5 + b_2c_4c_5d_1d_3d_6) \\[0.5em]
p_{\texttt{AGTGC}} &= \frac{1}{4}(a_1a_3b_4c_2c_5d_6 + a_1a_4b_3c_2c_6d_5 + a_1a_5b_6c_2c_3d_4 + a_1a_6b_5c_2c_4d_3 + a_2a_3b_4b_6c_1c_5 + a_2a_4a_6b_3c_1d_5 + a_2a_5c_1c_3d_4d_6 + a_2b_5c_1c_4c_6d_3 + a_3a_6b_2b_4c_5d_1 + a_3b_1b_4c_5c_6d_2 + a_4b_1b_3d_2d_5d_6 + a_4b_2b_3b_6d_1d_5 + a_5a_6b_1c_3d_2d_4 + a_5b_2c_3c_6d_1d_4 + b_1b_5b_6c_4d_2d_3 + b_2b_5c_4d_1d_3d_6) \\[0.5em]
p_{\texttt{AGTGA}} &= \frac{1}{4}(a_1a_3b_4c_2d_5d_6 + a_1a_4b_3c_2c_5c_6 + a_1a_5a_6c_2c_4d_3 + a_1b_5b_6c_2c_3d_4 + a_2a_3b_4b_6c_1d_5 + a_2a_4a_6b_3c_1c_5 + a_2a_5c_1c_4c_6d_3 + a_2b_5c_1c_3d_4d_6 + a_3a_6b_2b_4d_1d_5 + a_3b_1b_4c_6d_2d_5 + a_4b_1b_3c_5d_2d_6 + a_4b_2b_3b_6c_5d_1 + a_5b_1b_6c_4d_2d_3 + a_5b_2c_4d_1d_3d_6 + a_6b_1b_5c_3d_2d_4 + b_2b_5c_3c_6d_1d_4) \\[0.5em]
p_{\texttt{AGTCT}} &= \frac{1}{4}(a_1a_3a_5c_2c_4d_6 + a_1a_4b_6c_2c_3c_5 + a_1a_6b_4c_2d_3d_5 + a_1b_3b_5c_2c_6d_4 + a_2a_3a_5b_6c_1c_4 + a_2a_4c_1c_3c_5d_6 + a_2a_6b_3b_5c_1d_4 + a_2b_4c_1c_6d_3d_5 + a_3a_5a_6b_2c_4d_1 + a_3a_5b_1c_4c_6d_2 + a_4a_6b_1c_3c_5d_2 + a_4b_2c_3c_5c_6d_1 + b_1b_3b_5d_2d_4d_6 + b_1b_4b_6d_2d_3d_5 + b_2b_3b_5b_6d_1d_4 + b_2b_4d_1d_3d_5d_6) \\[0.5em]
p_{\texttt{AGTCG}} &= \frac{1}{4}(a_1a_3b_5c_2c_4d_6 + a_1a_4b_6c_2c_3d_5 + a_1a_5b_3c_2c_6d_4 + a_1a_6b_4c_2c_5d_3 + a_2a_3b_5b_6c_1c_4 + a_2a_4c_1c_3d_5d_6 + a_2a_5a_6b_3c_1d_4 + a_2b_4c_1c_5c_6d_3 + a_3a_6b_2b_5c_4d_1 + a_3b_1b_5c_4c_6d_2 + a_4a_6b_1c_3d_2d_5 + a_4b_2c_3c_6d_1d_5 + a_5b_1b_3d_2d_4d_6 + a_5b_2b_3b_6d_1d_4 + b_1b_4b_6c_5d_2d_3 + b_2b_4c_5d_1d_3d_6) \\[0.5em]
p_{\texttt{AGTCC}} &= \frac{1}{4}(a_1a_3c_2c_4c_5d_6 + a_1a_4a_5b_6c_2c_3 + a_1a_6b_4b_5c_2d_3 + a_1b_3c_2c_6d_4d_5 + a_2a_3b_6c_1c_4c_5 + a_2a_4a_5c_1c_3d_6 + a_2a_6b_3c_1d_4d_5 + a_2b_4b_5c_1c_6d_3 + a_3a_6b_2c_4c_5d_1 + a_3b_1c_4c_5c_6d_2 + a_4a_5a_6b_1c_3d_2 + a_4a_5b_2c_3c_6d_1 + b_1b_3d_2d_4d_5d_6 + b_1b_4b_5b_6d_2d_3 + b_2b_3b_6d_1d_4d_5 + b_2b_4b_5d_1d_3d_6) \\[0.5em]
p_{\texttt{AGTCA}} &= \frac{1}{4}(a_1a_3c_2c_4d_5d_6 + a_1a_4b_5b_6c_2c_3 + a_1a_5a_6b_4c_2d_3 + a_1b_3c_2c_5c_6d_4 + a_2a_3b_6c_1c_4d_5 + a_2a_4b_5c_1c_3d_6 + a_2a_5b_4c_1c_6d_3 + a_2a_6b_3c_1c_5d_4 + a_3a_6b_2c_4d_1d_5 + a_3b_1c_4c_6d_2d_5 + a_4a_6b_1b_5c_3d_2 + a_4b_2b_5c_3c_6d_1 + a_5b_1b_4b_6d_2d_3 + a_5b_2b_4d_1d_3d_6 + b_1b_3c_5d_2d_4d_6 + b_2b_3b_6c_5d_1d_4) \\[0.5em]
p_{\texttt{AGTAT}} &= \frac{1}{4}(a_1a_3a_5c_2d_4d_6 + a_1a_4a_6c_2d_3d_5 + a_1b_3b_5c_2c_4c_6 + a_1b_4b_6c_2c_3c_5 + a_2a_3a_5b_6c_1d_4 + a_2a_4c_1c_6d_3d_5 + a_2a_6b_3b_5c_1c_4 + a_2b_4c_1c_3c_5d_6 + a_3a_5a_6b_2d_1d_4 + a_3a_5b_1c_6d_2d_4 + a_4b_1b_6d_2d_3d_5 + a_4b_2d_1d_3d_5d_6 + a_6b_1b_4c_3c_5d_2 + b_1b_3b_5c_4d_2d_6 + b_2b_3b_5b_6c_4d_1 + b_2b_4c_3c_5c_6d_1) \\[0.5em]
p_{\texttt{AGTAG}} &= \frac{1}{4}(a_1a_3b_5c_2d_4d_6 + a_1a_4a_6c_2c_5d_3 + a_1a_5b_3c_2c_4c_6 + a_1b_4b_6c_2c_3d_5 + a_2a_3b_5b_6c_1d_4 + a_2a_4c_1c_5c_6d_3 + a_2a_5a_6b_3c_1c_4 + a_2b_4c_1c_3d_5d_6 + a_3a_6b_2b_5d_1d_4 + a_3b_1b_5c_6d_2d_4 + a_4b_1b_6c_5d_2d_3 + a_4b_2c_5d_1d_3d_6 + a_5b_1b_3c_4d_2d_6 + a_5b_2b_3b_6c_4d_1 + a_6b_1b_4c_3d_2d_5 + b_2b_4c_3c_6d_1d_5) \\[0.5em]
p_{\texttt{AGTAC}} &= \frac{1}{4}(a_1a_3c_2c_5d_4d_6 + a_1a_4a_6b_5c_2d_3 + a_1a_5b_4b_6c_2c_3 + a_1b_3c_2c_4c_6d_5 + a_2a_3b_6c_1c_5d_4 + a_2a_4b_5c_1c_6d_3 + a_2a_5b_4c_1c_3d_6 + a_2a_6b_3c_1c_4d_5 + a_3a_6b_2c_5d_1d_4 + a_3b_1c_5c_6d_2d_4 + a_4b_1b_5b_6d_2d_3 + a_4b_2b_5d_1d_3d_6 + a_5a_6b_1b_4c_3d_2 + a_5b_2b_4c_3c_6d_1 + b_1b_3c_4d_2d_5d_6 + b_2b_3b_6c_4d_1d_5) \\[0.5em]
p_{\texttt{AGTAA}} &= \frac{1}{4}(a_1a_3c_2d_4d_5d_6 + a_1a_4a_5a_6c_2d_3 + a_1b_3c_2c_4c_5c_6 + a_1b_4b_5b_6c_2c_3 + a_2a_3b_6c_1d_4d_5 + a_2a_4a_5c_1c_6d_3 + a_2a_6b_3c_1c_4c_5 + a_2b_4b_5c_1c_3d_6 + a_3a_6b_2d_1d_4d_5 + a_3b_1c_6d_2d_4d_5 + a_4a_5b_1b_6d_2d_3 + a_4a_5b_2d_1d_3d_6 + a_6b_1b_4b_5c_3d_2 + b_1b_3c_4c_5d_2d_6 + b_2b_3b_6c_4c_5d_1 + b_2b_4b_5c_3c_6d_1) \\[0.5em]
p_{\texttt{AGGTT}} &= \frac{1}{4}(a_1a_3b_4b_5c_2c_6 + a_1a_4a_5b_3c_2d_6 + a_1a_6c_2c_3d_4d_5 + a_1b_6c_2c_4c_5d_3 + a_2a_3a_6b_4b_5c_1 + a_2a_4a_5b_3b_6c_1 + a_2c_1c_3c_6d_4d_5 + a_2c_1c_4c_5d_3d_6 + a_3b_1b_4b_5d_2d_6 + a_3b_2b_4b_5b_6d_1 + a_4a_5a_6b_2b_3d_1 + a_4a_5b_1b_3c_6d_2 + a_6b_1c_4c_5d_2d_3 + b_1b_6c_3d_2d_4d_5 + b_2c_3d_1d_4d_5d_6 + b_2c_4c_5c_6d_1d_3) \\[0.5em]
p_{\texttt{AGGTG}} &= \frac{1}{4}(a_1a_3a_5b_4c_2c_6 + a_1a_4b_3b_5c_2d_6 + a_1a_6c_2c_3c_5d_4 + a_1b_6c_2c_4d_3d_5 + a_2a_3a_5a_6b_4c_1 + a_2a_4b_3b_5b_6c_1 + a_2c_1c_3c_5c_6d_4 + a_2c_1c_4d_3d_5d_6 + a_3a_5b_1b_4d_2d_6 + a_3a_5b_2b_4b_6d_1 + a_4a_6b_2b_3b_5d_1 + a_4b_1b_3b_5c_6d_2 + a_6b_1c_4d_2d_3d_5 + b_1b_6c_3c_5d_2d_4 + b_2c_3c_5d_1d_4d_6 + b_2c_4c_6d_1d_3d_5) \\[0.5em]
p_{\texttt{AGGTC}} &= \frac{1}{4}(a_1a_3b_4c_2c_6d_5 + a_1a_4b_3c_2c_5d_6 + a_1a_5b_6c_2c_4d_3 + a_1a_6b_5c_2c_3d_4 + a_2a_3a_6b_4c_1d_5 + a_2a_4b_3b_6c_1c_5 + a_2a_5c_1c_4d_3d_6 + a_2b_5c_1c_3c_6d_4 + a_3b_1b_4d_2d_5d_6 + a_3b_2b_4b_6d_1d_5 + a_4a_6b_2b_3c_5d_1 + a_4b_1b_3c_5c_6d_2 + a_5a_6b_1c_4d_2d_3 + a_5b_2c_4c_6d_1d_3 + b_1b_5b_6c_3d_2d_4 + b_2b_5c_3d_1d_4d_6) \\[0.5em]
p_{\texttt{AGGTA}} &= \frac{1}{4}(a_1a_3b_4c_2c_5c_6 + a_1a_4b_3c_2d_5d_6 + a_1a_5a_6c_2c_3d_4 + a_1b_5b_6c_2c_4d_3 + a_2a_3a_6b_4c_1c_5 + a_2a_4b_3b_6c_1d_5 + a_2a_5c_1c_3c_6d_4 + a_2b_5c_1c_4d_3d_6 + a_3b_1b_4c_5d_2d_6 + a_3b_2b_4b_6c_5d_1 + a_4a_6b_2b_3d_1d_5 + a_4b_1b_3c_6d_2d_5 + a_5b_1b_6c_3d_2d_4 + a_5b_2c_3d_1d_4d_6 + a_6b_1b_5c_4d_2d_3 + b_2b_5c_4c_6d_1d_3) \\[0.5em]
p_{\texttt{AGGGT}} &= \frac{1}{4}(a_1a_3a_4b_5c_2c_6 + a_1a_5b_3b_4c_2d_6 + a_1a_6c_2c_3c_4d_5 + a_1b_6c_2c_5d_3d_4 + a_2a_3a_4a_6b_5c_1 + a_2a_5b_3b_4b_6c_1 + a_2c_1c_3c_4c_6d_5 + a_2c_1c_5d_3d_4d_6 + a_3a_4b_1b_5d_2d_6 + a_3a_4b_2b_5b_6d_1 + a_5a_6b_2b_3b_4d_1 + a_5b_1b_3b_4c_6d_2 + a_6b_1c_5d_2d_3d_4 + b_1b_6c_3c_4d_2d_5 + b_2c_3c_4d_1d_5d_6 + b_2c_5c_6d_1d_3d_4) \\[0.5em]
p_{\texttt{AGGGG}} &= \frac{1}{4}(a_1a_3a_4a_5c_2c_6 + a_1a_6c_2c_3c_4c_5 + a_1b_3b_4b_5c_2d_6 + a_1b_6c_2d_3d_4d_5 + a_2a_3a_4a_5a_6c_1 + a_2b_3b_4b_5b_6c_1 + a_2c_1c_3c_4c_5c_6 + a_2c_1d_3d_4d_5d_6 + a_3a_4a_5b_1d_2d_6 + a_3a_4a_5b_2b_6d_1 + a_6b_1d_2d_3d_4d_5 + a_6b_2b_3b_4b_5d_1 + b_1b_3b_4b_5c_6d_2 + b_1b_6c_3c_4c_5d_2 + b_2c_3c_4c_5d_1d_6 + b_2c_6d_1d_3d_4d_5) \\[0.5em]
p_{\texttt{AGGGC}} &= \frac{1}{4}(a_1a_3a_4c_2c_6d_5 + a_1a_5b_6c_2d_3d_4 + a_1a_6b_5c_2c_3c_4 + a_1b_3b_4c_2c_5d_6 + a_2a_3a_4a_6c_1d_5 + a_2a_5c_1d_3d_4d_6 + a_2b_3b_4b_6c_1c_5 + a_2b_5c_1c_3c_4c_6 + a_3a_4b_1d_2d_5d_6 + a_3a_4b_2b_6d_1d_5 + a_5a_6b_1d_2d_3d_4 + a_5b_2c_6d_1d_3d_4 + a_6b_2b_3b_4c_5d_1 + b_1b_3b_4c_5c_6d_2 + b_1b_5b_6c_3c_4d_2 + b_2b_5c_3c_4d_1d_6) \\[0.5em]
p_{\texttt{AGGGA}} &= \frac{1}{4}(a_1a_3a_4c_2c_5c_6 + a_1a_5a_6c_2c_3c_4 + a_1b_3b_4c_2d_5d_6 + a_1b_5b_6c_2d_3d_4 + a_2a_3a_4a_6c_1c_5 + a_2a_5c_1c_3c_4c_6 + a_2b_3b_4b_6c_1d_5 + a_2b_5c_1d_3d_4d_6 + a_3a_4b_1c_5d_2d_6 + a_3a_4b_2b_6c_5d_1 + a_5b_1b_6c_3c_4d_2 + a_5b_2c_3c_4d_1d_6 + a_6b_1b_5d_2d_3d_4 + a_6b_2b_3b_4d_1d_5 + b_1b_3b_4c_6d_2d_5 + b_2b_5c_6d_1d_3d_4) \\[0.5em]
p_{\texttt{AGGCT}} &= \frac{1}{4}(a_1a_3b_5c_2c_6d_4 + a_1a_4b_6c_2c_5d_3 + a_1a_5b_3c_2c_4d_6 + a_1a_6b_4c_2c_3d_5 + a_2a_3a_6b_5c_1d_4 + a_2a_4c_1c_5d_3d_6 + a_2a_5b_3b_6c_1c_4 + a_2b_4c_1c_3c_6d_5 + a_3b_1b_5d_2d_4d_6 + a_3b_2b_5b_6d_1d_4 + a_4a_6b_1c_5d_2d_3 + a_4b_2c_5c_6d_1d_3 + a_5a_6b_2b_3c_4d_1 + a_5b_1b_3c_4c_6d_2 + b_1b_4b_6c_3d_2d_5 + b_2b_4c_3d_1d_5d_6) \\[0.5em]
p_{\texttt{AGGCG}} &= \frac{1}{4}(a_1a_3a_5c_2c_6d_4 + a_1a_4b_6c_2d_3d_5 + a_1a_6b_4c_2c_3c_5 + a_1b_3b_5c_2c_4d_6 + a_2a_3a_5a_6c_1d_4 + a_2a_4c_1d_3d_5d_6 + a_2b_3b_5b_6c_1c_4 + a_2b_4c_1c_3c_5c_6 + a_3a_5b_1d_2d_4d_6 + a_3a_5b_2b_6d_1d_4 + a_4a_6b_1d_2d_3d_5 + a_4b_2c_6d_1d_3d_5 + a_6b_2b_3b_5c_4d_1 + b_1b_3b_5c_4c_6d_2 + b_1b_4b_6c_3c_5d_2 + b_2b_4c_3c_5d_1d_6) \\[0.5em]
p_{\texttt{AGGCC}} &= \frac{1}{4}(a_1a_3c_2c_6d_4d_5 + a_1a_4a_5b_6c_2d_3 + a_1a_6b_4b_5c_2c_3 + a_1b_3c_2c_4c_5d_6 + a_2a_3a_6c_1d_4d_5 + a_2a_4a_5c_1d_3d_6 + a_2b_3b_6c_1c_4c_5 + a_2b_4b_5c_1c_3c_6 + a_3b_1d_2d_4d_5d_6 + a_3b_2b_6d_1d_4d_5 + a_4a_5a_6b_1d_2d_3 + a_4a_5b_2c_6d_1d_3 + a_6b_2b_3c_4c_5d_1 + b_1b_3c_4c_5c_6d_2 + b_1b_4b_5b_6c_3d_2 + b_2b_4b_5c_3d_1d_6) \\[0.5em]
p_{\texttt{AGGCA}} &= \frac{1}{4}(a_1a_3c_2c_5c_6d_4 + a_1a_4b_5b_6c_2d_3 + a_1a_5a_6b_4c_2c_3 + a_1b_3c_2c_4d_5d_6 + a_2a_3a_6c_1c_5d_4 + a_2a_4b_5c_1d_3d_6 + a_2a_5b_4c_1c_3c_6 + a_2b_3b_6c_1c_4d_5 + a_3b_1c_5d_2d_4d_6 + a_3b_2b_6c_5d_1d_4 + a_4a_6b_1b_5d_2d_3 + a_4b_2b_5c_6d_1d_3 + a_5b_1b_4b_6c_3d_2 + a_5b_2b_4c_3d_1d_6 + a_6b_2b_3c_4d_1d_5 + b_1b_3c_4c_6d_2d_5) \\[0.5em]
p_{\texttt{AGGAT}} &= \frac{1}{4}(a_1a_3b_5c_2c_4c_6 + a_1a_4a_6c_2c_3d_5 + a_1a_5b_3c_2d_4d_6 + a_1b_4b_6c_2c_5d_3 + a_2a_3a_6b_5c_1c_4 + a_2a_4c_1c_3c_6d_5 + a_2a_5b_3b_6c_1d_4 + a_2b_4c_1c_5d_3d_6 + a_3b_1b_5c_4d_2d_6 + a_3b_2b_5b_6c_4d_1 + a_4b_1b_6c_3d_2d_5 + a_4b_2c_3d_1d_5d_6 + a_5a_6b_2b_3d_1d_4 + a_5b_1b_3c_6d_2d_4 + a_6b_1b_4c_5d_2d_3 + b_2b_4c_5c_6d_1d_3) \\[0.5em]
p_{\texttt{AGGAG}} &= \frac{1}{4}(a_1a_3a_5c_2c_4c_6 + a_1a_4a_6c_2c_3c_5 + a_1b_3b_5c_2d_4d_6 + a_1b_4b_6c_2d_3d_5 + a_2a_3a_5a_6c_1c_4 + a_2a_4c_1c_3c_5c_6 + a_2b_3b_5b_6c_1d_4 + a_2b_4c_1d_3d_5d_6 + a_3a_5b_1c_4d_2d_6 + a_3a_5b_2b_6c_4d_1 + a_4b_1b_6c_3c_5d_2 + a_4b_2c_3c_5d_1d_6 + a_6b_1b_4d_2d_3d_5 + a_6b_2b_3b_5d_1d_4 + b_1b_3b_5c_6d_2d_4 + b_2b_4c_6d_1d_3d_5) \\[0.5em]
p_{\texttt{AGGAC}} &= \frac{1}{4}(a_1a_3c_2c_4c_6d_5 + a_1a_4a_6b_5c_2c_3 + a_1a_5b_4b_6c_2d_3 + a_1b_3c_2c_5d_4d_6 + a_2a_3a_6c_1c_4d_5 + a_2a_4b_5c_1c_3c_6 + a_2a_5b_4c_1d_3d_6 + a_2b_3b_6c_1c_5d_4 + a_3b_1c_4d_2d_5d_6 + a_3b_2b_6c_4d_1d_5 + a_4b_1b_5b_6c_3d_2 + a_4b_2b_5c_3d_1d_6 + a_5a_6b_1b_4d_2d_3 + a_5b_2b_4c_6d_1d_3 + a_6b_2b_3c_5d_1d_4 + b_1b_3c_5c_6d_2d_4) \\[0.5em]
p_{\texttt{AGGAA}} &= \frac{1}{4}(a_1a_3c_2c_4c_5c_6 + a_1a_4a_5a_6c_2c_3 + a_1b_3c_2d_4d_5d_6 + a_1b_4b_5b_6c_2d_3 + a_2a_3a_6c_1c_4c_5 + a_2a_4a_5c_1c_3c_6 + a_2b_3b_6c_1d_4d_5 + a_2b_4b_5c_1d_3d_6 + a_3b_1c_4c_5d_2d_6 + a_3b_2b_6c_4c_5d_1 + a_4a_5b_1b_6c_3d_2 + a_4a_5b_2c_3d_1d_6 + a_6b_1b_4b_5d_2d_3 + a_6b_2b_3d_1d_4d_5 + b_1b_3c_6d_2d_4d_5 + b_2b_4b_5c_6d_1d_3) \\[0.5em]
p_{\texttt{AGCTT}} &= \frac{1}{4}(a_1a_3b_6c_2c_4c_5 + a_1a_4a_5c_2c_3d_6 + a_1a_6b_3c_2d_4d_5 + a_1b_4b_5c_2c_6d_3 + a_2a_3c_1c_4c_5d_6 + a_2a_4a_5b_6c_1c_3 + a_2a_6b_4b_5c_1d_3 + a_2b_3c_1c_6d_4d_5 + a_3a_6b_1c_4c_5d_2 + a_3b_2c_4c_5c_6d_1 + a_4a_5a_6b_2c_3d_1 + a_4a_5b_1c_3c_6d_2 + b_1b_3b_6d_2d_4d_5 + b_1b_4b_5d_2d_3d_6 + b_2b_3d_1d_4d_5d_6 + b_2b_4b_5b_6d_1d_3) \\[0.5em]
p_{\texttt{AGCTG}} &= \frac{1}{4}(a_1a_3b_6c_2c_4d_5 + a_1a_4b_5c_2c_3d_6 + a_1a_5b_4c_2c_6d_3 + a_1a_6b_3c_2c_5d_4 + a_2a_3c_1c_4d_5d_6 + a_2a_4b_5b_6c_1c_3 + a_2a_5a_6b_4c_1d_3 + a_2b_3c_1c_5c_6d_4 + a_3a_6b_1c_4d_2d_5 + a_3b_2c_4c_6d_1d_5 + a_4a_6b_2b_5c_3d_1 + a_4b_1b_5c_3c_6d_2 + a_5b_1b_4d_2d_3d_6 + a_5b_2b_4b_6d_1d_3 + b_1b_3b_6c_5d_2d_4 + b_2b_3c_5d_1d_4d_6) \\[0.5em]
p_{\texttt{AGCTC}} &= \frac{1}{4}(a_1a_3a_5b_6c_2c_4 + a_1a_4c_2c_3c_5d_6 + a_1a_6b_3b_5c_2d_4 + a_1b_4c_2c_6d_3d_5 + a_2a_3a_5c_1c_4d_6 + a_2a_4b_6c_1c_3c_5 + a_2a_6b_4c_1d_3d_5 + a_2b_3b_5c_1c_6d_4 + a_3a_5a_6b_1c_4d_2 + a_3a_5b_2c_4c_6d_1 + a_4a_6b_2c_3c_5d_1 + a_4b_1c_3c_5c_6d_2 + b_1b_3b_5b_6d_2d_4 + b_1b_4d_2d_3d_5d_6 + b_2b_3b_5d_1d_4d_6 + b_2b_4b_6d_1d_3d_5) \\[0.5em]
p_{\texttt{AGCTA}} &= \frac{1}{4}(a_1a_3b_5b_6c_2c_4 + a_1a_4c_2c_3d_5d_6 + a_1a_5a_6b_3c_2d_4 + a_1b_4c_2c_5c_6d_3 + a_2a_3b_5c_1c_4d_6 + a_2a_4b_6c_1c_3d_5 + a_2a_5b_3c_1c_6d_4 + a_2a_6b_4c_1c_5d_3 + a_3a_6b_1b_5c_4d_2 + a_3b_2b_5c_4c_6d_1 + a_4a_6b_2c_3d_1d_5 + a_4b_1c_3c_6d_2d_5 + a_5b_1b_3b_6d_2d_4 + a_5b_2b_3d_1d_4d_6 + b_1b_4c_5d_2d_3d_6 + b_2b_4b_6c_5d_1d_3) \\[0.5em]
p_{\texttt{AGCGT}} &= \frac{1}{4}(a_1a_3b_6c_2c_5d_4 + a_1a_4b_5c_2c_6d_3 + a_1a_5b_4c_2c_3d_6 + a_1a_6b_3c_2c_4d_5 + a_2a_3c_1c_5d_4d_6 + a_2a_4a_6b_5c_1d_3 + a_2a_5b_4b_6c_1c_3 + a_2b_3c_1c_4c_6d_5 + a_3a_6b_1c_5d_2d_4 + a_3b_2c_5c_6d_1d_4 + a_4b_1b_5d_2d_3d_6 + a_4b_2b_5b_6d_1d_3 + a_5a_6b_2b_4c_3d_1 + a_5b_1b_4c_3c_6d_2 + b_1b_3b_6c_4d_2d_5 + b_2b_3c_4d_1d_5d_6) \\[0.5em]
p_{\texttt{AGCGG}} &= \frac{1}{4}(a_1a_3b_6c_2d_4d_5 + a_1a_4a_5c_2c_6d_3 + a_1a_6b_3c_2c_4c_5 + a_1b_4b_5c_2c_3d_6 + a_2a_3c_1d_4d_5d_6 + a_2a_4a_5a_6c_1d_3 + a_2b_3c_1c_4c_5c_6 + a_2b_4b_5b_6c_1c_3 + a_3a_6b_1d_2d_4d_5 + a_3b_2c_6d_1d_4d_5 + a_4a_5b_1d_2d_3d_6 + a_4a_5b_2b_6d_1d_3 + a_6b_2b_4b_5c_3d_1 + b_1b_3b_6c_4c_5d_2 + b_1b_4b_5c_3c_6d_2 + b_2b_3c_4c_5d_1d_6) \\[0.5em]
p_{\texttt{AGCGC}} &= \frac{1}{4}(a_1a_3a_5b_6c_2d_4 + a_1a_4c_2c_6d_3d_5 + a_1a_6b_3b_5c_2c_4 + a_1b_4c_2c_3c_5d_6 + a_2a_3a_5c_1d_4d_6 + a_2a_4a_6c_1d_3d_5 + a_2b_3b_5c_1c_4c_6 + a_2b_4b_6c_1c_3c_5 + a_3a_5a_6b_1d_2d_4 + a_3a_5b_2c_6d_1d_4 + a_4b_1d_2d_3d_5d_6 + a_4b_2b_6d_1d_3d_5 + a_6b_2b_4c_3c_5d_1 + b_1b_3b_5b_6c_4d_2 + b_1b_4c_3c_5c_6d_2 + b_2b_3b_5c_4d_1d_6) \\[0.5em]
p_{\texttt{AGCGA}} &= \frac{1}{4}(a_1a_3b_5b_6c_2d_4 + a_1a_4c_2c_5c_6d_3 + a_1a_5a_6b_3c_2c_4 + a_1b_4c_2c_3d_5d_6 + a_2a_3b_5c_1d_4d_6 + a_2a_4a_6c_1c_5d_3 + a_2a_5b_3c_1c_4c_6 + a_2b_4b_6c_1c_3d_5 + a_3a_6b_1b_5d_2d_4 + a_3b_2b_5c_6d_1d_4 + a_4b_1c_5d_2d_3d_6 + a_4b_2b_6c_5d_1d_3 + a_5b_1b_3b_6c_4d_2 + a_5b_2b_3c_4d_1d_6 + a_6b_2b_4c_3d_1d_5 + b_1b_4c_3c_6d_2d_5) \\[0.5em]
p_{\texttt{AGCCT}} &= \frac{1}{4}(a_1a_3a_4b_6c_2c_5 + a_1a_5c_2c_3c_4d_6 + a_1a_6b_3b_4c_2d_5 + a_1b_5c_2c_6d_3d_4 + a_2a_3a_4c_1c_5d_6 + a_2a_5b_6c_1c_3c_4 + a_2a_6b_5c_1d_3d_4 + a_2b_3b_4c_1c_6d_5 + a_3a_4a_6b_1c_5d_2 + a_3a_4b_2c_5c_6d_1 + a_5a_6b_2c_3c_4d_1 + a_5b_1c_3c_4c_6d_2 + b_1b_3b_4b_6d_2d_5 + b_1b_5d_2d_3d_4d_6 + b_2b_3b_4d_1d_5d_6 + b_2b_5b_6d_1d_3d_4) \\[0.5em]
p_{\texttt{AGCCG}} &= \frac{1}{4}(a_1a_3a_4b_6c_2d_5 + a_1a_5c_2c_6d_3d_4 + a_1a_6b_3b_4c_2c_5 + a_1b_5c_2c_3c_4d_6 + a_2a_3a_4c_1d_5d_6 + a_2a_5a_6c_1d_3d_4 + a_2b_3b_4c_1c_5c_6 + a_2b_5b_6c_1c_3c_4 + a_3a_4a_6b_1d_2d_5 + a_3a_4b_2c_6d_1d_5 + a_5b_1d_2d_3d_4d_6 + a_5b_2b_6d_1d_3d_4 + a_6b_2b_5c_3c_4d_1 + b_1b_3b_4b_6c_5d_2 + b_1b_5c_3c_4c_6d_2 + b_2b_3b_4c_5d_1d_6) \\[0.5em]
p_{\texttt{AGCCC}} &= \frac{1}{4}(a_1a_3a_4a_5b_6c_2 + a_1a_6b_3b_4b_5c_2 + a_1c_2c_3c_4c_5d_6 + a_1c_2c_6d_3d_4d_5 + a_2a_3a_4a_5c_1d_6 + a_2a_6c_1d_3d_4d_5 + a_2b_3b_4b_5c_1c_6 + a_2b_6c_1c_3c_4c_5 + a_3a_4a_5a_6b_1d_2 + a_3a_4a_5b_2c_6d_1 + a_6b_2c_3c_4c_5d_1 + b_1b_3b_4b_5b_6d_2 + b_1c_3c_4c_5c_6d_2 + b_1d_2d_3d_4d_5d_6 + b_2b_3b_4b_5d_1d_6 + b_2b_6d_1d_3d_4d_5) \\[0.5em]
p_{\texttt{AGCCA}} &= \frac{1}{4}(a_1a_3a_4b_5b_6c_2 + a_1a_5a_6b_3b_4c_2 + a_1c_2c_3c_4d_5d_6 + a_1c_2c_5c_6d_3d_4 + a_2a_3a_4b_5c_1d_6 + a_2a_5b_3b_4c_1c_6 + a_2a_6c_1c_5d_3d_4 + a_2b_6c_1c_3c_4d_5 + a_3a_4a_6b_1b_5d_2 + a_3a_4b_2b_5c_6d_1 + a_5b_1b_3b_4b_6d_2 + a_5b_2b_3b_4d_1d_6 + a_6b_2c_3c_4d_1d_5 + b_1c_3c_4c_6d_2d_5 + b_1c_5d_2d_3d_4d_6 + b_2b_6c_5d_1d_3d_4) \\[0.5em]
p_{\texttt{AGCAT}} &= \frac{1}{4}(a_1a_3b_4b_6c_2c_5 + a_1a_4a_6b_3c_2d_5 + a_1a_5c_2c_3d_4d_6 + a_1b_5c_2c_4c_6d_3 + a_2a_3b_4c_1c_5d_6 + a_2a_4b_3c_1c_6d_5 + a_2a_5b_6c_1c_3d_4 + a_2a_6b_5c_1c_4d_3 + a_3a_6b_1b_4c_5d_2 + a_3b_2b_4c_5c_6d_1 + a_4b_1b_3b_6d_2d_5 + a_4b_2b_3d_1d_5d_6 + a_5a_6b_2c_3d_1d_4 + a_5b_1c_3c_6d_2d_4 + b_1b_5c_4d_2d_3d_6 + b_2b_5b_6c_4d_1d_3) \\[0.5em]
p_{\texttt{AGCAG}} &= \frac{1}{4}(a_1a_3b_4b_6c_2d_5 + a_1a_4a_6b_3c_2c_5 + a_1a_5c_2c_4c_6d_3 + a_1b_5c_2c_3d_4d_6 + a_2a_3b_4c_1d_5d_6 + a_2a_4b_3c_1c_5c_6 + a_2a_5a_6c_1c_4d_3 + a_2b_5b_6c_1c_3d_4 + a_3a_6b_1b_4d_2d_5 + a_3b_2b_4c_6d_1d_5 + a_4b_1b_3b_6c_5d_2 + a_4b_2b_3c_5d_1d_6 + a_5b_1c_4d_2d_3d_6 + a_5b_2b_6c_4d_1d_3 + a_6b_2b_5c_3d_1d_4 + b_1b_5c_3c_6d_2d_4) \\[0.5em]
p_{\texttt{AGCAC}} &= \frac{1}{4}(a_1a_3a_5b_4b_6c_2 + a_1a_4a_6b_3b_5c_2 + a_1c_2c_3c_5d_4d_6 + a_1c_2c_4c_6d_3d_5 + a_2a_3a_5b_4c_1d_6 + a_2a_4b_3b_5c_1c_6 + a_2a_6c_1c_4d_3d_5 + a_2b_6c_1c_3c_5d_4 + a_3a_5a_6b_1b_4d_2 + a_3a_5b_2b_4c_6d_1 + a_4b_1b_3b_5b_6d_2 + a_4b_2b_3b_5d_1d_6 + a_6b_2c_3c_5d_1d_4 + b_1c_3c_5c_6d_2d_4 + b_1c_4d_2d_3d_5d_6 + b_2b_6c_4d_1d_3d_5) \\[0.5em]
p_{\texttt{AGCAA}} &= \frac{1}{4}(a_1a_3b_4b_5b_6c_2 + a_1a_4a_5a_6b_3c_2 + a_1c_2c_3d_4d_5d_6 + a_1c_2c_4c_5c_6d_3 + a_2a_3b_4b_5c_1d_6 + a_2a_4a_5b_3c_1c_6 + a_2a_6c_1c_4c_5d_3 + a_2b_6c_1c_3d_4d_5 + a_3a_6b_1b_4b_5d_2 + a_3b_2b_4b_5c_6d_1 + a_4a_5b_1b_3b_6d_2 + a_4a_5b_2b_3d_1d_6 + a_6b_2c_3d_1d_4d_5 + b_1c_3c_6d_2d_4d_5 + b_1c_4c_5d_2d_3d_6 + b_2b_6c_4c_5d_1d_3) \\[0.5em]
p_{\texttt{AGATT}} &= \frac{1}{4}(a_1a_3a_6c_2d_4d_5 + a_1a_4a_5c_2d_3d_6 + a_1b_3b_6c_2c_4c_5 + a_1b_4b_5c_2c_3c_6 + a_2a_3c_1c_6d_4d_5 + a_2a_4a_5b_6c_1d_3 + a_2a_6b_4b_5c_1c_3 + a_2b_3c_1c_4c_5d_6 + a_3b_1b_6d_2d_4d_5 + a_3b_2d_1d_4d_5d_6 + a_4a_5a_6b_2d_1d_3 + a_4a_5b_1c_6d_2d_3 + a_6b_1b_3c_4c_5d_2 + b_1b_4b_5c_3d_2d_6 + b_2b_3c_4c_5c_6d_1 + b_2b_4b_5b_6c_3d_1) \\[0.5em]
p_{\texttt{AGATG}} &= \frac{1}{4}(a_1a_3a_6c_2c_5d_4 + a_1a_4b_5c_2d_3d_6 + a_1a_5b_4c_2c_3c_6 + a_1b_3b_6c_2c_4d_5 + a_2a_3c_1c_5c_6d_4 + a_2a_4b_5b_6c_1d_3 + a_2a_5a_6b_4c_1c_3 + a_2b_3c_1c_4d_5d_6 + a_3b_1b_6c_5d_2d_4 + a_3b_2c_5d_1d_4d_6 + a_4a_6b_2b_5d_1d_3 + a_4b_1b_5c_6d_2d_3 + a_5b_1b_4c_3d_2d_6 + a_5b_2b_4b_6c_3d_1 + a_6b_1b_3c_4d_2d_5 + b_2b_3c_4c_6d_1d_5) \\[0.5em]
p_{\texttt{AGATC}} &= \frac{1}{4}(a_1a_3a_6b_5c_2d_4 + a_1a_4c_2c_5d_3d_6 + a_1a_5b_3b_6c_2c_4 + a_1b_4c_2c_3c_6d_5 + a_2a_3b_5c_1c_6d_4 + a_2a_4b_6c_1c_5d_3 + a_2a_5b_3c_1c_4d_6 + a_2a_6b_4c_1c_3d_5 + a_3b_1b_5b_6d_2d_4 + a_3b_2b_5d_1d_4d_6 + a_4a_6b_2c_5d_1d_3 + a_4b_1c_5c_6d_2d_3 + a_5a_6b_1b_3c_4d_2 + a_5b_2b_3c_4c_6d_1 + b_1b_4c_3d_2d_5d_6 + b_2b_4b_6c_3d_1d_5) \\[0.5em]
p_{\texttt{AGATA}} &= \frac{1}{4}(a_1a_3a_5a_6c_2d_4 + a_1a_4c_2d_3d_5d_6 + a_1b_3b_5b_6c_2c_4 + a_1b_4c_2c_3c_5c_6 + a_2a_3a_5c_1c_6d_4 + a_2a_4b_6c_1d_3d_5 + a_2a_6b_4c_1c_3c_5 + a_2b_3b_5c_1c_4d_6 + a_3a_5b_1b_6d_2d_4 + a_3a_5b_2d_1d_4d_6 + a_4a_6b_2d_1d_3d_5 + a_4b_1c_6d_2d_3d_5 + a_6b_1b_3b_5c_4d_2 + b_1b_4c_3c_5d_2d_6 + b_2b_3b_5c_4c_6d_1 + b_2b_4b_6c_3c_5d_1) \\[0.5em]
p_{\texttt{AGAGT}} &= \frac{1}{4}(a_1a_3a_6c_2c_4d_5 + a_1a_4b_5c_2c_3c_6 + a_1a_5b_4c_2d_3d_6 + a_1b_3b_6c_2c_5d_4 + a_2a_3c_1c_4c_6d_5 + a_2a_4a_6b_5c_1c_3 + a_2a_5b_4b_6c_1d_3 + a_2b_3c_1c_5d_4d_6 + a_3b_1b_6c_4d_2d_5 + a_3b_2c_4d_1d_5d_6 + a_4b_1b_5c_3d_2d_6 + a_4b_2b_5b_6c_3d_1 + a_5a_6b_2b_4d_1d_3 + a_5b_1b_4c_6d_2d_3 + a_6b_1b_3c_5d_2d_4 + b_2b_3c_5c_6d_1d_4) \\[0.5em]
p_{\texttt{AGAGG}} &= \frac{1}{4}(a_1a_3a_6c_2c_4c_5 + a_1a_4a_5c_2c_3c_6 + a_1b_3b_6c_2d_4d_5 + a_1b_4b_5c_2d_3d_6 + a_2a_3c_1c_4c_5c_6 + a_2a_4a_5a_6c_1c_3 + a_2b_3c_1d_4d_5d_6 + a_2b_4b_5b_6c_1d_3 + a_3b_1b_6c_4c_5d_2 + a_3b_2c_4c_5d_1d_6 + a_4a_5b_1c_3d_2d_6 + a_4a_5b_2b_6c_3d_1 + a_6b_1b_3d_2d_4d_5 + a_6b_2b_4b_5d_1d_3 + b_1b_4b_5c_6d_2d_3 + b_2b_3c_6d_1d_4d_5) \\[0.5em]
p_{\texttt{AGAGC}} &= \frac{1}{4}(a_1a_3a_6b_5c_2c_4 + a_1a_4c_2c_3c_6d_5 + a_1a_5b_3b_6c_2d_4 + a_1b_4c_2c_5d_3d_6 + a_2a_3b_5c_1c_4c_6 + a_2a_4a_6c_1c_3d_5 + a_2a_5b_3c_1d_4d_6 + a_2b_4b_6c_1c_5d_3 + a_3b_1b_5b_6c_4d_2 + a_3b_2b_5c_4d_1d_6 + a_4b_1c_3d_2d_5d_6 + a_4b_2b_6c_3d_1d_5 + a_5a_6b_1b_3d_2d_4 + a_5b_2b_3c_6d_1d_4 + a_6b_2b_4c_5d_1d_3 + b_1b_4c_5c_6d_2d_3) \\[0.5em]
p_{\texttt{AGAGA}} &= \frac{1}{4}(a_1a_3a_5a_6c_2c_4 + a_1a_4c_2c_3c_5c_6 + a_1b_3b_5b_6c_2d_4 + a_1b_4c_2d_3d_5d_6 + a_2a_3a_5c_1c_4c_6 + a_2a_4a_6c_1c_3c_5 + a_2b_3b_5c_1d_4d_6 + a_2b_4b_6c_1d_3d_5 + a_3a_5b_1b_6c_4d_2 + a_3a_5b_2c_4d_1d_6 + a_4b_1c_3c_5d_2d_6 + a_4b_2b_6c_3c_5d_1 + a_6b_1b_3b_5d_2d_4 + a_6b_2b_4d_1d_3d_5 + b_1b_4c_6d_2d_3d_5 + b_2b_3b_5c_6d_1d_4) \\[0.5em]
p_{\texttt{AGACT}} &= \frac{1}{4}(a_1a_3a_6b_4c_2d_5 + a_1a_4b_3b_6c_2c_5 + a_1a_5c_2c_4d_3d_6 + a_1b_5c_2c_3c_6d_4 + a_2a_3b_4c_1c_6d_5 + a_2a_4b_3c_1c_5d_6 + a_2a_5b_6c_1c_4d_3 + a_2a_6b_5c_1c_3d_4 + a_3b_1b_4b_6d_2d_5 + a_3b_2b_4d_1d_5d_6 + a_4a_6b_1b_3c_5d_2 + a_4b_2b_3c_5c_6d_1 + a_5a_6b_2c_4d_1d_3 + a_5b_1c_4c_6d_2d_3 + b_1b_5c_3d_2d_4d_6 + b_2b_5b_6c_3d_1d_4) \\[0.5em]
p_{\texttt{AGACG}} &= \frac{1}{4}(a_1a_3a_6b_4c_2c_5 + a_1a_4b_3b_6c_2d_5 + a_1a_5c_2c_3c_6d_4 + a_1b_5c_2c_4d_3d_6 + a_2a_3b_4c_1c_5c_6 + a_2a_4b_3c_1d_5d_6 + a_2a_5a_6c_1c_3d_4 + a_2b_5b_6c_1c_4d_3 + a_3b_1b_4b_6c_5d_2 + a_3b_2b_4c_5d_1d_6 + a_4a_6b_1b_3d_2d_5 + a_4b_2b_3c_6d_1d_5 + a_5b_1c_3d_2d_4d_6 + a_5b_2b_6c_3d_1d_4 + a_6b_2b_5c_4d_1d_3 + b_1b_5c_4c_6d_2d_3) \\[0.5em]
p_{\texttt{AGACC}} &= \frac{1}{4}(a_1a_3a_6b_4b_5c_2 + a_1a_4a_5b_3b_6c_2 + a_1c_2c_3c_6d_4d_5 + a_1c_2c_4c_5d_3d_6 + a_2a_3b_4b_5c_1c_6 + a_2a_4a_5b_3c_1d_6 + a_2a_6c_1c_3d_4d_5 + a_2b_6c_1c_4c_5d_3 + a_3b_1b_4b_5b_6d_2 + a_3b_2b_4b_5d_1d_6 + a_4a_5a_6b_1b_3d_2 + a_4a_5b_2b_3c_6d_1 + a_6b_2c_4c_5d_1d_3 + b_1c_3d_2d_4d_5d_6 + b_1c_4c_5c_6d_2d_3 + b_2b_6c_3d_1d_4d_5) \\[0.5em]
p_{\texttt{AGACA}} &= \frac{1}{4}(a_1a_3a_5a_6b_4c_2 + a_1a_4b_3b_5b_6c_2 + a_1c_2c_3c_5c_6d_4 + a_1c_2c_4d_3d_5d_6 + a_2a_3a_5b_4c_1c_6 + a_2a_4b_3b_5c_1d_6 + a_2a_6c_1c_3c_5d_4 + a_2b_6c_1c_4d_3d_5 + a_3a_5b_1b_4b_6d_2 + a_3a_5b_2b_4d_1d_6 + a_4a_6b_1b_3b_5d_2 + a_4b_2b_3b_5c_6d_1 + a_6b_2c_4d_1d_3d_5 + b_1c_3c_5d_2d_4d_6 + b_1c_4c_6d_2d_3d_5 + b_2b_6c_3c_5d_1d_4) \\[0.5em]
p_{\texttt{AGAAT}} &= \frac{1}{4}(a_1a_3a_4a_6c_2d_5 + a_1a_5c_2d_3d_4d_6 + a_1b_3b_4b_6c_2c_5 + a_1b_5c_2c_3c_4c_6 + a_2a_3a_4c_1c_6d_5 + a_2a_5b_6c_1d_3d_4 + a_2a_6b_5c_1c_3c_4 + a_2b_3b_4c_1c_5d_6 + a_3a_4b_1b_6d_2d_5 + a_3a_4b_2d_1d_5d_6 + a_5a_6b_2d_1d_3d_4 + a_5b_1c_6d_2d_3d_4 + a_6b_1b_3b_4c_5d_2 + b_1b_5c_3c_4d_2d_6 + b_2b_3b_4c_5c_6d_1 + b_2b_5b_6c_3c_4d_1) \\[0.5em]
p_{\texttt{AGAAG}} &= \frac{1}{4}(a_1a_3a_4a_6c_2c_5 + a_1a_5c_2c_3c_4c_6 + a_1b_3b_4b_6c_2d_5 + a_1b_5c_2d_3d_4d_6 + a_2a_3a_4c_1c_5c_6 + a_2a_5a_6c_1c_3c_4 + a_2b_3b_4c_1d_5d_6 + a_2b_5b_6c_1d_3d_4 + a_3a_4b_1b_6c_5d_2 + a_3a_4b_2c_5d_1d_6 + a_5b_1c_3c_4d_2d_6 + a_5b_2b_6c_3c_4d_1 + a_6b_1b_3b_4d_2d_5 + a_6b_2b_5d_1d_3d_4 + b_1b_5c_6d_2d_3d_4 + b_2b_3b_4c_6d_1d_5) \\[0.5em]
p_{\texttt{AGAAC}} &= \frac{1}{4}(a_1a_3a_4a_6b_5c_2 + a_1a_5b_3b_4b_6c_2 + a_1c_2c_3c_4c_6d_5 + a_1c_2c_5d_3d_4d_6 + a_2a_3a_4b_5c_1c_6 + a_2a_5b_3b_4c_1d_6 + a_2a_6c_1c_3c_4d_5 + a_2b_6c_1c_5d_3d_4 + a_3a_4b_1b_5b_6d_2 + a_3a_4b_2b_5d_1d_6 + a_5a_6b_1b_3b_4d_2 + a_5b_2b_3b_4c_6d_1 + a_6b_2c_5d_1d_3d_4 + b_1c_3c_4d_2d_5d_6 + b_1c_5c_6d_2d_3d_4 + b_2b_6c_3c_4d_1d_5) \\[0.5em]
p_{\texttt{AGAAA}} &= \frac{1}{4}(a_1a_3a_4a_5a_6c_2 + a_1b_3b_4b_5b_6c_2 + a_1c_2c_3c_4c_5c_6 + a_1c_2d_3d_4d_5d_6 + a_2a_3a_4a_5c_1c_6 + a_2a_6c_1c_3c_4c_5 + a_2b_3b_4b_5c_1d_6 + a_2b_6c_1d_3d_4d_5 + a_3a_4a_5b_1b_6d_2 + a_3a_4a_5b_2d_1d_6 + a_6b_1b_3b_4b_5d_2 + a_6b_2d_1d_3d_4d_5 + b_1c_3c_4c_5d_2d_6 + b_1c_6d_2d_3d_4d_5 + b_2b_3b_4b_5c_6d_1 + b_2b_6c_3c_4c_5d_1) \\[0.5em]
p_{\texttt{ACTTT}} &= \frac{1}{4}(a_1a_3a_4a_5b_2d_6 + a_1a_6b_2d_3d_4d_5 + a_1b_2b_3b_4b_5c_6 + a_1b_2b_6c_3c_4c_5 + a_2a_3a_4a_5b_1c_6 + a_2a_6b_1c_3c_4c_5 + a_2b_1b_3b_4b_5d_6 + a_2b_1b_6d_3d_4d_5 + a_3a_4a_5a_6c_2d_1 + a_3a_4a_5b_6c_1d_2 + a_6b_3b_4b_5c_1d_2 + b_3b_4b_5b_6c_2d_1 + c_1c_3c_4c_5d_2d_6 + c_1c_6d_2d_3d_4d_5 + c_2c_3c_4c_5c_6d_1 + c_2d_1d_3d_4d_5d_6) \\[0.5em]
p_{\texttt{ACTTG}} &= \frac{1}{4}(a_1a_3a_4b_2b_5d_6 + a_1a_5b_2b_3b_4c_6 + a_1a_6b_2c_5d_3d_4 + a_1b_2b_6c_3c_4d_5 + a_2a_3a_4b_1b_5c_6 + a_2a_5b_1b_3b_4d_6 + a_2a_6b_1c_3c_4d_5 + a_2b_1b_6c_5d_3d_4 + a_3a_4a_6b_5c_2d_1 + a_3a_4b_5b_6c_1d_2 + a_5a_6b_3b_4c_1d_2 + a_5b_3b_4b_6c_2d_1 + c_1c_3c_4d_2d_5d_6 + c_1c_5c_6d_2d_3d_4 + c_2c_3c_4c_6d_1d_5 + c_2c_5d_1d_3d_4d_6) \\[0.5em]
p_{\texttt{ACTTC}} &= \frac{1}{4}(a_1a_3a_4b_2c_5d_6 + a_1a_5b_2b_6c_3c_4 + a_1a_6b_2b_5d_3d_4 + a_1b_2b_3b_4c_6d_5 + a_2a_3a_4b_1c_5c_6 + a_2a_5a_6b_1c_3c_4 + a_2b_1b_3b_4d_5d_6 + a_2b_1b_5b_6d_3d_4 + a_3a_4a_6c_2c_5d_1 + a_3a_4b_6c_1c_5d_2 + a_5c_1c_3c_4d_2d_6 + a_5c_2c_3c_4c_6d_1 + a_6b_3b_4c_1d_2d_5 + b_3b_4b_6c_2d_1d_5 + b_5c_1c_6d_2d_3d_4 + b_5c_2d_1d_3d_4d_6) \\[0.5em]
p_{\texttt{ACTTA}} &= \frac{1}{4}(a_1a_3a_4b_2d_5d_6 + a_1a_5a_6b_2d_3d_4 + a_1b_2b_3b_4c_5c_6 + a_1b_2b_5b_6c_3c_4 + a_2a_3a_4b_1c_6d_5 + a_2a_5b_1b_6d_3d_4 + a_2a_6b_1b_5c_3c_4 + a_2b_1b_3b_4c_5d_6 + a_3a_4a_6c_2d_1d_5 + a_3a_4b_6c_1d_2d_5 + a_5c_1c_6d_2d_3d_4 + a_5c_2d_1d_3d_4d_6 + a_6b_3b_4c_1c_5d_2 + b_3b_4b_6c_2c_5d_1 + b_5c_1c_3c_4d_2d_6 + b_5c_2c_3c_4c_6d_1) \\[0.5em]
p_{\texttt{ACTGT}} &= \frac{1}{4}(a_1a_3a_5b_2b_4d_6 + a_1a_4b_2b_3b_5c_6 + a_1a_6b_2c_4d_3d_5 + a_1b_2b_6c_3c_5d_4 + a_2a_3a_5b_1b_4c_6 + a_2a_4b_1b_3b_5d_6 + a_2a_6b_1c_3c_5d_4 + a_2b_1b_6c_4d_3d_5 + a_3a_5a_6b_4c_2d_1 + a_3a_5b_4b_6c_1d_2 + a_4a_6b_3b_5c_1d_2 + a_4b_3b_5b_6c_2d_1 + c_1c_3c_5d_2d_4d_6 + c_1c_4c_6d_2d_3d_5 + c_2c_3c_5c_6d_1d_4 + c_2c_4d_1d_3d_5d_6) \\[0.5em]
p_{\texttt{ACTGG}} &= \frac{1}{4}(a_1a_3b_2b_4b_5d_6 + a_1a_4a_5b_2b_3c_6 + a_1a_6b_2c_4c_5d_3 + a_1b_2b_6c_3d_4d_5 + a_2a_3b_1b_4b_5c_6 + a_2a_4a_5b_1b_3d_6 + a_2a_6b_1c_3d_4d_5 + a_2b_1b_6c_4c_5d_3 + a_3a_6b_4b_5c_2d_1 + a_3b_4b_5b_6c_1d_2 + a_4a_5a_6b_3c_1d_2 + a_4a_5b_3b_6c_2d_1 + c_1c_3d_2d_4d_5d_6 + c_1c_4c_5c_6d_2d_3 + c_2c_3c_6d_1d_4d_5 + c_2c_4c_5d_1d_3d_6) \\[0.5em]
p_{\texttt{ACTGC}} &= \frac{1}{4}(a_1a_3b_2b_4c_5d_6 + a_1a_4b_2b_3c_6d_5 + a_1a_5b_2b_6c_3d_4 + a_1a_6b_2b_5c_4d_3 + a_2a_3b_1b_4c_5c_6 + a_2a_4b_1b_3d_5d_6 + a_2a_5a_6b_1c_3d_4 + a_2b_1b_5b_6c_4d_3 + a_3a_6b_4c_2c_5d_1 + a_3b_4b_6c_1c_5d_2 + a_4a_6b_3c_1d_2d_5 + a_4b_3b_6c_2d_1d_5 + a_5c_1c_3d_2d_4d_6 + a_5c_2c_3c_6d_1d_4 + b_5c_1c_4c_6d_2d_3 + b_5c_2c_4d_1d_3d_6) \\[0.5em]
p_{\texttt{ACTGA}} &= \frac{1}{4}(a_1a_3b_2b_4d_5d_6 + a_1a_4b_2b_3c_5c_6 + a_1a_5a_6b_2c_4d_3 + a_1b_2b_5b_6c_3d_4 + a_2a_3b_1b_4c_6d_5 + a_2a_4b_1b_3c_5d_6 + a_2a_5b_1b_6c_4d_3 + a_2a_6b_1b_5c_3d_4 + a_3a_6b_4c_2d_1d_5 + a_3b_4b_6c_1d_2d_5 + a_4a_6b_3c_1c_5d_2 + a_4b_3b_6c_2c_5d_1 + a_5c_1c_4c_6d_2d_3 + a_5c_2c_4d_1d_3d_6 + b_5c_1c_3d_2d_4d_6 + b_5c_2c_3c_6d_1d_4) \\[0.5em]
p_{\texttt{ACTCT}} &= \frac{1}{4}(a_1a_3a_5b_2c_4d_6 + a_1a_4b_2b_6c_3c_5 + a_1a_6b_2b_4d_3d_5 + a_1b_2b_3b_5c_6d_4 + a_2a_3a_5b_1c_4c_6 + a_2a_4a_6b_1c_3c_5 + a_2b_1b_3b_5d_4d_6 + a_2b_1b_4b_6d_3d_5 + a_3a_5a_6c_2c_4d_1 + a_3a_5b_6c_1c_4d_2 + a_4c_1c_3c_5d_2d_6 + a_4c_2c_3c_5c_6d_1 + a_6b_3b_5c_1d_2d_4 + b_3b_5b_6c_2d_1d_4 + b_4c_1c_6d_2d_3d_5 + b_4c_2d_1d_3d_5d_6) \\[0.5em]
p_{\texttt{ACTCG}} &= \frac{1}{4}(a_1a_3b_2b_5c_4d_6 + a_1a_4b_2b_6c_3d_5 + a_1a_5b_2b_3c_6d_4 + a_1a_6b_2b_4c_5d_3 + a_2a_3b_1b_5c_4c_6 + a_2a_4a_6b_1c_3d_5 + a_2a_5b_1b_3d_4d_6 + a_2b_1b_4b_6c_5d_3 + a_3a_6b_5c_2c_4d_1 + a_3b_5b_6c_1c_4d_2 + a_4c_1c_3d_2d_5d_6 + a_4c_2c_3c_6d_1d_5 + a_5a_6b_3c_1d_2d_4 + a_5b_3b_6c_2d_1d_4 + b_4c_1c_5c_6d_2d_3 + b_4c_2c_5d_1d_3d_6) \\[0.5em]
p_{\texttt{ACTCC}} &= \frac{1}{4}(a_1a_3b_2c_4c_5d_6 + a_1a_4a_5b_2b_6c_3 + a_1a_6b_2b_4b_5d_3 + a_1b_2b_3c_6d_4d_5 + a_2a_3b_1c_4c_5c_6 + a_2a_4a_5a_6b_1c_3 + a_2b_1b_3d_4d_5d_6 + a_2b_1b_4b_5b_6d_3 + a_3a_6c_2c_4c_5d_1 + a_3b_6c_1c_4c_5d_2 + a_4a_5c_1c_3d_2d_6 + a_4a_5c_2c_3c_6d_1 + a_6b_3c_1d_2d_4d_5 + b_3b_6c_2d_1d_4d_5 + b_4b_5c_1c_6d_2d_3 + b_4b_5c_2d_1d_3d_6) \\[0.5em]
p_{\texttt{ACTCA}} &= \frac{1}{4}(a_1a_3b_2c_4d_5d_6 + a_1a_4b_2b_5b_6c_3 + a_1a_5a_6b_2b_4d_3 + a_1b_2b_3c_5c_6d_4 + a_2a_3b_1c_4c_6d_5 + a_2a_4a_6b_1b_5c_3 + a_2a_5b_1b_4b_6d_3 + a_2b_1b_3c_5d_4d_6 + a_3a_6c_2c_4d_1d_5 + a_3b_6c_1c_4d_2d_5 + a_4b_5c_1c_3d_2d_6 + a_4b_5c_2c_3c_6d_1 + a_5b_4c_1c_6d_2d_3 + a_5b_4c_2d_1d_3d_6 + a_6b_3c_1c_5d_2d_4 + b_3b_6c_2c_5d_1d_4) \\[0.5em]
p_{\texttt{ACTAT}} &= \frac{1}{4}(a_1a_3a_5b_2d_4d_6 + a_1a_4a_6b_2d_3d_5 + a_1b_2b_3b_5c_4c_6 + a_1b_2b_4b_6c_3c_5 + a_2a_3a_5b_1c_6d_4 + a_2a_4b_1b_6d_3d_5 + a_2a_6b_1b_4c_3c_5 + a_2b_1b_3b_5c_4d_6 + a_3a_5a_6c_2d_1d_4 + a_3a_5b_6c_1d_2d_4 + a_4c_1c_6d_2d_3d_5 + a_4c_2d_1d_3d_5d_6 + a_6b_3b_5c_1c_4d_2 + b_3b_5b_6c_2c_4d_1 + b_4c_1c_3c_5d_2d_6 + b_4c_2c_3c_5c_6d_1) \\[0.5em]
p_{\texttt{ACTAG}} &= \frac{1}{4}(a_1a_3b_2b_5d_4d_6 + a_1a_4a_6b_2c_5d_3 + a_1a_5b_2b_3c_4c_6 + a_1b_2b_4b_6c_3d_5 + a_2a_3b_1b_5c_6d_4 + a_2a_4b_1b_6c_5d_3 + a_2a_5b_1b_3c_4d_6 + a_2a_6b_1b_4c_3d_5 + a_3a_6b_5c_2d_1d_4 + a_3b_5b_6c_1d_2d_4 + a_4c_1c_5c_6d_2d_3 + a_4c_2c_5d_1d_3d_6 + a_5a_6b_3c_1c_4d_2 + a_5b_3b_6c_2c_4d_1 + b_4c_1c_3d_2d_5d_6 + b_4c_2c_3c_6d_1d_5) \\[0.5em]
p_{\texttt{ACTAC}} &= \frac{1}{4}(a_1a_3b_2c_5d_4d_6 + a_1a_4a_6b_2b_5d_3 + a_1a_5b_2b_4b_6c_3 + a_1b_2b_3c_4c_6d_5 + a_2a_3b_1c_5c_6d_4 + a_2a_4b_1b_5b_6d_3 + a_2a_5a_6b_1b_4c_3 + a_2b_1b_3c_4d_5d_6 + a_3a_6c_2c_5d_1d_4 + a_3b_6c_1c_5d_2d_4 + a_4b_5c_1c_6d_2d_3 + a_4b_5c_2d_1d_3d_6 + a_5b_4c_1c_3d_2d_6 + a_5b_4c_2c_3c_6d_1 + a_6b_3c_1c_4d_2d_5 + b_3b_6c_2c_4d_1d_5) \\[0.5em]
p_{\texttt{ACTAA}} &= \frac{1}{4}(a_1a_3b_2d_4d_5d_6 + a_1a_4a_5a_6b_2d_3 + a_1b_2b_3c_4c_5c_6 + a_1b_2b_4b_5b_6c_3 + a_2a_3b_1c_6d_4d_5 + a_2a_4a_5b_1b_6d_3 + a_2a_6b_1b_4b_5c_3 + a_2b_1b_3c_4c_5d_6 + a_3a_6c_2d_1d_4d_5 + a_3b_6c_1d_2d_4d_5 + a_4a_5c_1c_6d_2d_3 + a_4a_5c_2d_1d_3d_6 + a_6b_3c_1c_4c_5d_2 + b_3b_6c_2c_4c_5d_1 + b_4b_5c_1c_3d_2d_6 + b_4b_5c_2c_3c_6d_1) \\[0.5em]
p_{\texttt{ACGTT}} &= \frac{1}{4}(a_1a_3b_2b_4b_5c_6 + a_1a_4a_5b_2b_3d_6 + a_1a_6b_2c_3d_4d_5 + a_1b_2b_6c_4c_5d_3 + a_2a_3b_1b_4b_5d_6 + a_2a_4a_5b_1b_3c_6 + a_2a_6b_1c_4c_5d_3 + a_2b_1b_6c_3d_4d_5 + a_3a_6b_4b_5c_1d_2 + a_3b_4b_5b_6c_2d_1 + a_4a_5a_6b_3c_2d_1 + a_4a_5b_3b_6c_1d_2 + c_1c_3c_6d_2d_4d_5 + c_1c_4c_5d_2d_3d_6 + c_2c_3d_1d_4d_5d_6 + c_2c_4c_5c_6d_1d_3) \\[0.5em]
p_{\texttt{ACGTG}} &= \frac{1}{4}(a_1a_3a_5b_2b_4c_6 + a_1a_4b_2b_3b_5d_6 + a_1a_6b_2c_3c_5d_4 + a_1b_2b_6c_4d_3d_5 + a_2a_3a_5b_1b_4d_6 + a_2a_4b_1b_3b_5c_6 + a_2a_6b_1c_4d_3d_5 + a_2b_1b_6c_3c_5d_4 + a_3a_5a_6b_4c_1d_2 + a_3a_5b_4b_6c_2d_1 + a_4a_6b_3b_5c_2d_1 + a_4b_3b_5b_6c_1d_2 + c_1c_3c_5c_6d_2d_4 + c_1c_4d_2d_3d_5d_6 + c_2c_3c_5d_1d_4d_6 + c_2c_4c_6d_1d_3d_5) \\[0.5em]
p_{\texttt{ACGTC}} &= \frac{1}{4}(a_1a_3b_2b_4c_6d_5 + a_1a_4b_2b_3c_5d_6 + a_1a_5b_2b_6c_4d_3 + a_1a_6b_2b_5c_3d_4 + a_2a_3b_1b_4d_5d_6 + a_2a_4b_1b_3c_5c_6 + a_2a_5a_6b_1c_4d_3 + a_2b_1b_5b_6c_3d_4 + a_3a_6b_4c_1d_2d_5 + a_3b_4b_6c_2d_1d_5 + a_4a_6b_3c_2c_5d_1 + a_4b_3b_6c_1c_5d_2 + a_5c_1c_4d_2d_3d_6 + a_5c_2c_4c_6d_1d_3 + b_5c_1c_3c_6d_2d_4 + b_5c_2c_3d_1d_4d_6) \\[0.5em]
p_{\texttt{ACGTA}} &= \frac{1}{4}(a_1a_3b_2b_4c_5c_6 + a_1a_4b_2b_3d_5d_6 + a_1a_5a_6b_2c_3d_4 + a_1b_2b_5b_6c_4d_3 + a_2a_3b_1b_4c_5d_6 + a_2a_4b_1b_3c_6d_5 + a_2a_5b_1b_6c_3d_4 + a_2a_6b_1b_5c_4d_3 + a_3a_6b_4c_1c_5d_2 + a_3b_4b_6c_2c_5d_1 + a_4a_6b_3c_2d_1d_5 + a_4b_3b_6c_1d_2d_5 + a_5c_1c_3c_6d_2d_4 + a_5c_2c_3d_1d_4d_6 + b_5c_1c_4d_2d_3d_6 + b_5c_2c_4c_6d_1d_3) \\[0.5em]
p_{\texttt{ACGGT}} &= \frac{1}{4}(a_1a_3a_4b_2b_5c_6 + a_1a_5b_2b_3b_4d_6 + a_1a_6b_2c_3c_4d_5 + a_1b_2b_6c_5d_3d_4 + a_2a_3a_4b_1b_5d_6 + a_2a_5b_1b_3b_4c_6 + a_2a_6b_1c_5d_3d_4 + a_2b_1b_6c_3c_4d_5 + a_3a_4a_6b_5c_1d_2 + a_3a_4b_5b_6c_2d_1 + a_5a_6b_3b_4c_2d_1 + a_5b_3b_4b_6c_1d_2 + c_1c_3c_4c_6d_2d_5 + c_1c_5d_2d_3d_4d_6 + c_2c_3c_4d_1d_5d_6 + c_2c_5c_6d_1d_3d_4) \\[0.5em]
p_{\texttt{ACGGG}} &= \frac{1}{4}(a_1a_3a_4a_5b_2c_6 + a_1a_6b_2c_3c_4c_5 + a_1b_2b_3b_4b_5d_6 + a_1b_2b_6d_3d_4d_5 + a_2a_3a_4a_5b_1d_6 + a_2a_6b_1d_3d_4d_5 + a_2b_1b_3b_4b_5c_6 + a_2b_1b_6c_3c_4c_5 + a_3a_4a_5a_6c_1d_2 + a_3a_4a_5b_6c_2d_1 + a_6b_3b_4b_5c_2d_1 + b_3b_4b_5b_6c_1d_2 + c_1c_3c_4c_5c_6d_2 + c_1d_2d_3d_4d_5d_6 + c_2c_3c_4c_5d_1d_6 + c_2c_6d_1d_3d_4d_5) \\[0.5em]
p_{\texttt{ACGGC}} &= \frac{1}{4}(a_1a_3a_4b_2c_6d_5 + a_1a_5b_2b_6d_3d_4 + a_1a_6b_2b_5c_3c_4 + a_1b_2b_3b_4c_5d_6 + a_2a_3a_4b_1d_5d_6 + a_2a_5a_6b_1d_3d_4 + a_2b_1b_3b_4c_5c_6 + a_2b_1b_5b_6c_3c_4 + a_3a_4a_6c_1d_2d_5 + a_3a_4b_6c_2d_1d_5 + a_5c_1d_2d_3d_4d_6 + a_5c_2c_6d_1d_3d_4 + a_6b_3b_4c_2c_5d_1 + b_3b_4b_6c_1c_5d_2 + b_5c_1c_3c_4c_6d_2 + b_5c_2c_3c_4d_1d_6) \\[0.5em]
p_{\texttt{ACGGA}} &= \frac{1}{4}(a_1a_3a_4b_2c_5c_6 + a_1a_5a_6b_2c_3c_4 + a_1b_2b_3b_4d_5d_6 + a_1b_2b_5b_6d_3d_4 + a_2a_3a_4b_1c_5d_6 + a_2a_5b_1b_6c_3c_4 + a_2a_6b_1b_5d_3d_4 + a_2b_1b_3b_4c_6d_5 + a_3a_4a_6c_1c_5d_2 + a_3a_4b_6c_2c_5d_1 + a_5c_1c_3c_4c_6d_2 + a_5c_2c_3c_4d_1d_6 + a_6b_3b_4c_2d_1d_5 + b_3b_4b_6c_1d_2d_5 + b_5c_1d_2d_3d_4d_6 + b_5c_2c_6d_1d_3d_4) \\[0.5em]
p_{\texttt{ACGCT}} &= \frac{1}{4}(a_1a_3b_2b_5c_6d_4 + a_1a_4b_2b_6c_5d_3 + a_1a_5b_2b_3c_4d_6 + a_1a_6b_2b_4c_3d_5 + a_2a_3b_1b_5d_4d_6 + a_2a_4a_6b_1c_5d_3 + a_2a_5b_1b_3c_4c_6 + a_2b_1b_4b_6c_3d_5 + a_3a_6b_5c_1d_2d_4 + a_3b_5b_6c_2d_1d_4 + a_4c_1c_5d_2d_3d_6 + a_4c_2c_5c_6d_1d_3 + a_5a_6b_3c_2c_4d_1 + a_5b_3b_6c_1c_4d_2 + b_4c_1c_3c_6d_2d_5 + b_4c_2c_3d_1d_5d_6) \\[0.5em]
p_{\texttt{ACGCG}} &= \frac{1}{4}(a_1a_3a_5b_2c_6d_4 + a_1a_4b_2b_6d_3d_5 + a_1a_6b_2b_4c_3c_5 + a_1b_2b_3b_5c_4d_6 + a_2a_3a_5b_1d_4d_6 + a_2a_4a_6b_1d_3d_5 + a_2b_1b_3b_5c_4c_6 + a_2b_1b_4b_6c_3c_5 + a_3a_5a_6c_1d_2d_4 + a_3a_5b_6c_2d_1d_4 + a_4c_1d_2d_3d_5d_6 + a_4c_2c_6d_1d_3d_5 + a_6b_3b_5c_2c_4d_1 + b_3b_5b_6c_1c_4d_2 + b_4c_1c_3c_5c_6d_2 + b_4c_2c_3c_5d_1d_6) \\[0.5em]
p_{\texttt{ACGCC}} &= \frac{1}{4}(a_1a_3b_2c_6d_4d_5 + a_1a_4a_5b_2b_6d_3 + a_1a_6b_2b_4b_5c_3 + a_1b_2b_3c_4c_5d_6 + a_2a_3b_1d_4d_5d_6 + a_2a_4a_5a_6b_1d_3 + a_2b_1b_3c_4c_5c_6 + a_2b_1b_4b_5b_6c_3 + a_3a_6c_1d_2d_4d_5 + a_3b_6c_2d_1d_4d_5 + a_4a_5c_1d_2d_3d_6 + a_4a_5c_2c_6d_1d_3 + a_6b_3c_2c_4c_5d_1 + b_3b_6c_1c_4c_5d_2 + b_4b_5c_1c_3c_6d_2 + b_4b_5c_2c_3d_1d_6) \\[0.5em]
p_{\texttt{ACGCA}} &= \frac{1}{4}(a_1a_3b_2c_5c_6d_4 + a_1a_4b_2b_5b_6d_3 + a_1a_5a_6b_2b_4c_3 + a_1b_2b_3c_4d_5d_6 + a_2a_3b_1c_5d_4d_6 + a_2a_4a_6b_1b_5d_3 + a_2a_5b_1b_4b_6c_3 + a_2b_1b_3c_4c_6d_5 + a_3a_6c_1c_5d_2d_4 + a_3b_6c_2c_5d_1d_4 + a_4b_5c_1d_2d_3d_6 + a_4b_5c_2c_6d_1d_3 + a_5b_4c_1c_3c_6d_2 + a_5b_4c_2c_3d_1d_6 + a_6b_3c_2c_4d_1d_5 + b_3b_6c_1c_4d_2d_5) \\[0.5em]
p_{\texttt{ACGAT}} &= \frac{1}{4}(a_1a_3b_2b_5c_4c_6 + a_1a_4a_6b_2c_3d_5 + a_1a_5b_2b_3d_4d_6 + a_1b_2b_4b_6c_5d_3 + a_2a_3b_1b_5c_4d_6 + a_2a_4b_1b_6c_3d_5 + a_2a_5b_1b_3c_6d_4 + a_2a_6b_1b_4c_5d_3 + a_3a_6b_5c_1c_4d_2 + a_3b_5b_6c_2c_4d_1 + a_4c_1c_3c_6d_2d_5 + a_4c_2c_3d_1d_5d_6 + a_5a_6b_3c_2d_1d_4 + a_5b_3b_6c_1d_2d_4 + b_4c_1c_5d_2d_3d_6 + b_4c_2c_5c_6d_1d_3) \\[0.5em]
p_{\texttt{ACGAG}} &= \frac{1}{4}(a_1a_3a_5b_2c_4c_6 + a_1a_4a_6b_2c_3c_5 + a_1b_2b_3b_5d_4d_6 + a_1b_2b_4b_6d_3d_5 + a_2a_3a_5b_1c_4d_6 + a_2a_4b_1b_6c_3c_5 + a_2a_6b_1b_4d_3d_5 + a_2b_1b_3b_5c_6d_4 + a_3a_5a_6c_1c_4d_2 + a_3a_5b_6c_2c_4d_1 + a_4c_1c_3c_5c_6d_2 + a_4c_2c_3c_5d_1d_6 + a_6b_3b_5c_2d_1d_4 + b_3b_5b_6c_1d_2d_4 + b_4c_1d_2d_3d_5d_6 + b_4c_2c_6d_1d_3d_5) \\[0.5em]
p_{\texttt{ACGAC}} &= \frac{1}{4}(a_1a_3b_2c_4c_6d_5 + a_1a_4a_6b_2b_5c_3 + a_1a_5b_2b_4b_6d_3 + a_1b_2b_3c_5d_4d_6 + a_2a_3b_1c_4d_5d_6 + a_2a_4b_1b_5b_6c_3 + a_2a_5a_6b_1b_4d_3 + a_2b_1b_3c_5c_6d_4 + a_3a_6c_1c_4d_2d_5 + a_3b_6c_2c_4d_1d_5 + a_4b_5c_1c_3c_6d_2 + a_4b_5c_2c_3d_1d_6 + a_5b_4c_1d_2d_3d_6 + a_5b_4c_2c_6d_1d_3 + a_6b_3c_2c_5d_1d_4 + b_3b_6c_1c_5d_2d_4) \\[0.5em]
p_{\texttt{ACGAA}} &= \frac{1}{4}(a_1a_3b_2c_4c_5c_6 + a_1a_4a_5a_6b_2c_3 + a_1b_2b_3d_4d_5d_6 + a_1b_2b_4b_5b_6d_3 + a_2a_3b_1c_4c_5d_6 + a_2a_4a_5b_1b_6c_3 + a_2a_6b_1b_4b_5d_3 + a_2b_1b_3c_6d_4d_5 + a_3a_6c_1c_4c_5d_2 + a_3b_6c_2c_4c_5d_1 + a_4a_5c_1c_3c_6d_2 + a_4a_5c_2c_3d_1d_6 + a_6b_3c_2d_1d_4d_5 + b_3b_6c_1d_2d_4d_5 + b_4b_5c_1d_2d_3d_6 + b_4b_5c_2c_6d_1d_3) \\[0.5em]
p_{\texttt{ACCTT}} &= \frac{1}{4}(a_1a_3b_2b_6c_4c_5 + a_1a_4a_5b_2c_3d_6 + a_1a_6b_2b_3d_4d_5 + a_1b_2b_4b_5c_6d_3 + a_2a_3a_6b_1c_4c_5 + a_2a_4a_5b_1c_3c_6 + a_2b_1b_3b_6d_4d_5 + a_2b_1b_4b_5d_3d_6 + a_3c_1c_4c_5d_2d_6 + a_3c_2c_4c_5c_6d_1 + a_4a_5a_6c_2c_3d_1 + a_4a_5b_6c_1c_3d_2 + a_6b_4b_5c_1d_2d_3 + b_3c_1c_6d_2d_4d_5 + b_3c_2d_1d_4d_5d_6 + b_4b_5b_6c_2d_1d_3) \\[0.5em]
p_{\texttt{ACCTG}} &= \frac{1}{4}(a_1a_3b_2b_6c_4d_5 + a_1a_4b_2b_5c_3d_6 + a_1a_5b_2b_4c_6d_3 + a_1a_6b_2b_3c_5d_4 + a_2a_3a_6b_1c_4d_5 + a_2a_4b_1b_5c_3c_6 + a_2a_5b_1b_4d_3d_6 + a_2b_1b_3b_6c_5d_4 + a_3c_1c_4d_2d_5d_6 + a_3c_2c_4c_6d_1d_5 + a_4a_6b_5c_2c_3d_1 + a_4b_5b_6c_1c_3d_2 + a_5a_6b_4c_1d_2d_3 + a_5b_4b_6c_2d_1d_3 + b_3c_1c_5c_6d_2d_4 + b_3c_2c_5d_1d_4d_6) \\[0.5em]
p_{\texttt{ACCTC}} &= \frac{1}{4}(a_1a_3a_5b_2b_6c_4 + a_1a_4b_2c_3c_5d_6 + a_1a_6b_2b_3b_5d_4 + a_1b_2b_4c_6d_3d_5 + a_2a_3a_5a_6b_1c_4 + a_2a_4b_1c_3c_5c_6 + a_2b_1b_3b_5b_6d_4 + a_2b_1b_4d_3d_5d_6 + a_3a_5c_1c_4d_2d_6 + a_3a_5c_2c_4c_6d_1 + a_4a_6c_2c_3c_5d_1 + a_4b_6c_1c_3c_5d_2 + a_6b_4c_1d_2d_3d_5 + b_3b_5c_1c_6d_2d_4 + b_3b_5c_2d_1d_4d_6 + b_4b_6c_2d_1d_3d_5) \\[0.5em]
p_{\texttt{ACCTA}} &= \frac{1}{4}(a_1a_3b_2b_5b_6c_4 + a_1a_4b_2c_3d_5d_6 + a_1a_5a_6b_2b_3d_4 + a_1b_2b_4c_5c_6d_3 + a_2a_3a_6b_1b_5c_4 + a_2a_4b_1c_3c_6d_5 + a_2a_5b_1b_3b_6d_4 + a_2b_1b_4c_5d_3d_6 + a_3b_5c_1c_4d_2d_6 + a_3b_5c_2c_4c_6d_1 + a_4a_6c_2c_3d_1d_5 + a_4b_6c_1c_3d_2d_5 + a_5b_3c_1c_6d_2d_4 + a_5b_3c_2d_1d_4d_6 + a_6b_4c_1c_5d_2d_3 + b_4b_6c_2c_5d_1d_3) \\[0.5em]
p_{\texttt{ACCGT}} &= \frac{1}{4}(a_1a_3b_2b_6c_5d_4 + a_1a_4b_2b_5c_6d_3 + a_1a_5b_2b_4c_3d_6 + a_1a_6b_2b_3c_4d_5 + a_2a_3a_6b_1c_5d_4 + a_2a_4b_1b_5d_3d_6 + a_2a_5b_1b_4c_3c_6 + a_2b_1b_3b_6c_4d_5 + a_3c_1c_5d_2d_4d_6 + a_3c_2c_5c_6d_1d_4 + a_4a_6b_5c_1d_2d_3 + a_4b_5b_6c_2d_1d_3 + a_5a_6b_4c_2c_3d_1 + a_5b_4b_6c_1c_3d_2 + b_3c_1c_4c_6d_2d_5 + b_3c_2c_4d_1d_5d_6) \\[0.5em]
p_{\texttt{ACCGG}} &= \frac{1}{4}(a_1a_3b_2b_6d_4d_5 + a_1a_4a_5b_2c_6d_3 + a_1a_6b_2b_3c_4c_5 + a_1b_2b_4b_5c_3d_6 + a_2a_3a_6b_1d_4d_5 + a_2a_4a_5b_1d_3d_6 + a_2b_1b_3b_6c_4c_5 + a_2b_1b_4b_5c_3c_6 + a_3c_1d_2d_4d_5d_6 + a_3c_2c_6d_1d_4d_5 + a_4a_5a_6c_1d_2d_3 + a_4a_5b_6c_2d_1d_3 + a_6b_4b_5c_2c_3d_1 + b_3c_1c_4c_5c_6d_2 + b_3c_2c_4c_5d_1d_6 + b_4b_5b_6c_1c_3d_2) \\[0.5em]
p_{\texttt{ACCGC}} &= \frac{1}{4}(a_1a_3a_5b_2b_6d_4 + a_1a_4b_2c_6d_3d_5 + a_1a_6b_2b_3b_5c_4 + a_1b_2b_4c_3c_5d_6 + a_2a_3a_5a_6b_1d_4 + a_2a_4b_1d_3d_5d_6 + a_2b_1b_3b_5b_6c_4 + a_2b_1b_4c_3c_5c_6 + a_3a_5c_1d_2d_4d_6 + a_3a_5c_2c_6d_1d_4 + a_4a_6c_1d_2d_3d_5 + a_4b_6c_2d_1d_3d_5 + a_6b_4c_2c_3c_5d_1 + b_3b_5c_1c_4c_6d_2 + b_3b_5c_2c_4d_1d_6 + b_4b_6c_1c_3c_5d_2) \\[0.5em]
p_{\texttt{ACCGA}} &= \frac{1}{4}(a_1a_3b_2b_5b_6d_4 + a_1a_4b_2c_5c_6d_3 + a_1a_5a_6b_2b_3c_4 + a_1b_2b_4c_3d_5d_6 + a_2a_3a_6b_1b_5d_4 + a_2a_4b_1c_5d_3d_6 + a_2a_5b_1b_3b_6c_4 + a_2b_1b_4c_3c_6d_5 + a_3b_5c_1d_2d_4d_6 + a_3b_5c_2c_6d_1d_4 + a_4a_6c_1c_5d_2d_3 + a_4b_6c_2c_5d_1d_3 + a_5b_3c_1c_4c_6d_2 + a_5b_3c_2c_4d_1d_6 + a_6b_4c_2c_3d_1d_5 + b_4b_6c_1c_3d_2d_5) \\[0.5em]
p_{\texttt{ACCCT}} &= \frac{1}{4}(a_1a_3a_4b_2b_6c_5 + a_1a_5b_2c_3c_4d_6 + a_1a_6b_2b_3b_4d_5 + a_1b_2b_5c_6d_3d_4 + a_2a_3a_4a_6b_1c_5 + a_2a_5b_1c_3c_4c_6 + a_2b_1b_3b_4b_6d_5 + a_2b_1b_5d_3d_4d_6 + a_3a_4c_1c_5d_2d_6 + a_3a_4c_2c_5c_6d_1 + a_5a_6c_2c_3c_4d_1 + a_5b_6c_1c_3c_4d_2 + a_6b_5c_1d_2d_3d_4 + b_3b_4c_1c_6d_2d_5 + b_3b_4c_2d_1d_5d_6 + b_5b_6c_2d_1d_3d_4) \\[0.5em]
p_{\texttt{ACCCG}} &= \frac{1}{4}(a_1a_3a_4b_2b_6d_5 + a_1a_5b_2c_6d_3d_4 + a_1a_6b_2b_3b_4c_5 + a_1b_2b_5c_3c_4d_6 + a_2a_3a_4a_6b_1d_5 + a_2a_5b_1d_3d_4d_6 + a_2b_1b_3b_4b_6c_5 + a_2b_1b_5c_3c_4c_6 + a_3a_4c_1d_2d_5d_6 + a_3a_4c_2c_6d_1d_5 + a_5a_6c_1d_2d_3d_4 + a_5b_6c_2d_1d_3d_4 + a_6b_5c_2c_3c_4d_1 + b_3b_4c_1c_5c_6d_2 + b_3b_4c_2c_5d_1d_6 + b_5b_6c_1c_3c_4d_2) \\[0.5em]
p_{\texttt{ACCCC}} &= \frac{1}{4}(a_1a_3a_4a_5b_2b_6 + a_1a_6b_2b_3b_4b_5 + a_1b_2c_3c_4c_5d_6 + a_1b_2c_6d_3d_4d_5 + a_2a_3a_4a_5a_6b_1 + a_2b_1b_3b_4b_5b_6 + a_2b_1c_3c_4c_5c_6 + a_2b_1d_3d_4d_5d_6 + a_3a_4a_5c_1d_2d_6 + a_3a_4a_5c_2c_6d_1 + a_6c_1d_2d_3d_4d_5 + a_6c_2c_3c_4c_5d_1 + b_3b_4b_5c_1c_6d_2 + b_3b_4b_5c_2d_1d_6 + b_6c_1c_3c_4c_5d_2 + b_6c_2d_1d_3d_4d_5) \\[0.5em]
p_{\texttt{ACCCA}} &= \frac{1}{4}(a_1a_3a_4b_2b_5b_6 + a_1a_5a_6b_2b_3b_4 + a_1b_2c_3c_4d_5d_6 + a_1b_2c_5c_6d_3d_4 + a_2a_3a_4a_6b_1b_5 + a_2a_5b_1b_3b_4b_6 + a_2b_1c_3c_4c_6d_5 + a_2b_1c_5d_3d_4d_6 + a_3a_4b_5c_1d_2d_6 + a_3a_4b_5c_2c_6d_1 + a_5b_3b_4c_1c_6d_2 + a_5b_3b_4c_2d_1d_6 + a_6c_1c_5d_2d_3d_4 + a_6c_2c_3c_4d_1d_5 + b_6c_1c_3c_4d_2d_5 + b_6c_2c_5d_1d_3d_4) \\[0.5em]
p_{\texttt{ACCAT}} &= \frac{1}{4}(a_1a_3b_2b_4b_6c_5 + a_1a_4a_6b_2b_3d_5 + a_1a_5b_2c_3d_4d_6 + a_1b_2b_5c_4c_6d_3 + a_2a_3a_6b_1b_4c_5 + a_2a_4b_1b_3b_6d_5 + a_2a_5b_1c_3c_6d_4 + a_2b_1b_5c_4d_3d_6 + a_3b_4c_1c_5d_2d_6 + a_3b_4c_2c_5c_6d_1 + a_4b_3c_1c_6d_2d_5 + a_4b_3c_2d_1d_5d_6 + a_5a_6c_2c_3d_1d_4 + a_5b_6c_1c_3d_2d_4 + a_6b_5c_1c_4d_2d_3 + b_5b_6c_2c_4d_1d_3) \\[0.5em]
p_{\texttt{ACCAG}} &= \frac{1}{4}(a_1a_3b_2b_4b_6d_5 + a_1a_4a_6b_2b_3c_5 + a_1a_5b_2c_4c_6d_3 + a_1b_2b_5c_3d_4d_6 + a_2a_3a_6b_1b_4d_5 + a_2a_4b_1b_3b_6c_5 + a_2a_5b_1c_4d_3d_6 + a_2b_1b_5c_3c_6d_4 + a_3b_4c_1d_2d_5d_6 + a_3b_4c_2c_6d_1d_5 + a_4b_3c_1c_5c_6d_2 + a_4b_3c_2c_5d_1d_6 + a_5a_6c_1c_4d_2d_3 + a_5b_6c_2c_4d_1d_3 + a_6b_5c_2c_3d_1d_4 + b_5b_6c_1c_3d_2d_4) \\[0.5em]
p_{\texttt{ACCAC}} &= \frac{1}{4}(a_1a_3a_5b_2b_4b_6 + a_1a_4a_6b_2b_3b_5 + a_1b_2c_3c_5d_4d_6 + a_1b_2c_4c_6d_3d_5 + a_2a_3a_5a_6b_1b_4 + a_2a_4b_1b_3b_5b_6 + a_2b_1c_3c_5c_6d_4 + a_2b_1c_4d_3d_5d_6 + a_3a_5b_4c_1d_2d_6 + a_3a_5b_4c_2c_6d_1 + a_4b_3b_5c_1c_6d_2 + a_4b_3b_5c_2d_1d_6 + a_6c_1c_4d_2d_3d_5 + a_6c_2c_3c_5d_1d_4 + b_6c_1c_3c_5d_2d_4 + b_6c_2c_4d_1d_3d_5) \\[0.5em]
p_{\texttt{ACCAA}} &= \frac{1}{4}(a_1a_3b_2b_4b_5b_6 + a_1a_4a_5a_6b_2b_3 + a_1b_2c_3d_4d_5d_6 + a_1b_2c_4c_5c_6d_3 + a_2a_3a_6b_1b_4b_5 + a_2a_4a_5b_1b_3b_6 + a_2b_1c_3c_6d_4d_5 + a_2b_1c_4c_5d_3d_6 + a_3b_4b_5c_1d_2d_6 + a_3b_4b_5c_2c_6d_1 + a_4a_5b_3c_1c_6d_2 + a_4a_5b_3c_2d_1d_6 + a_6c_1c_4c_5d_2d_3 + a_6c_2c_3d_1d_4d_5 + b_6c_1c_3d_2d_4d_5 + b_6c_2c_4c_5d_1d_3) \\[0.5em]
p_{\texttt{ACATT}} &= \frac{1}{4}(a_1a_3a_6b_2d_4d_5 + a_1a_4a_5b_2d_3d_6 + a_1b_2b_3b_6c_4c_5 + a_1b_2b_4b_5c_3c_6 + a_2a_3b_1b_6d_4d_5 + a_2a_4a_5b_1c_6d_3 + a_2a_6b_1b_3c_4c_5 + a_2b_1b_4b_5c_3d_6 + a_3c_1c_6d_2d_4d_5 + a_3c_2d_1d_4d_5d_6 + a_4a_5a_6c_2d_1d_3 + a_4a_5b_6c_1d_2d_3 + a_6b_4b_5c_1c_3d_2 + b_3c_1c_4c_5d_2d_6 + b_3c_2c_4c_5c_6d_1 + b_4b_5b_6c_2c_3d_1) \\[0.5em]
p_{\texttt{ACATG}} &= \frac{1}{4}(a_1a_3a_6b_2c_5d_4 + a_1a_4b_2b_5d_3d_6 + a_1a_5b_2b_4c_3c_6 + a_1b_2b_3b_6c_4d_5 + a_2a_3b_1b_6c_5d_4 + a_2a_4b_1b_5c_6d_3 + a_2a_5b_1b_4c_3d_6 + a_2a_6b_1b_3c_4d_5 + a_3c_1c_5c_6d_2d_4 + a_3c_2c_5d_1d_4d_6 + a_4a_6b_5c_2d_1d_3 + a_4b_5b_6c_1d_2d_3 + a_5a_6b_4c_1c_3d_2 + a_5b_4b_6c_2c_3d_1 + b_3c_1c_4d_2d_5d_6 + b_3c_2c_4c_6d_1d_5) \\[0.5em]
p_{\texttt{ACATC}} &= \frac{1}{4}(a_1a_3a_6b_2b_5d_4 + a_1a_4b_2c_5d_3d_6 + a_1a_5b_2b_3b_6c_4 + a_1b_2b_4c_3c_6d_5 + a_2a_3b_1b_5b_6d_4 + a_2a_4b_1c_5c_6d_3 + a_2a_5a_6b_1b_3c_4 + a_2b_1b_4c_3d_5d_6 + a_3b_5c_1c_6d_2d_4 + a_3b_5c_2d_1d_4d_6 + a_4a_6c_2c_5d_1d_3 + a_4b_6c_1c_5d_2d_3 + a_5b_3c_1c_4d_2d_6 + a_5b_3c_2c_4c_6d_1 + a_6b_4c_1c_3d_2d_5 + b_4b_6c_2c_3d_1d_5) \\[0.5em]
p_{\texttt{ACATA}} &= \frac{1}{4}(a_1a_3a_5a_6b_2d_4 + a_1a_4b_2d_3d_5d_6 + a_1b_2b_3b_5b_6c_4 + a_1b_2b_4c_3c_5c_6 + a_2a_3a_5b_1b_6d_4 + a_2a_4b_1c_6d_3d_5 + a_2a_6b_1b_3b_5c_4 + a_2b_1b_4c_3c_5d_6 + a_3a_5c_1c_6d_2d_4 + a_3a_5c_2d_1d_4d_6 + a_4a_6c_2d_1d_3d_5 + a_4b_6c_1d_2d_3d_5 + a_6b_4c_1c_3c_5d_2 + b_3b_5c_1c_4d_2d_6 + b_3b_5c_2c_4c_6d_1 + b_4b_6c_2c_3c_5d_1) \\[0.5em]
p_{\texttt{ACAGT}} &= \frac{1}{4}(a_1a_3a_6b_2c_4d_5 + a_1a_4b_2b_5c_3c_6 + a_1a_5b_2b_4d_3d_6 + a_1b_2b_3b_6c_5d_4 + a_2a_3b_1b_6c_4d_5 + a_2a_4b_1b_5c_3d_6 + a_2a_5b_1b_4c_6d_3 + a_2a_6b_1b_3c_5d_4 + a_3c_1c_4c_6d_2d_5 + a_3c_2c_4d_1d_5d_6 + a_4a_6b_5c_1c_3d_2 + a_4b_5b_6c_2c_3d_1 + a_5a_6b_4c_2d_1d_3 + a_5b_4b_6c_1d_2d_3 + b_3c_1c_5d_2d_4d_6 + b_3c_2c_5c_6d_1d_4) \\[0.5em]
p_{\texttt{ACAGG}} &= \frac{1}{4}(a_1a_3a_6b_2c_4c_5 + a_1a_4a_5b_2c_3c_6 + a_1b_2b_3b_6d_4d_5 + a_1b_2b_4b_5d_3d_6 + a_2a_3b_1b_6c_4c_5 + a_2a_4a_5b_1c_3d_6 + a_2a_6b_1b_3d_4d_5 + a_2b_1b_4b_5c_6d_3 + a_3c_1c_4c_5c_6d_2 + a_3c_2c_4c_5d_1d_6 + a_4a_5a_6c_1c_3d_2 + a_4a_5b_6c_2c_3d_1 + a_6b_4b_5c_2d_1d_3 + b_3c_1d_2d_4d_5d_6 + b_3c_2c_6d_1d_4d_5 + b_4b_5b_6c_1d_2d_3) \\[0.5em]
p_{\texttt{ACAGC}} &= \frac{1}{4}(a_1a_3a_6b_2b_5c_4 + a_1a_4b_2c_3c_6d_5 + a_1a_5b_2b_3b_6d_4 + a_1b_2b_4c_5d_3d_6 + a_2a_3b_1b_5b_6c_4 + a_2a_4b_1c_3d_5d_6 + a_2a_5a_6b_1b_3d_4 + a_2b_1b_4c_5c_6d_3 + a_3b_5c_1c_4c_6d_2 + a_3b_5c_2c_4d_1d_6 + a_4a_6c_1c_3d_2d_5 + a_4b_6c_2c_3d_1d_5 + a_5b_3c_1d_2d_4d_6 + a_5b_3c_2c_6d_1d_4 + a_6b_4c_2c_5d_1d_3 + b_4b_6c_1c_5d_2d_3) \\[0.5em]
p_{\texttt{ACAGA}} &= \frac{1}{4}(a_1a_3a_5a_6b_2c_4 + a_1a_4b_2c_3c_5c_6 + a_1b_2b_3b_5b_6d_4 + a_1b_2b_4d_3d_5d_6 + a_2a_3a_5b_1b_6c_4 + a_2a_4b_1c_3c_5d_6 + a_2a_6b_1b_3b_5d_4 + a_2b_1b_4c_6d_3d_5 + a_3a_5c_1c_4c_6d_2 + a_3a_5c_2c_4d_1d_6 + a_4a_6c_1c_3c_5d_2 + a_4b_6c_2c_3c_5d_1 + a_6b_4c_2d_1d_3d_5 + b_3b_5c_1d_2d_4d_6 + b_3b_5c_2c_6d_1d_4 + b_4b_6c_1d_2d_3d_5) \\[0.5em]
p_{\texttt{ACACT}} &= \frac{1}{4}(a_1a_3a_6b_2b_4d_5 + a_1a_4b_2b_3b_6c_5 + a_1a_5b_2c_4d_3d_6 + a_1b_2b_5c_3c_6d_4 + a_2a_3b_1b_4b_6d_5 + a_2a_4a_6b_1b_3c_5 + a_2a_5b_1c_4c_6d_3 + a_2b_1b_5c_3d_4d_6 + a_3b_4c_1c_6d_2d_5 + a_3b_4c_2d_1d_5d_6 + a_4b_3c_1c_5d_2d_6 + a_4b_3c_2c_5c_6d_1 + a_5a_6c_2c_4d_1d_3 + a_5b_6c_1c_4d_2d_3 + a_6b_5c_1c_3d_2d_4 + b_5b_6c_2c_3d_1d_4) \\[0.5em]
p_{\texttt{ACACG}} &= \frac{1}{4}(a_1a_3a_6b_2b_4c_5 + a_1a_4b_2b_3b_6d_5 + a_1a_5b_2c_3c_6d_4 + a_1b_2b_5c_4d_3d_6 + a_2a_3b_1b_4b_6c_5 + a_2a_4a_6b_1b_3d_5 + a_2a_5b_1c_3d_4d_6 + a_2b_1b_5c_4c_6d_3 + a_3b_4c_1c_5c_6d_2 + a_3b_4c_2c_5d_1d_6 + a_4b_3c_1d_2d_5d_6 + a_4b_3c_2c_6d_1d_5 + a_5a_6c_1c_3d_2d_4 + a_5b_6c_2c_3d_1d_4 + a_6b_5c_2c_4d_1d_3 + b_5b_6c_1c_4d_2d_3) \\[0.5em]
p_{\texttt{ACACC}} &= \frac{1}{4}(a_1a_3a_6b_2b_4b_5 + a_1a_4a_5b_2b_3b_6 + a_1b_2c_3c_6d_4d_5 + a_1b_2c_4c_5d_3d_6 + a_2a_3b_1b_4b_5b_6 + a_2a_4a_5a_6b_1b_3 + a_2b_1c_3d_4d_5d_6 + a_2b_1c_4c_5c_6d_3 + a_3b_4b_5c_1c_6d_2 + a_3b_4b_5c_2d_1d_6 + a_4a_5b_3c_1d_2d_6 + a_4a_5b_3c_2c_6d_1 + a_6c_1c_3d_2d_4d_5 + a_6c_2c_4c_5d_1d_3 + b_6c_1c_4c_5d_2d_3 + b_6c_2c_3d_1d_4d_5) \\[0.5em]
p_{\texttt{ACACA}} &= \frac{1}{4}(a_1a_3a_5a_6b_2b_4 + a_1a_4b_2b_3b_5b_6 + a_1b_2c_3c_5c_6d_4 + a_1b_2c_4d_3d_5d_6 + a_2a_3a_5b_1b_4b_6 + a_2a_4a_6b_1b_3b_5 + a_2b_1c_3c_5d_4d_6 + a_2b_1c_4c_6d_3d_5 + a_3a_5b_4c_1c_6d_2 + a_3a_5b_4c_2d_1d_6 + a_4b_3b_5c_1d_2d_6 + a_4b_3b_5c_2c_6d_1 + a_6c_1c_3c_5d_2d_4 + a_6c_2c_4d_1d_3d_5 + b_6c_1c_4d_2d_3d_5 + b_6c_2c_3c_5d_1d_4) \\[0.5em]
p_{\texttt{ACAAT}} &= \frac{1}{4}(a_1a_3a_4a_6b_2d_5 + a_1a_5b_2d_3d_4d_6 + a_1b_2b_3b_4b_6c_5 + a_1b_2b_5c_3c_4c_6 + a_2a_3a_4b_1b_6d_5 + a_2a_5b_1c_6d_3d_4 + a_2a_6b_1b_3b_4c_5 + a_2b_1b_5c_3c_4d_6 + a_3a_4c_1c_6d_2d_5 + a_3a_4c_2d_1d_5d_6 + a_5a_6c_2d_1d_3d_4 + a_5b_6c_1d_2d_3d_4 + a_6b_5c_1c_3c_4d_2 + b_3b_4c_1c_5d_2d_6 + b_3b_4c_2c_5c_6d_1 + b_5b_6c_2c_3c_4d_1) \\[0.5em]
p_{\texttt{ACAAG}} &= \frac{1}{4}(a_1a_3a_4a_6b_2c_5 + a_1a_5b_2c_3c_4c_6 + a_1b_2b_3b_4b_6d_5 + a_1b_2b_5d_3d_4d_6 + a_2a_3a_4b_1b_6c_5 + a_2a_5b_1c_3c_4d_6 + a_2a_6b_1b_3b_4d_5 + a_2b_1b_5c_6d_3d_4 + a_3a_4c_1c_5c_6d_2 + a_3a_4c_2c_5d_1d_6 + a_5a_6c_1c_3c_4d_2 + a_5b_6c_2c_3c_4d_1 + a_6b_5c_2d_1d_3d_4 + b_3b_4c_1d_2d_5d_6 + b_3b_4c_2c_6d_1d_5 + b_5b_6c_1d_2d_3d_4) \\[0.5em]
p_{\texttt{ACAAC}} &= \frac{1}{4}(a_1a_3a_4a_6b_2b_5 + a_1a_5b_2b_3b_4b_6 + a_1b_2c_3c_4c_6d_5 + a_1b_2c_5d_3d_4d_6 + a_2a_3a_4b_1b_5b_6 + a_2a_5a_6b_1b_3b_4 + a_2b_1c_3c_4d_5d_6 + a_2b_1c_5c_6d_3d_4 + a_3a_4b_5c_1c_6d_2 + a_3a_4b_5c_2d_1d_6 + a_5b_3b_4c_1d_2d_6 + a_5b_3b_4c_2c_6d_1 + a_6c_1c_3c_4d_2d_5 + a_6c_2c_5d_1d_3d_4 + b_6c_1c_5d_2d_3d_4 + b_6c_2c_3c_4d_1d_5) \\[0.5em]
p_{\texttt{ACAAA}} &= \frac{1}{4}(a_1a_3a_4a_5a_6b_2 + a_1b_2b_3b_4b_5b_6 + a_1b_2c_3c_4c_5c_6 + a_1b_2d_3d_4d_5d_6 + a_2a_3a_4a_5b_1b_6 + a_2a_6b_1b_3b_4b_5 + a_2b_1c_3c_4c_5d_6 + a_2b_1c_6d_3d_4d_5 + a_3a_4a_5c_1c_6d_2 + a_3a_4a_5c_2d_1d_6 + a_6c_1c_3c_4c_5d_2 + a_6c_2d_1d_3d_4d_5 + b_3b_4b_5c_1d_2d_6 + b_3b_4b_5c_2c_6d_1 + b_6c_1d_2d_3d_4d_5 + b_6c_2c_3c_4c_5d_1) \\[0.5em]
p_{\texttt{AATTT}} &= \frac{1}{4}(a_1a_2a_3a_4a_5d_6 + a_1a_2a_6d_3d_4d_5 + a_1a_2b_3b_4b_5c_6 + a_1a_2b_6c_3c_4c_5 + a_3a_4a_5a_6d_1d_2 + a_3a_4a_5b_1b_2c_6 + a_3a_4a_5b_6c_1c_2 + a_6b_1b_2c_3c_4c_5 + a_6b_3b_4b_5c_1c_2 + b_1b_2b_3b_4b_5d_6 + b_1b_2b_6d_3d_4d_5 + b_3b_4b_5b_6d_1d_2 + c_1c_2c_3c_4c_5d_6 + c_1c_2c_6d_3d_4d_5 + c_3c_4c_5c_6d_1d_2 + d_1d_2d_3d_4d_5d_6) \\[0.5em]
p_{\texttt{AATTG}} &= \frac{1}{4}(a_1a_2a_3a_4b_5d_6 + a_1a_2a_5b_3b_4c_6 + a_1a_2a_6c_5d_3d_4 + a_1a_2b_6c_3c_4d_5 + a_3a_4a_6b_5d_1d_2 + a_3a_4b_1b_2b_5c_6 + a_3a_4b_5b_6c_1c_2 + a_5a_6b_3b_4c_1c_2 + a_5b_1b_2b_3b_4d_6 + a_5b_3b_4b_6d_1d_2 + a_6b_1b_2c_3c_4d_5 + b_1b_2b_6c_5d_3d_4 + c_1c_2c_3c_4d_5d_6 + c_1c_2c_5c_6d_3d_4 + c_3c_4c_6d_1d_2d_5 + c_5d_1d_2d_3d_4d_6) \\[0.5em]
p_{\texttt{AATTC}} &= \frac{1}{4}(a_1a_2a_3a_4c_5d_6 + a_1a_2a_5b_6c_3c_4 + a_1a_2a_6b_5d_3d_4 + a_1a_2b_3b_4c_6d_5 + a_3a_4a_6c_5d_1d_2 + a_3a_4b_1b_2c_5c_6 + a_3a_4b_6c_1c_2c_5 + a_5a_6b_1b_2c_3c_4 + a_5c_1c_2c_3c_4d_6 + a_5c_3c_4c_6d_1d_2 + a_6b_3b_4c_1c_2d_5 + b_1b_2b_3b_4d_5d_6 + b_1b_2b_5b_6d_3d_4 + b_3b_4b_6d_1d_2d_5 + b_5c_1c_2c_6d_3d_4 + b_5d_1d_2d_3d_4d_6) \\[0.5em]
p_{\texttt{AATTA}} &= \frac{1}{4}(a_1a_2a_3a_4d_5d_6 + a_1a_2a_5a_6d_3d_4 + a_1a_2b_3b_4c_5c_6 + a_1a_2b_5b_6c_3c_4 + a_3a_4a_6d_1d_2d_5 + a_3a_4b_1b_2c_6d_5 + a_3a_4b_6c_1c_2d_5 + a_5b_1b_2b_6d_3d_4 + a_5c_1c_2c_6d_3d_4 + a_5d_1d_2d_3d_4d_6 + a_6b_1b_2b_5c_3c_4 + a_6b_3b_4c_1c_2c_5 + b_1b_2b_3b_4c_5d_6 + b_3b_4b_6c_5d_1d_2 + b_5c_1c_2c_3c_4d_6 + b_5c_3c_4c_6d_1d_2) \\[0.5em]
p_{\texttt{AATGT}} &= \frac{1}{4}(a_1a_2a_3a_5b_4d_6 + a_1a_2a_4b_3b_5c_6 + a_1a_2a_6c_4d_3d_5 + a_1a_2b_6c_3c_5d_4 + a_3a_5a_6b_4d_1d_2 + a_3a_5b_1b_2b_4c_6 + a_3a_5b_4b_6c_1c_2 + a_4a_6b_3b_5c_1c_2 + a_4b_1b_2b_3b_5d_6 + a_4b_3b_5b_6d_1d_2 + a_6b_1b_2c_3c_5d_4 + b_1b_2b_6c_4d_3d_5 + c_1c_2c_3c_5d_4d_6 + c_1c_2c_4c_6d_3d_5 + c_3c_5c_6d_1d_2d_4 + c_4d_1d_2d_3d_5d_6) \\[0.5em]
p_{\texttt{AATGG}} &= \frac{1}{4}(a_1a_2a_3b_4b_5d_6 + a_1a_2a_4a_5b_3c_6 + a_1a_2a_6c_4c_5d_3 + a_1a_2b_6c_3d_4d_5 + a_3a_6b_4b_5d_1d_2 + a_3b_1b_2b_4b_5c_6 + a_3b_4b_5b_6c_1c_2 + a_4a_5a_6b_3c_1c_2 + a_4a_5b_1b_2b_3d_6 + a_4a_5b_3b_6d_1d_2 + a_6b_1b_2c_3d_4d_5 + b_1b_2b_6c_4c_5d_3 + c_1c_2c_3d_4d_5d_6 + c_1c_2c_4c_5c_6d_3 + c_3c_6d_1d_2d_4d_5 + c_4c_5d_1d_2d_3d_6) \\[0.5em]
p_{\texttt{AATGC}} &= \frac{1}{4}(a_1a_2a_3b_4c_5d_6 + a_1a_2a_4b_3c_6d_5 + a_1a_2a_5b_6c_3d_4 + a_1a_2a_6b_5c_4d_3 + a_3a_6b_4c_5d_1d_2 + a_3b_1b_2b_4c_5c_6 + a_3b_4b_6c_1c_2c_5 + a_4a_6b_3c_1c_2d_5 + a_4b_1b_2b_3d_5d_6 + a_4b_3b_6d_1d_2d_5 + a_5a_6b_1b_2c_3d_4 + a_5c_1c_2c_3d_4d_6 + a_5c_3c_6d_1d_2d_4 + b_1b_2b_5b_6c_4d_3 + b_5c_1c_2c_4c_6d_3 + b_5c_4d_1d_2d_3d_6) \\[0.5em]
p_{\texttt{AATGA}} &= \frac{1}{4}(a_1a_2a_3b_4d_5d_6 + a_1a_2a_4b_3c_5c_6 + a_1a_2a_5a_6c_4d_3 + a_1a_2b_5b_6c_3d_4 + a_3a_6b_4d_1d_2d_5 + a_3b_1b_2b_4c_6d_5 + a_3b_4b_6c_1c_2d_5 + a_4a_6b_3c_1c_2c_5 + a_4b_1b_2b_3c_5d_6 + a_4b_3b_6c_5d_1d_2 + a_5b_1b_2b_6c_4d_3 + a_5c_1c_2c_4c_6d_3 + a_5c_4d_1d_2d_3d_6 + a_6b_1b_2b_5c_3d_4 + b_5c_1c_2c_3d_4d_6 + b_5c_3c_6d_1d_2d_4) \\[0.5em]
p_{\texttt{AATCT}} &= \frac{1}{4}(a_1a_2a_3a_5c_4d_6 + a_1a_2a_4b_6c_3c_5 + a_1a_2a_6b_4d_3d_5 + a_1a_2b_3b_5c_6d_4 + a_3a_5a_6c_4d_1d_2 + a_3a_5b_1b_2c_4c_6 + a_3a_5b_6c_1c_2c_4 + a_4a_6b_1b_2c_3c_5 + a_4c_1c_2c_3c_5d_6 + a_4c_3c_5c_6d_1d_2 + a_6b_3b_5c_1c_2d_4 + b_1b_2b_3b_5d_4d_6 + b_1b_2b_4b_6d_3d_5 + b_3b_5b_6d_1d_2d_4 + b_4c_1c_2c_6d_3d_5 + b_4d_1d_2d_3d_5d_6) \\[0.5em]
p_{\texttt{AATCG}} &= \frac{1}{4}(a_1a_2a_3b_5c_4d_6 + a_1a_2a_4b_6c_3d_5 + a_1a_2a_5b_3c_6d_4 + a_1a_2a_6b_4c_5d_3 + a_3a_6b_5c_4d_1d_2 + a_3b_1b_2b_5c_4c_6 + a_3b_5b_6c_1c_2c_4 + a_4a_6b_1b_2c_3d_5 + a_4c_1c_2c_3d_5d_6 + a_4c_3c_6d_1d_2d_5 + a_5a_6b_3c_1c_2d_4 + a_5b_1b_2b_3d_4d_6 + a_5b_3b_6d_1d_2d_4 + b_1b_2b_4b_6c_5d_3 + b_4c_1c_2c_5c_6d_3 + b_4c_5d_1d_2d_3d_6) \\[0.5em]
p_{\texttt{AATCC}} &= \frac{1}{4}(a_1a_2a_3c_4c_5d_6 + a_1a_2a_4a_5b_6c_3 + a_1a_2a_6b_4b_5d_3 + a_1a_2b_3c_6d_4d_5 + a_3a_6c_4c_5d_1d_2 + a_3b_1b_2c_4c_5c_6 + a_3b_6c_1c_2c_4c_5 + a_4a_5a_6b_1b_2c_3 + a_4a_5c_1c_2c_3d_6 + a_4a_5c_3c_6d_1d_2 + a_6b_3c_1c_2d_4d_5 + b_1b_2b_3d_4d_5d_6 + b_1b_2b_4b_5b_6d_3 + b_3b_6d_1d_2d_4d_5 + b_4b_5c_1c_2c_6d_3 + b_4b_5d_1d_2d_3d_6) \\[0.5em]
p_{\texttt{AATCA}} &= \frac{1}{4}(a_1a_2a_3c_4d_5d_6 + a_1a_2a_4b_5b_6c_3 + a_1a_2a_5a_6b_4d_3 + a_1a_2b_3c_5c_6d_4 + a_3a_6c_4d_1d_2d_5 + a_3b_1b_2c_4c_6d_5 + a_3b_6c_1c_2c_4d_5 + a_4a_6b_1b_2b_5c_3 + a_4b_5c_1c_2c_3d_6 + a_4b_5c_3c_6d_1d_2 + a_5b_1b_2b_4b_6d_3 + a_5b_4c_1c_2c_6d_3 + a_5b_4d_1d_2d_3d_6 + a_6b_3c_1c_2c_5d_4 + b_1b_2b_3c_5d_4d_6 + b_3b_6c_5d_1d_2d_4) \\[0.5em]
p_{\texttt{AATAT}} &= \frac{1}{4}(a_1a_2a_3a_5d_4d_6 + a_1a_2a_4a_6d_3d_5 + a_1a_2b_3b_5c_4c_6 + a_1a_2b_4b_6c_3c_5 + a_3a_5a_6d_1d_2d_4 + a_3a_5b_1b_2c_6d_4 + a_3a_5b_6c_1c_2d_4 + a_4b_1b_2b_6d_3d_5 + a_4c_1c_2c_6d_3d_5 + a_4d_1d_2d_3d_5d_6 + a_6b_1b_2b_4c_3c_5 + a_6b_3b_5c_1c_2c_4 + b_1b_2b_3b_5c_4d_6 + b_3b_5b_6c_4d_1d_2 + b_4c_1c_2c_3c_5d_6 + b_4c_3c_5c_6d_1d_2) \\[0.5em]
p_{\texttt{AATAG}} &= \frac{1}{4}(a_1a_2a_3b_5d_4d_6 + a_1a_2a_4a_6c_5d_3 + a_1a_2a_5b_3c_4c_6 + a_1a_2b_4b_6c_3d_5 + a_3a_6b_5d_1d_2d_4 + a_3b_1b_2b_5c_6d_4 + a_3b_5b_6c_1c_2d_4 + a_4b_1b_2b_6c_5d_3 + a_4c_1c_2c_5c_6d_3 + a_4c_5d_1d_2d_3d_6 + a_5a_6b_3c_1c_2c_4 + a_5b_1b_2b_3c_4d_6 + a_5b_3b_6c_4d_1d_2 + a_6b_1b_2b_4c_3d_5 + b_4c_1c_2c_3d_5d_6 + b_4c_3c_6d_1d_2d_5) \\[0.5em]
p_{\texttt{AATAC}} &= \frac{1}{4}(a_1a_2a_3c_5d_4d_6 + a_1a_2a_4a_6b_5d_3 + a_1a_2a_5b_4b_6c_3 + a_1a_2b_3c_4c_6d_5 + a_3a_6c_5d_1d_2d_4 + a_3b_1b_2c_5c_6d_4 + a_3b_6c_1c_2c_5d_4 + a_4b_1b_2b_5b_6d_3 + a_4b_5c_1c_2c_6d_3 + a_4b_5d_1d_2d_3d_6 + a_5a_6b_1b_2b_4c_3 + a_5b_4c_1c_2c_3d_6 + a_5b_4c_3c_6d_1d_2 + a_6b_3c_1c_2c_4d_5 + b_1b_2b_3c_4d_5d_6 + b_3b_6c_4d_1d_2d_5) \\[0.5em]
p_{\texttt{AATAA}} &= \frac{1}{4}(a_1a_2a_3d_4d_5d_6 + a_1a_2a_4a_5a_6d_3 + a_1a_2b_3c_4c_5c_6 + a_1a_2b_4b_5b_6c_3 + a_3a_6d_1d_2d_4d_5 + a_3b_1b_2c_6d_4d_5 + a_3b_6c_1c_2d_4d_5 + a_4a_5b_1b_2b_6d_3 + a_4a_5c_1c_2c_6d_3 + a_4a_5d_1d_2d_3d_6 + a_6b_1b_2b_4b_5c_3 + a_6b_3c_1c_2c_4c_5 + b_1b_2b_3c_4c_5d_6 + b_3b_6c_4c_5d_1d_2 + b_4b_5c_1c_2c_3d_6 + b_4b_5c_3c_6d_1d_2) \\[0.5em]
p_{\texttt{AAGTT}} &= \frac{1}{4}(a_1a_2a_3b_4b_5c_6 + a_1a_2a_4a_5b_3d_6 + a_1a_2a_6c_3d_4d_5 + a_1a_2b_6c_4c_5d_3 + a_3a_6b_4b_5c_1c_2 + a_3b_1b_2b_4b_5d_6 + a_3b_4b_5b_6d_1d_2 + a_4a_5a_6b_3d_1d_2 + a_4a_5b_1b_2b_3c_6 + a_4a_5b_3b_6c_1c_2 + a_6b_1b_2c_4c_5d_3 + b_1b_2b_6c_3d_4d_5 + c_1c_2c_3c_6d_4d_5 + c_1c_2c_4c_5d_3d_6 + c_3d_1d_2d_4d_5d_6 + c_4c_5c_6d_1d_2d_3) \\[0.5em]
p_{\texttt{AAGTG}} &= \frac{1}{4}(a_1a_2a_3a_5b_4c_6 + a_1a_2a_4b_3b_5d_6 + a_1a_2a_6c_3c_5d_4 + a_1a_2b_6c_4d_3d_5 + a_3a_5a_6b_4c_1c_2 + a_3a_5b_1b_2b_4d_6 + a_3a_5b_4b_6d_1d_2 + a_4a_6b_3b_5d_1d_2 + a_4b_1b_2b_3b_5c_6 + a_4b_3b_5b_6c_1c_2 + a_6b_1b_2c_4d_3d_5 + b_1b_2b_6c_3c_5d_4 + c_1c_2c_3c_5c_6d_4 + c_1c_2c_4d_3d_5d_6 + c_3c_5d_1d_2d_4d_6 + c_4c_6d_1d_2d_3d_5) \\[0.5em]
p_{\texttt{AAGTC}} &= \frac{1}{4}(a_1a_2a_3b_4c_6d_5 + a_1a_2a_4b_3c_5d_6 + a_1a_2a_5b_6c_4d_3 + a_1a_2a_6b_5c_3d_4 + a_3a_6b_4c_1c_2d_5 + a_3b_1b_2b_4d_5d_6 + a_3b_4b_6d_1d_2d_5 + a_4a_6b_3c_5d_1d_2 + a_4b_1b_2b_3c_5c_6 + a_4b_3b_6c_1c_2c_5 + a_5a_6b_1b_2c_4d_3 + a_5c_1c_2c_4d_3d_6 + a_5c_4c_6d_1d_2d_3 + b_1b_2b_5b_6c_3d_4 + b_5c_1c_2c_3c_6d_4 + b_5c_3d_1d_2d_4d_6) \\[0.5em]
p_{\texttt{AAGTA}} &= \frac{1}{4}(a_1a_2a_3b_4c_5c_6 + a_1a_2a_4b_3d_5d_6 + a_1a_2a_5a_6c_3d_4 + a_1a_2b_5b_6c_4d_3 + a_3a_6b_4c_1c_2c_5 + a_3b_1b_2b_4c_5d_6 + a_3b_4b_6c_5d_1d_2 + a_4a_6b_3d_1d_2d_5 + a_4b_1b_2b_3c_6d_5 + a_4b_3b_6c_1c_2d_5 + a_5b_1b_2b_6c_3d_4 + a_5c_1c_2c_3c_6d_4 + a_5c_3d_1d_2d_4d_6 + a_6b_1b_2b_5c_4d_3 + b_5c_1c_2c_4d_3d_6 + b_5c_4c_6d_1d_2d_3) \\[0.5em]
p_{\texttt{AAGGT}} &= \frac{1}{4}(a_1a_2a_3a_4b_5c_6 + a_1a_2a_5b_3b_4d_6 + a_1a_2a_6c_3c_4d_5 + a_1a_2b_6c_5d_3d_4 + a_3a_4a_6b_5c_1c_2 + a_3a_4b_1b_2b_5d_6 + a_3a_4b_5b_6d_1d_2 + a_5a_6b_3b_4d_1d_2 + a_5b_1b_2b_3b_4c_6 + a_5b_3b_4b_6c_1c_2 + a_6b_1b_2c_5d_3d_4 + b_1b_2b_6c_3c_4d_5 + c_1c_2c_3c_4c_6d_5 + c_1c_2c_5d_3d_4d_6 + c_3c_4d_1d_2d_5d_6 + c_5c_6d_1d_2d_3d_4) \\[0.5em]
p_{\texttt{AAGGG}} &= \frac{1}{4}(a_1a_2a_3a_4a_5c_6 + a_1a_2a_6c_3c_4c_5 + a_1a_2b_3b_4b_5d_6 + a_1a_2b_6d_3d_4d_5 + a_3a_4a_5a_6c_1c_2 + a_3a_4a_5b_1b_2d_6 + a_3a_4a_5b_6d_1d_2 + a_6b_1b_2d_3d_4d_5 + a_6b_3b_4b_5d_1d_2 + b_1b_2b_3b_4b_5c_6 + b_1b_2b_6c_3c_4c_5 + b_3b_4b_5b_6c_1c_2 + c_1c_2c_3c_4c_5c_6 + c_1c_2d_3d_4d_5d_6 + c_3c_4c_5d_1d_2d_6 + c_6d_1d_2d_3d_4d_5) \\[0.5em]
p_{\texttt{AAGGC}} &= \frac{1}{4}(a_1a_2a_3a_4c_6d_5 + a_1a_2a_5b_6d_3d_4 + a_1a_2a_6b_5c_3c_4 + a_1a_2b_3b_4c_5d_6 + a_3a_4a_6c_1c_2d_5 + a_3a_4b_1b_2d_5d_6 + a_3a_4b_6d_1d_2d_5 + a_5a_6b_1b_2d_3d_4 + a_5c_1c_2d_3d_4d_6 + a_5c_6d_1d_2d_3d_4 + a_6b_3b_4c_5d_1d_2 + b_1b_2b_3b_4c_5c_6 + b_1b_2b_5b_6c_3c_4 + b_3b_4b_6c_1c_2c_5 + b_5c_1c_2c_3c_4c_6 + b_5c_3c_4d_1d_2d_6) \\[0.5em]
p_{\texttt{AAGGA}} &= \frac{1}{4}(a_1a_2a_3a_4c_5c_6 + a_1a_2a_5a_6c_3c_4 + a_1a_2b_3b_4d_5d_6 + a_1a_2b_5b_6d_3d_4 + a_3a_4a_6c_1c_2c_5 + a_3a_4b_1b_2c_5d_6 + a_3a_4b_6c_5d_1d_2 + a_5b_1b_2b_6c_3c_4 + a_5c_1c_2c_3c_4c_6 + a_5c_3c_4d_1d_2d_6 + a_6b_1b_2b_5d_3d_4 + a_6b_3b_4d_1d_2d_5 + b_1b_2b_3b_4c_6d_5 + b_3b_4b_6c_1c_2d_5 + b_5c_1c_2d_3d_4d_6 + b_5c_6d_1d_2d_3d_4) \\[0.5em]
p_{\texttt{AAGCT}} &= \frac{1}{4}(a_1a_2a_3b_5c_6d_4 + a_1a_2a_4b_6c_5d_3 + a_1a_2a_5b_3c_4d_6 + a_1a_2a_6b_4c_3d_5 + a_3a_6b_5c_1c_2d_4 + a_3b_1b_2b_5d_4d_6 + a_3b_5b_6d_1d_2d_4 + a_4a_6b_1b_2c_5d_3 + a_4c_1c_2c_5d_3d_6 + a_4c_5c_6d_1d_2d_3 + a_5a_6b_3c_4d_1d_2 + a_5b_1b_2b_3c_4c_6 + a_5b_3b_6c_1c_2c_4 + b_1b_2b_4b_6c_3d_5 + b_4c_1c_2c_3c_6d_5 + b_4c_3d_1d_2d_5d_6) \\[0.5em]
p_{\texttt{AAGCG}} &= \frac{1}{4}(a_1a_2a_3a_5c_6d_4 + a_1a_2a_4b_6d_3d_5 + a_1a_2a_6b_4c_3c_5 + a_1a_2b_3b_5c_4d_6 + a_3a_5a_6c_1c_2d_4 + a_3a_5b_1b_2d_4d_6 + a_3a_5b_6d_1d_2d_4 + a_4a_6b_1b_2d_3d_5 + a_4c_1c_2d_3d_5d_6 + a_4c_6d_1d_2d_3d_5 + a_6b_3b_5c_4d_1d_2 + b_1b_2b_3b_5c_4c_6 + b_1b_2b_4b_6c_3c_5 + b_3b_5b_6c_1c_2c_4 + b_4c_1c_2c_3c_5c_6 + b_4c_3c_5d_1d_2d_6) \\[0.5em]
p_{\texttt{AAGCC}} &= \frac{1}{4}(a_1a_2a_3c_6d_4d_5 + a_1a_2a_4a_5b_6d_3 + a_1a_2a_6b_4b_5c_3 + a_1a_2b_3c_4c_5d_6 + a_3a_6c_1c_2d_4d_5 + a_3b_1b_2d_4d_5d_6 + a_3b_6d_1d_2d_4d_5 + a_4a_5a_6b_1b_2d_3 + a_4a_5c_1c_2d_3d_6 + a_4a_5c_6d_1d_2d_3 + a_6b_3c_4c_5d_1d_2 + b_1b_2b_3c_4c_5c_6 + b_1b_2b_4b_5b_6c_3 + b_3b_6c_1c_2c_4c_5 + b_4b_5c_1c_2c_3c_6 + b_4b_5c_3d_1d_2d_6) \\[0.5em]
p_{\texttt{AAGCA}} &= \frac{1}{4}(a_1a_2a_3c_5c_6d_4 + a_1a_2a_4b_5b_6d_3 + a_1a_2a_5a_6b_4c_3 + a_1a_2b_3c_4d_5d_6 + a_3a_6c_1c_2c_5d_4 + a_3b_1b_2c_5d_4d_6 + a_3b_6c_5d_1d_2d_4 + a_4a_6b_1b_2b_5d_3 + a_4b_5c_1c_2d_3d_6 + a_4b_5c_6d_1d_2d_3 + a_5b_1b_2b_4b_6c_3 + a_5b_4c_1c_2c_3c_6 + a_5b_4c_3d_1d_2d_6 + a_6b_3c_4d_1d_2d_5 + b_1b_2b_3c_4c_6d_5 + b_3b_6c_1c_2c_4d_5) \\[0.5em]
p_{\texttt{AAGAT}} &= \frac{1}{4}(a_1a_2a_3b_5c_4c_6 + a_1a_2a_4a_6c_3d_5 + a_1a_2a_5b_3d_4d_6 + a_1a_2b_4b_6c_5d_3 + a_3a_6b_5c_1c_2c_4 + a_3b_1b_2b_5c_4d_6 + a_3b_5b_6c_4d_1d_2 + a_4b_1b_2b_6c_3d_5 + a_4c_1c_2c_3c_6d_5 + a_4c_3d_1d_2d_5d_6 + a_5a_6b_3d_1d_2d_4 + a_5b_1b_2b_3c_6d_4 + a_5b_3b_6c_1c_2d_4 + a_6b_1b_2b_4c_5d_3 + b_4c_1c_2c_5d_3d_6 + b_4c_5c_6d_1d_2d_3) \\[0.5em]
p_{\texttt{AAGAG}} &= \frac{1}{4}(a_1a_2a_3a_5c_4c_6 + a_1a_2a_4a_6c_3c_5 + a_1a_2b_3b_5d_4d_6 + a_1a_2b_4b_6d_3d_5 + a_3a_5a_6c_1c_2c_4 + a_3a_5b_1b_2c_4d_6 + a_3a_5b_6c_4d_1d_2 + a_4b_1b_2b_6c_3c_5 + a_4c_1c_2c_3c_5c_6 + a_4c_3c_5d_1d_2d_6 + a_6b_1b_2b_4d_3d_5 + a_6b_3b_5d_1d_2d_4 + b_1b_2b_3b_5c_6d_4 + b_3b_5b_6c_1c_2d_4 + b_4c_1c_2d_3d_5d_6 + b_4c_6d_1d_2d_3d_5) \\[0.5em]
p_{\texttt{AAGAC}} &= \frac{1}{4}(a_1a_2a_3c_4c_6d_5 + a_1a_2a_4a_6b_5c_3 + a_1a_2a_5b_4b_6d_3 + a_1a_2b_3c_5d_4d_6 + a_3a_6c_1c_2c_4d_5 + a_3b_1b_2c_4d_5d_6 + a_3b_6c_4d_1d_2d_5 + a_4b_1b_2b_5b_6c_3 + a_4b_5c_1c_2c_3c_6 + a_4b_5c_3d_1d_2d_6 + a_5a_6b_1b_2b_4d_3 + a_5b_4c_1c_2d_3d_6 + a_5b_4c_6d_1d_2d_3 + a_6b_3c_5d_1d_2d_4 + b_1b_2b_3c_5c_6d_4 + b_3b_6c_1c_2c_5d_4) \\[0.5em]
p_{\texttt{AAGAA}} &= \frac{1}{4}(a_1a_2a_3c_4c_5c_6 + a_1a_2a_4a_5a_6c_3 + a_1a_2b_3d_4d_5d_6 + a_1a_2b_4b_5b_6d_3 + a_3a_6c_1c_2c_4c_5 + a_3b_1b_2c_4c_5d_6 + a_3b_6c_4c_5d_1d_2 + a_4a_5b_1b_2b_6c_3 + a_4a_5c_1c_2c_3c_6 + a_4a_5c_3d_1d_2d_6 + a_6b_1b_2b_4b_5d_3 + a_6b_3d_1d_2d_4d_5 + b_1b_2b_3c_6d_4d_5 + b_3b_6c_1c_2d_4d_5 + b_4b_5c_1c_2d_3d_6 + b_4b_5c_6d_1d_2d_3) \\[0.5em]
p_{\texttt{AACTT}} &= \frac{1}{4}(a_1a_2a_3b_6c_4c_5 + a_1a_2a_4a_5c_3d_6 + a_1a_2a_6b_3d_4d_5 + a_1a_2b_4b_5c_6d_3 + a_3a_6b_1b_2c_4c_5 + a_3c_1c_2c_4c_5d_6 + a_3c_4c_5c_6d_1d_2 + a_4a_5a_6c_3d_1d_2 + a_4a_5b_1b_2c_3c_6 + a_4a_5b_6c_1c_2c_3 + a_6b_4b_5c_1c_2d_3 + b_1b_2b_3b_6d_4d_5 + b_1b_2b_4b_5d_3d_6 + b_3c_1c_2c_6d_4d_5 + b_3d_1d_2d_4d_5d_6 + b_4b_5b_6d_1d_2d_3) \\[0.5em]
p_{\texttt{AACTG}} &= \frac{1}{4}(a_1a_2a_3b_6c_4d_5 + a_1a_2a_4b_5c_3d_6 + a_1a_2a_5b_4c_6d_3 + a_1a_2a_6b_3c_5d_4 + a_3a_6b_1b_2c_4d_5 + a_3c_1c_2c_4d_5d_6 + a_3c_4c_6d_1d_2d_5 + a_4a_6b_5c_3d_1d_2 + a_4b_1b_2b_5c_3c_6 + a_4b_5b_6c_1c_2c_3 + a_5a_6b_4c_1c_2d_3 + a_5b_1b_2b_4d_3d_6 + a_5b_4b_6d_1d_2d_3 + b_1b_2b_3b_6c_5d_4 + b_3c_1c_2c_5c_6d_4 + b_3c_5d_1d_2d_4d_6) \\[0.5em]
p_{\texttt{AACTC}} &= \frac{1}{4}(a_1a_2a_3a_5b_6c_4 + a_1a_2a_4c_3c_5d_6 + a_1a_2a_6b_3b_5d_4 + a_1a_2b_4c_6d_3d_5 + a_3a_5a_6b_1b_2c_4 + a_3a_5c_1c_2c_4d_6 + a_3a_5c_4c_6d_1d_2 + a_4a_6c_3c_5d_1d_2 + a_4b_1b_2c_3c_5c_6 + a_4b_6c_1c_2c_3c_5 + a_6b_4c_1c_2d_3d_5 + b_1b_2b_3b_5b_6d_4 + b_1b_2b_4d_3d_5d_6 + b_3b_5c_1c_2c_6d_4 + b_3b_5d_1d_2d_4d_6 + b_4b_6d_1d_2d_3d_5) \\[0.5em]
p_{\texttt{AACTA}} &= \frac{1}{4}(a_1a_2a_3b_5b_6c_4 + a_1a_2a_4c_3d_5d_6 + a_1a_2a_5a_6b_3d_4 + a_1a_2b_4c_5c_6d_3 + a_3a_6b_1b_2b_5c_4 + a_3b_5c_1c_2c_4d_6 + a_3b_5c_4c_6d_1d_2 + a_4a_6c_3d_1d_2d_5 + a_4b_1b_2c_3c_6d_5 + a_4b_6c_1c_2c_3d_5 + a_5b_1b_2b_3b_6d_4 + a_5b_3c_1c_2c_6d_4 + a_5b_3d_1d_2d_4d_6 + a_6b_4c_1c_2c_5d_3 + b_1b_2b_4c_5d_3d_6 + b_4b_6c_5d_1d_2d_3) \\[0.5em]
p_{\texttt{AACGT}} &= \frac{1}{4}(a_1a_2a_3b_6c_5d_4 + a_1a_2a_4b_5c_6d_3 + a_1a_2a_5b_4c_3d_6 + a_1a_2a_6b_3c_4d_5 + a_3a_6b_1b_2c_5d_4 + a_3c_1c_2c_5d_4d_6 + a_3c_5c_6d_1d_2d_4 + a_4a_6b_5c_1c_2d_3 + a_4b_1b_2b_5d_3d_6 + a_4b_5b_6d_1d_2d_3 + a_5a_6b_4c_3d_1d_2 + a_5b_1b_2b_4c_3c_6 + a_5b_4b_6c_1c_2c_3 + b_1b_2b_3b_6c_4d_5 + b_3c_1c_2c_4c_6d_5 + b_3c_4d_1d_2d_5d_6) \\[0.5em]
p_{\texttt{AACGG}} &= \frac{1}{4}(a_1a_2a_3b_6d_4d_5 + a_1a_2a_4a_5c_6d_3 + a_1a_2a_6b_3c_4c_5 + a_1a_2b_4b_5c_3d_6 + a_3a_6b_1b_2d_4d_5 + a_3c_1c_2d_4d_5d_6 + a_3c_6d_1d_2d_4d_5 + a_4a_5a_6c_1c_2d_3 + a_4a_5b_1b_2d_3d_6 + a_4a_5b_6d_1d_2d_3 + a_6b_4b_5c_3d_1d_2 + b_1b_2b_3b_6c_4c_5 + b_1b_2b_4b_5c_3c_6 + b_3c_1c_2c_4c_5c_6 + b_3c_4c_5d_1d_2d_6 + b_4b_5b_6c_1c_2c_3) \\[0.5em]
p_{\texttt{AACGC}} &= \frac{1}{4}(a_1a_2a_3a_5b_6d_4 + a_1a_2a_4c_6d_3d_5 + a_1a_2a_6b_3b_5c_4 + a_1a_2b_4c_3c_5d_6 + a_3a_5a_6b_1b_2d_4 + a_3a_5c_1c_2d_4d_6 + a_3a_5c_6d_1d_2d_4 + a_4a_6c_1c_2d_3d_5 + a_4b_1b_2d_3d_5d_6 + a_4b_6d_1d_2d_3d_5 + a_6b_4c_3c_5d_1d_2 + b_1b_2b_3b_5b_6c_4 + b_1b_2b_4c_3c_5c_6 + b_3b_5c_1c_2c_4c_6 + b_3b_5c_4d_1d_2d_6 + b_4b_6c_1c_2c_3c_5) \\[0.5em]
p_{\texttt{AACGA}} &= \frac{1}{4}(a_1a_2a_3b_5b_6d_4 + a_1a_2a_4c_5c_6d_3 + a_1a_2a_5a_6b_3c_4 + a_1a_2b_4c_3d_5d_6 + a_3a_6b_1b_2b_5d_4 + a_3b_5c_1c_2d_4d_6 + a_3b_5c_6d_1d_2d_4 + a_4a_6c_1c_2c_5d_3 + a_4b_1b_2c_5d_3d_6 + a_4b_6c_5d_1d_2d_3 + a_5b_1b_2b_3b_6c_4 + a_5b_3c_1c_2c_4c_6 + a_5b_3c_4d_1d_2d_6 + a_6b_4c_3d_1d_2d_5 + b_1b_2b_4c_3c_6d_5 + b_4b_6c_1c_2c_3d_5) \\[0.5em]
p_{\texttt{AACCT}} &= \frac{1}{4}(a_1a_2a_3a_4b_6c_5 + a_1a_2a_5c_3c_4d_6 + a_1a_2a_6b_3b_4d_5 + a_1a_2b_5c_6d_3d_4 + a_3a_4a_6b_1b_2c_5 + a_3a_4c_1c_2c_5d_6 + a_3a_4c_5c_6d_1d_2 + a_5a_6c_3c_4d_1d_2 + a_5b_1b_2c_3c_4c_6 + a_5b_6c_1c_2c_3c_4 + a_6b_5c_1c_2d_3d_4 + b_1b_2b_3b_4b_6d_5 + b_1b_2b_5d_3d_4d_6 + b_3b_4c_1c_2c_6d_5 + b_3b_4d_1d_2d_5d_6 + b_5b_6d_1d_2d_3d_4) \\[0.5em]
p_{\texttt{AACCG}} &= \frac{1}{4}(a_1a_2a_3a_4b_6d_5 + a_1a_2a_5c_6d_3d_4 + a_1a_2a_6b_3b_4c_5 + a_1a_2b_5c_3c_4d_6 + a_3a_4a_6b_1b_2d_5 + a_3a_4c_1c_2d_5d_6 + a_3a_4c_6d_1d_2d_5 + a_5a_6c_1c_2d_3d_4 + a_5b_1b_2d_3d_4d_6 + a_5b_6d_1d_2d_3d_4 + a_6b_5c_3c_4d_1d_2 + b_1b_2b_3b_4b_6c_5 + b_1b_2b_5c_3c_4c_6 + b_3b_4c_1c_2c_5c_6 + b_3b_4c_5d_1d_2d_6 + b_5b_6c_1c_2c_3c_4) \\[0.5em]
p_{\texttt{AACCC}} &= \frac{1}{4}(a_1a_2a_3a_4a_5b_6 + a_1a_2a_6b_3b_4b_5 + a_1a_2c_3c_4c_5d_6 + a_1a_2c_6d_3d_4d_5 + a_3a_4a_5a_6b_1b_2 + a_3a_4a_5c_1c_2d_6 + a_3a_4a_5c_6d_1d_2 + a_6c_1c_2d_3d_4d_5 + a_6c_3c_4c_5d_1d_2 + b_1b_2b_3b_4b_5b_6 + b_1b_2c_3c_4c_5c_6 + b_1b_2d_3d_4d_5d_6 + b_3b_4b_5c_1c_2c_6 + b_3b_4b_5d_1d_2d_6 + b_6c_1c_2c_3c_4c_5 + b_6d_1d_2d_3d_4d_5) \\[0.5em]
p_{\texttt{AACCA}} &= \frac{1}{4}(a_1a_2a_3a_4b_5b_6 + a_1a_2a_5a_6b_3b_4 + a_1a_2c_3c_4d_5d_6 + a_1a_2c_5c_6d_3d_4 + a_3a_4a_6b_1b_2b_5 + a_3a_4b_5c_1c_2d_6 + a_3a_4b_5c_6d_1d_2 + a_5b_1b_2b_3b_4b_6 + a_5b_3b_4c_1c_2c_6 + a_5b_3b_4d_1d_2d_6 + a_6c_1c_2c_5d_3d_4 + a_6c_3c_4d_1d_2d_5 + b_1b_2c_3c_4c_6d_5 + b_1b_2c_5d_3d_4d_6 + b_6c_1c_2c_3c_4d_5 + b_6c_5d_1d_2d_3d_4) \\[0.5em]
p_{\texttt{AACAT}} &= \frac{1}{4}(a_1a_2a_3b_4b_6c_5 + a_1a_2a_4a_6b_3d_5 + a_1a_2a_5c_3d_4d_6 + a_1a_2b_5c_4c_6d_3 + a_3a_6b_1b_2b_4c_5 + a_3b_4c_1c_2c_5d_6 + a_3b_4c_5c_6d_1d_2 + a_4b_1b_2b_3b_6d_5 + a_4b_3c_1c_2c_6d_5 + a_4b_3d_1d_2d_5d_6 + a_5a_6c_3d_1d_2d_4 + a_5b_1b_2c_3c_6d_4 + a_5b_6c_1c_2c_3d_4 + a_6b_5c_1c_2c_4d_3 + b_1b_2b_5c_4d_3d_6 + b_5b_6c_4d_1d_2d_3) \\[0.5em]
p_{\texttt{AACAG}} &= \frac{1}{4}(a_1a_2a_3b_4b_6d_5 + a_1a_2a_4a_6b_3c_5 + a_1a_2a_5c_4c_6d_3 + a_1a_2b_5c_3d_4d_6 + a_3a_6b_1b_2b_4d_5 + a_3b_4c_1c_2d_5d_6 + a_3b_4c_6d_1d_2d_5 + a_4b_1b_2b_3b_6c_5 + a_4b_3c_1c_2c_5c_6 + a_4b_3c_5d_1d_2d_6 + a_5a_6c_1c_2c_4d_3 + a_5b_1b_2c_4d_3d_6 + a_5b_6c_4d_1d_2d_3 + a_6b_5c_3d_1d_2d_4 + b_1b_2b_5c_3c_6d_4 + b_5b_6c_1c_2c_3d_4) \\[0.5em]
p_{\texttt{AACAC}} &= \frac{1}{4}(a_1a_2a_3a_5b_4b_6 + a_1a_2a_4a_6b_3b_5 + a_1a_2c_3c_5d_4d_6 + a_1a_2c_4c_6d_3d_5 + a_3a_5a_6b_1b_2b_4 + a_3a_5b_4c_1c_2d_6 + a_3a_5b_4c_6d_1d_2 + a_4b_1b_2b_3b_5b_6 + a_4b_3b_5c_1c_2c_6 + a_4b_3b_5d_1d_2d_6 + a_6c_1c_2c_4d_3d_5 + a_6c_3c_5d_1d_2d_4 + b_1b_2c_3c_5c_6d_4 + b_1b_2c_4d_3d_5d_6 + b_6c_1c_2c_3c_5d_4 + b_6c_4d_1d_2d_3d_5) \\[0.5em]
p_{\texttt{AACAA}} &= \frac{1}{4}(a_1a_2a_3b_4b_5b_6 + a_1a_2a_4a_5a_6b_3 + a_1a_2c_3d_4d_5d_6 + a_1a_2c_4c_5c_6d_3 + a_3a_6b_1b_2b_4b_5 + a_3b_4b_5c_1c_2d_6 + a_3b_4b_5c_6d_1d_2 + a_4a_5b_1b_2b_3b_6 + a_4a_5b_3c_1c_2c_6 + a_4a_5b_3d_1d_2d_6 + a_6c_1c_2c_4c_5d_3 + a_6c_3d_1d_2d_4d_5 + b_1b_2c_3c_6d_4d_5 + b_1b_2c_4c_5d_3d_6 + b_6c_1c_2c_3d_4d_5 + b_6c_4c_5d_1d_2d_3) \\[0.5em]
p_{\texttt{AAATT}} &= \frac{1}{4}(a_1a_2a_3a_6d_4d_5 + a_1a_2a_4a_5d_3d_6 + a_1a_2b_3b_6c_4c_5 + a_1a_2b_4b_5c_3c_6 + a_3b_1b_2b_6d_4d_5 + a_3c_1c_2c_6d_4d_5 + a_3d_1d_2d_4d_5d_6 + a_4a_5a_6d_1d_2d_3 + a_4a_5b_1b_2c_6d_3 + a_4a_5b_6c_1c_2d_3 + a_6b_1b_2b_3c_4c_5 + a_6b_4b_5c_1c_2c_3 + b_1b_2b_4b_5c_3d_6 + b_3c_1c_2c_4c_5d_6 + b_3c_4c_5c_6d_1d_2 + b_4b_5b_6c_3d_1d_2) \\[0.5em]
p_{\texttt{AAATG}} &= \frac{1}{4}(a_1a_2a_3a_6c_5d_4 + a_1a_2a_4b_5d_3d_6 + a_1a_2a_5b_4c_3c_6 + a_1a_2b_3b_6c_4d_5 + a_3b_1b_2b_6c_5d_4 + a_3c_1c_2c_5c_6d_4 + a_3c_5d_1d_2d_4d_6 + a_4a_6b_5d_1d_2d_3 + a_4b_1b_2b_5c_6d_3 + a_4b_5b_6c_1c_2d_3 + a_5a_6b_4c_1c_2c_3 + a_5b_1b_2b_4c_3d_6 + a_5b_4b_6c_3d_1d_2 + a_6b_1b_2b_3c_4d_5 + b_3c_1c_2c_4d_5d_6 + b_3c_4c_6d_1d_2d_5) \\[0.5em]
p_{\texttt{AAATC}} &= \frac{1}{4}(a_1a_2a_3a_6b_5d_4 + a_1a_2a_4c_5d_3d_6 + a_1a_2a_5b_3b_6c_4 + a_1a_2b_4c_3c_6d_5 + a_3b_1b_2b_5b_6d_4 + a_3b_5c_1c_2c_6d_4 + a_3b_5d_1d_2d_4d_6 + a_4a_6c_5d_1d_2d_3 + a_4b_1b_2c_5c_6d_3 + a_4b_6c_1c_2c_5d_3 + a_5a_6b_1b_2b_3c_4 + a_5b_3c_1c_2c_4d_6 + a_5b_3c_4c_6d_1d_2 + a_6b_4c_1c_2c_3d_5 + b_1b_2b_4c_3d_5d_6 + b_4b_6c_3d_1d_2d_5) \\[0.5em]
p_{\texttt{AAATA}} &= \frac{1}{4}(a_1a_2a_3a_5a_6d_4 + a_1a_2a_4d_3d_5d_6 + a_1a_2b_3b_5b_6c_4 + a_1a_2b_4c_3c_5c_6 + a_3a_5b_1b_2b_6d_4 + a_3a_5c_1c_2c_6d_4 + a_3a_5d_1d_2d_4d_6 + a_4a_6d_1d_2d_3d_5 + a_4b_1b_2c_6d_3d_5 + a_4b_6c_1c_2d_3d_5 + a_6b_1b_2b_3b_5c_4 + a_6b_4c_1c_2c_3c_5 + b_1b_2b_4c_3c_5d_6 + b_3b_5c_1c_2c_4d_6 + b_3b_5c_4c_6d_1d_2 + b_4b_6c_3c_5d_1d_2) \\[0.5em]
p_{\texttt{AAAGT}} &= \frac{1}{4}(a_1a_2a_3a_6c_4d_5 + a_1a_2a_4b_5c_3c_6 + a_1a_2a_5b_4d_3d_6 + a_1a_2b_3b_6c_5d_4 + a_3b_1b_2b_6c_4d_5 + a_3c_1c_2c_4c_6d_5 + a_3c_4d_1d_2d_5d_6 + a_4a_6b_5c_1c_2c_3 + a_4b_1b_2b_5c_3d_6 + a_4b_5b_6c_3d_1d_2 + a_5a_6b_4d_1d_2d_3 + a_5b_1b_2b_4c_6d_3 + a_5b_4b_6c_1c_2d_3 + a_6b_1b_2b_3c_5d_4 + b_3c_1c_2c_5d_4d_6 + b_3c_5c_6d_1d_2d_4) \\[0.5em]
p_{\texttt{AAAGG}} &= \frac{1}{4}(a_1a_2a_3a_6c_4c_5 + a_1a_2a_4a_5c_3c_6 + a_1a_2b_3b_6d_4d_5 + a_1a_2b_4b_5d_3d_6 + a_3b_1b_2b_6c_4c_5 + a_3c_1c_2c_4c_5c_6 + a_3c_4c_5d_1d_2d_6 + a_4a_5a_6c_1c_2c_3 + a_4a_5b_1b_2c_3d_6 + a_4a_5b_6c_3d_1d_2 + a_6b_1b_2b_3d_4d_5 + a_6b_4b_5d_1d_2d_3 + b_1b_2b_4b_5c_6d_3 + b_3c_1c_2d_4d_5d_6 + b_3c_6d_1d_2d_4d_5 + b_4b_5b_6c_1c_2d_3) \\[0.5em]
p_{\texttt{AAAGC}} &= \frac{1}{4}(a_1a_2a_3a_6b_5c_4 + a_1a_2a_4c_3c_6d_5 + a_1a_2a_5b_3b_6d_4 + a_1a_2b_4c_5d_3d_6 + a_3b_1b_2b_5b_6c_4 + a_3b_5c_1c_2c_4c_6 + a_3b_5c_4d_1d_2d_6 + a_4a_6c_1c_2c_3d_5 + a_4b_1b_2c_3d_5d_6 + a_4b_6c_3d_1d_2d_5 + a_5a_6b_1b_2b_3d_4 + a_5b_3c_1c_2d_4d_6 + a_5b_3c_6d_1d_2d_4 + a_6b_4c_5d_1d_2d_3 + b_1b_2b_4c_5c_6d_3 + b_4b_6c_1c_2c_5d_3) \\[0.5em]
p_{\texttt{AAAGA}} &= \frac{1}{4}(a_1a_2a_3a_5a_6c_4 + a_1a_2a_4c_3c_5c_6 + a_1a_2b_3b_5b_6d_4 + a_1a_2b_4d_3d_5d_6 + a_3a_5b_1b_2b_6c_4 + a_3a_5c_1c_2c_4c_6 + a_3a_5c_4d_1d_2d_6 + a_4a_6c_1c_2c_3c_5 + a_4b_1b_2c_3c_5d_6 + a_4b_6c_3c_5d_1d_2 + a_6b_1b_2b_3b_5d_4 + a_6b_4d_1d_2d_3d_5 + b_1b_2b_4c_6d_3d_5 + b_3b_5c_1c_2d_4d_6 + b_3b_5c_6d_1d_2d_4 + b_4b_6c_1c_2d_3d_5) \\[0.5em]
p_{\texttt{AAACT}} &= \frac{1}{4}(a_1a_2a_3a_6b_4d_5 + a_1a_2a_4b_3b_6c_5 + a_1a_2a_5c_4d_3d_6 + a_1a_2b_5c_3c_6d_4 + a_3b_1b_2b_4b_6d_5 + a_3b_4c_1c_2c_6d_5 + a_3b_4d_1d_2d_5d_6 + a_4a_6b_1b_2b_3c_5 + a_4b_3c_1c_2c_5d_6 + a_4b_3c_5c_6d_1d_2 + a_5a_6c_4d_1d_2d_3 + a_5b_1b_2c_4c_6d_3 + a_5b_6c_1c_2c_4d_3 + a_6b_5c_1c_2c_3d_4 + b_1b_2b_5c_3d_4d_6 + b_5b_6c_3d_1d_2d_4) \\[0.5em]
p_{\texttt{AAACG}} &= \frac{1}{4}(a_1a_2a_3a_6b_4c_5 + a_1a_2a_4b_3b_6d_5 + a_1a_2a_5c_3c_6d_4 + a_1a_2b_5c_4d_3d_6 + a_3b_1b_2b_4b_6c_5 + a_3b_4c_1c_2c_5c_6 + a_3b_4c_5d_1d_2d_6 + a_4a_6b_1b_2b_3d_5 + a_4b_3c_1c_2d_5d_6 + a_4b_3c_6d_1d_2d_5 + a_5a_6c_1c_2c_3d_4 + a_5b_1b_2c_3d_4d_6 + a_5b_6c_3d_1d_2d_4 + a_6b_5c_4d_1d_2d_3 + b_1b_2b_5c_4c_6d_3 + b_5b_6c_1c_2c_4d_3) \\[0.5em]
p_{\texttt{AAACC}} &= \frac{1}{4}(a_1a_2a_3a_6b_4b_5 + a_1a_2a_4a_5b_3b_6 + a_1a_2c_3c_6d_4d_5 + a_1a_2c_4c_5d_3d_6 + a_3b_1b_2b_4b_5b_6 + a_3b_4b_5c_1c_2c_6 + a_3b_4b_5d_1d_2d_6 + a_4a_5a_6b_1b_2b_3 + a_4a_5b_3c_1c_2d_6 + a_4a_5b_3c_6d_1d_2 + a_6c_1c_2c_3d_4d_5 + a_6c_4c_5d_1d_2d_3 + b_1b_2c_3d_4d_5d_6 + b_1b_2c_4c_5c_6d_3 + b_6c_1c_2c_4c_5d_3 + b_6c_3d_1d_2d_4d_5) \\[0.5em]
p_{\texttt{AAACA}} &= \frac{1}{4}(a_1a_2a_3a_5a_6b_4 + a_1a_2a_4b_3b_5b_6 + a_1a_2c_3c_5c_6d_4 + a_1a_2c_4d_3d_5d_6 + a_3a_5b_1b_2b_4b_6 + a_3a_5b_4c_1c_2c_6 + a_3a_5b_4d_1d_2d_6 + a_4a_6b_1b_2b_3b_5 + a_4b_3b_5c_1c_2d_6 + a_4b_3b_5c_6d_1d_2 + a_6c_1c_2c_3c_5d_4 + a_6c_4d_1d_2d_3d_5 + b_1b_2c_3c_5d_4d_6 + b_1b_2c_4c_6d_3d_5 + b_6c_1c_2c_4d_3d_5 + b_6c_3c_5d_1d_2d_4) \\[0.5em]
p_{\texttt{AAAAT}} &= \frac{1}{4}(a_1a_2a_3a_4a_6d_5 + a_1a_2a_5d_3d_4d_6 + a_1a_2b_3b_4b_6c_5 + a_1a_2b_5c_3c_4c_6 + a_3a_4b_1b_2b_6d_5 + a_3a_4c_1c_2c_6d_5 + a_3a_4d_1d_2d_5d_6 + a_5a_6d_1d_2d_3d_4 + a_5b_1b_2c_6d_3d_4 + a_5b_6c_1c_2d_3d_4 + a_6b_1b_2b_3b_4c_5 + a_6b_5c_1c_2c_3c_4 + b_1b_2b_5c_3c_4d_6 + b_3b_4c_1c_2c_5d_6 + b_3b_4c_5c_6d_1d_2 + b_5b_6c_3c_4d_1d_2) \\[0.5em]
p_{\texttt{AAAAG}} &= \frac{1}{4}(a_1a_2a_3a_4a_6c_5 + a_1a_2a_5c_3c_4c_6 + a_1a_2b_3b_4b_6d_5 + a_1a_2b_5d_3d_4d_6 + a_3a_4b_1b_2b_6c_5 + a_3a_4c_1c_2c_5c_6 + a_3a_4c_5d_1d_2d_6 + a_5a_6c_1c_2c_3c_4 + a_5b_1b_2c_3c_4d_6 + a_5b_6c_3c_4d_1d_2 + a_6b_1b_2b_3b_4d_5 + a_6b_5d_1d_2d_3d_4 + b_1b_2b_5c_6d_3d_4 + b_3b_4c_1c_2d_5d_6 + b_3b_4c_6d_1d_2d_5 + b_5b_6c_1c_2d_3d_4) \\[0.5em]
p_{\texttt{AAAAC}} &= \frac{1}{4}(a_1a_2a_3a_4a_6b_5 + a_1a_2a_5b_3b_4b_6 + a_1a_2c_3c_4c_6d_5 + a_1a_2c_5d_3d_4d_6 + a_3a_4b_1b_2b_5b_6 + a_3a_4b_5c_1c_2c_6 + a_3a_4b_5d_1d_2d_6 + a_5a_6b_1b_2b_3b_4 + a_5b_3b_4c_1c_2d_6 + a_5b_3b_4c_6d_1d_2 + a_6c_1c_2c_3c_4d_5 + a_6c_5d_1d_2d_3d_4 + b_1b_2c_3c_4d_5d_6 + b_1b_2c_5c_6d_3d_4 + b_6c_1c_2c_5d_3d_4 + b_6c_3c_4d_1d_2d_5) \\[0.5em]
p_{\texttt{AAAAA}} &= \frac{1}{4}(a_1a_2a_3a_4a_5a_6 + a_1a_2b_3b_4b_5b_6 + a_1a_2c_3c_4c_5c_6 + a_1a_2d_3d_4d_5d_6 + a_3a_4a_5b_1b_2b_6 + a_3a_4a_5c_1c_2c_6 + a_3a_4a_5d_1d_2d_6 + a_6b_1b_2b_3b_4b_5 + a_6c_1c_2c_3c_4c_5 + a_6d_1d_2d_3d_4d_5 + b_1b_2c_3c_4c_5d_6 + b_1b_2c_6d_3d_4d_5 + b_3b_4b_5c_1c_2d_6 + b_3b_4b_5c_6d_1d_2 + b_6c_1c_2d_3d_4d_5 + b_6c_3c_4c_5d_1d_2)
\end{align}$
Fourier parametrization
$\begin{align}
q_{\texttt{TTTTA}} &= x_5x_6t_1t_2t_3t_4 \\[0.5em]
q_{\texttt{TTTGC}} &= x_6y_5z_4t_1t_2t_3 \\[0.5em]
q_{\texttt{TTTCG}} &= x_6y_4z_5t_1t_2t_3 \\[0.5em]
q_{\texttt{TTTAT}} &= x_4x_6t_1t_2t_3t_5 \\[0.5em]
q_{\texttt{TTGTC}} &= x_6y_5z_3t_1t_2t_4 \\[0.5em]
q_{\texttt{TTGGA}} &= x_5x_6z_3z_4t_1t_2 \\[0.5em]
q_{\texttt{TTGCT}} &= x_6y_4z_3t_1t_2t_5 \\[0.5em]
q_{\texttt{TTGAG}} &= x_4x_6z_3z_5t_1t_2 \\[0.5em]
q_{\texttt{TTCTG}} &= x_6y_3z_5t_1t_2t_4 \\[0.5em]
q_{\texttt{TTCGT}} &= x_6y_3z_4t_1t_2t_5 \\[0.5em]
q_{\texttt{TTCCA}} &= x_5x_6y_3y_4t_1t_2 \\[0.5em]
q_{\texttt{TTCAC}} &= x_4x_6y_3y_5t_1t_2 \\[0.5em]
q_{\texttt{TTATT}} &= x_3x_6t_1t_2t_4t_5 \\[0.5em]
q_{\texttt{TTAGG}} &= x_3x_6z_4z_5t_1t_2 \\[0.5em]
q_{\texttt{TTACC}} &= x_3x_6y_4y_5t_1t_2 \\[0.5em]
q_{\texttt{TTAAA}} &= x_3x_4x_5x_6t_1t_2 \\[0.5em]
q_{\texttt{TGTTC}} &= y_5y_6z_2t_1t_3t_4 \\[0.5em]
q_{\texttt{TGTGA}} &= x_5y_6z_2z_4t_1t_3 \\[0.5em]
q_{\texttt{TGTCT}} &= y_4y_6z_2t_1t_3t_5 \\[0.5em]
q_{\texttt{TGTAG}} &= x_4y_6z_2z_5t_1t_3 \\[0.5em]
q_{\texttt{TGGTA}} &= x_5y_6z_2z_3t_1t_4 \\[0.5em]
q_{\texttt{TGGGC}} &= y_5y_6z_2z_3z_4t_1 \\[0.5em]
q_{\texttt{TGGCG}} &= y_4y_6z_2z_3z_5t_1 \\[0.5em]
q_{\texttt{TGGAT}} &= x_4y_6z_2z_3t_1t_5 \\[0.5em]
q_{\texttt{TGCTT}} &= y_3y_6z_2t_1t_4t_5 \\[0.5em]
q_{\texttt{TGCGG}} &= y_3y_6z_2z_4z_5t_1 \\[0.5em]
q_{\texttt{TGCCC}} &= y_3y_4y_5y_6z_2t_1 \\[0.5em]
q_{\texttt{TGCAA}} &= x_4x_5y_3y_6z_2t_1 \\[0.5em]
q_{\texttt{TGATG}} &= x_3y_6z_2z_5t_1t_4 \\[0.5em]
q_{\texttt{TGAGT}} &= x_3y_6z_2z_4t_1t_5 \\[0.5em]
q_{\texttt{TGACA}} &= x_3x_5y_4y_6z_2t_1 \\[0.5em]
q_{\texttt{TGAAC}} &= x_3x_4y_5y_6z_2t_1 \\[0.5em]
q_{\texttt{TCTTG}} &= y_2z_5z_6t_1t_3t_4 \\[0.5em]
q_{\texttt{TCTGT}} &= y_2z_4z_6t_1t_3t_5 \\[0.5em]
q_{\texttt{TCTCA}} &= x_5y_2y_4z_6t_1t_3 \\[0.5em]
q_{\texttt{TCTAC}} &= x_4y_2y_5z_6t_1t_3 \\[0.5em]
q_{\texttt{TCGTT}} &= y_2z_3z_6t_1t_4t_5 \\[0.5em]
q_{\texttt{TCGGG}} &= y_2z_3z_4z_5z_6t_1 \\[0.5em]
q_{\texttt{TCGCC}} &= y_2y_4y_5z_3z_6t_1 \\[0.5em]
q_{\texttt{TCGAA}} &= x_4x_5y_2z_3z_6t_1 \\[0.5em]
q_{\texttt{TCCTA}} &= x_5y_2y_3z_6t_1t_4 \\[0.5em]
q_{\texttt{TCCGC}} &= y_2y_3y_5z_4z_6t_1 \\[0.5em]
q_{\texttt{TCCCG}} &= y_2y_3y_4z_5z_6t_1 \\[0.5em]
q_{\texttt{TCCAT}} &= x_4y_2y_3z_6t_1t_5 \\[0.5em]
q_{\texttt{TCATC}} &= x_3y_2y_5z_6t_1t_4 \\[0.5em]
q_{\texttt{TCAGA}} &= x_3x_5y_2z_4z_6t_1 \\[0.5em]
q_{\texttt{TCACT}} &= x_3y_2y_4z_6t_1t_5 \\[0.5em]
q_{\texttt{TCAAG}} &= x_3x_4y_2z_5z_6t_1 \\[0.5em]
q_{\texttt{TATTT}} &= x_2t_1t_3t_4t_5t_6 \\[0.5em]
q_{\texttt{TATGG}} &= x_2z_4z_5t_1t_3t_6 \\[0.5em]
q_{\texttt{TATCC}} &= x_2y_4y_5t_1t_3t_6 \\[0.5em]
q_{\texttt{TATAA}} &= x_2x_4x_5t_1t_3t_6 \\[0.5em]
q_{\texttt{TAGTG}} &= x_2z_3z_5t_1t_4t_6 \\[0.5em]
q_{\texttt{TAGGT}} &= x_2z_3z_4t_1t_5t_6 \\[0.5em]
q_{\texttt{TAGCA}} &= x_2x_5y_4z_3t_1t_6 \\[0.5em]
q_{\texttt{TAGAC}} &= x_2x_4y_5z_3t_1t_6 \\[0.5em]
q_{\texttt{TACTC}} &= x_2y_3y_5t_1t_4t_6 \\[0.5em]
q_{\texttt{TACGA}} &= x_2x_5y_3z_4t_1t_6 \\[0.5em]
q_{\texttt{TACCT}} &= x_2y_3y_4t_1t_5t_6 \\[0.5em]
q_{\texttt{TACAG}} &= x_2x_4y_3z_5t_1t_6 \\[0.5em]
q_{\texttt{TAATA}} &= x_2x_3x_5t_1t_4t_6 \\[0.5em]
q_{\texttt{TAAGC}} &= x_2x_3y_5z_4t_1t_6 \\[0.5em]
q_{\texttt{TAACG}} &= x_2x_3y_4z_5t_1t_6 \\[0.5em]
q_{\texttt{TAAAT}} &= x_2x_3x_4t_1t_5t_6 \\[0.5em]
q_{\texttt{GTTTC}} &= y_5y_6z_1t_2t_3t_4 \\[0.5em]
q_{\texttt{GTTGA}} &= x_5y_6z_1z_4t_2t_3 \\[0.5em]
q_{\texttt{GTTCT}} &= y_4y_6z_1t_2t_3t_5 \\[0.5em]
q_{\texttt{GTTAG}} &= x_4y_6z_1z_5t_2t_3 \\[0.5em]
q_{\texttt{GTGTA}} &= x_5y_6z_1z_3t_2t_4 \\[0.5em]
q_{\texttt{GTGGC}} &= y_5y_6z_1z_3z_4t_2 \\[0.5em]
q_{\texttt{GTGCG}} &= y_4y_6z_1z_3z_5t_2 \\[0.5em]
q_{\texttt{GTGAT}} &= x_4y_6z_1z_3t_2t_5 \\[0.5em]
q_{\texttt{GTCTT}} &= y_3y_6z_1t_2t_4t_5 \\[0.5em]
q_{\texttt{GTCGG}} &= y_3y_6z_1z_4z_5t_2 \\[0.5em]
q_{\texttt{GTCCC}} &= y_3y_4y_5y_6z_1t_2 \\[0.5em]
q_{\texttt{GTCAA}} &= x_4x_5y_3y_6z_1t_2 \\[0.5em]
q_{\texttt{GTATG}} &= x_3y_6z_1z_5t_2t_4 \\[0.5em]
q_{\texttt{GTAGT}} &= x_3y_6z_1z_4t_2t_5 \\[0.5em]
q_{\texttt{GTACA}} &= x_3x_5y_4y_6z_1t_2 \\[0.5em]
q_{\texttt{GTAAC}} &= x_3x_4y_5y_6z_1t_2 \\[0.5em]
q_{\texttt{GGTTA}} &= x_5x_6z_1z_2t_3t_4 \\[0.5em]
q_{\texttt{GGTGC}} &= x_6y_5z_1z_2z_4t_3 \\[0.5em]
q_{\texttt{GGTCG}} &= x_6y_4z_1z_2z_5t_3 \\[0.5em]
q_{\texttt{GGTAT}} &= x_4x_6z_1z_2t_3t_5 \\[0.5em]
q_{\texttt{GGGTC}} &= x_6y_5z_1z_2z_3t_4 \\[0.5em]
q_{\texttt{GGGGA}} &= x_5x_6z_1z_2z_3z_4 \\[0.5em]
q_{\texttt{GGGCT}} &= x_6y_4z_1z_2z_3t_5 \\[0.5em]
q_{\texttt{GGGAG}} &= x_4x_6z_1z_2z_3z_5 \\[0.5em]
q_{\texttt{GGCTG}} &= x_6y_3z_1z_2z_5t_4 \\[0.5em]
q_{\texttt{GGCGT}} &= x_6y_3z_1z_2z_4t_5 \\[0.5em]
q_{\texttt{GGCCA}} &= x_5x_6y_3y_4z_1z_2 \\[0.5em]
q_{\texttt{GGCAC}} &= x_4x_6y_3y_5z_1z_2 \\[0.5em]
q_{\texttt{GGATT}} &= x_3x_6z_1z_2t_4t_5 \\[0.5em]
q_{\texttt{GGAGG}} &= x_3x_6z_1z_2z_4z_5 \\[0.5em]
q_{\texttt{GGACC}} &= x_3x_6y_4y_5z_1z_2 \\[0.5em]
q_{\texttt{GGAAA}} &= x_3x_4x_5x_6z_1z_2 \\[0.5em]
q_{\texttt{GCTTT}} &= y_2z_1t_3t_4t_5t_6 \\[0.5em]
q_{\texttt{GCTGG}} &= y_2z_1z_4z_5t_3t_6 \\[0.5em]
q_{\texttt{GCTCC}} &= y_2y_4y_5z_1t_3t_6 \\[0.5em]
q_{\texttt{GCTAA}} &= x_4x_5y_2z_1t_3t_6 \\[0.5em]
q_{\texttt{GCGTG}} &= y_2z_1z_3z_5t_4t_6 \\[0.5em]
q_{\texttt{GCGGT}} &= y_2z_1z_3z_4t_5t_6 \\[0.5em]
q_{\texttt{GCGCA}} &= x_5y_2y_4z_1z_3t_6 \\[0.5em]
q_{\texttt{GCGAC}} &= x_4y_2y_5z_1z_3t_6 \\[0.5em]
q_{\texttt{GCCTC}} &= y_2y_3y_5z_1t_4t_6 \\[0.5em]
q_{\texttt{GCCGA}} &= x_5y_2y_3z_1z_4t_6 \\[0.5em]
q_{\texttt{GCCCT}} &= y_2y_3y_4z_1t_5t_6 \\[0.5em]
q_{\texttt{GCCAG}} &= x_4y_2y_3z_1z_5t_6 \\[0.5em]
q_{\texttt{GCATA}} &= x_3x_5y_2z_1t_4t_6 \\[0.5em]
q_{\texttt{GCAGC}} &= x_3y_2y_5z_1z_4t_6 \\[0.5em]
q_{\texttt{GCACG}} &= x_3y_2y_4z_1z_5t_6 \\[0.5em]
q_{\texttt{GCAAT}} &= x_3x_4y_2z_1t_5t_6 \\[0.5em]
q_{\texttt{GATTG}} &= x_2z_1z_5z_6t_3t_4 \\[0.5em]
q_{\texttt{GATGT}} &= x_2z_1z_4z_6t_3t_5 \\[0.5em]
q_{\texttt{GATCA}} &= x_2x_5y_4z_1z_6t_3 \\[0.5em]
q_{\texttt{GATAC}} &= x_2x_4y_5z_1z_6t_3 \\[0.5em]
q_{\texttt{GAGTT}} &= x_2z_1z_3z_6t_4t_5 \\[0.5em]
q_{\texttt{GAGGG}} &= x_2z_1z_3z_4z_5z_6 \\[0.5em]
q_{\texttt{GAGCC}} &= x_2y_4y_5z_1z_3z_6 \\[0.5em]
q_{\texttt{GAGAA}} &= x_2x_4x_5z_1z_3z_6 \\[0.5em]
q_{\texttt{GACTA}} &= x_2x_5y_3z_1z_6t_4 \\[0.5em]
q_{\texttt{GACGC}} &= x_2y_3y_5z_1z_4z_6 \\[0.5em]
q_{\texttt{GACCG}} &= x_2y_3y_4z_1z_5z_6 \\[0.5em]
q_{\texttt{GACAT}} &= x_2x_4y_3z_1z_6t_5 \\[0.5em]
q_{\texttt{GAATC}} &= x_2x_3y_5z_1z_6t_4 \\[0.5em]
q_{\texttt{GAAGA}} &= x_2x_3x_5z_1z_4z_6 \\[0.5em]
q_{\texttt{GAACT}} &= x_2x_3y_4z_1z_6t_5 \\[0.5em]
q_{\texttt{GAAAG}} &= x_2x_3x_4z_1z_5z_6 \\[0.5em]
q_{\texttt{CTTTG}} &= y_1z_5z_6t_2t_3t_4 \\[0.5em]
q_{\texttt{CTTGT}} &= y_1z_4z_6t_2t_3t_5 \\[0.5em]
q_{\texttt{CTTCA}} &= x_5y_1y_4z_6t_2t_3 \\[0.5em]
q_{\texttt{CTTAC}} &= x_4y_1y_5z_6t_2t_3 \\[0.5em]
q_{\texttt{CTGTT}} &= y_1z_3z_6t_2t_4t_5 \\[0.5em]
q_{\texttt{CTGGG}} &= y_1z_3z_4z_5z_6t_2 \\[0.5em]
q_{\texttt{CTGCC}} &= y_1y_4y_5z_3z_6t_2 \\[0.5em]
q_{\texttt{CTGAA}} &= x_4x_5y_1z_3z_6t_2 \\[0.5em]
q_{\texttt{CTCTA}} &= x_5y_1y_3z_6t_2t_4 \\[0.5em]
q_{\texttt{CTCGC}} &= y_1y_3y_5z_4z_6t_2 \\[0.5em]
q_{\texttt{CTCCG}} &= y_1y_3y_4z_5z_6t_2 \\[0.5em]
q_{\texttt{CTCAT}} &= x_4y_1y_3z_6t_2t_5 \\[0.5em]
q_{\texttt{CTATC}} &= x_3y_1y_5z_6t_2t_4 \\[0.5em]
q_{\texttt{CTAGA}} &= x_3x_5y_1z_4z_6t_2 \\[0.5em]
q_{\texttt{CTACT}} &= x_3y_1y_4z_6t_2t_5 \\[0.5em]
q_{\texttt{CTAAG}} &= x_3x_4y_1z_5z_6t_2 \\[0.5em]
q_{\texttt{CGTTT}} &= y_1z_2t_3t_4t_5t_6 \\[0.5em]
q_{\texttt{CGTGG}} &= y_1z_2z_4z_5t_3t_6 \\[0.5em]
q_{\texttt{CGTCC}} &= y_1y_4y_5z_2t_3t_6 \\[0.5em]
q_{\texttt{CGTAA}} &= x_4x_5y_1z_2t_3t_6 \\[0.5em]
q_{\texttt{CGGTG}} &= y_1z_2z_3z_5t_4t_6 \\[0.5em]
q_{\texttt{CGGGT}} &= y_1z_2z_3z_4t_5t_6 \\[0.5em]
q_{\texttt{CGGCA}} &= x_5y_1y_4z_2z_3t_6 \\[0.5em]
q_{\texttt{CGGAC}} &= x_4y_1y_5z_2z_3t_6 \\[0.5em]
q_{\texttt{CGCTC}} &= y_1y_3y_5z_2t_4t_6 \\[0.5em]
q_{\texttt{CGCGA}} &= x_5y_1y_3z_2z_4t_6 \\[0.5em]
q_{\texttt{CGCCT}} &= y_1y_3y_4z_2t_5t_6 \\[0.5em]
q_{\texttt{CGCAG}} &= x_4y_1y_3z_2z_5t_6 \\[0.5em]
q_{\texttt{CGATA}} &= x_3x_5y_1z_2t_4t_6 \\[0.5em]
q_{\texttt{CGAGC}} &= x_3y_1y_5z_2z_4t_6 \\[0.5em]
q_{\texttt{CGACG}} &= x_3y_1y_4z_2z_5t_6 \\[0.5em]
q_{\texttt{CGAAT}} &= x_3x_4y_1z_2t_5t_6 \\[0.5em]
q_{\texttt{CCTTA}} &= x_5x_6y_1y_2t_3t_4 \\[0.5em]
q_{\texttt{CCTGC}} &= x_6y_1y_2y_5z_4t_3 \\[0.5em]
q_{\texttt{CCTCG}} &= x_6y_1y_2y_4z_5t_3 \\[0.5em]
q_{\texttt{CCTAT}} &= x_4x_6y_1y_2t_3t_5 \\[0.5em]
q_{\texttt{CCGTC}} &= x_6y_1y_2y_5z_3t_4 \\[0.5em]
q_{\texttt{CCGGA}} &= x_5x_6y_1y_2z_3z_4 \\[0.5em]
q_{\texttt{CCGCT}} &= x_6y_1y_2y_4z_3t_5 \\[0.5em]
q_{\texttt{CCGAG}} &= x_4x_6y_1y_2z_3z_5 \\[0.5em]
q_{\texttt{CCCTG}} &= x_6y_1y_2y_3z_5t_4 \\[0.5em]
q_{\texttt{CCCGT}} &= x_6y_1y_2y_3z_4t_5 \\[0.5em]
q_{\texttt{CCCCA}} &= x_5x_6y_1y_2y_3y_4 \\[0.5em]
q_{\texttt{CCCAC}} &= x_4x_6y_1y_2y_3y_5 \\[0.5em]
q_{\texttt{CCATT}} &= x_3x_6y_1y_2t_4t_5 \\[0.5em]
q_{\texttt{CCAGG}} &= x_3x_6y_1y_2z_4z_5 \\[0.5em]
q_{\texttt{CCACC}} &= x_3x_6y_1y_2y_4y_5 \\[0.5em]
q_{\texttt{CCAAA}} &= x_3x_4x_5x_6y_1y_2 \\[0.5em]
q_{\texttt{CATTC}} &= x_2y_1y_5y_6t_3t_4 \\[0.5em]
q_{\texttt{CATGA}} &= x_2x_5y_1y_6z_4t_3 \\[0.5em]
q_{\texttt{CATCT}} &= x_2y_1y_4y_6t_3t_5 \\[0.5em]
q_{\texttt{CATAG}} &= x_2x_4y_1y_6z_5t_3 \\[0.5em]
q_{\texttt{CAGTA}} &= x_2x_5y_1y_6z_3t_4 \\[0.5em]
q_{\texttt{CAGGC}} &= x_2y_1y_5y_6z_3z_4 \\[0.5em]
q_{\texttt{CAGCG}} &= x_2y_1y_4y_6z_3z_5 \\[0.5em]
q_{\texttt{CAGAT}} &= x_2x_4y_1y_6z_3t_5 \\[0.5em]
q_{\texttt{CACTT}} &= x_2y_1y_3y_6t_4t_5 \\[0.5em]
q_{\texttt{CACGG}} &= x_2y_1y_3y_6z_4z_5 \\[0.5em]
q_{\texttt{CACCC}} &= x_2y_1y_3y_4y_5y_6 \\[0.5em]
q_{\texttt{CACAA}} &= x_2x_4x_5y_1y_3y_6 \\[0.5em]
q_{\texttt{CAATG}} &= x_2x_3y_1y_6z_5t_4 \\[0.5em]
q_{\texttt{CAAGT}} &= x_2x_3y_1y_6z_4t_5 \\[0.5em]
q_{\texttt{CAACA}} &= x_2x_3x_5y_1y_4y_6 \\[0.5em]
q_{\texttt{CAAAC}} &= x_2x_3x_4y_1y_5y_6 \\[0.5em]
q_{\texttt{ATTTT}} &= x_1t_2t_3t_4t_5t_6 \\[0.5em]
q_{\texttt{ATTGG}} &= x_1z_4z_5t_2t_3t_6 \\[0.5em]
q_{\texttt{ATTCC}} &= x_1y_4y_5t_2t_3t_6 \\[0.5em]
q_{\texttt{ATTAA}} &= x_1x_4x_5t_2t_3t_6 \\[0.5em]
q_{\texttt{ATGTG}} &= x_1z_3z_5t_2t_4t_6 \\[0.5em]
q_{\texttt{ATGGT}} &= x_1z_3z_4t_2t_5t_6 \\[0.5em]
q_{\texttt{ATGCA}} &= x_1x_5y_4z_3t_2t_6 \\[0.5em]
q_{\texttt{ATGAC}} &= x_1x_4y_5z_3t_2t_6 \\[0.5em]
q_{\texttt{ATCTC}} &= x_1y_3y_5t_2t_4t_6 \\[0.5em]
q_{\texttt{ATCGA}} &= x_1x_5y_3z_4t_2t_6 \\[0.5em]
q_{\texttt{ATCCT}} &= x_1y_3y_4t_2t_5t_6 \\[0.5em]
q_{\texttt{ATCAG}} &= x_1x_4y_3z_5t_2t_6 \\[0.5em]
q_{\texttt{ATATA}} &= x_1x_3x_5t_2t_4t_6 \\[0.5em]
q_{\texttt{ATAGC}} &= x_1x_3y_5z_4t_2t_6 \\[0.5em]
q_{\texttt{ATACG}} &= x_1x_3y_4z_5t_2t_6 \\[0.5em]
q_{\texttt{ATAAT}} &= x_1x_3x_4t_2t_5t_6 \\[0.5em]
q_{\texttt{AGTTG}} &= x_1z_2z_5z_6t_3t_4 \\[0.5em]
q_{\texttt{AGTGT}} &= x_1z_2z_4z_6t_3t_5 \\[0.5em]
q_{\texttt{AGTCA}} &= x_1x_5y_4z_2z_6t_3 \\[0.5em]
q_{\texttt{AGTAC}} &= x_1x_4y_5z_2z_6t_3 \\[0.5em]
q_{\texttt{AGGTT}} &= x_1z_2z_3z_6t_4t_5 \\[0.5em]
q_{\texttt{AGGGG}} &= x_1z_2z_3z_4z_5z_6 \\[0.5em]
q_{\texttt{AGGCC}} &= x_1y_4y_5z_2z_3z_6 \\[0.5em]
q_{\texttt{AGGAA}} &= x_1x_4x_5z_2z_3z_6 \\[0.5em]
q_{\texttt{AGCTA}} &= x_1x_5y_3z_2z_6t_4 \\[0.5em]
q_{\texttt{AGCGC}} &= x_1y_3y_5z_2z_4z_6 \\[0.5em]
q_{\texttt{AGCCG}} &= x_1y_3y_4z_2z_5z_6 \\[0.5em]
q_{\texttt{AGCAT}} &= x_1x_4y_3z_2z_6t_5 \\[0.5em]
q_{\texttt{AGATC}} &= x_1x_3y_5z_2z_6t_4 \\[0.5em]
q_{\texttt{AGAGA}} &= x_1x_3x_5z_2z_4z_6 \\[0.5em]
q_{\texttt{AGACT}} &= x_1x_3y_4z_2z_6t_5 \\[0.5em]
q_{\texttt{AGAAG}} &= x_1x_3x_4z_2z_5z_6 \\[0.5em]
q_{\texttt{ACTTC}} &= x_1y_2y_5y_6t_3t_4 \\[0.5em]
q_{\texttt{ACTGA}} &= x_1x_5y_2y_6z_4t_3 \\[0.5em]
q_{\texttt{ACTCT}} &= x_1y_2y_4y_6t_3t_5 \\[0.5em]
q_{\texttt{ACTAG}} &= x_1x_4y_2y_6z_5t_3 \\[0.5em]
q_{\texttt{ACGTA}} &= x_1x_5y_2y_6z_3t_4 \\[0.5em]
q_{\texttt{ACGGC}} &= x_1y_2y_5y_6z_3z_4 \\[0.5em]
q_{\texttt{ACGCG}} &= x_1y_2y_4y_6z_3z_5 \\[0.5em]
q_{\texttt{ACGAT}} &= x_1x_4y_2y_6z_3t_5 \\[0.5em]
q_{\texttt{ACCTT}} &= x_1y_2y_3y_6t_4t_5 \\[0.5em]
q_{\texttt{ACCGG}} &= x_1y_2y_3y_6z_4z_5 \\[0.5em]
q_{\texttt{ACCCC}} &= x_1y_2y_3y_4y_5y_6 \\[0.5em]
q_{\texttt{ACCAA}} &= x_1x_4x_5y_2y_3y_6 \\[0.5em]
q_{\texttt{ACATG}} &= x_1x_3y_2y_6z_5t_4 \\[0.5em]
q_{\texttt{ACAGT}} &= x_1x_3y_2y_6z_4t_5 \\[0.5em]
q_{\texttt{ACACA}} &= x_1x_3x_5y_2y_4y_6 \\[0.5em]
q_{\texttt{ACAAC}} &= x_1x_3x_4y_2y_5y_6 \\[0.5em]
q_{\texttt{AATTA}} &= x_1x_2x_5x_6t_3t_4 \\[0.5em]
q_{\texttt{AATGC}} &= x_1x_2x_6y_5z_4t_3 \\[0.5em]
q_{\texttt{AATCG}} &= x_1x_2x_6y_4z_5t_3 \\[0.5em]
q_{\texttt{AATAT}} &= x_1x_2x_4x_6t_3t_5 \\[0.5em]
q_{\texttt{AAGTC}} &= x_1x_2x_6y_5z_3t_4 \\[0.5em]
q_{\texttt{AAGGA}} &= x_1x_2x_5x_6z_3z_4 \\[0.5em]
q_{\texttt{AAGCT}} &= x_1x_2x_6y_4z_3t_5 \\[0.5em]
q_{\texttt{AAGAG}} &= x_1x_2x_4x_6z_3z_5 \\[0.5em]
q_{\texttt{AACTG}} &= x_1x_2x_6y_3z_5t_4 \\[0.5em]
q_{\texttt{AACGT}} &= x_1x_2x_6y_3z_4t_5 \\[0.5em]
q_{\texttt{AACCA}} &= x_1x_2x_5x_6y_3y_4 \\[0.5em]
q_{\texttt{AACAC}} &= x_1x_2x_4x_6y_3y_5 \\[0.5em]
q_{\texttt{AAATT}} &= x_1x_2x_3x_6t_4t_5 \\[0.5em]
q_{\texttt{AAAGG}} &= x_1x_2x_3x_6z_4z_5 \\[0.5em]
q_{\texttt{AAACC}} &= x_1x_2x_3x_6y_4y_5 \\[0.5em]
q_{\texttt{AAAAA}} &= x_1x_2x_3x_4x_5x_6
\end{align}$
Equivalent classes of probability parametrization
$\begin{align}
\text{Class } &p_{\texttt{AAAAA}}:\ p_{\texttt{AAAAA}},\ p_{\texttt{CCCCC}},\ p_{\texttt{GGGGG}},\ p_{\texttt{TTTTT}} \\[0.5em]
\text{Class } &p_{\texttt{AAAAC}}:\ p_{\texttt{AAAAC}},\ p_{\texttt{CCCCA}},\ p_{\texttt{GGGGT}},\ p_{\texttt{TTTTG}} \\[0.5em]
\text{Class } &p_{\texttt{AAAAG}}:\ p_{\texttt{AAAAG}},\ p_{\texttt{CCCCT}},\ p_{\texttt{GGGGA}},\ p_{\texttt{TTTTC}} \\[0.5em]
\text{Class } &p_{\texttt{AAAAT}}:\ p_{\texttt{AAAAT}},\ p_{\texttt{CCCCG}},\ p_{\texttt{GGGGC}},\ p_{\texttt{TTTTA}} \\[0.5em]
\text{Class } &p_{\texttt{AAACA}}:\ p_{\texttt{AAACA}},\ p_{\texttt{CCCAC}},\ p_{\texttt{GGGTG}},\ p_{\texttt{TTTGT}} \\[0.5em]
\text{Class } &p_{\texttt{AAACC}}:\ p_{\texttt{AAACC}},\ p_{\texttt{CCCAA}},\ p_{\texttt{GGGTT}},\ p_{\texttt{TTTGG}} \\[0.5em]
\text{Class } &p_{\texttt{AAACG}}:\ p_{\texttt{AAACG}},\ p_{\texttt{CCCAT}},\ p_{\texttt{GGGTA}},\ p_{\texttt{TTTGC}} \\[0.5em]
\text{Class } &p_{\texttt{AAACT}}:\ p_{\texttt{AAACT}},\ p_{\texttt{CCCAG}},\ p_{\texttt{GGGTC}},\ p_{\texttt{TTTGA}} \\[0.5em]
\text{Class } &p_{\texttt{AAAGA}}:\ p_{\texttt{AAAGA}},\ p_{\texttt{CCCTC}},\ p_{\texttt{GGGAG}},\ p_{\texttt{TTTCT}} \\[0.5em]
\text{Class } &p_{\texttt{AAAGC}}:\ p_{\texttt{AAAGC}},\ p_{\texttt{CCCTA}},\ p_{\texttt{GGGAT}},\ p_{\texttt{TTTCG}} \\[0.5em]
\text{Class } &p_{\texttt{AAAGG}}:\ p_{\texttt{AAAGG}},\ p_{\texttt{CCCTT}},\ p_{\texttt{GGGAA}},\ p_{\texttt{TTTCC}} \\[0.5em]
\text{Class } &p_{\texttt{AAAGT}}:\ p_{\texttt{AAAGT}},\ p_{\texttt{CCCTG}},\ p_{\texttt{GGGAC}},\ p_{\texttt{TTTCA}} \\[0.5em]
\text{Class } &p_{\texttt{AAATA}}:\ p_{\texttt{AAATA}},\ p_{\texttt{CCCGC}},\ p_{\texttt{GGGCG}},\ p_{\texttt{TTTAT}} \\[0.5em]
\text{Class } &p_{\texttt{AAATC}}:\ p_{\texttt{AAATC}},\ p_{\texttt{CCCGA}},\ p_{\texttt{GGGCT}},\ p_{\texttt{TTTAG}} \\[0.5em]
\text{Class } &p_{\texttt{AAATG}}:\ p_{\texttt{AAATG}},\ p_{\texttt{CCCGT}},\ p_{\texttt{GGGCA}},\ p_{\texttt{TTTAC}} \\[0.5em]
\text{Class } &p_{\texttt{AAATT}}:\ p_{\texttt{AAATT}},\ p_{\texttt{CCCGG}},\ p_{\texttt{GGGCC}},\ p_{\texttt{TTTAA}} \\[0.5em]
\text{Class } &p_{\texttt{AACAA}}:\ p_{\texttt{AACAA}},\ p_{\texttt{CCACC}},\ p_{\texttt{GGTGG}},\ p_{\texttt{TTGTT}} \\[0.5em]
\text{Class } &p_{\texttt{AACAC}}:\ p_{\texttt{AACAC}},\ p_{\texttt{CCACA}},\ p_{\texttt{GGTGT}},\ p_{\texttt{TTGTG}} \\[0.5em]
\text{Class } &p_{\texttt{AACAG}}:\ p_{\texttt{AACAG}},\ p_{\texttt{CCACT}},\ p_{\texttt{GGTGA}},\ p_{\texttt{TTGTC}} \\[0.5em]
\text{Class } &p_{\texttt{AACAT}}:\ p_{\texttt{AACAT}},\ p_{\texttt{CCACG}},\ p_{\texttt{GGTGC}},\ p_{\texttt{TTGTA}} \\[0.5em]
\text{Class } &p_{\texttt{AACCA}}:\ p_{\texttt{AACCA}},\ p_{\texttt{CCAAC}},\ p_{\texttt{GGTTG}},\ p_{\texttt{TTGGT}} \\[0.5em]
\text{Class } &p_{\texttt{AACCC}}:\ p_{\texttt{AACCC}},\ p_{\texttt{CCAAA}},\ p_{\texttt{GGTTT}},\ p_{\texttt{TTGGG}} \\[0.5em]
\text{Class } &p_{\texttt{AACCG}}:\ p_{\texttt{AACCG}},\ p_{\texttt{CCAAT}},\ p_{\texttt{GGTTA}},\ p_{\texttt{TTGGC}} \\[0.5em]
\text{Class } &p_{\texttt{AACCT}}:\ p_{\texttt{AACCT}},\ p_{\texttt{CCAAG}},\ p_{\texttt{GGTTC}},\ p_{\texttt{TTGGA}} \\[0.5em]
\text{Class } &p_{\texttt{AACGA}}:\ p_{\texttt{AACGA}},\ p_{\texttt{CCATC}},\ p_{\texttt{GGTAG}},\ p_{\texttt{TTGCT}} \\[0.5em]
\text{Class } &p_{\texttt{AACGC}}:\ p_{\texttt{AACGC}},\ p_{\texttt{CCATA}},\ p_{\texttt{GGTAT}},\ p_{\texttt{TTGCG}} \\[0.5em]
\text{Class } &p_{\texttt{AACGG}}:\ p_{\texttt{AACGG}},\ p_{\texttt{CCATT}},\ p_{\texttt{GGTAA}},\ p_{\texttt{TTGCC}} \\[0.5em]
\text{Class } &p_{\texttt{AACGT}}:\ p_{\texttt{AACGT}},\ p_{\texttt{CCATG}},\ p_{\texttt{GGTAC}},\ p_{\texttt{TTGCA}} \\[0.5em]
\text{Class } &p_{\texttt{AACTA}}:\ p_{\texttt{AACTA}},\ p_{\texttt{CCAGC}},\ p_{\texttt{GGTCG}},\ p_{\texttt{TTGAT}} \\[0.5em]
\text{Class } &p_{\texttt{AACTC}}:\ p_{\texttt{AACTC}},\ p_{\texttt{CCAGA}},\ p_{\texttt{GGTCT}},\ p_{\texttt{TTGAG}} \\[0.5em]
\text{Class } &p_{\texttt{AACTG}}:\ p_{\texttt{AACTG}},\ p_{\texttt{CCAGT}},\ p_{\texttt{GGTCA}},\ p_{\texttt{TTGAC}} \\[0.5em]
\text{Class } &p_{\texttt{AACTT}}:\ p_{\texttt{AACTT}},\ p_{\texttt{CCAGG}},\ p_{\texttt{GGTCC}},\ p_{\texttt{TTGAA}} \\[0.5em]
\text{Class } &p_{\texttt{AAGAA}}:\ p_{\texttt{AAGAA}},\ p_{\texttt{CCTCC}},\ p_{\texttt{GGAGG}},\ p_{\texttt{TTCTT}} \\[0.5em]
\text{Class } &p_{\texttt{AAGAC}}:\ p_{\texttt{AAGAC}},\ p_{\texttt{CCTCA}},\ p_{\texttt{GGAGT}},\ p_{\texttt{TTCTG}} \\[0.5em]
\text{Class } &p_{\texttt{AAGAG}}:\ p_{\texttt{AAGAG}},\ p_{\texttt{CCTCT}},\ p_{\texttt{GGAGA}},\ p_{\texttt{TTCTC}} \\[0.5em]
\text{Class } &p_{\texttt{AAGAT}}:\ p_{\texttt{AAGAT}},\ p_{\texttt{CCTCG}},\ p_{\texttt{GGAGC}},\ p_{\texttt{TTCTA}} \\[0.5em]
\text{Class } &p_{\texttt{AAGCA}}:\ p_{\texttt{AAGCA}},\ p_{\texttt{CCTAC}},\ p_{\texttt{GGATG}},\ p_{\texttt{TTCGT}} \\[0.5em]
\text{Class } &p_{\texttt{AAGCC}}:\ p_{\texttt{AAGCC}},\ p_{\texttt{CCTAA}},\ p_{\texttt{GGATT}},\ p_{\texttt{TTCGG}} \\[0.5em]
\text{Class } &p_{\texttt{AAGCG}}:\ p_{\texttt{AAGCG}},\ p_{\texttt{CCTAT}},\ p_{\texttt{GGATA}},\ p_{\texttt{TTCGC}} \\[0.5em]
\text{Class } &p_{\texttt{AAGCT}}:\ p_{\texttt{AAGCT}},\ p_{\texttt{CCTAG}},\ p_{\texttt{GGATC}},\ p_{\texttt{TTCGA}} \\[0.5em]
\text{Class } &p_{\texttt{AAGGA}}:\ p_{\texttt{AAGGA}},\ p_{\texttt{CCTTC}},\ p_{\texttt{GGAAG}},\ p_{\texttt{TTCCT}} \\[0.5em]
\text{Class } &p_{\texttt{AAGGC}}:\ p_{\texttt{AAGGC}},\ p_{\texttt{CCTTA}},\ p_{\texttt{GGAAT}},\ p_{\texttt{TTCCG}} \\[0.5em]
\text{Class } &p_{\texttt{AAGGG}}:\ p_{\texttt{AAGGG}},\ p_{\texttt{CCTTT}},\ p_{\texttt{GGAAA}},\ p_{\texttt{TTCCC}} \\[0.5em]
\text{Class } &p_{\texttt{AAGGT}}:\ p_{\texttt{AAGGT}},\ p_{\texttt{CCTTG}},\ p_{\texttt{GGAAC}},\ p_{\texttt{TTCCA}} \\[0.5em]
\text{Class } &p_{\texttt{AAGTA}}:\ p_{\texttt{AAGTA}},\ p_{\texttt{CCTGC}},\ p_{\texttt{GGACG}},\ p_{\texttt{TTCAT}} \\[0.5em]
\text{Class } &p_{\texttt{AAGTC}}:\ p_{\texttt{AAGTC}},\ p_{\texttt{CCTGA}},\ p_{\texttt{GGACT}},\ p_{\texttt{TTCAG}} \\[0.5em]
\text{Class } &p_{\texttt{AAGTG}}:\ p_{\texttt{AAGTG}},\ p_{\texttt{CCTGT}},\ p_{\texttt{GGACA}},\ p_{\texttt{TTCAC}} \\[0.5em]
\text{Class } &p_{\texttt{AAGTT}}:\ p_{\texttt{AAGTT}},\ p_{\texttt{CCTGG}},\ p_{\texttt{GGACC}},\ p_{\texttt{TTCAA}} \\[0.5em]
\text{Class } &p_{\texttt{AATAA}}:\ p_{\texttt{AATAA}},\ p_{\texttt{CCGCC}},\ p_{\texttt{GGCGG}},\ p_{\texttt{TTATT}} \\[0.5em]
\text{Class } &p_{\texttt{AATAC}}:\ p_{\texttt{AATAC}},\ p_{\texttt{CCGCA}},\ p_{\texttt{GGCGT}},\ p_{\texttt{TTATG}} \\[0.5em]
\text{Class } &p_{\texttt{AATAG}}:\ p_{\texttt{AATAG}},\ p_{\texttt{CCGCT}},\ p_{\texttt{GGCGA}},\ p_{\texttt{TTATC}} \\[0.5em]
\text{Class } &p_{\texttt{AATAT}}:\ p_{\texttt{AATAT}},\ p_{\texttt{CCGCG}},\ p_{\texttt{GGCGC}},\ p_{\texttt{TTATA}} \\[0.5em]
\text{Class } &p_{\texttt{AATCA}}:\ p_{\texttt{AATCA}},\ p_{\texttt{CCGAC}},\ p_{\texttt{GGCTG}},\ p_{\texttt{TTAGT}} \\[0.5em]
\text{Class } &p_{\texttt{AATCC}}:\ p_{\texttt{AATCC}},\ p_{\texttt{CCGAA}},\ p_{\texttt{GGCTT}},\ p_{\texttt{TTAGG}} \\[0.5em]
\text{Class } &p_{\texttt{AATCG}}:\ p_{\texttt{AATCG}},\ p_{\texttt{CCGAT}},\ p_{\texttt{GGCTA}},\ p_{\texttt{TTAGC}} \\[0.5em]
\text{Class } &p_{\texttt{AATCT}}:\ p_{\texttt{AATCT}},\ p_{\texttt{CCGAG}},\ p_{\texttt{GGCTC}},\ p_{\texttt{TTAGA}} \\[0.5em]
\text{Class } &p_{\texttt{AATGA}}:\ p_{\texttt{AATGA}},\ p_{\texttt{CCGTC}},\ p_{\texttt{GGCAG}},\ p_{\texttt{TTACT}} \\[0.5em]
\text{Class } &p_{\texttt{AATGC}}:\ p_{\texttt{AATGC}},\ p_{\texttt{CCGTA}},\ p_{\texttt{GGCAT}},\ p_{\texttt{TTACG}} \\[0.5em]
\text{Class } &p_{\texttt{AATGG}}:\ p_{\texttt{AATGG}},\ p_{\texttt{CCGTT}},\ p_{\texttt{GGCAA}},\ p_{\texttt{TTACC}} \\[0.5em]
\text{Class } &p_{\texttt{AATGT}}:\ p_{\texttt{AATGT}},\ p_{\texttt{CCGTG}},\ p_{\texttt{GGCAC}},\ p_{\texttt{TTACA}} \\[0.5em]
\text{Class } &p_{\texttt{AATTA}}:\ p_{\texttt{AATTA}},\ p_{\texttt{CCGGC}},\ p_{\texttt{GGCCG}},\ p_{\texttt{TTAAT}} \\[0.5em]
\text{Class } &p_{\texttt{AATTC}}:\ p_{\texttt{AATTC}},\ p_{\texttt{CCGGA}},\ p_{\texttt{GGCCT}},\ p_{\texttt{TTAAG}} \\[0.5em]
\text{Class } &p_{\texttt{AATTG}}:\ p_{\texttt{AATTG}},\ p_{\texttt{CCGGT}},\ p_{\texttt{GGCCA}},\ p_{\texttt{TTAAC}} \\[0.5em]
\text{Class } &p_{\texttt{AATTT}}:\ p_{\texttt{AATTT}},\ p_{\texttt{CCGGG}},\ p_{\texttt{GGCCC}},\ p_{\texttt{TTAAA}} \\[0.5em]
\text{Class } &p_{\texttt{ACAAA}}:\ p_{\texttt{ACAAA}},\ p_{\texttt{CACCC}},\ p_{\texttt{GTGGG}},\ p_{\texttt{TGTTT}} \\[0.5em]
\text{Class } &p_{\texttt{ACAAC}}:\ p_{\texttt{ACAAC}},\ p_{\texttt{CACCA}},\ p_{\texttt{GTGGT}},\ p_{\texttt{TGTTG}} \\[0.5em]
\text{Class } &p_{\texttt{ACAAG}}:\ p_{\texttt{ACAAG}},\ p_{\texttt{CACCT}},\ p_{\texttt{GTGGA}},\ p_{\texttt{TGTTC}} \\[0.5em]
\text{Class } &p_{\texttt{ACAAT}}:\ p_{\texttt{ACAAT}},\ p_{\texttt{CACCG}},\ p_{\texttt{GTGGC}},\ p_{\texttt{TGTTA}} \\[0.5em]
\text{Class } &p_{\texttt{ACACA}}:\ p_{\texttt{ACACA}},\ p_{\texttt{CACAC}},\ p_{\texttt{GTGTG}},\ p_{\texttt{TGTGT}} \\[0.5em]
\text{Class } &p_{\texttt{ACACC}}:\ p_{\texttt{ACACC}},\ p_{\texttt{CACAA}},\ p_{\texttt{GTGTT}},\ p_{\texttt{TGTGG}} \\[0.5em]
\text{Class } &p_{\texttt{ACACG}}:\ p_{\texttt{ACACG}},\ p_{\texttt{CACAT}},\ p_{\texttt{GTGTA}},\ p_{\texttt{TGTGC}} \\[0.5em]
\text{Class } &p_{\texttt{ACACT}}:\ p_{\texttt{ACACT}},\ p_{\texttt{CACAG}},\ p_{\texttt{GTGTC}},\ p_{\texttt{TGTGA}} \\[0.5em]
\text{Class } &p_{\texttt{ACAGA}}:\ p_{\texttt{ACAGA}},\ p_{\texttt{CACTC}},\ p_{\texttt{GTGAG}},\ p_{\texttt{TGTCT}} \\[0.5em]
\text{Class } &p_{\texttt{ACAGC}}:\ p_{\texttt{ACAGC}},\ p_{\texttt{CACTA}},\ p_{\texttt{GTGAT}},\ p_{\texttt{TGTCG}} \\[0.5em]
\text{Class } &p_{\texttt{ACAGG}}:\ p_{\texttt{ACAGG}},\ p_{\texttt{CACTT}},\ p_{\texttt{GTGAA}},\ p_{\texttt{TGTCC}} \\[0.5em]
\text{Class } &p_{\texttt{ACAGT}}:\ p_{\texttt{ACAGT}},\ p_{\texttt{CACTG}},\ p_{\texttt{GTGAC}},\ p_{\texttt{TGTCA}} \\[0.5em]
\text{Class } &p_{\texttt{ACATA}}:\ p_{\texttt{ACATA}},\ p_{\texttt{CACGC}},\ p_{\texttt{GTGCG}},\ p_{\texttt{TGTAT}} \\[0.5em]
\text{Class } &p_{\texttt{ACATC}}:\ p_{\texttt{ACATC}},\ p_{\texttt{CACGA}},\ p_{\texttt{GTGCT}},\ p_{\texttt{TGTAG}} \\[0.5em]
\text{Class } &p_{\texttt{ACATG}}:\ p_{\texttt{ACATG}},\ p_{\texttt{CACGT}},\ p_{\texttt{GTGCA}},\ p_{\texttt{TGTAC}} \\[0.5em]
\text{Class } &p_{\texttt{ACATT}}:\ p_{\texttt{ACATT}},\ p_{\texttt{CACGG}},\ p_{\texttt{GTGCC}},\ p_{\texttt{TGTAA}} \\[0.5em]
\text{Class } &p_{\texttt{ACCAA}}:\ p_{\texttt{ACCAA}},\ p_{\texttt{CAACC}},\ p_{\texttt{GTTGG}},\ p_{\texttt{TGGTT}} \\[0.5em]
\text{Class } &p_{\texttt{ACCAC}}:\ p_{\texttt{ACCAC}},\ p_{\texttt{CAACA}},\ p_{\texttt{GTTGT}},\ p_{\texttt{TGGTG}} \\[0.5em]
\text{Class } &p_{\texttt{ACCAG}}:\ p_{\texttt{ACCAG}},\ p_{\texttt{CAACT}},\ p_{\texttt{GTTGA}},\ p_{\texttt{TGGTC}} \\[0.5em]
\text{Class } &p_{\texttt{ACCAT}}:\ p_{\texttt{ACCAT}},\ p_{\texttt{CAACG}},\ p_{\texttt{GTTGC}},\ p_{\texttt{TGGTA}} \\[0.5em]
\text{Class } &p_{\texttt{ACCCA}}:\ p_{\texttt{ACCCA}},\ p_{\texttt{CAAAC}},\ p_{\texttt{GTTTG}},\ p_{\texttt{TGGGT}} \\[0.5em]
\text{Class } &p_{\texttt{ACCCC}}:\ p_{\texttt{ACCCC}},\ p_{\texttt{CAAAA}},\ p_{\texttt{GTTTT}},\ p_{\texttt{TGGGG}} \\[0.5em]
\text{Class } &p_{\texttt{ACCCG}}:\ p_{\texttt{ACCCG}},\ p_{\texttt{CAAAT}},\ p_{\texttt{GTTTA}},\ p_{\texttt{TGGGC}} \\[0.5em]
\text{Class } &p_{\texttt{ACCCT}}:\ p_{\texttt{ACCCT}},\ p_{\texttt{CAAAG}},\ p_{\texttt{GTTTC}},\ p_{\texttt{TGGGA}} \\[0.5em]
\text{Class } &p_{\texttt{ACCGA}}:\ p_{\texttt{ACCGA}},\ p_{\texttt{CAATC}},\ p_{\texttt{GTTAG}},\ p_{\texttt{TGGCT}} \\[0.5em]
\text{Class } &p_{\texttt{ACCGC}}:\ p_{\texttt{ACCGC}},\ p_{\texttt{CAATA}},\ p_{\texttt{GTTAT}},\ p_{\texttt{TGGCG}} \\[0.5em]
\text{Class } &p_{\texttt{ACCGG}}:\ p_{\texttt{ACCGG}},\ p_{\texttt{CAATT}},\ p_{\texttt{GTTAA}},\ p_{\texttt{TGGCC}} \\[0.5em]
\text{Class } &p_{\texttt{ACCGT}}:\ p_{\texttt{ACCGT}},\ p_{\texttt{CAATG}},\ p_{\texttt{GTTAC}},\ p_{\texttt{TGGCA}} \\[0.5em]
\text{Class } &p_{\texttt{ACCTA}}:\ p_{\texttt{ACCTA}},\ p_{\texttt{CAAGC}},\ p_{\texttt{GTTCG}},\ p_{\texttt{TGGAT}} \\[0.5em]
\text{Class } &p_{\texttt{ACCTC}}:\ p_{\texttt{ACCTC}},\ p_{\texttt{CAAGA}},\ p_{\texttt{GTTCT}},\ p_{\texttt{TGGAG}} \\[0.5em]
\text{Class } &p_{\texttt{ACCTG}}:\ p_{\texttt{ACCTG}},\ p_{\texttt{CAAGT}},\ p_{\texttt{GTTCA}},\ p_{\texttt{TGGAC}} \\[0.5em]
\text{Class } &p_{\texttt{ACCTT}}:\ p_{\texttt{ACCTT}},\ p_{\texttt{CAAGG}},\ p_{\texttt{GTTCC}},\ p_{\texttt{TGGAA}} \\[0.5em]
\text{Class } &p_{\texttt{ACGAA}}:\ p_{\texttt{ACGAA}},\ p_{\texttt{CATCC}},\ p_{\texttt{GTAGG}},\ p_{\texttt{TGCTT}} \\[0.5em]
\text{Class } &p_{\texttt{ACGAC}}:\ p_{\texttt{ACGAC}},\ p_{\texttt{CATCA}},\ p_{\texttt{GTAGT}},\ p_{\texttt{TGCTG}} \\[0.5em]
\text{Class } &p_{\texttt{ACGAG}}:\ p_{\texttt{ACGAG}},\ p_{\texttt{CATCT}},\ p_{\texttt{GTAGA}},\ p_{\texttt{TGCTC}} \\[0.5em]
\text{Class } &p_{\texttt{ACGAT}}:\ p_{\texttt{ACGAT}},\ p_{\texttt{CATCG}},\ p_{\texttt{GTAGC}},\ p_{\texttt{TGCTA}} \\[0.5em]
\text{Class } &p_{\texttt{ACGCA}}:\ p_{\texttt{ACGCA}},\ p_{\texttt{CATAC}},\ p_{\texttt{GTATG}},\ p_{\texttt{TGCGT}} \\[0.5em]
\text{Class } &p_{\texttt{ACGCC}}:\ p_{\texttt{ACGCC}},\ p_{\texttt{CATAA}},\ p_{\texttt{GTATT}},\ p_{\texttt{TGCGG}} \\[0.5em]
\text{Class } &p_{\texttt{ACGCG}}:\ p_{\texttt{ACGCG}},\ p_{\texttt{CATAT}},\ p_{\texttt{GTATA}},\ p_{\texttt{TGCGC}} \\[0.5em]
\text{Class } &p_{\texttt{ACGCT}}:\ p_{\texttt{ACGCT}},\ p_{\texttt{CATAG}},\ p_{\texttt{GTATC}},\ p_{\texttt{TGCGA}} \\[0.5em]
\text{Class } &p_{\texttt{ACGGA}}:\ p_{\texttt{ACGGA}},\ p_{\texttt{CATTC}},\ p_{\texttt{GTAAG}},\ p_{\texttt{TGCCT}} \\[0.5em]
\text{Class } &p_{\texttt{ACGGC}}:\ p_{\texttt{ACGGC}},\ p_{\texttt{CATTA}},\ p_{\texttt{GTAAT}},\ p_{\texttt{TGCCG}} \\[0.5em]
\text{Class } &p_{\texttt{ACGGG}}:\ p_{\texttt{ACGGG}},\ p_{\texttt{CATTT}},\ p_{\texttt{GTAAA}},\ p_{\texttt{TGCCC}} \\[0.5em]
\text{Class } &p_{\texttt{ACGGT}}:\ p_{\texttt{ACGGT}},\ p_{\texttt{CATTG}},\ p_{\texttt{GTAAC}},\ p_{\texttt{TGCCA}} \\[0.5em]
\text{Class } &p_{\texttt{ACGTA}}:\ p_{\texttt{ACGTA}},\ p_{\texttt{CATGC}},\ p_{\texttt{GTACG}},\ p_{\texttt{TGCAT}} \\[0.5em]
\text{Class } &p_{\texttt{ACGTC}}:\ p_{\texttt{ACGTC}},\ p_{\texttt{CATGA}},\ p_{\texttt{GTACT}},\ p_{\texttt{TGCAG}} \\[0.5em]
\text{Class } &p_{\texttt{ACGTG}}:\ p_{\texttt{ACGTG}},\ p_{\texttt{CATGT}},\ p_{\texttt{GTACA}},\ p_{\texttt{TGCAC}} \\[0.5em]
\text{Class } &p_{\texttt{ACGTT}}:\ p_{\texttt{ACGTT}},\ p_{\texttt{CATGG}},\ p_{\texttt{GTACC}},\ p_{\texttt{TGCAA}} \\[0.5em]
\text{Class } &p_{\texttt{ACTAA}}:\ p_{\texttt{ACTAA}},\ p_{\texttt{CAGCC}},\ p_{\texttt{GTCGG}},\ p_{\texttt{TGATT}} \\[0.5em]
\text{Class } &p_{\texttt{ACTAC}}:\ p_{\texttt{ACTAC}},\ p_{\texttt{CAGCA}},\ p_{\texttt{GTCGT}},\ p_{\texttt{TGATG}} \\[0.5em]
\text{Class } &p_{\texttt{ACTAG}}:\ p_{\texttt{ACTAG}},\ p_{\texttt{CAGCT}},\ p_{\texttt{GTCGA}},\ p_{\texttt{TGATC}} \\[0.5em]
\text{Class } &p_{\texttt{ACTAT}}:\ p_{\texttt{ACTAT}},\ p_{\texttt{CAGCG}},\ p_{\texttt{GTCGC}},\ p_{\texttt{TGATA}} \\[0.5em]
\text{Class } &p_{\texttt{ACTCA}}:\ p_{\texttt{ACTCA}},\ p_{\texttt{CAGAC}},\ p_{\texttt{GTCTG}},\ p_{\texttt{TGAGT}} \\[0.5em]
\text{Class } &p_{\texttt{ACTCC}}:\ p_{\texttt{ACTCC}},\ p_{\texttt{CAGAA}},\ p_{\texttt{GTCTT}},\ p_{\texttt{TGAGG}} \\[0.5em]
\text{Class } &p_{\texttt{ACTCG}}:\ p_{\texttt{ACTCG}},\ p_{\texttt{CAGAT}},\ p_{\texttt{GTCTA}},\ p_{\texttt{TGAGC}} \\[0.5em]
\text{Class } &p_{\texttt{ACTCT}}:\ p_{\texttt{ACTCT}},\ p_{\texttt{CAGAG}},\ p_{\texttt{GTCTC}},\ p_{\texttt{TGAGA}} \\[0.5em]
\text{Class } &p_{\texttt{ACTGA}}:\ p_{\texttt{ACTGA}},\ p_{\texttt{CAGTC}},\ p_{\texttt{GTCAG}},\ p_{\texttt{TGACT}} \\[0.5em]
\text{Class } &p_{\texttt{ACTGC}}:\ p_{\texttt{ACTGC}},\ p_{\texttt{CAGTA}},\ p_{\texttt{GTCAT}},\ p_{\texttt{TGACG}} \\[0.5em]
\text{Class } &p_{\texttt{ACTGG}}:\ p_{\texttt{ACTGG}},\ p_{\texttt{CAGTT}},\ p_{\texttt{GTCAA}},\ p_{\texttt{TGACC}} \\[0.5em]
\text{Class } &p_{\texttt{ACTGT}}:\ p_{\texttt{ACTGT}},\ p_{\texttt{CAGTG}},\ p_{\texttt{GTCAC}},\ p_{\texttt{TGACA}} \\[0.5em]
\text{Class } &p_{\texttt{ACTTA}}:\ p_{\texttt{ACTTA}},\ p_{\texttt{CAGGC}},\ p_{\texttt{GTCCG}},\ p_{\texttt{TGAAT}} \\[0.5em]
\text{Class } &p_{\texttt{ACTTC}}:\ p_{\texttt{ACTTC}},\ p_{\texttt{CAGGA}},\ p_{\texttt{GTCCT}},\ p_{\texttt{TGAAG}} \\[0.5em]
\text{Class } &p_{\texttt{ACTTG}}:\ p_{\texttt{ACTTG}},\ p_{\texttt{CAGGT}},\ p_{\texttt{GTCCA}},\ p_{\texttt{TGAAC}} \\[0.5em]
\text{Class } &p_{\texttt{ACTTT}}:\ p_{\texttt{ACTTT}},\ p_{\texttt{CAGGG}},\ p_{\texttt{GTCCC}},\ p_{\texttt{TGAAA}} \\[0.5em]
\text{Class } &p_{\texttt{AGAAA}}:\ p_{\texttt{AGAAA}},\ p_{\texttt{CTCCC}},\ p_{\texttt{GAGGG}},\ p_{\texttt{TCTTT}} \\[0.5em]
\text{Class } &p_{\texttt{AGAAC}}:\ p_{\texttt{AGAAC}},\ p_{\texttt{CTCCA}},\ p_{\texttt{GAGGT}},\ p_{\texttt{TCTTG}} \\[0.5em]
\text{Class } &p_{\texttt{AGAAG}}:\ p_{\texttt{AGAAG}},\ p_{\texttt{CTCCT}},\ p_{\texttt{GAGGA}},\ p_{\texttt{TCTTC}} \\[0.5em]
\text{Class } &p_{\texttt{AGAAT}}:\ p_{\texttt{AGAAT}},\ p_{\texttt{CTCCG}},\ p_{\texttt{GAGGC}},\ p_{\texttt{TCTTA}} \\[0.5em]
\text{Class } &p_{\texttt{AGACA}}:\ p_{\texttt{AGACA}},\ p_{\texttt{CTCAC}},\ p_{\texttt{GAGTG}},\ p_{\texttt{TCTGT}} \\[0.5em]
\text{Class } &p_{\texttt{AGACC}}:\ p_{\texttt{AGACC}},\ p_{\texttt{CTCAA}},\ p_{\texttt{GAGTT}},\ p_{\texttt{TCTGG}} \\[0.5em]
\text{Class } &p_{\texttt{AGACG}}:\ p_{\texttt{AGACG}},\ p_{\texttt{CTCAT}},\ p_{\texttt{GAGTA}},\ p_{\texttt{TCTGC}} \\[0.5em]
\text{Class } &p_{\texttt{AGACT}}:\ p_{\texttt{AGACT}},\ p_{\texttt{CTCAG}},\ p_{\texttt{GAGTC}},\ p_{\texttt{TCTGA}} \\[0.5em]
\text{Class } &p_{\texttt{AGAGA}}:\ p_{\texttt{AGAGA}},\ p_{\texttt{CTCTC}},\ p_{\texttt{GAGAG}},\ p_{\texttt{TCTCT}} \\[0.5em]
\text{Class } &p_{\texttt{AGAGC}}:\ p_{\texttt{AGAGC}},\ p_{\texttt{CTCTA}},\ p_{\texttt{GAGAT}},\ p_{\texttt{TCTCG}} \\[0.5em]
\text{Class } &p_{\texttt{AGAGG}}:\ p_{\texttt{AGAGG}},\ p_{\texttt{CTCTT}},\ p_{\texttt{GAGAA}},\ p_{\texttt{TCTCC}} \\[0.5em]
\text{Class } &p_{\texttt{AGAGT}}:\ p_{\texttt{AGAGT}},\ p_{\texttt{CTCTG}},\ p_{\texttt{GAGAC}},\ p_{\texttt{TCTCA}} \\[0.5em]
\text{Class } &p_{\texttt{AGATA}}:\ p_{\texttt{AGATA}},\ p_{\texttt{CTCGC}},\ p_{\texttt{GAGCG}},\ p_{\texttt{TCTAT}} \\[0.5em]
\text{Class } &p_{\texttt{AGATC}}:\ p_{\texttt{AGATC}},\ p_{\texttt{CTCGA}},\ p_{\texttt{GAGCT}},\ p_{\texttt{TCTAG}} \\[0.5em]
\text{Class } &p_{\texttt{AGATG}}:\ p_{\texttt{AGATG}},\ p_{\texttt{CTCGT}},\ p_{\texttt{GAGCA}},\ p_{\texttt{TCTAC}} \\[0.5em]
\text{Class } &p_{\texttt{AGATT}}:\ p_{\texttt{AGATT}},\ p_{\texttt{CTCGG}},\ p_{\texttt{GAGCC}},\ p_{\texttt{TCTAA}} \\[0.5em]
\text{Class } &p_{\texttt{AGCAA}}:\ p_{\texttt{AGCAA}},\ p_{\texttt{CTACC}},\ p_{\texttt{GATGG}},\ p_{\texttt{TCGTT}} \\[0.5em]
\text{Class } &p_{\texttt{AGCAC}}:\ p_{\texttt{AGCAC}},\ p_{\texttt{CTACA}},\ p_{\texttt{GATGT}},\ p_{\texttt{TCGTG}} \\[0.5em]
\text{Class } &p_{\texttt{AGCAG}}:\ p_{\texttt{AGCAG}},\ p_{\texttt{CTACT}},\ p_{\texttt{GATGA}},\ p_{\texttt{TCGTC}} \\[0.5em]
\text{Class } &p_{\texttt{AGCAT}}:\ p_{\texttt{AGCAT}},\ p_{\texttt{CTACG}},\ p_{\texttt{GATGC}},\ p_{\texttt{TCGTA}} \\[0.5em]
\text{Class } &p_{\texttt{AGCCA}}:\ p_{\texttt{AGCCA}},\ p_{\texttt{CTAAC}},\ p_{\texttt{GATTG}},\ p_{\texttt{TCGGT}} \\[0.5em]
\text{Class } &p_{\texttt{AGCCC}}:\ p_{\texttt{AGCCC}},\ p_{\texttt{CTAAA}},\ p_{\texttt{GATTT}},\ p_{\texttt{TCGGG}} \\[0.5em]
\text{Class } &p_{\texttt{AGCCG}}:\ p_{\texttt{AGCCG}},\ p_{\texttt{CTAAT}},\ p_{\texttt{GATTA}},\ p_{\texttt{TCGGC}} \\[0.5em]
\text{Class } &p_{\texttt{AGCCT}}:\ p_{\texttt{AGCCT}},\ p_{\texttt{CTAAG}},\ p_{\texttt{GATTC}},\ p_{\texttt{TCGGA}} \\[0.5em]
\text{Class } &p_{\texttt{AGCGA}}:\ p_{\texttt{AGCGA}},\ p_{\texttt{CTATC}},\ p_{\texttt{GATAG}},\ p_{\texttt{TCGCT}} \\[0.5em]
\text{Class } &p_{\texttt{AGCGC}}:\ p_{\texttt{AGCGC}},\ p_{\texttt{CTATA}},\ p_{\texttt{GATAT}},\ p_{\texttt{TCGCG}} \\[0.5em]
\text{Class } &p_{\texttt{AGCGG}}:\ p_{\texttt{AGCGG}},\ p_{\texttt{CTATT}},\ p_{\texttt{GATAA}},\ p_{\texttt{TCGCC}} \\[0.5em]
\text{Class } &p_{\texttt{AGCGT}}:\ p_{\texttt{AGCGT}},\ p_{\texttt{CTATG}},\ p_{\texttt{GATAC}},\ p_{\texttt{TCGCA}} \\[0.5em]
\text{Class } &p_{\texttt{AGCTA}}:\ p_{\texttt{AGCTA}},\ p_{\texttt{CTAGC}},\ p_{\texttt{GATCG}},\ p_{\texttt{TCGAT}} \\[0.5em]
\text{Class } &p_{\texttt{AGCTC}}:\ p_{\texttt{AGCTC}},\ p_{\texttt{CTAGA}},\ p_{\texttt{GATCT}},\ p_{\texttt{TCGAG}} \\[0.5em]
\text{Class } &p_{\texttt{AGCTG}}:\ p_{\texttt{AGCTG}},\ p_{\texttt{CTAGT}},\ p_{\texttt{GATCA}},\ p_{\texttt{TCGAC}} \\[0.5em]
\text{Class } &p_{\texttt{AGCTT}}:\ p_{\texttt{AGCTT}},\ p_{\texttt{CTAGG}},\ p_{\texttt{GATCC}},\ p_{\texttt{TCGAA}} \\[0.5em]
\text{Class } &p_{\texttt{AGGAA}}:\ p_{\texttt{AGGAA}},\ p_{\texttt{CTTCC}},\ p_{\texttt{GAAGG}},\ p_{\texttt{TCCTT}} \\[0.5em]
\text{Class } &p_{\texttt{AGGAC}}:\ p_{\texttt{AGGAC}},\ p_{\texttt{CTTCA}},\ p_{\texttt{GAAGT}},\ p_{\texttt{TCCTG}} \\[0.5em]
\text{Class } &p_{\texttt{AGGAG}}:\ p_{\texttt{AGGAG}},\ p_{\texttt{CTTCT}},\ p_{\texttt{GAAGA}},\ p_{\texttt{TCCTC}} \\[0.5em]
\text{Class } &p_{\texttt{AGGAT}}:\ p_{\texttt{AGGAT}},\ p_{\texttt{CTTCG}},\ p_{\texttt{GAAGC}},\ p_{\texttt{TCCTA}} \\[0.5em]
\text{Class } &p_{\texttt{AGGCA}}:\ p_{\texttt{AGGCA}},\ p_{\texttt{CTTAC}},\ p_{\texttt{GAATG}},\ p_{\texttt{TCCGT}} \\[0.5em]
\text{Class } &p_{\texttt{AGGCC}}:\ p_{\texttt{AGGCC}},\ p_{\texttt{CTTAA}},\ p_{\texttt{GAATT}},\ p_{\texttt{TCCGG}} \\[0.5em]
\text{Class } &p_{\texttt{AGGCG}}:\ p_{\texttt{AGGCG}},\ p_{\texttt{CTTAT}},\ p_{\texttt{GAATA}},\ p_{\texttt{TCCGC}} \\[0.5em]
\text{Class } &p_{\texttt{AGGCT}}:\ p_{\texttt{AGGCT}},\ p_{\texttt{CTTAG}},\ p_{\texttt{GAATC}},\ p_{\texttt{TCCGA}} \\[0.5em]
\text{Class } &p_{\texttt{AGGGA}}:\ p_{\texttt{AGGGA}},\ p_{\texttt{CTTTC}},\ p_{\texttt{GAAAG}},\ p_{\texttt{TCCCT}} \\[0.5em]
\text{Class } &p_{\texttt{AGGGC}}:\ p_{\texttt{AGGGC}},\ p_{\texttt{CTTTA}},\ p_{\texttt{GAAAT}},\ p_{\texttt{TCCCG}} \\[0.5em]
\text{Class } &p_{\texttt{AGGGG}}:\ p_{\texttt{AGGGG}},\ p_{\texttt{CTTTT}},\ p_{\texttt{GAAAA}},\ p_{\texttt{TCCCC}} \\[0.5em]
\text{Class } &p_{\texttt{AGGGT}}:\ p_{\texttt{AGGGT}},\ p_{\texttt{CTTTG}},\ p_{\texttt{GAAAC}},\ p_{\texttt{TCCCA}} \\[0.5em]
\text{Class } &p_{\texttt{AGGTA}}:\ p_{\texttt{AGGTA}},\ p_{\texttt{CTTGC}},\ p_{\texttt{GAACG}},\ p_{\texttt{TCCAT}} \\[0.5em]
\text{Class } &p_{\texttt{AGGTC}}:\ p_{\texttt{AGGTC}},\ p_{\texttt{CTTGA}},\ p_{\texttt{GAACT}},\ p_{\texttt{TCCAG}} \\[0.5em]
\text{Class } &p_{\texttt{AGGTG}}:\ p_{\texttt{AGGTG}},\ p_{\texttt{CTTGT}},\ p_{\texttt{GAACA}},\ p_{\texttt{TCCAC}} \\[0.5em]
\text{Class } &p_{\texttt{AGGTT}}:\ p_{\texttt{AGGTT}},\ p_{\texttt{CTTGG}},\ p_{\texttt{GAACC}},\ p_{\texttt{TCCAA}} \\[0.5em]
\text{Class } &p_{\texttt{AGTAA}}:\ p_{\texttt{AGTAA}},\ p_{\texttt{CTGCC}},\ p_{\texttt{GACGG}},\ p_{\texttt{TCATT}} \\[0.5em]
\text{Class } &p_{\texttt{AGTAC}}:\ p_{\texttt{AGTAC}},\ p_{\texttt{CTGCA}},\ p_{\texttt{GACGT}},\ p_{\texttt{TCATG}} \\[0.5em]
\text{Class } &p_{\texttt{AGTAG}}:\ p_{\texttt{AGTAG}},\ p_{\texttt{CTGCT}},\ p_{\texttt{GACGA}},\ p_{\texttt{TCATC}} \\[0.5em]
\text{Class } &p_{\texttt{AGTAT}}:\ p_{\texttt{AGTAT}},\ p_{\texttt{CTGCG}},\ p_{\texttt{GACGC}},\ p_{\texttt{TCATA}} \\[0.5em]
\text{Class } &p_{\texttt{AGTCA}}:\ p_{\texttt{AGTCA}},\ p_{\texttt{CTGAC}},\ p_{\texttt{GACTG}},\ p_{\texttt{TCAGT}} \\[0.5em]
\text{Class } &p_{\texttt{AGTCC}}:\ p_{\texttt{AGTCC}},\ p_{\texttt{CTGAA}},\ p_{\texttt{GACTT}},\ p_{\texttt{TCAGG}} \\[0.5em]
\text{Class } &p_{\texttt{AGTCG}}:\ p_{\texttt{AGTCG}},\ p_{\texttt{CTGAT}},\ p_{\texttt{GACTA}},\ p_{\texttt{TCAGC}} \\[0.5em]
\text{Class } &p_{\texttt{AGTCT}}:\ p_{\texttt{AGTCT}},\ p_{\texttt{CTGAG}},\ p_{\texttt{GACTC}},\ p_{\texttt{TCAGA}} \\[0.5em]
\text{Class } &p_{\texttt{AGTGA}}:\ p_{\texttt{AGTGA}},\ p_{\texttt{CTGTC}},\ p_{\texttt{GACAG}},\ p_{\texttt{TCACT}} \\[0.5em]
\text{Class } &p_{\texttt{AGTGC}}:\ p_{\texttt{AGTGC}},\ p_{\texttt{CTGTA}},\ p_{\texttt{GACAT}},\ p_{\texttt{TCACG}} \\[0.5em]
\text{Class } &p_{\texttt{AGTGG}}:\ p_{\texttt{AGTGG}},\ p_{\texttt{CTGTT}},\ p_{\texttt{GACAA}},\ p_{\texttt{TCACC}} \\[0.5em]
\text{Class } &p_{\texttt{AGTGT}}:\ p_{\texttt{AGTGT}},\ p_{\texttt{CTGTG}},\ p_{\texttt{GACAC}},\ p_{\texttt{TCACA}} \\[0.5em]
\text{Class } &p_{\texttt{AGTTA}}:\ p_{\texttt{AGTTA}},\ p_{\texttt{CTGGC}},\ p_{\texttt{GACCG}},\ p_{\texttt{TCAAT}} \\[0.5em]
\text{Class } &p_{\texttt{AGTTC}}:\ p_{\texttt{AGTTC}},\ p_{\texttt{CTGGA}},\ p_{\texttt{GACCT}},\ p_{\texttt{TCAAG}} \\[0.5em]
\text{Class } &p_{\texttt{AGTTG}}:\ p_{\texttt{AGTTG}},\ p_{\texttt{CTGGT}},\ p_{\texttt{GACCA}},\ p_{\texttt{TCAAC}} \\[0.5em]
\text{Class } &p_{\texttt{AGTTT}}:\ p_{\texttt{AGTTT}},\ p_{\texttt{CTGGG}},\ p_{\texttt{GACCC}},\ p_{\texttt{TCAAA}} \\[0.5em]
\text{Class } &p_{\texttt{ATAAA}}:\ p_{\texttt{ATAAA}},\ p_{\texttt{CGCCC}},\ p_{\texttt{GCGGG}},\ p_{\texttt{TATTT}} \\[0.5em]
\text{Class } &p_{\texttt{ATAAC}}:\ p_{\texttt{ATAAC}},\ p_{\texttt{CGCCA}},\ p_{\texttt{GCGGT}},\ p_{\texttt{TATTG}} \\[0.5em]
\text{Class } &p_{\texttt{ATAAG}}:\ p_{\texttt{ATAAG}},\ p_{\texttt{CGCCT}},\ p_{\texttt{GCGGA}},\ p_{\texttt{TATTC}} \\[0.5em]
\text{Class } &p_{\texttt{ATAAT}}:\ p_{\texttt{ATAAT}},\ p_{\texttt{CGCCG}},\ p_{\texttt{GCGGC}},\ p_{\texttt{TATTA}} \\[0.5em]
\text{Class } &p_{\texttt{ATACA}}:\ p_{\texttt{ATACA}},\ p_{\texttt{CGCAC}},\ p_{\texttt{GCGTG}},\ p_{\texttt{TATGT}} \\[0.5em]
\text{Class } &p_{\texttt{ATACC}}:\ p_{\texttt{ATACC}},\ p_{\texttt{CGCAA}},\ p_{\texttt{GCGTT}},\ p_{\texttt{TATGG}} \\[0.5em]
\text{Class } &p_{\texttt{ATACG}}:\ p_{\texttt{ATACG}},\ p_{\texttt{CGCAT}},\ p_{\texttt{GCGTA}},\ p_{\texttt{TATGC}} \\[0.5em]
\text{Class } &p_{\texttt{ATACT}}:\ p_{\texttt{ATACT}},\ p_{\texttt{CGCAG}},\ p_{\texttt{GCGTC}},\ p_{\texttt{TATGA}} \\[0.5em]
\text{Class } &p_{\texttt{ATAGA}}:\ p_{\texttt{ATAGA}},\ p_{\texttt{CGCTC}},\ p_{\texttt{GCGAG}},\ p_{\texttt{TATCT}} \\[0.5em]
\text{Class } &p_{\texttt{ATAGC}}:\ p_{\texttt{ATAGC}},\ p_{\texttt{CGCTA}},\ p_{\texttt{GCGAT}},\ p_{\texttt{TATCG}} \\[0.5em]
\text{Class } &p_{\texttt{ATAGG}}:\ p_{\texttt{ATAGG}},\ p_{\texttt{CGCTT}},\ p_{\texttt{GCGAA}},\ p_{\texttt{TATCC}} \\[0.5em]
\text{Class } &p_{\texttt{ATAGT}}:\ p_{\texttt{ATAGT}},\ p_{\texttt{CGCTG}},\ p_{\texttt{GCGAC}},\ p_{\texttt{TATCA}} \\[0.5em]
\text{Class } &p_{\texttt{ATATA}}:\ p_{\texttt{ATATA}},\ p_{\texttt{CGCGC}},\ p_{\texttt{GCGCG}},\ p_{\texttt{TATAT}} \\[0.5em]
\text{Class } &p_{\texttt{ATATC}}:\ p_{\texttt{ATATC}},\ p_{\texttt{CGCGA}},\ p_{\texttt{GCGCT}},\ p_{\texttt{TATAG}} \\[0.5em]
\text{Class } &p_{\texttt{ATATG}}:\ p_{\texttt{ATATG}},\ p_{\texttt{CGCGT}},\ p_{\texttt{GCGCA}},\ p_{\texttt{TATAC}} \\[0.5em]
\text{Class } &p_{\texttt{ATATT}}:\ p_{\texttt{ATATT}},\ p_{\texttt{CGCGG}},\ p_{\texttt{GCGCC}},\ p_{\texttt{TATAA}} \\[0.5em]
\text{Class } &p_{\texttt{ATCAA}}:\ p_{\texttt{ATCAA}},\ p_{\texttt{CGACC}},\ p_{\texttt{GCTGG}},\ p_{\texttt{TAGTT}} \\[0.5em]
\text{Class } &p_{\texttt{ATCAC}}:\ p_{\texttt{ATCAC}},\ p_{\texttt{CGACA}},\ p_{\texttt{GCTGT}},\ p_{\texttt{TAGTG}} \\[0.5em]
\text{Class } &p_{\texttt{ATCAG}}:\ p_{\texttt{ATCAG}},\ p_{\texttt{CGACT}},\ p_{\texttt{GCTGA}},\ p_{\texttt{TAGTC}} \\[0.5em]
\text{Class } &p_{\texttt{ATCAT}}:\ p_{\texttt{ATCAT}},\ p_{\texttt{CGACG}},\ p_{\texttt{GCTGC}},\ p_{\texttt{TAGTA}} \\[0.5em]
\text{Class } &p_{\texttt{ATCCA}}:\ p_{\texttt{ATCCA}},\ p_{\texttt{CGAAC}},\ p_{\texttt{GCTTG}},\ p_{\texttt{TAGGT}} \\[0.5em]
\text{Class } &p_{\texttt{ATCCC}}:\ p_{\texttt{ATCCC}},\ p_{\texttt{CGAAA}},\ p_{\texttt{GCTTT}},\ p_{\texttt{TAGGG}} \\[0.5em]
\text{Class } &p_{\texttt{ATCCG}}:\ p_{\texttt{ATCCG}},\ p_{\texttt{CGAAT}},\ p_{\texttt{GCTTA}},\ p_{\texttt{TAGGC}} \\[0.5em]
\text{Class } &p_{\texttt{ATCCT}}:\ p_{\texttt{ATCCT}},\ p_{\texttt{CGAAG}},\ p_{\texttt{GCTTC}},\ p_{\texttt{TAGGA}} \\[0.5em]
\text{Class } &p_{\texttt{ATCGA}}:\ p_{\texttt{ATCGA}},\ p_{\texttt{CGATC}},\ p_{\texttt{GCTAG}},\ p_{\texttt{TAGCT}} \\[0.5em]
\text{Class } &p_{\texttt{ATCGC}}:\ p_{\texttt{ATCGC}},\ p_{\texttt{CGATA}},\ p_{\texttt{GCTAT}},\ p_{\texttt{TAGCG}} \\[0.5em]
\text{Class } &p_{\texttt{ATCGG}}:\ p_{\texttt{ATCGG}},\ p_{\texttt{CGATT}},\ p_{\texttt{GCTAA}},\ p_{\texttt{TAGCC}} \\[0.5em]
\text{Class } &p_{\texttt{ATCGT}}:\ p_{\texttt{ATCGT}},\ p_{\texttt{CGATG}},\ p_{\texttt{GCTAC}},\ p_{\texttt{TAGCA}} \\[0.5em]
\text{Class } &p_{\texttt{ATCTA}}:\ p_{\texttt{ATCTA}},\ p_{\texttt{CGAGC}},\ p_{\texttt{GCTCG}},\ p_{\texttt{TAGAT}} \\[0.5em]
\text{Class } &p_{\texttt{ATCTC}}:\ p_{\texttt{ATCTC}},\ p_{\texttt{CGAGA}},\ p_{\texttt{GCTCT}},\ p_{\texttt{TAGAG}} \\[0.5em]
\text{Class } &p_{\texttt{ATCTG}}:\ p_{\texttt{ATCTG}},\ p_{\texttt{CGAGT}},\ p_{\texttt{GCTCA}},\ p_{\texttt{TAGAC}} \\[0.5em]
\text{Class } &p_{\texttt{ATCTT}}:\ p_{\texttt{ATCTT}},\ p_{\texttt{CGAGG}},\ p_{\texttt{GCTCC}},\ p_{\texttt{TAGAA}} \\[0.5em]
\text{Class } &p_{\texttt{ATGAA}}:\ p_{\texttt{ATGAA}},\ p_{\texttt{CGTCC}},\ p_{\texttt{GCAGG}},\ p_{\texttt{TACTT}} \\[0.5em]
\text{Class } &p_{\texttt{ATGAC}}:\ p_{\texttt{ATGAC}},\ p_{\texttt{CGTCA}},\ p_{\texttt{GCAGT}},\ p_{\texttt{TACTG}} \\[0.5em]
\text{Class } &p_{\texttt{ATGAG}}:\ p_{\texttt{ATGAG}},\ p_{\texttt{CGTCT}},\ p_{\texttt{GCAGA}},\ p_{\texttt{TACTC}} \\[0.5em]
\text{Class } &p_{\texttt{ATGAT}}:\ p_{\texttt{ATGAT}},\ p_{\texttt{CGTCG}},\ p_{\texttt{GCAGC}},\ p_{\texttt{TACTA}} \\[0.5em]
\text{Class } &p_{\texttt{ATGCA}}:\ p_{\texttt{ATGCA}},\ p_{\texttt{CGTAC}},\ p_{\texttt{GCATG}},\ p_{\texttt{TACGT}} \\[0.5em]
\text{Class } &p_{\texttt{ATGCC}}:\ p_{\texttt{ATGCC}},\ p_{\texttt{CGTAA}},\ p_{\texttt{GCATT}},\ p_{\texttt{TACGG}} \\[0.5em]
\text{Class } &p_{\texttt{ATGCG}}:\ p_{\texttt{ATGCG}},\ p_{\texttt{CGTAT}},\ p_{\texttt{GCATA}},\ p_{\texttt{TACGC}} \\[0.5em]
\text{Class } &p_{\texttt{ATGCT}}:\ p_{\texttt{ATGCT}},\ p_{\texttt{CGTAG}},\ p_{\texttt{GCATC}},\ p_{\texttt{TACGA}} \\[0.5em]
\text{Class } &p_{\texttt{ATGGA}}:\ p_{\texttt{ATGGA}},\ p_{\texttt{CGTTC}},\ p_{\texttt{GCAAG}},\ p_{\texttt{TACCT}} \\[0.5em]
\text{Class } &p_{\texttt{ATGGC}}:\ p_{\texttt{ATGGC}},\ p_{\texttt{CGTTA}},\ p_{\texttt{GCAAT}},\ p_{\texttt{TACCG}} \\[0.5em]
\text{Class } &p_{\texttt{ATGGG}}:\ p_{\texttt{ATGGG}},\ p_{\texttt{CGTTT}},\ p_{\texttt{GCAAA}},\ p_{\texttt{TACCC}} \\[0.5em]
\text{Class } &p_{\texttt{ATGGT}}:\ p_{\texttt{ATGGT}},\ p_{\texttt{CGTTG}},\ p_{\texttt{GCAAC}},\ p_{\texttt{TACCA}} \\[0.5em]
\text{Class } &p_{\texttt{ATGTA}}:\ p_{\texttt{ATGTA}},\ p_{\texttt{CGTGC}},\ p_{\texttt{GCACG}},\ p_{\texttt{TACAT}} \\[0.5em]
\text{Class } &p_{\texttt{ATGTC}}:\ p_{\texttt{ATGTC}},\ p_{\texttt{CGTGA}},\ p_{\texttt{GCACT}},\ p_{\texttt{TACAG}} \\[0.5em]
\text{Class } &p_{\texttt{ATGTG}}:\ p_{\texttt{ATGTG}},\ p_{\texttt{CGTGT}},\ p_{\texttt{GCACA}},\ p_{\texttt{TACAC}} \\[0.5em]
\text{Class } &p_{\texttt{ATGTT}}:\ p_{\texttt{ATGTT}},\ p_{\texttt{CGTGG}},\ p_{\texttt{GCACC}},\ p_{\texttt{TACAA}} \\[0.5em]
\text{Class } &p_{\texttt{ATTAA}}:\ p_{\texttt{ATTAA}},\ p_{\texttt{CGGCC}},\ p_{\texttt{GCCGG}},\ p_{\texttt{TAATT}} \\[0.5em]
\text{Class } &p_{\texttt{ATTAC}}:\ p_{\texttt{ATTAC}},\ p_{\texttt{CGGCA}},\ p_{\texttt{GCCGT}},\ p_{\texttt{TAATG}} \\[0.5em]
\text{Class } &p_{\texttt{ATTAG}}:\ p_{\texttt{ATTAG}},\ p_{\texttt{CGGCT}},\ p_{\texttt{GCCGA}},\ p_{\texttt{TAATC}} \\[0.5em]
\text{Class } &p_{\texttt{ATTAT}}:\ p_{\texttt{ATTAT}},\ p_{\texttt{CGGCG}},\ p_{\texttt{GCCGC}},\ p_{\texttt{TAATA}} \\[0.5em]
\text{Class } &p_{\texttt{ATTCA}}:\ p_{\texttt{ATTCA}},\ p_{\texttt{CGGAC}},\ p_{\texttt{GCCTG}},\ p_{\texttt{TAAGT}} \\[0.5em]
\text{Class } &p_{\texttt{ATTCC}}:\ p_{\texttt{ATTCC}},\ p_{\texttt{CGGAA}},\ p_{\texttt{GCCTT}},\ p_{\texttt{TAAGG}} \\[0.5em]
\text{Class } &p_{\texttt{ATTCG}}:\ p_{\texttt{ATTCG}},\ p_{\texttt{CGGAT}},\ p_{\texttt{GCCTA}},\ p_{\texttt{TAAGC}} \\[0.5em]
\text{Class } &p_{\texttt{ATTCT}}:\ p_{\texttt{ATTCT}},\ p_{\texttt{CGGAG}},\ p_{\texttt{GCCTC}},\ p_{\texttt{TAAGA}} \\[0.5em]
\text{Class } &p_{\texttt{ATTGA}}:\ p_{\texttt{ATTGA}},\ p_{\texttt{CGGTC}},\ p_{\texttt{GCCAG}},\ p_{\texttt{TAACT}} \\[0.5em]
\text{Class } &p_{\texttt{ATTGC}}:\ p_{\texttt{ATTGC}},\ p_{\texttt{CGGTA}},\ p_{\texttt{GCCAT}},\ p_{\texttt{TAACG}} \\[0.5em]
\text{Class } &p_{\texttt{ATTGG}}:\ p_{\texttt{ATTGG}},\ p_{\texttt{CGGTT}},\ p_{\texttt{GCCAA}},\ p_{\texttt{TAACC}} \\[0.5em]
\text{Class } &p_{\texttt{ATTGT}}:\ p_{\texttt{ATTGT}},\ p_{\texttt{CGGTG}},\ p_{\texttt{GCCAC}},\ p_{\texttt{TAACA}} \\[0.5em]
\text{Class } &p_{\texttt{ATTTA}}:\ p_{\texttt{ATTTA}},\ p_{\texttt{CGGGC}},\ p_{\texttt{GCCCG}},\ p_{\texttt{TAAAT}} \\[0.5em]
\text{Class } &p_{\texttt{ATTTC}}:\ p_{\texttt{ATTTC}},\ p_{\texttt{CGGGA}},\ p_{\texttt{GCCCT}},\ p_{\texttt{TAAAG}} \\[0.5em]
\text{Class } &p_{\texttt{ATTTG}}:\ p_{\texttt{ATTTG}},\ p_{\texttt{CGGGT}},\ p_{\texttt{GCCCA}},\ p_{\texttt{TAAAC}} \\[0.5em]
\text{Class } &p_{\texttt{ATTTT}}:\ p_{\texttt{ATTTT}},\ p_{\texttt{CGGGG}},\ p_{\texttt{GCCCC}},\ p_{\texttt{TAAAA}}
\end{align}$
Equivalent classes of Fourier parametrization
$\begin{align}
\text{Class } &0:\ q_{\texttt{AAAAC}}, q_{\texttt{AAAAG}}, q_{\texttt{AAAAT}}, q_{\texttt{AAACA}}, q_{\texttt{AAACG}}, q_{\texttt{AAACT}}, q_{\texttt{AAAGA}}, q_{\texttt{AAAGC}}, q_{\texttt{AAAGT}}, q_{\texttt{AAATA}}, q_{\texttt{AAATC}}, q_{\texttt{AAATG}}, q_{\texttt{AACAA}}, q_{\texttt{AACAG}}, q_{\texttt{AACAT}}, q_{\texttt{AACCC}}, q_{\texttt{AACCG}}, q_{\texttt{AACCT}}, q_{\texttt{AACGA}}, q_{\texttt{AACGC}}, q_{\texttt{AACGG}}, q_{\texttt{AACTA}}, q_{\texttt{AACTC}}, q_{\texttt{AACTT}}, q_{\texttt{AAGAA}}, q_{\texttt{AAGAC}}, q_{\texttt{AAGAT}}, q_{\texttt{AAGCA}}, q_{\texttt{AAGCC}}, q_{\texttt{AAGCG}}, q_{\texttt{AAGGC}}, q_{\texttt{AAGGG}}, q_{\texttt{AAGGT}}, q_{\texttt{AAGTA}}, q_{\texttt{AAGTG}}, q_{\texttt{AAGTT}}, q_{\texttt{AATAA}}, q_{\texttt{AATAC}}, q_{\texttt{AATAG}}, q_{\texttt{AATCA}}, q_{\texttt{AATCC}}, q_{\texttt{AATCT}}, q_{\texttt{AATGA}}, q_{\texttt{AATGG}}, q_{\texttt{AATGT}}, q_{\texttt{AATTC}}, q_{\texttt{AATTG}}, q_{\texttt{AATTT}}, q_{\texttt{ACAAA}}, q_{\texttt{ACAAG}}, q_{\texttt{ACAAT}}, q_{\texttt{ACACC}}, q_{\texttt{ACACG}}, q_{\texttt{ACACT}}, q_{\texttt{ACAGA}}, q_{\texttt{ACAGC}}, q_{\texttt{ACAGG}}, q_{\texttt{ACATA}}, q_{\texttt{ACATC}}, q_{\texttt{ACATT}}, q_{\texttt{ACCAC}}, q_{\texttt{ACCAG}}, q_{\texttt{ACCAT}}, q_{\texttt{ACCCA}}, q_{\texttt{ACCCG}}, q_{\texttt{ACCCT}}, q_{\texttt{ACCGA}}, q_{\texttt{ACCGC}}, q_{\texttt{ACCGT}}, q_{\texttt{ACCTA}}, q_{\texttt{ACCTC}}, q_{\texttt{ACCTG}}, q_{\texttt{ACGAA}}, q_{\texttt{ACGAC}}, q_{\texttt{ACGAG}}, q_{\texttt{ACGCA}}, q_{\texttt{ACGCC}}, q_{\texttt{ACGCT}}, q_{\texttt{ACGGA}}, q_{\texttt{ACGGG}}, q_{\texttt{ACGGT}}, q_{\texttt{ACGTC}}, q_{\texttt{ACGTG}}, q_{\texttt{ACGTT}}, q_{\texttt{ACTAA}}, q_{\texttt{ACTAC}}, q_{\texttt{ACTAT}}, q_{\texttt{ACTCA}}, q_{\texttt{ACTCC}}, q_{\texttt{ACTCG}}, q_{\texttt{ACTGC}}, q_{\texttt{ACTGG}}, q_{\texttt{ACTGT}}, q_{\texttt{ACTTA}}, q_{\texttt{ACTTG}}, q_{\texttt{ACTTT}}, q_{\texttt{AGAAA}}, q_{\texttt{AGAAC}}, q_{\texttt{AGAAT}}, q_{\texttt{AGACA}}, q_{\texttt{AGACC}}, q_{\texttt{AGACG}}, q_{\texttt{AGAGC}}, q_{\texttt{AGAGG}}, q_{\texttt{AGAGT}}, q_{\texttt{AGATA}}, q_{\texttt{AGATG}}, q_{\texttt{AGATT}}, q_{\texttt{AGCAA}}, q_{\texttt{AGCAC}}, q_{\texttt{AGCAG}}, q_{\texttt{AGCCA}}, q_{\texttt{AGCCC}}, q_{\texttt{AGCCT}}, q_{\texttt{AGCGA}}, q_{\texttt{AGCGG}}, q_{\texttt{AGCGT}}, q_{\texttt{AGCTC}}, q_{\texttt{AGCTG}}, q_{\texttt{AGCTT}}, q_{\texttt{AGGAC}}, q_{\texttt{AGGAG}}, q_{\texttt{AGGAT}}, q_{\texttt{AGGCA}}, q_{\texttt{AGGCG}}, q_{\texttt{AGGCT}}, q_{\texttt{AGGGA}}, q_{\texttt{AGGGC}}, q_{\texttt{AGGGT}}, q_{\texttt{AGGTA}}, q_{\texttt{AGGTC}}, q_{\texttt{AGGTG}}, q_{\texttt{AGTAA}}, q_{\texttt{AGTAG}}, q_{\texttt{AGTAT}}, q_{\texttt{AGTCC}}, q_{\texttt{AGTCG}}, q_{\texttt{AGTCT}}, q_{\texttt{AGTGA}}, q_{\texttt{AGTGC}}, q_{\texttt{AGTGG}}, q_{\texttt{AGTTA}}, q_{\texttt{AGTTC}}, q_{\texttt{AGTTT}}, q_{\texttt{ATAAA}}, q_{\texttt{ATAAC}}, q_{\texttt{ATAAG}}, q_{\texttt{ATACA}}, q_{\texttt{ATACC}}, q_{\texttt{ATACT}}, q_{\texttt{ATAGA}}, q_{\texttt{ATAGG}}, q_{\texttt{ATAGT}}, q_{\texttt{ATATC}}, q_{\texttt{ATATG}}, q_{\texttt{ATATT}}, q_{\texttt{ATCAA}}, q_{\texttt{ATCAC}}, q_{\texttt{ATCAT}}, q_{\texttt{ATCCA}}, q_{\texttt{ATCCC}}, q_{\texttt{ATCCG}}, q_{\texttt{ATCGC}}, q_{\texttt{ATCGG}}, q_{\texttt{ATCGT}}, q_{\texttt{ATCTA}}, q_{\texttt{ATCTG}}, q_{\texttt{ATCTT}}, q_{\texttt{ATGAA}}, q_{\texttt{ATGAG}}, q_{\texttt{ATGAT}}, q_{\texttt{ATGCC}}, q_{\texttt{ATGCG}}, q_{\texttt{ATGCT}}, q_{\texttt{ATGGA}}, q_{\texttt{ATGGC}}, q_{\texttt{ATGGG}}, q_{\texttt{ATGTA}}, q_{\texttt{ATGTC}}, q_{\texttt{ATGTT}}, q_{\texttt{ATTAC}}, q_{\texttt{ATTAG}}, q_{\texttt{ATTAT}}, q_{\texttt{ATTCA}}, q_{\texttt{ATTCG}}, q_{\texttt{ATTCT}}, q_{\texttt{ATTGA}}, q_{\texttt{ATTGC}}, q_{\texttt{ATTGT}}, q_{\texttt{ATTTA}}, q_{\texttt{ATTTC}}, q_{\texttt{ATTTG}}, q_{\texttt{CAAAA}}, q_{\texttt{CAAAG}}, q_{\texttt{CAAAT}}, q_{\texttt{CAACC}}, q_{\texttt{CAACG}}, q_{\texttt{CAACT}}, q_{\texttt{CAAGA}}, q_{\texttt{CAAGC}}, q_{\texttt{CAAGG}}, q_{\texttt{CAATA}}, q_{\texttt{CAATC}}, q_{\texttt{CAATT}}, q_{\texttt{CACAC}}, q_{\texttt{CACAG}}, q_{\texttt{CACAT}}, q_{\texttt{CACCA}}, q_{\texttt{CACCG}}, q_{\texttt{CACCT}}, q_{\texttt{CACGA}}, q_{\texttt{CACGC}}, q_{\texttt{CACGT}}, q_{\texttt{CACTA}}, q_{\texttt{CACTC}}, q_{\texttt{CACTG}}, q_{\texttt{CAGAA}}, q_{\texttt{CAGAC}}, q_{\texttt{CAGAG}}, q_{\texttt{CAGCA}}, q_{\texttt{CAGCC}}, q_{\texttt{CAGCT}}, q_{\texttt{CAGGA}}, q_{\texttt{CAGGG}}, q_{\texttt{CAGGT}}, q_{\texttt{CAGTC}}, q_{\texttt{CAGTG}}, q_{\texttt{CAGTT}}, q_{\texttt{CATAA}}, q_{\texttt{CATAC}}, q_{\texttt{CATAT}}, q_{\texttt{CATCA}}, q_{\texttt{CATCC}}, q_{\texttt{CATCG}}, q_{\texttt{CATGC}}, q_{\texttt{CATGG}}, q_{\texttt{CATGT}}, q_{\texttt{CATTA}}, q_{\texttt{CATTG}}, q_{\texttt{CATTT}}, q_{\texttt{CCAAC}}, q_{\texttt{CCAAG}}, q_{\texttt{CCAAT}}, q_{\texttt{CCACA}}, q_{\texttt{CCACG}}, q_{\texttt{CCACT}}, q_{\texttt{CCAGA}}, q_{\texttt{CCAGC}}, q_{\texttt{CCAGT}}, q_{\texttt{CCATA}}, q_{\texttt{CCATC}}, q_{\texttt{CCATG}}, q_{\texttt{CCCAA}}, q_{\texttt{CCCAG}}, q_{\texttt{CCCAT}}, q_{\texttt{CCCCC}}, q_{\texttt{CCCCG}}, q_{\texttt{CCCCT}}, q_{\texttt{CCCGA}}, q_{\texttt{CCCGC}}, q_{\texttt{CCCGG}}, q_{\texttt{CCCTA}}, q_{\texttt{CCCTC}}, q_{\texttt{CCCTT}}, q_{\texttt{CCGAA}}, q_{\texttt{CCGAC}}, q_{\texttt{CCGAT}}, q_{\texttt{CCGCA}}, q_{\texttt{CCGCC}}, q_{\texttt{CCGCG}}, q_{\texttt{CCGGC}}, q_{\texttt{CCGGG}}, q_{\texttt{CCGGT}}, q_{\texttt{CCGTA}}, q_{\texttt{CCGTG}}, q_{\texttt{CCGTT}}, q_{\texttt{CCTAA}}, q_{\texttt{CCTAC}}, q_{\texttt{CCTAG}}, q_{\texttt{CCTCA}}, q_{\texttt{CCTCC}}, q_{\texttt{CCTCT}}, q_{\texttt{CCTGA}}, q_{\texttt{CCTGG}}, q_{\texttt{CCTGT}}, q_{\texttt{CCTTC}}, q_{\texttt{CCTTG}}, q_{\texttt{CCTTT}}, q_{\texttt{CGAAA}}, q_{\texttt{CGAAC}}, q_{\texttt{CGAAG}}, q_{\texttt{CGACA}}, q_{\texttt{CGACC}}, q_{\texttt{CGACT}}, q_{\texttt{CGAGA}}, q_{\texttt{CGAGG}}, q_{\texttt{CGAGT}}, q_{\texttt{CGATC}}, q_{\texttt{CGATG}}, q_{\texttt{CGATT}}, q_{\texttt{CGCAA}}, q_{\texttt{CGCAC}}, q_{\texttt{CGCAT}}, q_{\texttt{CGCCA}}, q_{\texttt{CGCCC}}, q_{\texttt{CGCCG}}, q_{\texttt{CGCGC}}, q_{\texttt{CGCGG}}, q_{\texttt{CGCGT}}, q_{\texttt{CGCTA}}, q_{\texttt{CGCTG}}, q_{\texttt{CGCTT}}, q_{\texttt{CGGAA}}, q_{\texttt{CGGAG}}, q_{\texttt{CGGAT}}, q_{\texttt{CGGCC}}, q_{\texttt{CGGCG}}, q_{\texttt{CGGCT}}, q_{\texttt{CGGGA}}, q_{\texttt{CGGGC}}, q_{\texttt{CGGGG}}, q_{\texttt{CGGTA}}, q_{\texttt{CGGTC}}, q_{\texttt{CGGTT}}, q_{\texttt{CGTAC}}, q_{\texttt{CGTAG}}, q_{\texttt{CGTAT}}, q_{\texttt{CGTCA}}, q_{\texttt{CGTCG}}, q_{\texttt{CGTCT}}, q_{\texttt{CGTGA}}, q_{\texttt{CGTGC}}, q_{\texttt{CGTGT}}, q_{\texttt{CGTTA}}, q_{\texttt{CGTTC}}, q_{\texttt{CGTTG}}, q_{\texttt{CTAAA}}, q_{\texttt{CTAAC}}, q_{\texttt{CTAAT}}, q_{\texttt{CTACA}}, q_{\texttt{CTACC}}, q_{\texttt{CTACG}}, q_{\texttt{CTAGC}}, q_{\texttt{CTAGG}}, q_{\texttt{CTAGT}}, q_{\texttt{CTATA}}, q_{\texttt{CTATG}}, q_{\texttt{CTATT}}, q_{\texttt{CTCAA}}, q_{\texttt{CTCAC}}, q_{\texttt{CTCAG}}, q_{\texttt{CTCCA}}, q_{\texttt{CTCCC}}, q_{\texttt{CTCCT}}, q_{\texttt{CTCGA}}, q_{\texttt{CTCGG}}, q_{\texttt{CTCGT}}, q_{\texttt{CTCTC}}, q_{\texttt{CTCTG}}, q_{\texttt{CTCTT}}, q_{\texttt{CTGAC}}, q_{\texttt{CTGAG}}, q_{\texttt{CTGAT}}, q_{\texttt{CTGCA}}, q_{\texttt{CTGCG}}, q_{\texttt{CTGCT}}, q_{\texttt{CTGGA}}, q_{\texttt{CTGGC}}, q_{\texttt{CTGGT}}, q_{\texttt{CTGTA}}, q_{\texttt{CTGTC}}, q_{\texttt{CTGTG}}, q_{\texttt{CTTAA}}, q_{\texttt{CTTAG}}, q_{\texttt{CTTAT}}, q_{\texttt{CTTCC}}, q_{\texttt{CTTCG}}, q_{\texttt{CTTCT}}, q_{\texttt{CTTGA}}, q_{\texttt{CTTGC}}, q_{\texttt{CTTGG}}, q_{\texttt{CTTTA}}, q_{\texttt{CTTTC}}, q_{\texttt{CTTTT}}, q_{\texttt{GAAAA}}, q_{\texttt{GAAAC}}, q_{\texttt{GAAAT}}, q_{\texttt{GAACA}}, q_{\texttt{GAACC}}, q_{\texttt{GAACG}}, q_{\texttt{GAAGC}}, q_{\texttt{GAAGG}}, q_{\texttt{GAAGT}}, q_{\texttt{GAATA}}, q_{\texttt{GAATG}}, q_{\texttt{GAATT}}, q_{\texttt{GACAA}}, q_{\texttt{GACAC}}, q_{\texttt{GACAG}}, q_{\texttt{GACCA}}, q_{\texttt{GACCC}}, q_{\texttt{GACCT}}, q_{\texttt{GACGA}}, q_{\texttt{GACGG}}, q_{\texttt{GACGT}}, q_{\texttt{GACTC}}, q_{\texttt{GACTG}}, q_{\texttt{GACTT}}, q_{\texttt{GAGAC}}, q_{\texttt{GAGAG}}, q_{\texttt{GAGAT}}, q_{\texttt{GAGCA}}, q_{\texttt{GAGCG}}, q_{\texttt{GAGCT}}, q_{\texttt{GAGGA}}, q_{\texttt{GAGGC}}, q_{\texttt{GAGGT}}, q_{\texttt{GAGTA}}, q_{\texttt{GAGTC}}, q_{\texttt{GAGTG}}, q_{\texttt{GATAA}}, q_{\texttt{GATAG}}, q_{\texttt{GATAT}}, q_{\texttt{GATCC}}, q_{\texttt{GATCG}}, q_{\texttt{GATCT}}, q_{\texttt{GATGA}}, q_{\texttt{GATGC}}, q_{\texttt{GATGG}}, q_{\texttt{GATTA}}, q_{\texttt{GATTC}}, q_{\texttt{GATTT}}, q_{\texttt{GCAAA}}, q_{\texttt{GCAAC}}, q_{\texttt{GCAAG}}, q_{\texttt{GCACA}}, q_{\texttt{GCACC}}, q_{\texttt{GCACT}}, q_{\texttt{GCAGA}}, q_{\texttt{GCAGG}}, q_{\texttt{GCAGT}}, q_{\texttt{GCATC}}, q_{\texttt{GCATG}}, q_{\texttt{GCATT}}, q_{\texttt{GCCAA}}, q_{\texttt{GCCAC}}, q_{\texttt{GCCAT}}, q_{\texttt{GCCCA}}, q_{\texttt{GCCCC}}, q_{\texttt{GCCCG}}, q_{\texttt{GCCGC}}, q_{\texttt{GCCGG}}, q_{\texttt{GCCGT}}, q_{\texttt{GCCTA}}, q_{\texttt{GCCTG}}, q_{\texttt{GCCTT}}, q_{\texttt{GCGAA}}, q_{\texttt{GCGAG}}, q_{\texttt{GCGAT}}, q_{\texttt{GCGCC}}, q_{\texttt{GCGCG}}, q_{\texttt{GCGCT}}, q_{\texttt{GCGGA}}, q_{\texttt{GCGGC}}, q_{\texttt{GCGGG}}, q_{\texttt{GCGTA}}, q_{\texttt{GCGTC}}, q_{\texttt{GCGTT}}, q_{\texttt{GCTAC}}, q_{\texttt{GCTAG}}, q_{\texttt{GCTAT}}, q_{\texttt{GCTCA}}, q_{\texttt{GCTCG}}, q_{\texttt{GCTCT}}, q_{\texttt{GCTGA}}, q_{\texttt{GCTGC}}, q_{\texttt{GCTGT}}, q_{\texttt{GCTTA}}, q_{\texttt{GCTTC}}, q_{\texttt{GCTTG}}, q_{\texttt{GGAAC}}, q_{\texttt{GGAAG}}, q_{\texttt{GGAAT}}, q_{\texttt{GGACA}}, q_{\texttt{GGACG}}, q_{\texttt{GGACT}}, q_{\texttt{GGAGA}}, q_{\texttt{GGAGC}}, q_{\texttt{GGAGT}}, q_{\texttt{GGATA}}, q_{\texttt{GGATC}}, q_{\texttt{GGATG}}, q_{\texttt{GGCAA}}, q_{\texttt{GGCAG}}, q_{\texttt{GGCAT}}, q_{\texttt{GGCCC}}, q_{\texttt{GGCCG}}, q_{\texttt{GGCCT}}, q_{\texttt{GGCGA}}, q_{\texttt{GGCGC}}, q_{\texttt{GGCGG}}, q_{\texttt{GGCTA}}, q_{\texttt{GGCTC}}, q_{\texttt{GGCTT}}, q_{\texttt{GGGAA}}, q_{\texttt{GGGAC}}, q_{\texttt{GGGAT}}, q_{\texttt{GGGCA}}, q_{\texttt{GGGCC}}, q_{\texttt{GGGCG}}, q_{\texttt{GGGGC}}, q_{\texttt{GGGGG}}, q_{\texttt{GGGGT}}, q_{\texttt{GGGTA}}, q_{\texttt{GGGTG}}, q_{\texttt{GGGTT}}, q_{\texttt{GGTAA}}, q_{\texttt{GGTAC}}, q_{\texttt{GGTAG}}, q_{\texttt{GGTCA}}, q_{\texttt{GGTCC}}, q_{\texttt{GGTCT}}, q_{\texttt{GGTGA}}, q_{\texttt{GGTGG}}, q_{\texttt{GGTGT}}, q_{\texttt{GGTTC}}, q_{\texttt{GGTTG}}, q_{\texttt{GGTTT}}, q_{\texttt{GTAAA}}, q_{\texttt{GTAAG}}, q_{\texttt{GTAAT}}, q_{\texttt{GTACC}}, q_{\texttt{GTACG}}, q_{\texttt{GTACT}}, q_{\texttt{GTAGA}}, q_{\texttt{GTAGC}}, q_{\texttt{GTAGG}}, q_{\texttt{GTATA}}, q_{\texttt{GTATC}}, q_{\texttt{GTATT}}, q_{\texttt{GTCAC}}, q_{\texttt{GTCAG}}, q_{\texttt{GTCAT}}, q_{\texttt{GTCCA}}, q_{\texttt{GTCCG}}, q_{\texttt{GTCCT}}, q_{\texttt{GTCGA}}, q_{\texttt{GTCGC}}, q_{\texttt{GTCGT}}, q_{\texttt{GTCTA}}, q_{\texttt{GTCTC}}, q_{\texttt{GTCTG}}, q_{\texttt{GTGAA}}, q_{\texttt{GTGAC}}, q_{\texttt{GTGAG}}, q_{\texttt{GTGCA}}, q_{\texttt{GTGCC}}, q_{\texttt{GTGCT}}, q_{\texttt{GTGGA}}, q_{\texttt{GTGGG}}, q_{\texttt{GTGGT}}, q_{\texttt{GTGTC}}, q_{\texttt{GTGTG}}, q_{\texttt{GTGTT}}, q_{\texttt{GTTAA}}, q_{\texttt{GTTAC}}, q_{\texttt{GTTAT}}, q_{\texttt{GTTCA}}, q_{\texttt{GTTCC}}, q_{\texttt{GTTCG}}, q_{\texttt{GTTGC}}, q_{\texttt{GTTGG}}, q_{\texttt{GTTGT}}, q_{\texttt{GTTTA}}, q_{\texttt{GTTTG}}, q_{\texttt{GTTTT}}, q_{\texttt{TAAAA}}, q_{\texttt{TAAAC}}, q_{\texttt{TAAAG}}, q_{\texttt{TAACA}}, q_{\texttt{TAACC}}, q_{\texttt{TAACT}}, q_{\texttt{TAAGA}}, q_{\texttt{TAAGG}}, q_{\texttt{TAAGT}}, q_{\texttt{TAATC}}, q_{\texttt{TAATG}}, q_{\texttt{TAATT}}, q_{\texttt{TACAA}}, q_{\texttt{TACAC}}, q_{\texttt{TACAT}}, q_{\texttt{TACCA}}, q_{\texttt{TACCC}}, q_{\texttt{TACCG}}, q_{\texttt{TACGC}}, q_{\texttt{TACGG}}, q_{\texttt{TACGT}}, q_{\texttt{TACTA}}, q_{\texttt{TACTG}}, q_{\texttt{TACTT}}, q_{\texttt{TAGAA}}, q_{\texttt{TAGAG}}, q_{\texttt{TAGAT}}, q_{\texttt{TAGCC}}, q_{\texttt{TAGCG}}, q_{\texttt{TAGCT}}, q_{\texttt{TAGGA}}, q_{\texttt{TAGGC}}, q_{\texttt{TAGGG}}, q_{\texttt{TAGTA}}, q_{\texttt{TAGTC}}, q_{\texttt{TAGTT}}, q_{\texttt{TATAC}}, q_{\texttt{TATAG}}, q_{\texttt{TATAT}}, q_{\texttt{TATCA}}, q_{\texttt{TATCG}}, q_{\texttt{TATCT}}, q_{\texttt{TATGA}}, q_{\texttt{TATGC}}, q_{\texttt{TATGT}}, q_{\texttt{TATTA}}, q_{\texttt{TATTC}}, q_{\texttt{TATTG}}, q_{\texttt{TCAAA}}, q_{\texttt{TCAAC}}, q_{\texttt{TCAAT}}, q_{\texttt{TCACA}}, q_{\texttt{TCACC}}, q_{\texttt{TCACG}}, q_{\texttt{TCAGC}}, q_{\texttt{TCAGG}}, q_{\texttt{TCAGT}}, q_{\texttt{TCATA}}, q_{\texttt{TCATG}}, q_{\texttt{TCATT}}, q_{\texttt{TCCAA}}, q_{\texttt{TCCAC}}, q_{\texttt{TCCAG}}, q_{\texttt{TCCCA}}, q_{\texttt{TCCCC}}, q_{\texttt{TCCCT}}, q_{\texttt{TCCGA}}, q_{\texttt{TCCGG}}, q_{\texttt{TCCGT}}, q_{\texttt{TCCTC}}, q_{\texttt{TCCTG}}, q_{\texttt{TCCTT}}, q_{\texttt{TCGAC}}, q_{\texttt{TCGAG}}, q_{\texttt{TCGAT}}, q_{\texttt{TCGCA}}, q_{\texttt{TCGCG}}, q_{\texttt{TCGCT}}, q_{\texttt{TCGGA}}, q_{\texttt{TCGGC}}, q_{\texttt{TCGGT}}, q_{\texttt{TCGTA}}, q_{\texttt{TCGTC}}, q_{\texttt{TCGTG}}, q_{\texttt{TCTAA}}, q_{\texttt{TCTAG}}, q_{\texttt{TCTAT}}, q_{\texttt{TCTCC}}, q_{\texttt{TCTCG}}, q_{\texttt{TCTCT}}, q_{\texttt{TCTGA}}, q_{\texttt{TCTGC}}, q_{\texttt{TCTGG}}, q_{\texttt{TCTTA}}, q_{\texttt{TCTTC}}, q_{\texttt{TCTTT}}, q_{\texttt{TGAAA}}, q_{\texttt{TGAAG}}, q_{\texttt{TGAAT}}, q_{\texttt{TGACC}}, q_{\texttt{TGACG}}, q_{\texttt{TGACT}}, q_{\texttt{TGAGA}}, q_{\texttt{TGAGC}}, q_{\texttt{TGAGG}}, q_{\texttt{TGATA}}, q_{\texttt{TGATC}}, q_{\texttt{TGATT}}, q_{\texttt{TGCAC}}, q_{\texttt{TGCAG}}, q_{\texttt{TGCAT}}, q_{\texttt{TGCCA}}, q_{\texttt{TGCCG}}, q_{\texttt{TGCCT}}, q_{\texttt{TGCGA}}, q_{\texttt{TGCGC}}, q_{\texttt{TGCGT}}, q_{\texttt{TGCTA}}, q_{\texttt{TGCTC}}, q_{\texttt{TGCTG}}, q_{\texttt{TGGAA}}, q_{\texttt{TGGAC}}, q_{\texttt{TGGAG}}, q_{\texttt{TGGCA}}, q_{\texttt{TGGCC}}, q_{\texttt{TGGCT}}, q_{\texttt{TGGGA}}, q_{\texttt{TGGGG}}, q_{\texttt{TGGGT}}, q_{\texttt{TGGTC}}, q_{\texttt{TGGTG}}, q_{\texttt{TGGTT}}, q_{\texttt{TGTAA}}, q_{\texttt{TGTAC}}, q_{\texttt{TGTAT}}, q_{\texttt{TGTCA}}, q_{\texttt{TGTCC}}, q_{\texttt{TGTCG}}, q_{\texttt{TGTGC}}, q_{\texttt{TGTGG}}, q_{\texttt{TGTGT}}, q_{\texttt{TGTTA}}, q_{\texttt{TGTTG}}, q_{\texttt{TGTTT}}, q_{\texttt{TTAAC}}, q_{\texttt{TTAAG}}, q_{\texttt{TTAAT}}, q_{\texttt{TTACA}}, q_{\texttt{TTACG}}, q_{\texttt{TTACT}}, q_{\texttt{TTAGA}}, q_{\texttt{TTAGC}}, q_{\texttt{TTAGT}}, q_{\texttt{TTATA}}, q_{\texttt{TTATC}}, q_{\texttt{TTATG}}, q_{\texttt{TTCAA}}, q_{\texttt{TTCAG}}, q_{\texttt{TTCAT}}, q_{\texttt{TTCCC}}, q_{\texttt{TTCCG}}, q_{\texttt{TTCCT}}, q_{\texttt{TTCGA}}, q_{\texttt{TTCGC}}, q_{\texttt{TTCGG}}, q_{\texttt{TTCTA}}, q_{\texttt{TTCTC}}, q_{\texttt{TTCTT}}, q_{\texttt{TTGAA}}, q_{\texttt{TTGAC}}, q_{\texttt{TTGAT}}, q_{\texttt{TTGCA}}, q_{\texttt{TTGCC}}, q_{\texttt{TTGCG}}, q_{\texttt{TTGGC}}, q_{\texttt{TTGGG}}, q_{\texttt{TTGGT}}, q_{\texttt{TTGTA}}, q_{\texttt{TTGTG}}, q_{\texttt{TTGTT}}, q_{\texttt{TTTAA}}, q_{\texttt{TTTAC}}, q_{\texttt{TTTAG}}, q_{\texttt{TTTCA}}, q_{\texttt{TTTCC}}, q_{\texttt{TTTCT}}, q_{\texttt{TTTGA}}, q_{\texttt{TTTGG}}, q_{\texttt{TTTGT}}, q_{\texttt{TTTTC}}, q_{\texttt{TTTTG}}, q_{\texttt{TTTTT}} \\[0.5em]
\text{Class } &q_{\texttt{AAAAA}}:\ q_{\texttt{AAAAA}} \\[0.5em]
\text{Class } &q_{\texttt{AAACC}}:\ q_{\texttt{AAACC}} \\[0.5em]
\text{Class } &q_{\texttt{AAAGG}}:\ q_{\texttt{AAAGG}} \\[0.5em]
\text{Class } &q_{\texttt{AAATT}}:\ q_{\texttt{AAATT}} \\[0.5em]
\text{Class } &q_{\texttt{AACAC}}:\ q_{\texttt{AACAC}} \\[0.5em]
\text{Class } &q_{\texttt{AACCA}}:\ q_{\texttt{AACCA}} \\[0.5em]
\text{Class } &q_{\texttt{AACGT}}:\ q_{\texttt{AACGT}} \\[0.5em]
\text{Class } &q_{\texttt{AACTG}}:\ q_{\texttt{AACTG}} \\[0.5em]
\text{Class } &q_{\texttt{AAGAG}}:\ q_{\texttt{AAGAG}} \\[0.5em]
\text{Class } &q_{\texttt{AAGCT}}:\ q_{\texttt{AAGCT}} \\[0.5em]
\text{Class } &q_{\texttt{AAGGA}}:\ q_{\texttt{AAGGA}} \\[0.5em]
\text{Class } &q_{\texttt{AAGTC}}:\ q_{\texttt{AAGTC}} \\[0.5em]
\text{Class } &q_{\texttt{AATAT}}:\ q_{\texttt{AATAT}} \\[0.5em]
\text{Class } &q_{\texttt{AATCG}}:\ q_{\texttt{AATCG}} \\[0.5em]
\text{Class } &q_{\texttt{AATGC}}:\ q_{\texttt{AATGC}} \\[0.5em]
\text{Class } &q_{\texttt{AATTA}}:\ q_{\texttt{AATTA}} \\[0.5em]
\text{Class } &q_{\texttt{ACAAC}}:\ q_{\texttt{ACAAC}} \\[0.5em]
\text{Class } &q_{\texttt{ACACA}}:\ q_{\texttt{ACACA}} \\[0.5em]
\text{Class } &q_{\texttt{ACAGT}}:\ q_{\texttt{ACAGT}} \\[0.5em]
\text{Class } &q_{\texttt{ACATG}}:\ q_{\texttt{ACATG}} \\[0.5em]
\text{Class } &q_{\texttt{ACCAA}}:\ q_{\texttt{ACCAA}} \\[0.5em]
\text{Class } &q_{\texttt{ACCCC}}:\ q_{\texttt{ACCCC}} \\[0.5em]
\text{Class } &q_{\texttt{ACCGG}}:\ q_{\texttt{ACCGG}} \\[0.5em]
\text{Class } &q_{\texttt{ACCTT}}:\ q_{\texttt{ACCTT}} \\[0.5em]
\text{Class } &q_{\texttt{ACGAT}}:\ q_{\texttt{ACGAT}} \\[0.5em]
\text{Class } &q_{\texttt{ACGCG}}:\ q_{\texttt{ACGCG}} \\[0.5em]
\text{Class } &q_{\texttt{ACGGC}}:\ q_{\texttt{ACGGC}} \\[0.5em]
\text{Class } &q_{\texttt{ACGTA}}:\ q_{\texttt{ACGTA}} \\[0.5em]
\text{Class } &q_{\texttt{ACTAG}}:\ q_{\texttt{ACTAG}} \\[0.5em]
\text{Class } &q_{\texttt{ACTCT}}:\ q_{\texttt{ACTCT}} \\[0.5em]
\text{Class } &q_{\texttt{ACTGA}}:\ q_{\texttt{ACTGA}} \\[0.5em]
\text{Class } &q_{\texttt{ACTTC}}:\ q_{\texttt{ACTTC}} \\[0.5em]
\text{Class } &q_{\texttt{AGAAG}}:\ q_{\texttt{AGAAG}} \\[0.5em]
\text{Class } &q_{\texttt{AGACT}}:\ q_{\texttt{AGACT}} \\[0.5em]
\text{Class } &q_{\texttt{AGAGA}}:\ q_{\texttt{AGAGA}} \\[0.5em]
\text{Class } &q_{\texttt{AGATC}}:\ q_{\texttt{AGATC}} \\[0.5em]
\text{Class } &q_{\texttt{AGCAT}}:\ q_{\texttt{AGCAT}} \\[0.5em]
\text{Class } &q_{\texttt{AGCCG}}:\ q_{\texttt{AGCCG}} \\[0.5em]
\text{Class } &q_{\texttt{AGCGC}}:\ q_{\texttt{AGCGC}} \\[0.5em]
\text{Class } &q_{\texttt{AGCTA}}:\ q_{\texttt{AGCTA}} \\[0.5em]
\text{Class } &q_{\texttt{AGGAA}}:\ q_{\texttt{AGGAA}} \\[0.5em]
\text{Class } &q_{\texttt{AGGCC}}:\ q_{\texttt{AGGCC}} \\[0.5em]
\text{Class } &q_{\texttt{AGGGG}}:\ q_{\texttt{AGGGG}} \\[0.5em]
\text{Class } &q_{\texttt{AGGTT}}:\ q_{\texttt{AGGTT}} \\[0.5em]
\text{Class } &q_{\texttt{AGTAC}}:\ q_{\texttt{AGTAC}} \\[0.5em]
\text{Class } &q_{\texttt{AGTCA}}:\ q_{\texttt{AGTCA}} \\[0.5em]
\text{Class } &q_{\texttt{AGTGT}}:\ q_{\texttt{AGTGT}} \\[0.5em]
\text{Class } &q_{\texttt{AGTTG}}:\ q_{\texttt{AGTTG}} \\[0.5em]
\text{Class } &q_{\texttt{ATAAT}}:\ q_{\texttt{ATAAT}} \\[0.5em]
\text{Class } &q_{\texttt{ATACG}}:\ q_{\texttt{ATACG}} \\[0.5em]
\text{Class } &q_{\texttt{ATAGC}}:\ q_{\texttt{ATAGC}} \\[0.5em]
\text{Class } &q_{\texttt{ATATA}}:\ q_{\texttt{ATATA}} \\[0.5em]
\text{Class } &q_{\texttt{ATCAG}}:\ q_{\texttt{ATCAG}} \\[0.5em]
\text{Class } &q_{\texttt{ATCCT}}:\ q_{\texttt{ATCCT}} \\[0.5em]
\text{Class } &q_{\texttt{ATCGA}}:\ q_{\texttt{ATCGA}} \\[0.5em]
\text{Class } &q_{\texttt{ATCTC}}:\ q_{\texttt{ATCTC}} \\[0.5em]
\text{Class } &q_{\texttt{ATGAC}}:\ q_{\texttt{ATGAC}} \\[0.5em]
\text{Class } &q_{\texttt{ATGCA}}:\ q_{\texttt{ATGCA}} \\[0.5em]
\text{Class } &q_{\texttt{ATGGT}}:\ q_{\texttt{ATGGT}} \\[0.5em]
\text{Class } &q_{\texttt{ATGTG}}:\ q_{\texttt{ATGTG}} \\[0.5em]
\text{Class } &q_{\texttt{ATTAA}}:\ q_{\texttt{ATTAA}} \\[0.5em]
\text{Class } &q_{\texttt{ATTCC}}:\ q_{\texttt{ATTCC}} \\[0.5em]
\text{Class } &q_{\texttt{ATTGG}}:\ q_{\texttt{ATTGG}} \\[0.5em]
\text{Class } &q_{\texttt{ATTTT}}:\ q_{\texttt{ATTTT}} \\[0.5em]
\text{Class } &q_{\texttt{CAAAC}}:\ q_{\texttt{CAAAC}} \\[0.5em]
\text{Class } &q_{\texttt{CAACA}}:\ q_{\texttt{CAACA}} \\[0.5em]
\text{Class } &q_{\texttt{CAAGT}}:\ q_{\texttt{CAAGT}} \\[0.5em]
\text{Class } &q_{\texttt{CAATG}}:\ q_{\texttt{CAATG}} \\[0.5em]
\text{Class } &q_{\texttt{CACAA}}:\ q_{\texttt{CACAA}} \\[0.5em]
\text{Class } &q_{\texttt{CACCC}}:\ q_{\texttt{CACCC}} \\[0.5em]
\text{Class } &q_{\texttt{CACGG}}:\ q_{\texttt{CACGG}} \\[0.5em]
\text{Class } &q_{\texttt{CACTT}}:\ q_{\texttt{CACTT}} \\[0.5em]
\text{Class } &q_{\texttt{CAGAT}}:\ q_{\texttt{CAGAT}} \\[0.5em]
\text{Class } &q_{\texttt{CAGCG}}:\ q_{\texttt{CAGCG}} \\[0.5em]
\text{Class } &q_{\texttt{CAGGC}}:\ q_{\texttt{CAGGC}} \\[0.5em]
\text{Class } &q_{\texttt{CAGTA}}:\ q_{\texttt{CAGTA}} \\[0.5em]
\text{Class } &q_{\texttt{CATAG}}:\ q_{\texttt{CATAG}} \\[0.5em]
\text{Class } &q_{\texttt{CATCT}}:\ q_{\texttt{CATCT}} \\[0.5em]
\text{Class } &q_{\texttt{CATGA}}:\ q_{\texttt{CATGA}} \\[0.5em]
\text{Class } &q_{\texttt{CATTC}}:\ q_{\texttt{CATTC}} \\[0.5em]
\text{Class } &q_{\texttt{CCAAA}}:\ q_{\texttt{CCAAA}} \\[0.5em]
\text{Class } &q_{\texttt{CCACC}}:\ q_{\texttt{CCACC}} \\[0.5em]
\text{Class } &q_{\texttt{CCAGG}}:\ q_{\texttt{CCAGG}} \\[0.5em]
\text{Class } &q_{\texttt{CCATT}}:\ q_{\texttt{CCATT}} \\[0.5em]
\text{Class } &q_{\texttt{CCCAC}}:\ q_{\texttt{CCCAC}} \\[0.5em]
\text{Class } &q_{\texttt{CCCCA}}:\ q_{\texttt{CCCCA}} \\[0.5em]
\text{Class } &q_{\texttt{CCCGT}}:\ q_{\texttt{CCCGT}} \\[0.5em]
\text{Class } &q_{\texttt{CCCTG}}:\ q_{\texttt{CCCTG}} \\[0.5em]
\text{Class } &q_{\texttt{CCGAG}}:\ q_{\texttt{CCGAG}} \\[0.5em]
\text{Class } &q_{\texttt{CCGCT}}:\ q_{\texttt{CCGCT}} \\[0.5em]
\text{Class } &q_{\texttt{CCGGA}}:\ q_{\texttt{CCGGA}} \\[0.5em]
\text{Class } &q_{\texttt{CCGTC}}:\ q_{\texttt{CCGTC}} \\[0.5em]
\text{Class } &q_{\texttt{CCTAT}}:\ q_{\texttt{CCTAT}} \\[0.5em]
\text{Class } &q_{\texttt{CCTCG}}:\ q_{\texttt{CCTCG}} \\[0.5em]
\text{Class } &q_{\texttt{CCTGC}}:\ q_{\texttt{CCTGC}} \\[0.5em]
\text{Class } &q_{\texttt{CCTTA}}:\ q_{\texttt{CCTTA}} \\[0.5em]
\text{Class } &q_{\texttt{CGAAT}}:\ q_{\texttt{CGAAT}} \\[0.5em]
\text{Class } &q_{\texttt{CGACG}}:\ q_{\texttt{CGACG}} \\[0.5em]
\text{Class } &q_{\texttt{CGAGC}}:\ q_{\texttt{CGAGC}} \\[0.5em]
\text{Class } &q_{\texttt{CGATA}}:\ q_{\texttt{CGATA}} \\[0.5em]
\text{Class } &q_{\texttt{CGCAG}}:\ q_{\texttt{CGCAG}} \\[0.5em]
\text{Class } &q_{\texttt{CGCCT}}:\ q_{\texttt{CGCCT}} \\[0.5em]
\text{Class } &q_{\texttt{CGCGA}}:\ q_{\texttt{CGCGA}} \\[0.5em]
\text{Class } &q_{\texttt{CGCTC}}:\ q_{\texttt{CGCTC}} \\[0.5em]
\text{Class } &q_{\texttt{CGGAC}}:\ q_{\texttt{CGGAC}} \\[0.5em]
\text{Class } &q_{\texttt{CGGCA}}:\ q_{\texttt{CGGCA}} \\[0.5em]
\text{Class } &q_{\texttt{CGGGT}}:\ q_{\texttt{CGGGT}} \\[0.5em]
\text{Class } &q_{\texttt{CGGTG}}:\ q_{\texttt{CGGTG}} \\[0.5em]
\text{Class } &q_{\texttt{CGTAA}}:\ q_{\texttt{CGTAA}} \\[0.5em]
\text{Class } &q_{\texttt{CGTCC}}:\ q_{\texttt{CGTCC}} \\[0.5em]
\text{Class } &q_{\texttt{CGTGG}}:\ q_{\texttt{CGTGG}} \\[0.5em]
\text{Class } &q_{\texttt{CGTTT}}:\ q_{\texttt{CGTTT}} \\[0.5em]
\text{Class } &q_{\texttt{CTAAG}}:\ q_{\texttt{CTAAG}} \\[0.5em]
\text{Class } &q_{\texttt{CTACT}}:\ q_{\texttt{CTACT}} \\[0.5em]
\text{Class } &q_{\texttt{CTAGA}}:\ q_{\texttt{CTAGA}} \\[0.5em]
\text{Class } &q_{\texttt{CTATC}}:\ q_{\texttt{CTATC}} \\[0.5em]
\text{Class } &q_{\texttt{CTCAT}}:\ q_{\texttt{CTCAT}} \\[0.5em]
\text{Class } &q_{\texttt{CTCCG}}:\ q_{\texttt{CTCCG}} \\[0.5em]
\text{Class } &q_{\texttt{CTCGC}}:\ q_{\texttt{CTCGC}} \\[0.5em]
\text{Class } &q_{\texttt{CTCTA}}:\ q_{\texttt{CTCTA}} \\[0.5em]
\text{Class } &q_{\texttt{CTGAA}}:\ q_{\texttt{CTGAA}} \\[0.5em]
\text{Class } &q_{\texttt{CTGCC}}:\ q_{\texttt{CTGCC}} \\[0.5em]
\text{Class } &q_{\texttt{CTGGG}}:\ q_{\texttt{CTGGG}} \\[0.5em]
\text{Class } &q_{\texttt{CTGTT}}:\ q_{\texttt{CTGTT}} \\[0.5em]
\text{Class } &q_{\texttt{CTTAC}}:\ q_{\texttt{CTTAC}} \\[0.5em]
\text{Class } &q_{\texttt{CTTCA}}:\ q_{\texttt{CTTCA}} \\[0.5em]
\text{Class } &q_{\texttt{CTTGT}}:\ q_{\texttt{CTTGT}} \\[0.5em]
\text{Class } &q_{\texttt{CTTTG}}:\ q_{\texttt{CTTTG}} \\[0.5em]
\text{Class } &q_{\texttt{GAAAG}}:\ q_{\texttt{GAAAG}} \\[0.5em]
\text{Class } &q_{\texttt{GAACT}}:\ q_{\texttt{GAACT}} \\[0.5em]
\text{Class } &q_{\texttt{GAAGA}}:\ q_{\texttt{GAAGA}} \\[0.5em]
\text{Class } &q_{\texttt{GAATC}}:\ q_{\texttt{GAATC}} \\[0.5em]
\text{Class } &q_{\texttt{GACAT}}:\ q_{\texttt{GACAT}} \\[0.5em]
\text{Class } &q_{\texttt{GACCG}}:\ q_{\texttt{GACCG}} \\[0.5em]
\text{Class } &q_{\texttt{GACGC}}:\ q_{\texttt{GACGC}} \\[0.5em]
\text{Class } &q_{\texttt{GACTA}}:\ q_{\texttt{GACTA}} \\[0.5em]
\text{Class } &q_{\texttt{GAGAA}}:\ q_{\texttt{GAGAA}} \\[0.5em]
\text{Class } &q_{\texttt{GAGCC}}:\ q_{\texttt{GAGCC}} \\[0.5em]
\text{Class } &q_{\texttt{GAGGG}}:\ q_{\texttt{GAGGG}} \\[0.5em]
\text{Class } &q_{\texttt{GAGTT}}:\ q_{\texttt{GAGTT}} \\[0.5em]
\text{Class } &q_{\texttt{GATAC}}:\ q_{\texttt{GATAC}} \\[0.5em]
\text{Class } &q_{\texttt{GATCA}}:\ q_{\texttt{GATCA}} \\[0.5em]
\text{Class } &q_{\texttt{GATGT}}:\ q_{\texttt{GATGT}} \\[0.5em]
\text{Class } &q_{\texttt{GATTG}}:\ q_{\texttt{GATTG}} \\[0.5em]
\text{Class } &q_{\texttt{GCAAT}}:\ q_{\texttt{GCAAT}} \\[0.5em]
\text{Class } &q_{\texttt{GCACG}}:\ q_{\texttt{GCACG}} \\[0.5em]
\text{Class } &q_{\texttt{GCAGC}}:\ q_{\texttt{GCAGC}} \\[0.5em]
\text{Class } &q_{\texttt{GCATA}}:\ q_{\texttt{GCATA}} \\[0.5em]
\text{Class } &q_{\texttt{GCCAG}}:\ q_{\texttt{GCCAG}} \\[0.5em]
\text{Class } &q_{\texttt{GCCCT}}:\ q_{\texttt{GCCCT}} \\[0.5em]
\text{Class } &q_{\texttt{GCCGA}}:\ q_{\texttt{GCCGA}} \\[0.5em]
\text{Class } &q_{\texttt{GCCTC}}:\ q_{\texttt{GCCTC}} \\[0.5em]
\text{Class } &q_{\texttt{GCGAC}}:\ q_{\texttt{GCGAC}} \\[0.5em]
\text{Class } &q_{\texttt{GCGCA}}:\ q_{\texttt{GCGCA}} \\[0.5em]
\text{Class } &q_{\texttt{GCGGT}}:\ q_{\texttt{GCGGT}} \\[0.5em]
\text{Class } &q_{\texttt{GCGTG}}:\ q_{\texttt{GCGTG}} \\[0.5em]
\text{Class } &q_{\texttt{GCTAA}}:\ q_{\texttt{GCTAA}} \\[0.5em]
\text{Class } &q_{\texttt{GCTCC}}:\ q_{\texttt{GCTCC}} \\[0.5em]
\text{Class } &q_{\texttt{GCTGG}}:\ q_{\texttt{GCTGG}} \\[0.5em]
\text{Class } &q_{\texttt{GCTTT}}:\ q_{\texttt{GCTTT}} \\[0.5em]
\text{Class } &q_{\texttt{GGAAA}}:\ q_{\texttt{GGAAA}} \\[0.5em]
\text{Class } &q_{\texttt{GGACC}}:\ q_{\texttt{GGACC}} \\[0.5em]
\text{Class } &q_{\texttt{GGAGG}}:\ q_{\texttt{GGAGG}} \\[0.5em]
\text{Class } &q_{\texttt{GGATT}}:\ q_{\texttt{GGATT}} \\[0.5em]
\text{Class } &q_{\texttt{GGCAC}}:\ q_{\texttt{GGCAC}} \\[0.5em]
\text{Class } &q_{\texttt{GGCCA}}:\ q_{\texttt{GGCCA}} \\[0.5em]
\text{Class } &q_{\texttt{GGCGT}}:\ q_{\texttt{GGCGT}} \\[0.5em]
\text{Class } &q_{\texttt{GGCTG}}:\ q_{\texttt{GGCTG}} \\[0.5em]
\text{Class } &q_{\texttt{GGGAG}}:\ q_{\texttt{GGGAG}} \\[0.5em]
\text{Class } &q_{\texttt{GGGCT}}:\ q_{\texttt{GGGCT}} \\[0.5em]
\text{Class } &q_{\texttt{GGGGA}}:\ q_{\texttt{GGGGA}} \\[0.5em]
\text{Class } &q_{\texttt{GGGTC}}:\ q_{\texttt{GGGTC}} \\[0.5em]
\text{Class } &q_{\texttt{GGTAT}}:\ q_{\texttt{GGTAT}} \\[0.5em]
\text{Class } &q_{\texttt{GGTCG}}:\ q_{\texttt{GGTCG}} \\[0.5em]
\text{Class } &q_{\texttt{GGTGC}}:\ q_{\texttt{GGTGC}} \\[0.5em]
\text{Class } &q_{\texttt{GGTTA}}:\ q_{\texttt{GGTTA}} \\[0.5em]
\text{Class } &q_{\texttt{GTAAC}}:\ q_{\texttt{GTAAC}} \\[0.5em]
\text{Class } &q_{\texttt{GTACA}}:\ q_{\texttt{GTACA}} \\[0.5em]
\text{Class } &q_{\texttt{GTAGT}}:\ q_{\texttt{GTAGT}} \\[0.5em]
\text{Class } &q_{\texttt{GTATG}}:\ q_{\texttt{GTATG}} \\[0.5em]
\text{Class } &q_{\texttt{GTCAA}}:\ q_{\texttt{GTCAA}} \\[0.5em]
\text{Class } &q_{\texttt{GTCCC}}:\ q_{\texttt{GTCCC}} \\[0.5em]
\text{Class } &q_{\texttt{GTCGG}}:\ q_{\texttt{GTCGG}} \\[0.5em]
\text{Class } &q_{\texttt{GTCTT}}:\ q_{\texttt{GTCTT}} \\[0.5em]
\text{Class } &q_{\texttt{GTGAT}}:\ q_{\texttt{GTGAT}} \\[0.5em]
\text{Class } &q_{\texttt{GTGCG}}:\ q_{\texttt{GTGCG}} \\[0.5em]
\text{Class } &q_{\texttt{GTGGC}}:\ q_{\texttt{GTGGC}} \\[0.5em]
\text{Class } &q_{\texttt{GTGTA}}:\ q_{\texttt{GTGTA}} \\[0.5em]
\text{Class } &q_{\texttt{GTTAG}}:\ q_{\texttt{GTTAG}} \\[0.5em]
\text{Class } &q_{\texttt{GTTCT}}:\ q_{\texttt{GTTCT}} \\[0.5em]
\text{Class } &q_{\texttt{GTTGA}}:\ q_{\texttt{GTTGA}} \\[0.5em]
\text{Class } &q_{\texttt{GTTTC}}:\ q_{\texttt{GTTTC}} \\[0.5em]
\text{Class } &q_{\texttt{TAAAT}}:\ q_{\texttt{TAAAT}} \\[0.5em]
\text{Class } &q_{\texttt{TAACG}}:\ q_{\texttt{TAACG}} \\[0.5em]
\text{Class } &q_{\texttt{TAAGC}}:\ q_{\texttt{TAAGC}} \\[0.5em]
\text{Class } &q_{\texttt{TAATA}}:\ q_{\texttt{TAATA}} \\[0.5em]
\text{Class } &q_{\texttt{TACAG}}:\ q_{\texttt{TACAG}} \\[0.5em]
\text{Class } &q_{\texttt{TACCT}}:\ q_{\texttt{TACCT}} \\[0.5em]
\text{Class } &q_{\texttt{TACGA}}:\ q_{\texttt{TACGA}} \\[0.5em]
\text{Class } &q_{\texttt{TACTC}}:\ q_{\texttt{TACTC}} \\[0.5em]
\text{Class } &q_{\texttt{TAGAC}}:\ q_{\texttt{TAGAC}} \\[0.5em]
\text{Class } &q_{\texttt{TAGCA}}:\ q_{\texttt{TAGCA}} \\[0.5em]
\text{Class } &q_{\texttt{TAGGT}}:\ q_{\texttt{TAGGT}} \\[0.5em]
\text{Class } &q_{\texttt{TAGTG}}:\ q_{\texttt{TAGTG}} \\[0.5em]
\text{Class } &q_{\texttt{TATAA}}:\ q_{\texttt{TATAA}} \\[0.5em]
\text{Class } &q_{\texttt{TATCC}}:\ q_{\texttt{TATCC}} \\[0.5em]
\text{Class } &q_{\texttt{TATGG}}:\ q_{\texttt{TATGG}} \\[0.5em]
\text{Class } &q_{\texttt{TATTT}}:\ q_{\texttt{TATTT}} \\[0.5em]
\text{Class } &q_{\texttt{TCAAG}}:\ q_{\texttt{TCAAG}} \\[0.5em]
\text{Class } &q_{\texttt{TCACT}}:\ q_{\texttt{TCACT}} \\[0.5em]
\text{Class } &q_{\texttt{TCAGA}}:\ q_{\texttt{TCAGA}} \\[0.5em]
\text{Class } &q_{\texttt{TCATC}}:\ q_{\texttt{TCATC}} \\[0.5em]
\text{Class } &q_{\texttt{TCCAT}}:\ q_{\texttt{TCCAT}} \\[0.5em]
\text{Class } &q_{\texttt{TCCCG}}:\ q_{\texttt{TCCCG}} \\[0.5em]
\text{Class } &q_{\texttt{TCCGC}}:\ q_{\texttt{TCCGC}} \\[0.5em]
\text{Class } &q_{\texttt{TCCTA}}:\ q_{\texttt{TCCTA}} \\[0.5em]
\text{Class } &q_{\texttt{TCGAA}}:\ q_{\texttt{TCGAA}} \\[0.5em]
\text{Class } &q_{\texttt{TCGCC}}:\ q_{\texttt{TCGCC}} \\[0.5em]
\text{Class } &q_{\texttt{TCGGG}}:\ q_{\texttt{TCGGG}} \\[0.5em]
\text{Class } &q_{\texttt{TCGTT}}:\ q_{\texttt{TCGTT}} \\[0.5em]
\text{Class } &q_{\texttt{TCTAC}}:\ q_{\texttt{TCTAC}} \\[0.5em]
\text{Class } &q_{\texttt{TCTCA}}:\ q_{\texttt{TCTCA}} \\[0.5em]
\text{Class } &q_{\texttt{TCTGT}}:\ q_{\texttt{TCTGT}} \\[0.5em]
\text{Class } &q_{\texttt{TCTTG}}:\ q_{\texttt{TCTTG}} \\[0.5em]
\text{Class } &q_{\texttt{TGAAC}}:\ q_{\texttt{TGAAC}} \\[0.5em]
\text{Class } &q_{\texttt{TGACA}}:\ q_{\texttt{TGACA}} \\[0.5em]
\text{Class } &q_{\texttt{TGAGT}}:\ q_{\texttt{TGAGT}} \\[0.5em]
\text{Class } &q_{\texttt{TGATG}}:\ q_{\texttt{TGATG}} \\[0.5em]
\text{Class } &q_{\texttt{TGCAA}}:\ q_{\texttt{TGCAA}} \\[0.5em]
\text{Class } &q_{\texttt{TGCCC}}:\ q_{\texttt{TGCCC}} \\[0.5em]
\text{Class } &q_{\texttt{TGCGG}}:\ q_{\texttt{TGCGG}} \\[0.5em]
\text{Class } &q_{\texttt{TGCTT}}:\ q_{\texttt{TGCTT}} \\[0.5em]
\text{Class } &q_{\texttt{TGGAT}}:\ q_{\texttt{TGGAT}} \\[0.5em]
\text{Class } &q_{\texttt{TGGCG}}:\ q_{\texttt{TGGCG}} \\[0.5em]
\text{Class } &q_{\texttt{TGGGC}}:\ q_{\texttt{TGGGC}} \\[0.5em]
\text{Class } &q_{\texttt{TGGTA}}:\ q_{\texttt{TGGTA}} \\[0.5em]
\text{Class } &q_{\texttt{TGTAG}}:\ q_{\texttt{TGTAG}} \\[0.5em]
\text{Class } &q_{\texttt{TGTCT}}:\ q_{\texttt{TGTCT}} \\[0.5em]
\text{Class } &q_{\texttt{TGTGA}}:\ q_{\texttt{TGTGA}} \\[0.5em]
\text{Class } &q_{\texttt{TGTTC}}:\ q_{\texttt{TGTTC}} \\[0.5em]
\text{Class } &q_{\texttt{TTAAA}}:\ q_{\texttt{TTAAA}} \\[0.5em]
\text{Class } &q_{\texttt{TTACC}}:\ q_{\texttt{TTACC}} \\[0.5em]
\text{Class } &q_{\texttt{TTAGG}}:\ q_{\texttt{TTAGG}} \\[0.5em]
\text{Class } &q_{\texttt{TTATT}}:\ q_{\texttt{TTATT}} \\[0.5em]
\text{Class } &q_{\texttt{TTCAC}}:\ q_{\texttt{TTCAC}} \\[0.5em]
\text{Class } &q_{\texttt{TTCCA}}:\ q_{\texttt{TTCCA}} \\[0.5em]
\text{Class } &q_{\texttt{TTCGT}}:\ q_{\texttt{TTCGT}} \\[0.5em]
\text{Class } &q_{\texttt{TTCTG}}:\ q_{\texttt{TTCTG}} \\[0.5em]
\text{Class } &q_{\texttt{TTGAG}}:\ q_{\texttt{TTGAG}} \\[0.5em]
\text{Class } &q_{\texttt{TTGCT}}:\ q_{\texttt{TTGCT}} \\[0.5em]
\text{Class } &q_{\texttt{TTGGA}}:\ q_{\texttt{TTGGA}} \\[0.5em]
\text{Class } &q_{\texttt{TTGTC}}:\ q_{\texttt{TTGTC}} \\[0.5em]
\text{Class } &q_{\texttt{TTTAT}}:\ q_{\texttt{TTTAT}} \\[0.5em]
\text{Class } &q_{\texttt{TTTCG}}:\ q_{\texttt{TTTCG}} \\[0.5em]
\text{Class } &q_{\texttt{TTTGC}}:\ q_{\texttt{TTTGC}} \\[0.5em]
\text{Class } &q_{\texttt{TTTTA}}:\ q_{\texttt{TTTTA}}
\end{align}$
Phylogenetic invariants
Minimal generating set of the vanishing ideal
Ideal not computed
Gröbner basis of the vanishing ideal
Gröbner basis not computed
Additional information
Cardinality of the smallest set of generators for the ideal
-
Cardinality of the degree reverse lexicographic reduced Gröbner basis
-
Largest degree in a minimal generating set for the ideal
-
Largest degree of a generator in the reduced Gröbner basis
-
Linear coordinate transformations
Probability $\to$ Fourier
This expression is too large to render. Here is the raw LaTeX:
$\begin{align}
q_{\texttt{TTTTA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTTGC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTTCG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTTAT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTGTC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTGGA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTGCT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTGAG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTCTG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTCGT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTCCA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTCAC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTATT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTAGG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTACC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TTAAA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGTTC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGTGA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGTCT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGTAG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGGTA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGGGC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGGCG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGGAT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGCTT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGCGG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGCCC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGCAA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGATG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGAGT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGACA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TGAAC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCTTG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCTGT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCTCA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCTAC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCGTT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCGGG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCGCC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCGAA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCCTA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCCGC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCCCG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCCAT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCATC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCAGA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCACT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TCAAG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TATTT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TATGG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TATCC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TATAA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TAGTG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TAGGT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TAGCA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TAGAC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TACTC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TACGA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TACCT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TACAG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TAATA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TAAGC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TAACG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{TAAAT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTTTC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTTGA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTTCT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTTAG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTGTA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTGGC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTGCG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTGAT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTCTT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTCGG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTCCC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTCAA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTATG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTAGT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTACA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GTAAC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGTTA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGTGC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGTCG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGTAT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGGTC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGGGA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGGCT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGGAG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGCTG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGCGT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGCCA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGCAC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGATT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGAGG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGACC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GGAAA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCTTT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCTGG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCTCC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCTAA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCGTG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCGGT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCGCA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCGAC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCCTC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCCGA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCCCT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCCAG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCATA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCAGC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCACG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GCAAT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GATTG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GATGT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GATCA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GATAC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GAGTT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GAGGG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GAGCC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GAGAA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GACTA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GACGC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GACCG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GACAT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GAATC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GAAGA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GAACT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{GAAAG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} - p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTTTG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTTGT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTTCA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTTAC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTGTT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTGGG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTGCC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTGAA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTCTA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTCGC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTCCG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTCAT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTATC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTAGA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTACT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CTAAG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGTTT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGTGG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGTCC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGTAA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGGTG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGGGT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGGCA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGGAC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGCTC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGCGA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGCCT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGCAG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGATA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGAGC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGACG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CGAAT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCTTA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCTGC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCTCG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCTAT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCGTC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCGGA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCGCT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCGAG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCCTG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCCGT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCCCA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCCAC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCATT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCAGG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCACC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CCAAA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CATTC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CATGA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CATCT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CATAG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CAGTA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CAGGC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CAGCG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CAGAT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CACTT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CACGG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CACCC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CACAA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CAATG}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CAAGT}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CAACA}} &= -p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{CAAAC}} &= -p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} - p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATTTT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATTGG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATTCC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATTAA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATGTG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATGGT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATGCA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATGAC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATCTC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATCGA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATCCT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATCAG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATATA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATAGC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATACG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ATAAT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGTTG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGTGT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGTCA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGTAC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGGTT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGGGG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGGCC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGGAA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGCTA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGCGC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGCCG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGCAT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGATC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGAGA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGACT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AGAAG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} - p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} - p_{\texttt{AGAAA}} - p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} - p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACTTC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACTGA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACTCT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACTAG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACGTA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACGGC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACGCG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACGAT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACCTT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACCGG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACCCC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACCAA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACATG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACAGT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACACA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} - p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{ACAAC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} - p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} - p_{\texttt{ATAAA}} - p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} - p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} - p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} - p_{\texttt{ACAAA}} - p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} - p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AATTA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AATGC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AATCG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AATAT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AAGTC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AAGGA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AAGCT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} - p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AAGAG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} - p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} - p_{\texttt{ATGAA}} - p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} - p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} - p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} - p_{\texttt{AGGAA}} - p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} - p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} - p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} - p_{\texttt{ACGAA}} - p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} - p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} - p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} - p_{\texttt{AAGAA}} - p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} - p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AACTG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AACGT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AACCA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} - p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} - p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} - p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} - p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} - p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} - p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AACAC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} - p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} - p_{\texttt{ATTAA}} - p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} - p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} - p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} - p_{\texttt{ATCAA}} - p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} - p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} - p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} - p_{\texttt{AGTAA}} - p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} - p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} - p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} - p_{\texttt{AGCAA}} - p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} - p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} - p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} - p_{\texttt{ACTAA}} - p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} - p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} - p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} - p_{\texttt{ACCAA}} - p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} - p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} - p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} - p_{\texttt{AATAA}} - p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} - p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} - p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} - p_{\texttt{AACAA}} - p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} - p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AAATT}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} - p_{\texttt{ATATC}} + p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} - p_{\texttt{AGATC}} + p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} - p_{\texttt{ACATC}} + p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} - p_{\texttt{AATTC}} + p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} + p_{\texttt{AATAT}} - p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} - p_{\texttt{AACTC}} + p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} + p_{\texttt{AACAT}} - p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} - p_{\texttt{AAATC}} + p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AAAGG}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} - p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} - p_{\texttt{ATTGA}} - p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} - p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} - p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} - p_{\texttt{ATGGA}} - p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} - p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} - p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} - p_{\texttt{ATCGA}} - p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} - p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} - p_{\texttt{ATATC}} - p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} - p_{\texttt{ATAGA}} - p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} - p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} - p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} - p_{\texttt{AGTGA}} - p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} - p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} - p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} - p_{\texttt{AGGGA}} - p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} - p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} - p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} - p_{\texttt{AGCGA}} - p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} - p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} - p_{\texttt{AGATC}} - p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} - p_{\texttt{AGAGA}} - p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} - p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} - p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} - p_{\texttt{ACTGA}} - p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} - p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} - p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} - p_{\texttt{ACGGA}} - p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} - p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} - p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} - p_{\texttt{ACCGA}} - p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} - p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} - p_{\texttt{ACATC}} - p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} - p_{\texttt{ACAGA}} - p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} - p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} - p_{\texttt{AATTC}} - p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} - p_{\texttt{AATGA}} - p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} - p_{\texttt{AATAT}} - p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} - p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} - p_{\texttt{AAGGA}} - p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} - p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} - p_{\texttt{AACTC}} - p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} - p_{\texttt{AACGA}} - p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} - p_{\texttt{AACAT}} - p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} - p_{\texttt{AAATC}} - p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} - p_{\texttt{AAAGA}} - p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} - p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AAACC}} &= p_{\texttt{ATTTT}} - p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} - p_{\texttt{ATTTA}} - p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} - p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} - p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} - p_{\texttt{ATTCA}} - p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} - p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} - p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} - p_{\texttt{ATGTA}} - p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} - p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} - p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} - p_{\texttt{ATGCA}} - p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} - p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} - p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} - p_{\texttt{ATCTA}} - p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} - p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} - p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} - p_{\texttt{ATCCA}} - p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} - p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} - p_{\texttt{ATATG}} + p_{\texttt{ATATC}} - p_{\texttt{ATATA}} - p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} - p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} - p_{\texttt{ATACG}} + p_{\texttt{ATACC}} - p_{\texttt{ATACA}} - p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} - p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} - p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} - p_{\texttt{AGTTA}} - p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} - p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} - p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} - p_{\texttt{AGTCA}} - p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} - p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} - p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} - p_{\texttt{AGGTA}} - p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} - p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} - p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} - p_{\texttt{AGGCA}} - p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} - p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} - p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} - p_{\texttt{AGCTA}} - p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} - p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} - p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} - p_{\texttt{AGCCA}} - p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} - p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} - p_{\texttt{AGATG}} + p_{\texttt{AGATC}} - p_{\texttt{AGATA}} - p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} - p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} - p_{\texttt{AGACG}} + p_{\texttt{AGACC}} - p_{\texttt{AGACA}} - p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} - p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} - p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} - p_{\texttt{ACTTA}} - p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} - p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} - p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} - p_{\texttt{ACTCA}} - p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} - p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} - p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} - p_{\texttt{ACGTA}} - p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} - p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} - p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} - p_{\texttt{ACGCA}} - p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} - p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} - p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} - p_{\texttt{ACCTA}} - p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} - p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} - p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} - p_{\texttt{ACCCA}} - p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} - p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} - p_{\texttt{ACATG}} + p_{\texttt{ACATC}} - p_{\texttt{ACATA}} - p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} - p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} - p_{\texttt{ACACG}} + p_{\texttt{ACACC}} - p_{\texttt{ACACA}} - p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} - p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} - p_{\texttt{AATTG}} + p_{\texttt{AATTC}} - p_{\texttt{AATTA}} - p_{\texttt{AATGT}} + p_{\texttt{AATGG}} - p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} - p_{\texttt{AATCG}} + p_{\texttt{AATCC}} - p_{\texttt{AATCA}} - p_{\texttt{AATAT}} + p_{\texttt{AATAG}} - p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} - p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} - p_{\texttt{AAGTA}} - p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} - p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} - p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} - p_{\texttt{AAGCA}} - p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} - p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} - p_{\texttt{AACTG}} + p_{\texttt{AACTC}} - p_{\texttt{AACTA}} - p_{\texttt{AACGT}} + p_{\texttt{AACGG}} - p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} - p_{\texttt{AACCG}} + p_{\texttt{AACCC}} - p_{\texttt{AACCA}} - p_{\texttt{AACAT}} + p_{\texttt{AACAG}} - p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} - p_{\texttt{AAATG}} + p_{\texttt{AAATC}} - p_{\texttt{AAATA}} - p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} - p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} - p_{\texttt{AAACG}} + p_{\texttt{AAACC}} - p_{\texttt{AAACA}} - p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} - p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}} \\[0.5em]
q_{\texttt{AAAAA}} &= p_{\texttt{ATTTT}} + p_{\texttt{ATTTG}} + p_{\texttt{ATTTC}} + p_{\texttt{ATTTA}} + p_{\texttt{ATTGT}} + p_{\texttt{ATTGG}} + p_{\texttt{ATTGC}} + p_{\texttt{ATTGA}} + p_{\texttt{ATTCT}} + p_{\texttt{ATTCG}} + p_{\texttt{ATTCC}} + p_{\texttt{ATTCA}} + p_{\texttt{ATTAT}} + p_{\texttt{ATTAG}} + p_{\texttt{ATTAC}} + p_{\texttt{ATTAA}} + p_{\texttt{ATGTT}} + p_{\texttt{ATGTG}} + p_{\texttt{ATGTC}} + p_{\texttt{ATGTA}} + p_{\texttt{ATGGT}} + p_{\texttt{ATGGG}} + p_{\texttt{ATGGC}} + p_{\texttt{ATGGA}} + p_{\texttt{ATGCT}} + p_{\texttt{ATGCG}} + p_{\texttt{ATGCC}} + p_{\texttt{ATGCA}} + p_{\texttt{ATGAT}} + p_{\texttt{ATGAG}} + p_{\texttt{ATGAC}} + p_{\texttt{ATGAA}} + p_{\texttt{ATCTT}} + p_{\texttt{ATCTG}} + p_{\texttt{ATCTC}} + p_{\texttt{ATCTA}} + p_{\texttt{ATCGT}} + p_{\texttt{ATCGG}} + p_{\texttt{ATCGC}} + p_{\texttt{ATCGA}} + p_{\texttt{ATCCT}} + p_{\texttt{ATCCG}} + p_{\texttt{ATCCC}} + p_{\texttt{ATCCA}} + p_{\texttt{ATCAT}} + p_{\texttt{ATCAG}} + p_{\texttt{ATCAC}} + p_{\texttt{ATCAA}} + p_{\texttt{ATATT}} + p_{\texttt{ATATG}} + p_{\texttt{ATATC}} + p_{\texttt{ATATA}} + p_{\texttt{ATAGT}} + p_{\texttt{ATAGG}} + p_{\texttt{ATAGC}} + p_{\texttt{ATAGA}} + p_{\texttt{ATACT}} + p_{\texttt{ATACG}} + p_{\texttt{ATACC}} + p_{\texttt{ATACA}} + p_{\texttt{ATAAT}} + p_{\texttt{ATAAG}} + p_{\texttt{ATAAC}} + p_{\texttt{ATAAA}} + p_{\texttt{AGTTT}} + p_{\texttt{AGTTG}} + p_{\texttt{AGTTC}} + p_{\texttt{AGTTA}} + p_{\texttt{AGTGT}} + p_{\texttt{AGTGG}} + p_{\texttt{AGTGC}} + p_{\texttt{AGTGA}} + p_{\texttt{AGTCT}} + p_{\texttt{AGTCG}} + p_{\texttt{AGTCC}} + p_{\texttt{AGTCA}} + p_{\texttt{AGTAT}} + p_{\texttt{AGTAG}} + p_{\texttt{AGTAC}} + p_{\texttt{AGTAA}} + p_{\texttt{AGGTT}} + p_{\texttt{AGGTG}} + p_{\texttt{AGGTC}} + p_{\texttt{AGGTA}} + p_{\texttt{AGGGT}} + p_{\texttt{AGGGG}} + p_{\texttt{AGGGC}} + p_{\texttt{AGGGA}} + p_{\texttt{AGGCT}} + p_{\texttt{AGGCG}} + p_{\texttt{AGGCC}} + p_{\texttt{AGGCA}} + p_{\texttt{AGGAT}} + p_{\texttt{AGGAG}} + p_{\texttt{AGGAC}} + p_{\texttt{AGGAA}} + p_{\texttt{AGCTT}} + p_{\texttt{AGCTG}} + p_{\texttt{AGCTC}} + p_{\texttt{AGCTA}} + p_{\texttt{AGCGT}} + p_{\texttt{AGCGG}} + p_{\texttt{AGCGC}} + p_{\texttt{AGCGA}} + p_{\texttt{AGCCT}} + p_{\texttt{AGCCG}} + p_{\texttt{AGCCC}} + p_{\texttt{AGCCA}} + p_{\texttt{AGCAT}} + p_{\texttt{AGCAG}} + p_{\texttt{AGCAC}} + p_{\texttt{AGCAA}} + p_{\texttt{AGATT}} + p_{\texttt{AGATG}} + p_{\texttt{AGATC}} + p_{\texttt{AGATA}} + p_{\texttt{AGAGT}} + p_{\texttt{AGAGG}} + p_{\texttt{AGAGC}} + p_{\texttt{AGAGA}} + p_{\texttt{AGACT}} + p_{\texttt{AGACG}} + p_{\texttt{AGACC}} + p_{\texttt{AGACA}} + p_{\texttt{AGAAT}} + p_{\texttt{AGAAG}} + p_{\texttt{AGAAC}} + p_{\texttt{AGAAA}} + p_{\texttt{ACTTT}} + p_{\texttt{ACTTG}} + p_{\texttt{ACTTC}} + p_{\texttt{ACTTA}} + p_{\texttt{ACTGT}} + p_{\texttt{ACTGG}} + p_{\texttt{ACTGC}} + p_{\texttt{ACTGA}} + p_{\texttt{ACTCT}} + p_{\texttt{ACTCG}} + p_{\texttt{ACTCC}} + p_{\texttt{ACTCA}} + p_{\texttt{ACTAT}} + p_{\texttt{ACTAG}} + p_{\texttt{ACTAC}} + p_{\texttt{ACTAA}} + p_{\texttt{ACGTT}} + p_{\texttt{ACGTG}} + p_{\texttt{ACGTC}} + p_{\texttt{ACGTA}} + p_{\texttt{ACGGT}} + p_{\texttt{ACGGG}} + p_{\texttt{ACGGC}} + p_{\texttt{ACGGA}} + p_{\texttt{ACGCT}} + p_{\texttt{ACGCG}} + p_{\texttt{ACGCC}} + p_{\texttt{ACGCA}} + p_{\texttt{ACGAT}} + p_{\texttt{ACGAG}} + p_{\texttt{ACGAC}} + p_{\texttt{ACGAA}} + p_{\texttt{ACCTT}} + p_{\texttt{ACCTG}} + p_{\texttt{ACCTC}} + p_{\texttt{ACCTA}} + p_{\texttt{ACCGT}} + p_{\texttt{ACCGG}} + p_{\texttt{ACCGC}} + p_{\texttt{ACCGA}} + p_{\texttt{ACCCT}} + p_{\texttt{ACCCG}} + p_{\texttt{ACCCC}} + p_{\texttt{ACCCA}} + p_{\texttt{ACCAT}} + p_{\texttt{ACCAG}} + p_{\texttt{ACCAC}} + p_{\texttt{ACCAA}} + p_{\texttt{ACATT}} + p_{\texttt{ACATG}} + p_{\texttt{ACATC}} + p_{\texttt{ACATA}} + p_{\texttt{ACAGT}} + p_{\texttt{ACAGG}} + p_{\texttt{ACAGC}} + p_{\texttt{ACAGA}} + p_{\texttt{ACACT}} + p_{\texttt{ACACG}} + p_{\texttt{ACACC}} + p_{\texttt{ACACA}} + p_{\texttt{ACAAT}} + p_{\texttt{ACAAG}} + p_{\texttt{ACAAC}} + p_{\texttt{ACAAA}} + p_{\texttt{AATTT}} + p_{\texttt{AATTG}} + p_{\texttt{AATTC}} + p_{\texttt{AATTA}} + p_{\texttt{AATGT}} + p_{\texttt{AATGG}} + p_{\texttt{AATGC}} + p_{\texttt{AATGA}} + p_{\texttt{AATCT}} + p_{\texttt{AATCG}} + p_{\texttt{AATCC}} + p_{\texttt{AATCA}} + p_{\texttt{AATAT}} + p_{\texttt{AATAG}} + p_{\texttt{AATAC}} + p_{\texttt{AATAA}} + p_{\texttt{AAGTT}} + p_{\texttt{AAGTG}} + p_{\texttt{AAGTC}} + p_{\texttt{AAGTA}} + p_{\texttt{AAGGT}} + p_{\texttt{AAGGG}} + p_{\texttt{AAGGC}} + p_{\texttt{AAGGA}} + p_{\texttt{AAGCT}} + p_{\texttt{AAGCG}} + p_{\texttt{AAGCC}} + p_{\texttt{AAGCA}} + p_{\texttt{AAGAT}} + p_{\texttt{AAGAG}} + p_{\texttt{AAGAC}} + p_{\texttt{AAGAA}} + p_{\texttt{AACTT}} + p_{\texttt{AACTG}} + p_{\texttt{AACTC}} + p_{\texttt{AACTA}} + p_{\texttt{AACGT}} + p_{\texttt{AACGG}} + p_{\texttt{AACGC}} + p_{\texttt{AACGA}} + p_{\texttt{AACCT}} + p_{\texttt{AACCG}} + p_{\texttt{AACCC}} + p_{\texttt{AACCA}} + p_{\texttt{AACAT}} + p_{\texttt{AACAG}} + p_{\texttt{AACAC}} + p_{\texttt{AACAA}} + p_{\texttt{AAATT}} + p_{\texttt{AAATG}} + p_{\texttt{AAATC}} + p_{\texttt{AAATA}} + p_{\texttt{AAAGT}} + p_{\texttt{AAAGG}} + p_{\texttt{AAAGC}} + p_{\texttt{AAAGA}} + p_{\texttt{AAACT}} + p_{\texttt{AAACG}} + p_{\texttt{AAACC}} + p_{\texttt{AAACA}} + p_{\texttt{AAAAT}} + p_{\texttt{AAAAG}} + p_{\texttt{AAAAC}} + p_{\texttt{AAAAA}}
\end{align}$
Fourier $\to$ Probability
This expression is too large to render. Here is the raw LaTeX:
$\begin{align}
p_{\texttt{ATTTT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTTG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTTC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTTA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTGT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTGG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTGC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTGA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTCT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTCG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTCC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTCA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTAT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTAG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTAC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATTAA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGTT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGTG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGTC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGTA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGGT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGGG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGGC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGGA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGCT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGCG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGCC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGCA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGAT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGAG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGAC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATGAA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCTT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCTG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCTC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCTA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCGT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCGG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCGC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCGA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCCT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCCG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCCC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCCA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCAT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCAG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCAC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATCAA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATATT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATATG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATATC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATATA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATAGT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATAGG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATAGC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATAGA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATACT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATACG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATACC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATACA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATAAT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATAAG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATAAC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ATAAA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTTT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTTG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTTC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTTA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTGT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTGG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTGC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTGA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTCT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTCG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTCC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTCA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTAT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTAG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTAC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGTAA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGTT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGTG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGTC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGTA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGGT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGGG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGGC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGGA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGCT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGCG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGCC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGCA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGAT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGAG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGAC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGGAA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCTT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCTG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCTC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCTA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCGT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCGG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCGC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCGA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCCT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCCG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCCC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCCA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCAT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCAG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCAC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGCAA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGATT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGATG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGATC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGATA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGAGT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGAGG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGAGC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGAGA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGACT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGACG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGACC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGACA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGAAT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGAAG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGAAC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AGAAA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} - \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTTT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTTG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTTC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTTA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTGT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTGG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTGC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTGA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTCT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTCG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTCC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTCA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTAT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTAG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTAC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACTAA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGTT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGTG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGTC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGTA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGGT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGGG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGGC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGGA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGCT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGCG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGCC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGCA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGAT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGAG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGAC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACGAA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCTT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCTG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCTC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCTA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCGT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCGG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCGC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCGA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCCT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCCG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCCC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCCA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCAT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCAG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCAC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACCAA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACATT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACATG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACATC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACATA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACAGT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACAGG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACAGC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACAGA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACACT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACACG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACACC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACACA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACAAT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACAAG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACAAC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{ACAAA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} - \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} - \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATTT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATTG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATTC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATTA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATGT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATGG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATGC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATGA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATCT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATCG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATCC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATCA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATAT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATAG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATAC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AATAA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGTT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGTG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGTC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGTA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGGT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGGG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGGC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGGA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGCT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGCG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGCC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGCA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGAT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGAG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGAC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAGAA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} - \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} - \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} - \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} - \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACTT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACTG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACTC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACTA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACGT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACGG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACGC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACGA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACCT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACCG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACCC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACCA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACAT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACAG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACAC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AACAA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} - \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} - \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} - \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} - \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} - \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} - \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} - \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} - \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAATT}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAATG}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAATC}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAATA}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAAGT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAAGG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAAGC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAAGA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} - \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} - \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} - \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} - \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} - \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} - \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} - \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} - \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} - \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} - \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} - \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} - \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} - \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} - \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} - \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} - \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAACT}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAACG}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAACC}} &= -\frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAACA}} &= -\frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} - \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} - \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} - \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} - \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} - \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} - \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} - \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} - \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} - \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} - \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} - \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} - \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} - \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} - \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} - \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} - \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} - \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} - \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} - \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} - \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} - \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} - \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} - \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} - \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} - \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} - \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} - \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} - \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} - \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} - \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} - \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAAAT}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAAAG}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} - \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} - \frac{1}{256}q_{\texttt{TTGAG}} - \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} - \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} - \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} - \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} - \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} - \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} - \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} - \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} - \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} - \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} - \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} - \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} - \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} - \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} - \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} - \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} - \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} - \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} - \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} - \frac{1}{256}q_{\texttt{GGGAG}} - \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} - \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} - \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} - \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} - \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} - \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} - \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} - \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} - \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} - \frac{1}{256}q_{\texttt{GAAAG}} - \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} - \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} - \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} - \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} - \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} - \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} - \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} - \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} - \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} - \frac{1}{256}q_{\texttt{CCGAG}} - \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} - \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} - \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} - \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} - \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} - \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} - \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} - \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} - \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} - \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} - \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} - \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} - \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} - \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} - \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} - \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} - \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} - \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} - \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} - \frac{1}{256}q_{\texttt{AAGAG}} - \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} - \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAAAC}} &= \frac{1}{256}q_{\texttt{TTTTA}} - \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} - \frac{1}{256}q_{\texttt{TTTAT}} - \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} - \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} - \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} - \frac{1}{256}q_{\texttt{TTCAC}} - \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} - \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} - \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} - \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} - \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} - \frac{1}{256}q_{\texttt{TGGAT}} - \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} - \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} - \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} - \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} - \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} - \frac{1}{256}q_{\texttt{TCTAC}} - \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} - \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} - \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} - \frac{1}{256}q_{\texttt{TCCAT}} - \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} - \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} - \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} - \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} - \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} - \frac{1}{256}q_{\texttt{TAGAC}} - \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} - \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} - \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} - \frac{1}{256}q_{\texttt{TAAAT}} - \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} - \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} - \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} - \frac{1}{256}q_{\texttt{GTGAT}} - \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} - \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} - \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} - \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} - \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} - \frac{1}{256}q_{\texttt{GGTAT}} - \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} - \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} - \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} - \frac{1}{256}q_{\texttt{GGCAC}} - \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} - \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} - \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} - \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} - \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} - \frac{1}{256}q_{\texttt{GCGAC}} - \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} - \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} - \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} - \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} - \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} - \frac{1}{256}q_{\texttt{GATAC}} - \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} - \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} - \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} - \frac{1}{256}q_{\texttt{GACAT}} - \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} - \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} - \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} - \frac{1}{256}q_{\texttt{CTTAC}} - \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} - \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} - \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} - \frac{1}{256}q_{\texttt{CTCAT}} - \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} - \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} - \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} - \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} - \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} - \frac{1}{256}q_{\texttt{CGGAC}} - \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} - \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} - \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} - \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} - \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} - \frac{1}{256}q_{\texttt{CCTAT}} - \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} - \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} - \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} - \frac{1}{256}q_{\texttt{CCCAC}} - \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} - \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} - \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} - \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} - \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} - \frac{1}{256}q_{\texttt{CAGAT}} - \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} - \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} - \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} - \frac{1}{256}q_{\texttt{CAAAC}} - \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} - \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} - \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} - \frac{1}{256}q_{\texttt{ATGAC}} - \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} - \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} - \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} - \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} - \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} - \frac{1}{256}q_{\texttt{AGTAC}} - \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} - \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} - \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} - \frac{1}{256}q_{\texttt{AGCAT}} - \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} - \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} - \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} - \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} - \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} - \frac{1}{256}q_{\texttt{ACGAT}} - \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} - \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} - \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} - \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} - \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} - \frac{1}{256}q_{\texttt{AATAT}} - \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} - \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} - \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} - \frac{1}{256}q_{\texttt{AACAC}} - \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} - \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}} \\[0.5em]
p_{\texttt{AAAAA}} &= \frac{1}{256}q_{\texttt{TTTTA}} + \frac{1}{256}q_{\texttt{TTTGC}} + \frac{1}{256}q_{\texttt{TTTCG}} + \frac{1}{256}q_{\texttt{TTTAT}} + \frac{1}{256}q_{\texttt{TTGTC}} + \frac{1}{256}q_{\texttt{TTGGA}} + \frac{1}{256}q_{\texttt{TTGCT}} + \frac{1}{256}q_{\texttt{TTGAG}} + \frac{1}{256}q_{\texttt{TTCTG}} + \frac{1}{256}q_{\texttt{TTCGT}} + \frac{1}{256}q_{\texttt{TTCCA}} + \frac{1}{256}q_{\texttt{TTCAC}} + \frac{1}{256}q_{\texttt{TTATT}} + \frac{1}{256}q_{\texttt{TTAGG}} + \frac{1}{256}q_{\texttt{TTACC}} + \frac{1}{256}q_{\texttt{TTAAA}} + \frac{1}{256}q_{\texttt{TGTTC}} + \frac{1}{256}q_{\texttt{TGTGA}} + \frac{1}{256}q_{\texttt{TGTCT}} + \frac{1}{256}q_{\texttt{TGTAG}} + \frac{1}{256}q_{\texttt{TGGTA}} + \frac{1}{256}q_{\texttt{TGGGC}} + \frac{1}{256}q_{\texttt{TGGCG}} + \frac{1}{256}q_{\texttt{TGGAT}} + \frac{1}{256}q_{\texttt{TGCTT}} + \frac{1}{256}q_{\texttt{TGCGG}} + \frac{1}{256}q_{\texttt{TGCCC}} + \frac{1}{256}q_{\texttt{TGCAA}} + \frac{1}{256}q_{\texttt{TGATG}} + \frac{1}{256}q_{\texttt{TGAGT}} + \frac{1}{256}q_{\texttt{TGACA}} + \frac{1}{256}q_{\texttt{TGAAC}} + \frac{1}{256}q_{\texttt{TCTTG}} + \frac{1}{256}q_{\texttt{TCTGT}} + \frac{1}{256}q_{\texttt{TCTCA}} + \frac{1}{256}q_{\texttt{TCTAC}} + \frac{1}{256}q_{\texttt{TCGTT}} + \frac{1}{256}q_{\texttt{TCGGG}} + \frac{1}{256}q_{\texttt{TCGCC}} + \frac{1}{256}q_{\texttt{TCGAA}} + \frac{1}{256}q_{\texttt{TCCTA}} + \frac{1}{256}q_{\texttt{TCCGC}} + \frac{1}{256}q_{\texttt{TCCCG}} + \frac{1}{256}q_{\texttt{TCCAT}} + \frac{1}{256}q_{\texttt{TCATC}} + \frac{1}{256}q_{\texttt{TCAGA}} + \frac{1}{256}q_{\texttt{TCACT}} + \frac{1}{256}q_{\texttt{TCAAG}} + \frac{1}{256}q_{\texttt{TATTT}} + \frac{1}{256}q_{\texttt{TATGG}} + \frac{1}{256}q_{\texttt{TATCC}} + \frac{1}{256}q_{\texttt{TATAA}} + \frac{1}{256}q_{\texttt{TAGTG}} + \frac{1}{256}q_{\texttt{TAGGT}} + \frac{1}{256}q_{\texttt{TAGCA}} + \frac{1}{256}q_{\texttt{TAGAC}} + \frac{1}{256}q_{\texttt{TACTC}} + \frac{1}{256}q_{\texttt{TACGA}} + \frac{1}{256}q_{\texttt{TACCT}} + \frac{1}{256}q_{\texttt{TACAG}} + \frac{1}{256}q_{\texttt{TAATA}} + \frac{1}{256}q_{\texttt{TAAGC}} + \frac{1}{256}q_{\texttt{TAACG}} + \frac{1}{256}q_{\texttt{TAAAT}} + \frac{1}{256}q_{\texttt{GTTTC}} + \frac{1}{256}q_{\texttt{GTTGA}} + \frac{1}{256}q_{\texttt{GTTCT}} + \frac{1}{256}q_{\texttt{GTTAG}} + \frac{1}{256}q_{\texttt{GTGTA}} + \frac{1}{256}q_{\texttt{GTGGC}} + \frac{1}{256}q_{\texttt{GTGCG}} + \frac{1}{256}q_{\texttt{GTGAT}} + \frac{1}{256}q_{\texttt{GTCTT}} + \frac{1}{256}q_{\texttt{GTCGG}} + \frac{1}{256}q_{\texttt{GTCCC}} + \frac{1}{256}q_{\texttt{GTCAA}} + \frac{1}{256}q_{\texttt{GTATG}} + \frac{1}{256}q_{\texttt{GTAGT}} + \frac{1}{256}q_{\texttt{GTACA}} + \frac{1}{256}q_{\texttt{GTAAC}} + \frac{1}{256}q_{\texttt{GGTTA}} + \frac{1}{256}q_{\texttt{GGTGC}} + \frac{1}{256}q_{\texttt{GGTCG}} + \frac{1}{256}q_{\texttt{GGTAT}} + \frac{1}{256}q_{\texttt{GGGTC}} + \frac{1}{256}q_{\texttt{GGGGA}} + \frac{1}{256}q_{\texttt{GGGCT}} + \frac{1}{256}q_{\texttt{GGGAG}} + \frac{1}{256}q_{\texttt{GGCTG}} + \frac{1}{256}q_{\texttt{GGCGT}} + \frac{1}{256}q_{\texttt{GGCCA}} + \frac{1}{256}q_{\texttt{GGCAC}} + \frac{1}{256}q_{\texttt{GGATT}} + \frac{1}{256}q_{\texttt{GGAGG}} + \frac{1}{256}q_{\texttt{GGACC}} + \frac{1}{256}q_{\texttt{GGAAA}} + \frac{1}{256}q_{\texttt{GCTTT}} + \frac{1}{256}q_{\texttt{GCTGG}} + \frac{1}{256}q_{\texttt{GCTCC}} + \frac{1}{256}q_{\texttt{GCTAA}} + \frac{1}{256}q_{\texttt{GCGTG}} + \frac{1}{256}q_{\texttt{GCGGT}} + \frac{1}{256}q_{\texttt{GCGCA}} + \frac{1}{256}q_{\texttt{GCGAC}} + \frac{1}{256}q_{\texttt{GCCTC}} + \frac{1}{256}q_{\texttt{GCCGA}} + \frac{1}{256}q_{\texttt{GCCCT}} + \frac{1}{256}q_{\texttt{GCCAG}} + \frac{1}{256}q_{\texttt{GCATA}} + \frac{1}{256}q_{\texttt{GCAGC}} + \frac{1}{256}q_{\texttt{GCACG}} + \frac{1}{256}q_{\texttt{GCAAT}} + \frac{1}{256}q_{\texttt{GATTG}} + \frac{1}{256}q_{\texttt{GATGT}} + \frac{1}{256}q_{\texttt{GATCA}} + \frac{1}{256}q_{\texttt{GATAC}} + \frac{1}{256}q_{\texttt{GAGTT}} + \frac{1}{256}q_{\texttt{GAGGG}} + \frac{1}{256}q_{\texttt{GAGCC}} + \frac{1}{256}q_{\texttt{GAGAA}} + \frac{1}{256}q_{\texttt{GACTA}} + \frac{1}{256}q_{\texttt{GACGC}} + \frac{1}{256}q_{\texttt{GACCG}} + \frac{1}{256}q_{\texttt{GACAT}} + \frac{1}{256}q_{\texttt{GAATC}} + \frac{1}{256}q_{\texttt{GAAGA}} + \frac{1}{256}q_{\texttt{GAACT}} + \frac{1}{256}q_{\texttt{GAAAG}} + \frac{1}{256}q_{\texttt{CTTTG}} + \frac{1}{256}q_{\texttt{CTTGT}} + \frac{1}{256}q_{\texttt{CTTCA}} + \frac{1}{256}q_{\texttt{CTTAC}} + \frac{1}{256}q_{\texttt{CTGTT}} + \frac{1}{256}q_{\texttt{CTGGG}} + \frac{1}{256}q_{\texttt{CTGCC}} + \frac{1}{256}q_{\texttt{CTGAA}} + \frac{1}{256}q_{\texttt{CTCTA}} + \frac{1}{256}q_{\texttt{CTCGC}} + \frac{1}{256}q_{\texttt{CTCCG}} + \frac{1}{256}q_{\texttt{CTCAT}} + \frac{1}{256}q_{\texttt{CTATC}} + \frac{1}{256}q_{\texttt{CTAGA}} + \frac{1}{256}q_{\texttt{CTACT}} + \frac{1}{256}q_{\texttt{CTAAG}} + \frac{1}{256}q_{\texttt{CGTTT}} + \frac{1}{256}q_{\texttt{CGTGG}} + \frac{1}{256}q_{\texttt{CGTCC}} + \frac{1}{256}q_{\texttt{CGTAA}} + \frac{1}{256}q_{\texttt{CGGTG}} + \frac{1}{256}q_{\texttt{CGGGT}} + \frac{1}{256}q_{\texttt{CGGCA}} + \frac{1}{256}q_{\texttt{CGGAC}} + \frac{1}{256}q_{\texttt{CGCTC}} + \frac{1}{256}q_{\texttt{CGCGA}} + \frac{1}{256}q_{\texttt{CGCCT}} + \frac{1}{256}q_{\texttt{CGCAG}} + \frac{1}{256}q_{\texttt{CGATA}} + \frac{1}{256}q_{\texttt{CGAGC}} + \frac{1}{256}q_{\texttt{CGACG}} + \frac{1}{256}q_{\texttt{CGAAT}} + \frac{1}{256}q_{\texttt{CCTTA}} + \frac{1}{256}q_{\texttt{CCTGC}} + \frac{1}{256}q_{\texttt{CCTCG}} + \frac{1}{256}q_{\texttt{CCTAT}} + \frac{1}{256}q_{\texttt{CCGTC}} + \frac{1}{256}q_{\texttt{CCGGA}} + \frac{1}{256}q_{\texttt{CCGCT}} + \frac{1}{256}q_{\texttt{CCGAG}} + \frac{1}{256}q_{\texttt{CCCTG}} + \frac{1}{256}q_{\texttt{CCCGT}} + \frac{1}{256}q_{\texttt{CCCCA}} + \frac{1}{256}q_{\texttt{CCCAC}} + \frac{1}{256}q_{\texttt{CCATT}} + \frac{1}{256}q_{\texttt{CCAGG}} + \frac{1}{256}q_{\texttt{CCACC}} + \frac{1}{256}q_{\texttt{CCAAA}} + \frac{1}{256}q_{\texttt{CATTC}} + \frac{1}{256}q_{\texttt{CATGA}} + \frac{1}{256}q_{\texttt{CATCT}} + \frac{1}{256}q_{\texttt{CATAG}} + \frac{1}{256}q_{\texttt{CAGTA}} + \frac{1}{256}q_{\texttt{CAGGC}} + \frac{1}{256}q_{\texttt{CAGCG}} + \frac{1}{256}q_{\texttt{CAGAT}} + \frac{1}{256}q_{\texttt{CACTT}} + \frac{1}{256}q_{\texttt{CACGG}} + \frac{1}{256}q_{\texttt{CACCC}} + \frac{1}{256}q_{\texttt{CACAA}} + \frac{1}{256}q_{\texttt{CAATG}} + \frac{1}{256}q_{\texttt{CAAGT}} + \frac{1}{256}q_{\texttt{CAACA}} + \frac{1}{256}q_{\texttt{CAAAC}} + \frac{1}{256}q_{\texttt{ATTTT}} + \frac{1}{256}q_{\texttt{ATTGG}} + \frac{1}{256}q_{\texttt{ATTCC}} + \frac{1}{256}q_{\texttt{ATTAA}} + \frac{1}{256}q_{\texttt{ATGTG}} + \frac{1}{256}q_{\texttt{ATGGT}} + \frac{1}{256}q_{\texttt{ATGCA}} + \frac{1}{256}q_{\texttt{ATGAC}} + \frac{1}{256}q_{\texttt{ATCTC}} + \frac{1}{256}q_{\texttt{ATCGA}} + \frac{1}{256}q_{\texttt{ATCCT}} + \frac{1}{256}q_{\texttt{ATCAG}} + \frac{1}{256}q_{\texttt{ATATA}} + \frac{1}{256}q_{\texttt{ATAGC}} + \frac{1}{256}q_{\texttt{ATACG}} + \frac{1}{256}q_{\texttt{ATAAT}} + \frac{1}{256}q_{\texttt{AGTTG}} + \frac{1}{256}q_{\texttt{AGTGT}} + \frac{1}{256}q_{\texttt{AGTCA}} + \frac{1}{256}q_{\texttt{AGTAC}} + \frac{1}{256}q_{\texttt{AGGTT}} + \frac{1}{256}q_{\texttt{AGGGG}} + \frac{1}{256}q_{\texttt{AGGCC}} + \frac{1}{256}q_{\texttt{AGGAA}} + \frac{1}{256}q_{\texttt{AGCTA}} + \frac{1}{256}q_{\texttt{AGCGC}} + \frac{1}{256}q_{\texttt{AGCCG}} + \frac{1}{256}q_{\texttt{AGCAT}} + \frac{1}{256}q_{\texttt{AGATC}} + \frac{1}{256}q_{\texttt{AGAGA}} + \frac{1}{256}q_{\texttt{AGACT}} + \frac{1}{256}q_{\texttt{AGAAG}} + \frac{1}{256}q_{\texttt{ACTTC}} + \frac{1}{256}q_{\texttt{ACTGA}} + \frac{1}{256}q_{\texttt{ACTCT}} + \frac{1}{256}q_{\texttt{ACTAG}} + \frac{1}{256}q_{\texttt{ACGTA}} + \frac{1}{256}q_{\texttt{ACGGC}} + \frac{1}{256}q_{\texttt{ACGCG}} + \frac{1}{256}q_{\texttt{ACGAT}} + \frac{1}{256}q_{\texttt{ACCTT}} + \frac{1}{256}q_{\texttt{ACCGG}} + \frac{1}{256}q_{\texttt{ACCCC}} + \frac{1}{256}q_{\texttt{ACCAA}} + \frac{1}{256}q_{\texttt{ACATG}} + \frac{1}{256}q_{\texttt{ACAGT}} + \frac{1}{256}q_{\texttt{ACACA}} + \frac{1}{256}q_{\texttt{ACAAC}} + \frac{1}{256}q_{\texttt{AATTA}} + \frac{1}{256}q_{\texttt{AATGC}} + \frac{1}{256}q_{\texttt{AATCG}} + \frac{1}{256}q_{\texttt{AATAT}} + \frac{1}{256}q_{\texttt{AAGTC}} + \frac{1}{256}q_{\texttt{AAGGA}} + \frac{1}{256}q_{\texttt{AAGCT}} + \frac{1}{256}q_{\texttt{AAGAG}} + \frac{1}{256}q_{\texttt{AACTG}} + \frac{1}{256}q_{\texttt{AACGT}} + \frac{1}{256}q_{\texttt{AACCA}} + \frac{1}{256}q_{\texttt{AACAC}} + \frac{1}{256}q_{\texttt{AAATT}} + \frac{1}{256}q_{\texttt{AAAGG}} + \frac{1}{256}q_{\texttt{AAACC}} + \frac{1}{256}q_{\texttt{AAAAA}}
\end{align}$